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DE60317935D1 - Alpha-aminoamid-derivate als mittel gegen migräne - Google Patents

Alpha-aminoamid-derivate als mittel gegen migräne

Info

Publication number
DE60317935D1
DE60317935D1 DE60317935T DE60317935T DE60317935D1 DE 60317935 D1 DE60317935 D1 DE 60317935D1 DE 60317935 T DE60317935 T DE 60317935T DE 60317935 T DE60317935 T DE 60317935T DE 60317935 D1 DE60317935 D1 DE 60317935D1
Authority
DE
Germany
Prior art keywords
agents against
alpha
aminoamide derivatives
against migraine
migraine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317935T
Other languages
English (en)
Other versions
DE60317935T2 (de
Inventor
Patricia Salvati
Marcello Calabresi
Luciano Dho
Orietta Veneroni
Piero Melloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newron Pharmaceuticals SpA
Original Assignee
Newron Pharmaceuticals SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharmaceuticals SpA filed Critical Newron Pharmaceuticals SpA
Application granted granted Critical
Publication of DE60317935D1 publication Critical patent/DE60317935D1/de
Publication of DE60317935T2 publication Critical patent/DE60317935T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE60317935T 2003-01-16 2003-11-18 Alpha-aminoamid-derivate als mittel gegen migräne Expired - Lifetime DE60317935T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03000921A EP1438956A1 (de) 2003-01-16 2003-01-16 Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
EP03000921 2003-01-16
PCT/EP2003/012889 WO2004062655A1 (en) 2003-01-16 2003-11-18 Alpha-aminoamide derivatives useful as antimigraine agents

Publications (2)

Publication Number Publication Date
DE60317935D1 true DE60317935D1 (de) 2008-01-17
DE60317935T2 DE60317935T2 (de) 2008-11-27

Family

ID=32524140

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317935T Expired - Lifetime DE60317935T2 (de) 2003-01-16 2003-11-18 Alpha-aminoamid-derivate als mittel gegen migräne

Country Status (20)

Country Link
US (2) US7709523B2 (de)
EP (2) EP1438956A1 (de)
JP (1) JP4885455B2 (de)
KR (1) KR101049694B1 (de)
CN (1) CN100418517C (de)
AT (1) ATE380026T1 (de)
AU (1) AU2003279399B8 (de)
BR (1) BRPI0317795B8 (de)
CA (1) CA2510514C (de)
CY (1) CY1107274T1 (de)
DE (1) DE60317935T2 (de)
DK (1) DK1585510T3 (de)
ES (1) ES2295658T3 (de)
MX (1) MXPA05007339A (de)
NO (1) NO333610B1 (de)
NZ (1) NZ541117A (de)
PT (1) PT1585510E (de)
RU (1) RU2336077C2 (de)
SI (1) SI1585510T1 (de)
WO (1) WO2004062655A1 (de)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
ATE317280T1 (de) * 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
PT1658062E (pt) * 2003-08-25 2010-03-31 Newron Pharm Spa Derivados de alfa-amino amida úteis como agentes antiinflamatórios
MX2007002713A (es) * 2004-09-10 2007-05-23 Newron Pharm Spa Uso de las (halobenciloxi) bencilamino-propanamidas para la fabricacion de medicamentos activos como moduladores selectivos de los canales de sodio y/o calcio.
BRPI0620239B8 (pt) 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
MX2008015704A (es) * 2006-06-19 2009-01-09 Newron Pharm Spa Proceso para la produccion de 2-[4-(3-y 2-fluoro benciloxi) bencilamino]propanamidas.
FR2903985B1 (fr) 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
MX2009013119A (es) 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
CN104523668B (zh) 2007-12-11 2020-06-09 纽朗制药有限公司 高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类及其用途
EP2314569A1 (de) 2009-10-22 2011-04-27 Merck Patent GmbH Neuartige polymorphe Formen von (S)-2-[4-(3-Fluor-benzyloxy)-benzylamino]-Propionamidmesylatsalz und Herstellungsverfahren dafür
PT2563355T (pt) * 2010-04-27 2016-09-02 Newron Pharm Spa Processo para a produção de sais metanossulfonato de ralfinamida ou dos seus enantiómeros r
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
WO2019205147A1 (zh) * 2018-04-28 2019-10-31 上海璃道医药科技有限公司 包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
CN112716927B (zh) * 2020-10-12 2022-10-14 复旦大学 α-氨基酰胺类化合物及其制备方法与应用

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CH480308A (de) * 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
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IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
DE3928488A1 (de) 1989-08-29 1991-03-07 Standard Elektrik Lorenz Ag Interferometrisches messsystem
EP0525360B1 (de) 1991-07-30 1998-03-25 Korea Research Institute Of Chemical Technology Neue Phenylacetamidderivate und Verfahren zu ihrer Herstellung
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
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US5475007A (en) * 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
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DE69829048T2 (de) 1997-04-22 2006-02-09 Euro-Celtique S.A. Die verwendung von durch carbozyklische und heterozyklische reste substituierte semicarbazonen und thiosemicarbazonen als natriumkanalblocker
WO1999026614A1 (en) * 1997-11-21 1999-06-03 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
AU754681B2 (en) 1998-02-04 2002-11-21 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
WO2000023075A1 (fr) * 1998-10-19 2000-04-27 Eisai Co., Ltd. Analgesiques
JP2000191533A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 鎮痛剤
US6281211B1 (en) * 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
BR0009322A (pt) * 1999-03-26 2002-04-30 Euro Celtique Sa Pirazóis, imidazóis, oxazóis, tiazóis e pirróis substituìdos com arila e o uso dos mesmos
DK1169060T3 (da) * 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
ATE317280T1 (de) * 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (de) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen
MX2007002713A (es) * 2004-09-10 2007-05-23 Newron Pharm Spa Uso de las (halobenciloxi) bencilamino-propanamidas para la fabricacion de medicamentos activos como moduladores selectivos de los canales de sodio y/o calcio.

Also Published As

Publication number Publication date
AU2003279399A1 (en) 2004-08-10
AU2003279399B8 (en) 2009-01-29
AU2003279399B2 (en) 2008-11-27
ATE380026T1 (de) 2007-12-15
BR0317795A (pt) 2005-11-22
BRPI0317795B8 (pt) 2021-05-25
NO20053780L (no) 2005-10-13
US20060079570A1 (en) 2006-04-13
KR101049694B1 (ko) 2011-07-19
JP2006514060A (ja) 2006-04-27
HK1086487A1 (zh) 2006-09-22
US7709523B2 (en) 2010-05-04
KR20050094852A (ko) 2005-09-28
NO333610B1 (no) 2013-07-22
US20100267835A1 (en) 2010-10-21
RU2005125919A (ru) 2006-01-10
NZ541117A (en) 2008-02-29
EP1585510A1 (de) 2005-10-19
NO20053780D0 (no) 2005-08-09
CN1738611A (zh) 2006-02-22
PT1585510E (pt) 2008-02-28
WO2004062655A1 (en) 2004-07-29
SI1585510T1 (sl) 2008-04-30
RU2336077C2 (ru) 2008-10-20
EP1438956A1 (de) 2004-07-21
JP4885455B2 (ja) 2012-02-29
DK1585510T3 (da) 2008-02-25
ES2295658T3 (es) 2008-04-16
MXPA05007339A (es) 2005-09-30
CA2510514C (en) 2011-07-26
CY1107274T1 (el) 2012-11-21
DE60317935T2 (de) 2008-11-27
EP1585510B1 (de) 2007-12-05
BRPI0317795B1 (pt) 2019-04-02
CN100418517C (zh) 2008-09-17
CA2510514A1 (en) 2004-07-29

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Legal Events

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