DE60317214D1 - Kristallines gamma-lacton der17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carbonsäure - Google Patents
Kristallines gamma-lacton der17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carbonsäureInfo
- Publication number
- DE60317214D1 DE60317214D1 DE60317214T DE60317214T DE60317214D1 DE 60317214 D1 DE60317214 D1 DE 60317214D1 DE 60317214 T DE60317214 T DE 60317214T DE 60317214 T DE60317214 T DE 60317214T DE 60317214 D1 DE60317214 D1 DE 60317214D1
- Authority
- DE
- Germany
- Prior art keywords
- 7alpha
- der17beta
- lacton
- pregna
- furyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical compound C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 abstract 1
- 229960001208 eplerenone Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41187402P | 2002-09-19 | 2002-09-19 | |
| US411874P | 2002-09-19 | ||
| US42559602P | 2002-11-12 | 2002-11-12 | |
| US425596P | 2002-11-12 | ||
| US392833 | 2003-03-21 | ||
| US10/392,833 US7235655B2 (en) | 2002-03-22 | 2003-03-21 | Processes to prepare eplerenone |
| PCT/US2003/029923 WO2004037844A1 (en) | 2002-09-19 | 2003-09-19 | Crystalline 17beta-hydroxy-7alpha- (5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma-lactone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60317214D1 true DE60317214D1 (de) | 2007-12-13 |
| DE60317214T2 DE60317214T2 (de) | 2008-08-07 |
Family
ID=32180478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60317214T Expired - Fee Related DE60317214T2 (de) | 2002-09-19 | 2003-09-19 | Kristallines gamma-lacton der 17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-on-21-carbonsäure |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US7235655B2 (de) |
| EP (1) | EP1539795B1 (de) |
| JP (1) | JP2006505624A (de) |
| AT (1) | ATE377020T1 (de) |
| AU (1) | AU2003282868A1 (de) |
| DE (1) | DE60317214T2 (de) |
| ES (1) | ES2295663T3 (de) |
| WO (1) | WO2004037844A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1487859T1 (sl) * | 2002-03-22 | 2008-10-31 | Pharmacia & Upjohn Co Llc | Postopek priprave eplerenona |
| US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| CL2004000574A1 (es) * | 2003-03-21 | 2005-02-11 | Pharmacia Corp Sa Organizada B | Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. |
| US8110699B2 (en) * | 2008-09-12 | 2012-02-07 | University Of South Florida | Cobalt-catalyzed asymmetric cyclopropanation of alkenes with α-nitrodiazoacetates |
| WO2017156132A1 (en) | 2016-03-08 | 2017-09-14 | 3D Systems, Incorporated | Non-isocyanate polyurethane inks for 3d printing |
| CN112980910B (zh) * | 2021-03-19 | 2024-01-05 | 上海应用技术大学 | 一种在相转移催化剂体系中微生物转化11α-羟基坎利酮的方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3053856A (en) * | 1958-10-29 | 1962-09-11 | Shell Oil Co | Epoxidation of ethylenic compounds with peroxycarboximidic acids |
| US3200113A (en) * | 1963-01-09 | 1965-08-10 | Sterling Drug Inc | 7-cyano steroids and derivatives thereof |
| US3300489A (en) * | 1964-07-24 | 1967-01-24 | Smith Kline French Lab | Steroidal c-17 spirolactones and processes and intermediates used in the preparation thereof |
| US3413288A (en) * | 1965-07-07 | 1968-11-26 | Parke Davis & Co | Process for the production of steroidal c-17 spirolactones |
| US3565924A (en) | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| US3833622A (en) | 1969-03-17 | 1974-09-03 | Upjohn Co | Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds |
| US3759791A (en) * | 1970-12-10 | 1973-09-18 | Searle & Co | Selective microbiological preparation of androst-4-ene-3,17-dione |
| DE2404946C3 (de) | 1973-02-06 | 1978-03-02 | Roussel-Uclaf S.A., Paris | Verfahren zur Herstellung von 7alpha-Acylthio-Steroidspirolactonen |
| FR2216273B1 (de) | 1973-02-06 | 1977-07-22 | Roussel Uclaf | |
| US3874417A (en) * | 1973-05-24 | 1975-04-01 | Robert B Clay | Pneumatic pump surge chamber |
| GB1455220A (de) | 1973-09-14 | 1976-11-10 | Searle & Co | |
| DE2349022A1 (de) | 1973-09-26 | 1975-04-10 | Schering Ag | Neue d-homo-steroide |
| FR2260569B1 (de) * | 1974-02-08 | 1978-06-16 | Ugine Kuhlmann | |
| IE44711B1 (en) * | 1976-03-05 | 1982-03-10 | Schering Ag | 17 -hydroxypropyl-4-3-keto-steroids and esters thereof, and process for their manufacture |
| GB1532682A (en) | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
| YU41412B (en) | 1978-08-15 | 1987-04-30 | Gist Brocades Nv | Process for obtaining 17 beta-hydroxy -3-dxo-17 alpha-pregn-4-en-21-carboxylic acid |
| US4270994A (en) * | 1980-02-20 | 1981-06-02 | G. D. Searle & Co. | Electrochemical dehydrogenation of steroidal Δ3,5 enol ethers under basic conditions to provide steroidal Δ4,6 dienones |
| IL63968A (en) | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
| DE3344057A1 (de) | 1982-12-09 | 1984-06-14 | Ciba-Geigy Ag, Basel | Eine neue lactonverbindung und pharmazeutische zusammensetzungen davon, sowie verfahren zu ihrer herstellung |
| JPS59139400A (ja) * | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
| FI77669C (fi) | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| EP0123734A1 (de) | 1983-04-29 | 1984-11-07 | Gist-Brocades N.V. | 17-(Isocyano-sulfonylmethylen)-Steroide, 17-(Formamido-sulfonylmethylen)-Steroide und ihre Herstellung |
| US4670551A (en) | 1984-06-21 | 1987-06-02 | Ciba-Geigy Corporation | Epoxy steroids |
| NZ222103A (en) | 1986-10-10 | 1990-08-28 | Gist Brocades Nv | 9-alpha-hydroxy steroids and pharmaceutical preparations containing them |
| FR2610933B1 (fr) | 1987-02-18 | 1989-06-09 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
| DE3903988A1 (de) * | 1989-02-10 | 1990-08-30 | Basf Ag | Oxidierte diphenylheteroalkane, ihre herstellung und verwendung |
| US5962697A (en) * | 1993-05-06 | 1999-10-05 | Pharmacia & Upjohn Company | Optically active 3-(1-(alkylamino))alkyl pyrrolidines |
| CN1123544A (zh) * | 1993-05-06 | 1996-05-29 | 厄普约翰公司 | 旋光的3-(1-(烷氨基))烷基吡咯烷 |
| US5502222A (en) * | 1994-06-01 | 1996-03-26 | Schering Corporation | Process for preparing delta 9,11 and 21-chloro corticosteroids |
| US5655888A (en) * | 1994-10-14 | 1997-08-12 | Tlv Co., Ltd. | Pump and combination pump and trap with snap-over mechanism and double-seal outlet valve |
| US5565888A (en) * | 1995-02-17 | 1996-10-15 | International Business Machines Corporation | Method and apparatus for improving visibility and selectability of icons |
| AT404597B (de) * | 1995-11-24 | 1998-12-28 | Immuno Ag | Verfahren zur herstellung von proteinen |
| US5981744A (en) * | 1995-12-11 | 1999-11-09 | G. D. Searle And Co. | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein |
| JP2001509792A (ja) | 1996-12-11 | 2001-07-24 | ジー．ディー．サール アンド カンパニー | ９，１１−エポキシステロイドの製造法ならびに該方法に有用な中間体 |
| US6638937B2 (en) * | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| CN100413881C (zh) | 1999-12-08 | 2008-08-27 | 法马西亚公司 | 依匹乐酮晶形 |
| MXPA01008056A (es) | 1999-12-08 | 2003-07-21 | Pharmacia Corp | Forma cristalina de eplerenona que exhibe velocidad de disolucion intensificada. |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| US6716829B2 (en) * | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
| US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| SI1487859T1 (sl) | 2002-03-22 | 2008-10-31 | Pharmacia & Upjohn Co Llc | Postopek priprave eplerenona |
| AU2003213807A1 (en) * | 2002-11-06 | 2004-06-03 | Pharmacia & Upjohn Company Llc | Processes for preparing 7-carboxy substituted steroids |
| TWI280133B (en) * | 2002-11-07 | 2007-05-01 | Upjohn Co | Process for preparing C-7 substituted steroids |
-
2003
- 2003-03-21 US US10/392,833 patent/US7235655B2/en not_active Expired - Fee Related
- 2003-09-19 AT AT03774488T patent/ATE377020T1/de not_active IP Right Cessation
- 2003-09-19 US US10/666,175 patent/US7112670B2/en not_active Expired - Fee Related
- 2003-09-19 JP JP2005501605A patent/JP2006505624A/ja not_active Withdrawn
- 2003-09-19 EP EP03774488A patent/EP1539795B1/de not_active Expired - Lifetime
- 2003-09-19 WO PCT/US2003/029923 patent/WO2004037844A1/en not_active Ceased
- 2003-09-19 ES ES03774488T patent/ES2295663T3/es not_active Expired - Lifetime
- 2003-09-19 DE DE60317214T patent/DE60317214T2/de not_active Expired - Fee Related
- 2003-09-19 AU AU2003282868A patent/AU2003282868A1/en not_active Abandoned
-
2006
- 2006-12-21 US US11/614,456 patent/US7411062B2/en not_active Expired - Fee Related
- 2006-12-21 US US11/614,446 patent/US20070106072A1/en not_active Abandoned
- 2006-12-21 US US11/614,510 patent/US7417140B2/en not_active Expired - Fee Related
- 2006-12-21 US US11/614,490 patent/US7414127B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7411062B2 (en) | 2008-08-12 |
| EP1539795A1 (de) | 2005-06-15 |
| US20070123704A1 (en) | 2007-05-31 |
| EP1539795B1 (de) | 2007-10-31 |
| US20040127702A1 (en) | 2004-07-01 |
| US7414127B2 (en) | 2008-08-19 |
| US20030232981A1 (en) | 2003-12-18 |
| US20070106072A1 (en) | 2007-05-10 |
| US7417140B2 (en) | 2008-08-26 |
| AU2003282868A1 (en) | 2004-05-13 |
| US7112670B2 (en) | 2006-09-26 |
| JP2006505624A (ja) | 2006-02-16 |
| WO2004037844A1 (en) | 2004-05-06 |
| ATE377020T1 (de) | 2007-11-15 |
| ES2295663T3 (es) | 2008-04-16 |
| DE60317214T2 (de) | 2008-08-07 |
| US20070100140A1 (en) | 2007-05-03 |
| US7235655B2 (en) | 2007-06-26 |
| WO2004037844A8 (en) | 2004-06-10 |
| US20070117780A1 (en) | 2007-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |