DE60316718D1 - Lösliche notch basierte substrate für gamma secretase, methoden, zusammensetzungen und verwendungen davon - Google Patents
Lösliche notch basierte substrate für gamma secretase, methoden, zusammensetzungen und verwendungen davonInfo
- Publication number
- DE60316718D1 DE60316718D1 DE60316718T DE60316718T DE60316718D1 DE 60316718 D1 DE60316718 D1 DE 60316718D1 DE 60316718 T DE60316718 T DE 60316718T DE 60316718 T DE60316718 T DE 60316718T DE 60316718 D1 DE60316718 D1 DE 60316718D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- methods
- gamma secretase
- based substrates
- notch based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 title abstract 2
- 241001195348 Nusa Species 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42920602P | 2002-11-26 | 2002-11-26 | |
| US429206P | 2002-11-26 | ||
| PCT/IB2003/005233 WO2004048578A1 (en) | 2002-11-26 | 2003-11-17 | Soluble notch-based substrates for gamma secretase and methods and compositions for using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60316718D1 true DE60316718D1 (de) | 2007-11-15 |
| DE60316718T2 DE60316718T2 (de) | 2008-01-24 |
Family
ID=32393521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60316718T Expired - Fee Related DE60316718T2 (de) | 2002-11-26 | 2003-11-17 | Lösliche notch basierte substrate für gamma secretase, methoden, zusammensetzungen und verwendungen davon |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110098227A1 (de) |
| EP (1) | EP1567647B1 (de) |
| JP (1) | JP2006508653A (de) |
| KR (1) | KR20050085177A (de) |
| CN (1) | CN1717485A (de) |
| AT (1) | ATE374824T1 (de) |
| AU (1) | AU2003283619A1 (de) |
| CA (1) | CA2505764A1 (de) |
| DE (1) | DE60316718T2 (de) |
| ES (1) | ES2293047T3 (de) |
| HR (1) | HRP20050461A2 (de) |
| NO (1) | NO20052552L (de) |
| RU (1) | RU2005115973A (de) |
| WO (1) | WO2004048578A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0518232D0 (en) * | 2005-09-07 | 2005-10-19 | Merck Sharp & Dohme | New methods |
| EP2166110B1 (de) | 2007-06-08 | 2012-02-22 | Eisai R&D Management Co., Ltd. | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
| EP2219028B1 (de) | 2007-11-15 | 2012-09-12 | Eisai R&D Management Co., Ltd. | Screening-verfahren mit nutzung des neuen substrats epha7 für gamma-sekretase |
| US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
| US9632088B2 (en) * | 2010-09-07 | 2017-04-25 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for gamma-secretase assay |
| DK2653552T3 (en) | 2010-12-17 | 2017-01-16 | Eisai R&D Man Co Ltd | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 DIVISION REACTION AS INDICATOR |
| US9784751B2 (en) | 2011-04-25 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain |
| TWI808882B (zh) | 2019-07-01 | 2023-07-11 | 日商衛材R&D企管股份有限公司 | 抗ＥｐｈＡ４抗體 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001237412A1 (en) * | 2000-02-25 | 2001-09-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines |
-
2003
- 2003-11-07 HR HR20050461A patent/HRP20050461A2/hr not_active Application Discontinuation
- 2003-11-17 EP EP03775599A patent/EP1567647B1/de not_active Expired - Lifetime
- 2003-11-17 ES ES03775599T patent/ES2293047T3/es not_active Expired - Lifetime
- 2003-11-17 KR KR1020057009579A patent/KR20050085177A/ko not_active Abandoned
- 2003-11-17 AU AU2003283619A patent/AU2003283619A1/en not_active Abandoned
- 2003-11-17 RU RU2005115973/13A patent/RU2005115973A/ru not_active Application Discontinuation
- 2003-11-17 JP JP2004554808A patent/JP2006508653A/ja active Pending
- 2003-11-17 CA CA002505764A patent/CA2505764A1/en not_active Abandoned
- 2003-11-17 DE DE60316718T patent/DE60316718T2/de not_active Expired - Fee Related
- 2003-11-17 AT AT03775599T patent/ATE374824T1/de not_active IP Right Cessation
- 2003-11-17 CN CNA2003801042336A patent/CN1717485A/zh active Pending
- 2003-11-17 WO PCT/IB2003/005233 patent/WO2004048578A1/en not_active Ceased
- 2003-11-19 US US10/717,244 patent/US20110098227A1/en not_active Abandoned
-
2005
- 2005-05-26 NO NO20052552A patent/NO20052552L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE374824T1 (de) | 2007-10-15 |
| EP1567647A1 (de) | 2005-08-31 |
| NO20052552D0 (no) | 2005-05-26 |
| WO2004048578A1 (en) | 2004-06-10 |
| CN1717485A (zh) | 2006-01-04 |
| HRP20050461A2 (en) | 2005-08-31 |
| US20110098227A1 (en) | 2011-04-28 |
| RU2005115973A (ru) | 2005-12-20 |
| NO20052552L (no) | 2005-08-25 |
| EP1567647B1 (de) | 2007-10-03 |
| CA2505764A1 (en) | 2004-06-10 |
| ES2293047T3 (es) | 2008-03-16 |
| DE60316718T2 (de) | 2008-01-24 |
| JP2006508653A (ja) | 2006-03-16 |
| AU2003283619A1 (en) | 2004-06-18 |
| KR20050085177A (ko) | 2005-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |