DE60316044D1 - Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse - Google Patents
Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisseInfo
- Publication number
- DE60316044D1 DE60316044D1 DE60316044T DE60316044T DE60316044D1 DE 60316044 D1 DE60316044 D1 DE 60316044D1 DE 60316044 T DE60316044 T DE 60316044T DE 60316044 T DE60316044 T DE 60316044T DE 60316044 D1 DE60316044 D1 DE 60316044D1
- Authority
- DE
- Germany
- Prior art keywords
- cellulent
- classifying
- characterizing
- events
- label
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000019491 signal transduction Effects 0.000 abstract 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 230000010799 Receptor Interactions Effects 0.000 abstract 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 102000006255 nuclear receptors Human genes 0.000 abstract 1
- 108020004017 nuclear receptors Proteins 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
- G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Mobile Radio Communication Systems (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Sorting Of Articles (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2003/001060 WO2005005979A1 (en) | 2003-07-14 | 2003-07-14 | Label-free method for classification and characterization of cellular events |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60316044D1 true DE60316044D1 (de) | 2007-10-11 |
| DE60316044T2 DE60316044T2 (de) | 2008-05-15 |
Family
ID=33569429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60316044T Expired - Lifetime DE60316044T2 (de) | 2003-07-14 | 2003-07-14 | Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1664765B1 (de) |
| JP (1) | JP4668786B2 (de) |
| AT (1) | ATE371865T1 (de) |
| AU (1) | AU2003250657A1 (de) |
| CA (1) | CA2531342C (de) |
| DE (1) | DE60316044T2 (de) |
| WO (1) | WO2005005979A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470533B2 (en) | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
| US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
| US7468255B2 (en) | 2002-12-20 | 2008-12-23 | Acea Biosciences | Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology |
| US7732127B2 (en) | 2002-12-20 | 2010-06-08 | Acea Biosciences, Inc. | Dynamic monitoring of cell adhesion and spreading using the RT-CES system |
| US8206903B2 (en) | 2002-12-20 | 2012-06-26 | Acea Biosciences | Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses |
| JP2005537498A (ja) | 2002-07-20 | 2005-12-08 | アセア バイオサイエンシーズ，インク． | インピーダンスによる測定装置および方法 |
| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US9612234B2 (en) | 2008-05-05 | 2017-04-04 | Acea Biosciences, Inc. | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments |
| BR0317782B1 (pt) | 2002-12-27 | 2016-06-07 | Imerys Pigments Inc | Composição de pigmento de revestimento para papel e produto revestido com revestimento |
| EP1692258A4 (de) | 2003-11-12 | 2007-03-21 | Xiao Xu | Elektronische echtzeit-zellwahrnehmungssysteme und anwendungen für tests auf zellbasis |
| CA2575297C (en) | 2004-08-04 | 2014-09-23 | Acea Biosciences, Inc. | Method for assaying for natural killer, cytotoxic t-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology |
| US20070087326A1 (en) * | 2005-08-15 | 2007-04-19 | Lisa Minor | Method of measuring the biological activity of an urotensin II receptor |
| US7459918B2 (en) * | 2005-09-09 | 2008-12-02 | David Jones | Impedance measurement system with incorporated internal measurement drift compensation networks |
| KR100801694B1 (ko) * | 2005-09-15 | 2008-02-11 | 삼성전자주식회사 | 원핵 세포를 이용한 독성물질 유해성의 전기적 분석방법 및분석장치 |
| US8041515B2 (en) | 2006-09-20 | 2011-10-18 | Acea Biosciences, Inc. | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
| WO2008036375A2 (en) * | 2006-09-20 | 2008-03-27 | Acea Biosciences Corporation | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
| JP5168478B2 (ja) * | 2007-06-04 | 2013-03-21 | 株式会社リコー | 電子写真感光体、電子写真方法、電子写真装置、並びに電子写真装置用プロセスカートリッジ |
| US8703428B2 (en) | 2007-10-06 | 2014-04-22 | Corning Incorporated | Single-cell label-free assay |
| US8426148B2 (en) | 2007-10-06 | 2013-04-23 | Corning Incorporated | Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways |
| US8846575B2 (en) | 2008-03-05 | 2014-09-30 | Corning Incorporated | High-throughput high-information content label-free cell biology screening methods |
| US8313898B2 (en) | 2008-03-05 | 2012-11-20 | Corning Incorporated | Dual-target biosensor cell assays |
| US8759013B2 (en) | 2008-03-05 | 2014-06-24 | Corning Incorporated | Dual-target biosensor cell assays |
| JP2009244197A (ja) * | 2008-03-31 | 2009-10-22 | Hioki Ee Corp | 薬剤感受性試験方法及び装置 |
| WO2009137440A1 (en) | 2008-05-05 | 2009-11-12 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| KR101527797B1 (ko) * | 2014-06-03 | 2015-06-15 | 한국과학기술원 | 신호전달경로의 활성화 상태 분석방법 및 이를 이용한 개인 맞춤형 치료제의 선정방법 |
| US12066428B2 (en) | 2015-11-20 | 2024-08-20 | Agilent Technologies, Inc. | Cell-substrate impedance monitoring of cancer cells |
| EP3589299B1 (de) | 2017-03-03 | 2025-04-09 | Agilent Technologies, Inc. | Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc |
| CN112730821B (zh) * | 2019-10-14 | 2024-04-09 | 泰州医药城国科化物生物医药科技有限公司 | 一种受体拮抗剂长效性分析方法 |
| US20210301245A1 (en) | 2020-03-29 | 2021-09-30 | Agilent Technologies, Inc. | Systems and methods for electronically and optically monitoring biological samples |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792668A (en) * | 1993-08-06 | 1998-08-11 | Solid State Farms, Inc. | Radio frequency spectral analysis for in-vitro or in-vivo environments |
| US6048692A (en) * | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
| US6377057B1 (en) * | 1999-02-18 | 2002-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential |
| JPWO2003016555A1 (ja) * | 2001-08-09 | 2004-12-02 | 松下電器産業株式会社 | 細胞診断方法、ならびにそれに用いるデバイスおよび装置 |
| US20030032000A1 (en) * | 2001-08-13 | 2003-02-13 | Signature Bioscience Inc. | Method for analyzing cellular events |
-
2003
- 2003-07-14 JP JP2005503785A patent/JP4668786B2/ja not_active Expired - Fee Related
- 2003-07-14 WO PCT/CA2003/001060 patent/WO2005005979A1/en not_active Ceased
- 2003-07-14 EP EP03817382A patent/EP1664765B1/de not_active Expired - Lifetime
- 2003-07-14 CA CA2531342A patent/CA2531342C/en not_active Expired - Fee Related
- 2003-07-14 AT AT03817382T patent/ATE371865T1/de not_active IP Right Cessation
- 2003-07-14 AU AU2003250657A patent/AU2003250657A1/en not_active Abandoned
- 2003-07-14 DE DE60316044T patent/DE60316044T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2531342C (en) | 2011-07-05 |
| AU2003250657A1 (en) | 2005-01-28 |
| JP2007504801A (ja) | 2007-03-08 |
| CA2531342A1 (en) | 2005-01-20 |
| JP4668786B2 (ja) | 2011-04-13 |
| ATE371865T1 (de) | 2007-09-15 |
| EP1664765B1 (de) | 2007-08-29 |
| EP1664765A1 (de) | 2006-06-07 |
| WO2005005979A1 (en) | 2005-01-20 |
| DE60316044T2 (de) | 2008-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60316044D1 (de) | Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse | |
| MA45517A (fr) | Molécules de liaison inhibant la croissance de cancer | |
| PT1725540E (pt) | Diaminopirimidinas como antagonistas de p2x3 e p2x2/3 | |
| EA200702619A1 (ru) | Антагонисты мускариновых ацетилхолиновых рецепторов | |
| DK2049529T3 (da) | Substituerede diazepan-orexin-receptor- antagonister | |
| CY1118325T1 (el) | Διαλογη αντικαρκινικων ενωσεων μεσω της δραστικοτητας της νετρινης-1 | |
| WO2007123976A3 (en) | Antibody profiling for determination of patient responsiveness | |
| CY1116967T1 (el) | Συνθεσεις και μεθοδοι για θεραπευτικη αγωγη και διαγνωση καρκινου | |
| Schepetkin et al. | Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives | |
| EA201170636A1 (ru) | Антагонисты толл-подобного рецептора 3 | |
| ATE540944T1 (de) | Pyridylpiperidinorexin-rezeptorantagonisten | |
| BRPI0410454A (pt) | composições e compostos imunossupressores | |
| GT200900187A (es) | Derivados de oxindol sustituido, medicamentos que los comprenden y uso los mismos | |
| Dunlop et al. | Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist | |
| AT10541U3 (de) | Vorrichtung zur bestimmung der konzentration von feststoffpartikeln | |
| ATE540676T1 (de) | Egfr-inhibitoren zur behandlung und diagnose von metastasierendem prostatakrebs | |
| DE602005014386D1 (de) | Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome | |
| DE60314896D1 (de) | 5-ht 1b/1d rezeptor agonisten zur behandlung von kopfschmerz der aus der verabreichung von endothelin rezeptor antagonisten resultiert | |
| WO2007019234A3 (en) | Aminoethane sulfonamide orexin receptor antagonists | |
| Edlinger et al. | Expansion of BCR/ABL 1+ cells requires PAK 2 but not PAK 1 | |
| EA200600787A1 (ru) | Антагонисты мускариновых ацетилхолиновых рецепторов | |
| Guerrini et al. | N-and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands | |
| ATE531822T1 (de) | Diagnose von prostatakrebs | |
| WO2006076041A3 (en) | Pan-her antagonists and methods of use | |
| EP4259181A4 (de) | Antagonist des interleukin-17b-rezeptors (il-17rb) und verwendung davon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |