DE60316425D1 - NF-kappaB-INHIBITOREN - Google Patents

NF-kappaB-INHIBITOREN

Info

Publication number: DE60316425D1
Authority: DE; Germany
Prior art keywords: kappab inhibitors; kappab; inhibitors
Prior art date: 2002-04-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60316425T

Other languages

English (en)

Other versions

DE60316425T2 (de

Inventor

James F Callahan

Yue H Li

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-11

Filing date

2003-04-11

Publication date

2007-10-31

2003-04-11 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2007-10-31 Application granted granted Critical

2007-10-31 Publication of DE60316425D1 publication Critical patent/DE60316425D1/de

2008-06-19 Publication of DE60316425T2 publication Critical patent/DE60316425T2/de

2023-04-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Obesity (AREA)

DE60316425T 2002-04-11 2003-04-11 NF-kappaB-INHIBITOREN Expired - Fee Related DE60316425T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37194602P	2002-04-11	2002-04-11
US371946P		2002-04-11
PCT/US2003/011297 WO2003086309A2 (en)	2002-04-11	2003-04-11	NF-κB INHIBITORS

Publications (2)

Publication Number	Publication Date
DE60316425D1 true DE60316425D1 (de)	2007-10-31
DE60316425T2 DE60316425T2 (de)	2008-06-19

Family

ID=29250761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60316425T Expired - Fee Related DE60316425T2 (de)	2002-04-11	2003-04-11	NF-kappaB-INHIBITOREN

Country Status (10)

Country	Link
US (1)	US7183311B2 (de)
EP (1)	EP1499605B1 (de)
JP (1)	JP2005528386A (de)
AR (1)	AR039280A1 (de)
AT (1)	ATE373648T1 (de)
AU (1)	AU2003224941A1 (de)
DE (1)	DE60316425T2 (de)
ES (1)	ES2294276T3 (de)
TW (1)	TW200403991A (de)
WO (1)	WO2003086309A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003270701B2 (en)	2002-10-31	2009-11-12	Amgen Inc.	Antiinflammation agents
GB0400895D0 (en) *	2004-01-15	2004-02-18	Smithkline Beecham Corp	Chemical compounds
TW200616967A (en) *	2004-06-24	2006-06-01	Smithkline Beecham Corp	Novel indazole carboxamides and their use
WO2006036031A1 (ja) *	2004-09-30	2006-04-06	Takeda Pharmaceutical Company Limited	縮合フラン誘導体およびその用途
US8063071B2 (en) *	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
JP2010006717A (ja) *	2008-06-24	2010-01-14	Kyorin Pharmaceut Co Ltd	ジヒドロチエノ［２，３−ｅ］インダゾール化合物
US8354539B2 (en)	2009-03-10	2013-01-15	Glaxo Group Limited	Indole derivatives as IKK2 inhibitors
WO2011077502A1 (ja) *	2009-12-21	2011-06-30	杏林製薬株式会社	ジヒドロチエノ［２，３－ｅ］インダゾール化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2803984A1 (de) *	1977-02-08	1978-08-10	Sandoz Ag	Oxaminsaeurederivate, ihre herstellung und verwendung
DE4039734A1 (de) *	1990-12-13	1992-06-17	Basf Ag	Substituierte 2-aminothiophene enthaltende herbizide mittel
US5763609A (en) *	1996-03-21	1998-06-09	Neurogen Corporation	Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US6624177B1 (en) *	1996-09-04	2003-09-23	Warner-Lambert Company	Matrix metalloproteinase inhibitors and their therapeutic uses
TW416953B (en) *	1996-09-25	2001-01-01	Takeda Chemical Industries Ltd	Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
US7084136B2 (en) *	2000-06-02	2006-08-01	Shionogi & Co., Ltd.	Drug composition antagonistic to both PGD2/TXA2 receptors
US6414013B1 (en) *	2000-06-19	2002-07-02	Pharmacia & Upjohn S.P.A.	Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
EP1383463B1 (de) *	2001-03-30	2011-04-27	King Pharmaceuticals, Inc.	Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen
WO2003029242A1 (en) *	2001-10-04	2003-04-10	Smithkline Beecham Corporation	NF-λB INHIBITORS

2003
- 2003-04-09 AR ARP030101254A patent/AR039280A1/es not_active Application Discontinuation
- 2003-04-09 TW TW092108058A patent/TW200403991A/zh unknown
- 2003-04-11 ES ES03721638T patent/ES2294276T3/es not_active Expired - Lifetime
- 2003-04-11 JP JP2003583335A patent/JP2005528386A/ja not_active Withdrawn
- 2003-04-11 DE DE60316425T patent/DE60316425T2/de not_active Expired - Fee Related
- 2003-04-11 AU AU2003224941A patent/AU2003224941A1/en not_active Abandoned
- 2003-04-11 WO PCT/US2003/011297 patent/WO2003086309A2/en not_active Ceased
- 2003-04-11 AT AT03721638T patent/ATE373648T1/de not_active IP Right Cessation
- 2003-04-11 EP EP03721638A patent/EP1499605B1/de not_active Expired - Lifetime
- 2003-04-11 US US10/510,841 patent/US7183311B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7183311B2 (en)	2007-02-27
AR039280A1 (es)	2005-02-16
EP1499605B1 (de)	2007-09-19
JP2005528386A (ja)	2005-09-22
US20050165086A1 (en)	2005-07-28
EP1499605A4 (de)	2006-01-25
DE60316425T2 (de)	2008-06-19
EP1499605A2 (de)	2005-01-26
AU2003224941A1 (en)	2003-10-27
ATE373648T1 (de)	2007-10-15
TW200403991A (en)	2004-03-16
ES2294276T3 (es)	2008-04-01
WO2003086309A3 (en)	2003-12-04
WO2003086309A2 (en)	2003-10-23
AU2003224941A8 (en)	2003-10-27

Publication	Publication Date	Title
DE60320933D1 (de)	2008-06-26	Rho-kinase inhibitoren
ATE505471T1 (de)	2011-04-15	Azaindol-kinaseinhibitoren
EG25482A (en)	2012-01-15	Inhibitors
DE602004018837D1 (de)	2009-02-12	Ptidase-iv-inhibitoren
AU2003300832A8 (en)	2004-06-30	Nf-kappab inhibitors
DE60234125D1 (de)	2009-12-03	E inhibitoren
PT1370553E (pt)	2006-09-29	Inibidores de rhoquinase
EP1499336A4 (de)	2005-06-01	Proteasehemmer
EP1535609A4 (de)	2009-01-07	Nf-kb-aktivierungshemmer
EP1532133A4 (de)	2006-11-15	Nf-:b-inhibitoren
NO20044269L (no)	2004-10-08	Smamolekylaere inntrengningsinhibitorer
EP1570847A4 (de)	2008-10-08	Phosphodiesterase 10a-hemmer
DE60316425D1 (de)	2007-10-31	NF-kappaB-INHIBITOREN
ATA4142004A (de)	2005-12-15	Trägerverbau
NO20043610L (no)	2004-10-05	Fenylpyrimidinaminer som IgE inhibitorer
DE50305973D1 (de)	2007-01-25	Auffangwanne
ATA19152002A (de)	2004-11-15	Hubkupplung
DE60307471D1 (de)	2006-09-21	Hemmung
AT5889U3 (de)	2003-04-25	Brennholzspleisser
ES1053294Y (es)	2003-07-16	Escarpia
ATA5582002A (de)	2003-03-15	Getränkeerhitzer
ATA8092002A (de)	2005-01-15	Pibf
GB0208094D0 (en)	2002-05-22	Inhibitors
GB0206031D0 (en)	2002-04-24	Inhibitors
GB0207491D0 (en)	2002-05-08	Inhibitors

Legal Events

Date	Code	Title	Description
2008-10-09	8364	No opposition during term of opposition
2010-02-18	8339	Ceased/non-payment of the annual fee