DE60314731D1 - Vorrichtung zur unterstützung der patientenatmung mit variablen ramp-perioden zur anhebung des behandlungsdruckes - Google Patents
Vorrichtung zur unterstützung der patientenatmung mit variablen ramp-perioden zur anhebung des behandlungsdruckesInfo
- Publication number
- DE60314731D1 DE60314731D1 DE60314731T DE60314731T DE60314731D1 DE 60314731 D1 DE60314731 D1 DE 60314731D1 DE 60314731 T DE60314731 T DE 60314731T DE 60314731 T DE60314731 T DE 60314731T DE 60314731 D1 DE60314731 D1 DE 60314731D1
- Authority
- DE
- Germany
- Prior art keywords
- patient
- pressure
- treatment pressure
- mask
- control unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000009423 ventilation Methods 0.000 title 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 3
Classifications
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P6/00—Arrangements for controlling synchronous motors or other dynamo-electric motors using electronic commutation dependent on the rotor position; Electronic commutators therefor
- H02P6/14—Electronic commutators
- H02P6/16—Circuit arrangements for detecting position
- H02P6/18—Circuit arrangements for detecting position without separate position detecting elements
- H02P6/182—Circuit arrangements for detecting position without separate position detecting elements using back-emf in windings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0066—Blowers or centrifugal pumps
- A61M16/0069—Blowers or centrifugal pumps the speed thereof being controlled by respiratory parameters, e.g. by inhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P6/00—Arrangements for controlling synchronous motors or other dynamo-electric motors using electronic commutation dependent on the rotor position; Electronic commutators therefor
- H02P6/34—Modelling or simulation for control purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0042—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the expiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/42—Rate
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Power Engineering (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Percussion Or Vibration Massage (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measuring Fluid Pressure (AREA)
- Massaging Devices (AREA)
- Surgical Instruments (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36244102P | 2002-03-08 | 2002-03-08 | |
| US362441P | 2002-03-08 | ||
| PCT/IB2003/001422 WO2003075991A1 (en) | 2002-03-08 | 2003-03-10 | Apparatus to assist a patient's breathing with a variable ramp period to rise to treatment pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60314731D1 true DE60314731D1 (de) | 2007-08-16 |
| DE60314731T2 DE60314731T2 (de) | 2008-04-10 |
Family
ID=27805175
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60311969T Revoked DE60311969T2 (de) | 2002-03-08 | 2003-03-10 | Luftunterstützungsapparat für schnellen druckanstieg und -absenkung während eines atemzuges eines patienten |
| DE60314731T Expired - Lifetime DE60314731T2 (de) | 2002-03-08 | 2003-03-10 | Vorrichtung zur unterstützung der patientenatmung mit variablen ramp-perioden zur anhebung des behandlungsdruckes |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60311969T Revoked DE60311969T2 (de) | 2002-03-08 | 2003-03-10 | Luftunterstützungsapparat für schnellen druckanstieg und -absenkung während eines atemzuges eines patienten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7500481B2 (de) |
| EP (3) | EP1483007B1 (de) |
| AT (2) | ATE366127T1 (de) |
| AU (3) | AU2003214570A1 (de) |
| DE (2) | DE60311969T2 (de) |
| WO (3) | WO2003075990A2 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5881723A (en) | 1997-03-14 | 1999-03-16 | Nellcor Puritan Bennett Incorporated | Ventilator breath display and graphic user interface |
| EP3064242A1 (de) | 2003-04-28 | 2016-09-07 | Advanced Circulatory Systems Inc. | Lüfter und verfahren zur behandlung von kopftrauma und geringer blutzirkulation |
| AU2003903138A0 (en) | 2003-06-20 | 2003-07-03 | Resmed Limited | Method and apparatus for improving the comfort of cpap |
| DE102004006396B4 (de) * | 2004-02-10 | 2021-11-04 | Löwenstein Medical Technology S.A. | Vorrichtung zur Beatmung sowie Verfahren zur Steuerung eines Beatmungsgerätes |
| EP2526991B1 (de) * | 2004-09-03 | 2019-02-20 | ResMed Ltd. | Anpassung der Zielbelüftung in einem Servoventilator |
| WO2006034549A2 (en) * | 2004-09-28 | 2006-04-06 | Resmed Limited | Method and apparatus for resolving upper airway obstruction, resistance or instability |
| US8021310B2 (en) | 2006-04-21 | 2011-09-20 | Nellcor Puritan Bennett Llc | Work of breathing display for a ventilation system |
| US7909033B2 (en) | 2006-05-03 | 2011-03-22 | Comedica Incorporated | Breathing treatment apparatus |
| US8051854B2 (en) * | 2006-09-15 | 2011-11-08 | Comedica Incorporated | Continuous high-frequency oscillation breathing treatment apparatus |
| US7784461B2 (en) | 2006-09-26 | 2010-08-31 | Nellcor Puritan Bennett Llc | Three-dimensional waveform display for a breathing assistance system |
| FR2906474B3 (fr) * | 2006-09-29 | 2009-01-09 | Nellcor Puritan Bennett Incorp | Systeme et procede de commande d'une therapie respiratoire sur la base d'evenements respiratoires detectes |
| FR2906450B3 (fr) | 2006-09-29 | 2009-04-24 | Nellcor Puritan Bennett Incorp | Systeme et procede de detection d'evenements respiratoires |
| US8151790B2 (en) | 2007-04-19 | 2012-04-10 | Advanced Circulatory Systems, Inc. | Volume exchanger valve system and method to increase circulation during CPR |
| US9352111B2 (en) | 2007-04-19 | 2016-05-31 | Advanced Circulatory Systems, Inc. | Systems and methods to increase survival with favorable neurological function after cardiac arrest |
| US9050434B2 (en) * | 2007-05-18 | 2015-06-09 | Comedica Incorporated | Lung therapy device |
| US8210176B2 (en) * | 2007-06-18 | 2012-07-03 | Advanced Circulatory Systems, Inc. | Method and system to decrease intracranial pressure, enhance circulation, and encourage spontaneous respiration |
| US20090078255A1 (en) * | 2007-09-21 | 2009-03-26 | Bowman Bruce R | Methods for pressure regulation in positive pressure respiratory therapy |
| US20090078258A1 (en) * | 2007-09-21 | 2009-03-26 | Bowman Bruce R | Pressure regulation methods for positive pressure respiratory therapy |
| US8251876B2 (en) | 2008-04-22 | 2012-08-28 | Hill-Rom Services, Inc. | Breathing exercise apparatus |
| GB2474917B (en) * | 2009-11-02 | 2015-12-23 | Scott Health & Safety Ltd | Improvements to powered air breathing apparatus |
| US20110100360A1 (en) * | 2009-11-02 | 2011-05-05 | Joseph Dee Faram | Composite lung therapy device and method |
| US9151425B2 (en) * | 2009-11-02 | 2015-10-06 | Comedica Incorporated | Multiple conduit connector apparatus and method |
| US8335992B2 (en) | 2009-12-04 | 2012-12-18 | Nellcor Puritan Bennett Llc | Visual indication of settings changes on a ventilator graphical user interface |
| US8924878B2 (en) | 2009-12-04 | 2014-12-30 | Covidien Lp | Display and access to settings on a ventilator graphical user interface |
| US9119925B2 (en) | 2009-12-04 | 2015-09-01 | Covidien Lp | Quick initiation of respiratory support via a ventilator user interface |
| US8499252B2 (en) | 2009-12-18 | 2013-07-30 | Covidien Lp | Display of respiratory data graphs on a ventilator graphical user interface |
| US9262588B2 (en) | 2009-12-18 | 2016-02-16 | Covidien Lp | Display of respiratory data graphs on a ventilator graphical user interface |
| US9724266B2 (en) | 2010-02-12 | 2017-08-08 | Zoll Medical Corporation | Enhanced guided active compression decompression cardiopulmonary resuscitation systems and methods |
| US12016820B2 (en) | 2010-02-12 | 2024-06-25 | Zoll Medical Corporation | Enhanced guided active compression decompression cardiopulmonary resuscitation systems and methods |
| CA2859814A1 (en) | 2011-12-19 | 2013-06-27 | ResQSystems, Inc. | Systems and methods for therapeutic intrathoracic pressure regulation |
| US9180271B2 (en) | 2012-03-05 | 2015-11-10 | Hill-Rom Services Pte. Ltd. | Respiratory therapy device having standard and oscillatory PEP with nebulizer |
| US10362967B2 (en) | 2012-07-09 | 2019-07-30 | Covidien Lp | Systems and methods for missed breath detection and indication |
| US10384023B2 (en) | 2012-08-03 | 2019-08-20 | Breathe Technologies, Inc. | Selective ramping of therapeutic pressure in a patient breathing apparatus |
| US12080401B2 (en) | 2012-12-03 | 2024-09-03 | Metrohealth Ventures Llc | Combination respiratory therapy device, system and method |
| US9795752B2 (en) | 2012-12-03 | 2017-10-24 | Mhs Care-Innovation, Llc | Combination respiratory therapy device, system, and method |
| US9811634B2 (en) | 2013-04-25 | 2017-11-07 | Zoll Medical Corporation | Systems and methods to predict the chances of neurologically intact survival while performing CPR |
| US20140358047A1 (en) | 2013-05-30 | 2014-12-04 | ResQSystems, Inc. | End-tidal carbon dioxide and amplitude spectral area as non-invasive markers of coronary perfusion pressure and arterial pressure |
| US10183135B2 (en) | 2013-09-10 | 2019-01-22 | Breathe Technologies, Inc. | Zero pressure start continuous positive airway pressure therapy |
| US10265495B2 (en) | 2013-11-22 | 2019-04-23 | Zoll Medical Corporation | Pressure actuated valve systems and methods |
| TWI658845B (zh) * | 2014-03-05 | 2019-05-11 | 澳大利亞商瑞思邁有限公司 | 治療呼吸障礙之方法及裝置 |
| JP6599881B2 (ja) * | 2014-03-05 | 2019-10-30 | レスメド・プロプライエタリー・リミテッド | 呼吸器疾患の治療のための方法及び装置 |
| US10369310B2 (en) * | 2014-03-05 | 2019-08-06 | ResMed Pty Ltd | Method and apparatus for treatment of respiratory disorders |
| US9950129B2 (en) | 2014-10-27 | 2018-04-24 | Covidien Lp | Ventilation triggering using change-point detection |
| EP4186548A1 (de) | 2015-04-02 | 2023-05-31 | Hill-Rom Services PTE. LTD. | Maskenleckdetektion für eine atemvorrichtung |
| US11103661B2 (en) | 2016-09-14 | 2021-08-31 | ResMed Pty Ltd | Apparatus and method for adaptive ramped control of positive airway pressure (PAP) |
| US12070554B2 (en) | 2019-11-11 | 2024-08-27 | Hill-Rom Services Pte. Ltd. | Pneumatic connector apparatus and method |
| US11672934B2 (en) | 2020-05-12 | 2023-06-13 | Covidien Lp | Remote ventilator adjustment |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5199424A (en) * | 1987-06-26 | 1993-04-06 | Sullivan Colin E | Device for monitoring breathing during sleep and control of CPAP treatment that is patient controlled |
| US5134995A (en) | 1989-05-19 | 1992-08-04 | Puritan-Bennett Corporation | Inspiratory airway pressure system with admittance determining apparatus and method |
| US5239995A (en) * | 1989-09-22 | 1993-08-31 | Respironics, Inc. | Sleep apnea treatment apparatus |
| US5503146A (en) * | 1994-10-26 | 1996-04-02 | Devilbiss Health Care, Inc. | Standby control for CPAP apparatus |
| SE9602913D0 (sv) | 1996-08-02 | 1996-08-02 | Siemens Elema Ab | Ventilator system and method of operating a ventilator system |
| AUPO742297A0 (en) * | 1997-06-18 | 1997-07-10 | Resmed Limited | An apparatus for supplying breathable gas |
| US5977737A (en) * | 1998-09-09 | 1999-11-02 | Labriola, Ii; Donald P. | Digital motor driver circuit and method |
| DE50107173D1 (de) * | 2000-06-26 | 2005-09-29 | Draegerwerk Ag | Gasfördervorrichtung für Beatmungs- und Narkosegeräte |
| SE0002449D0 (sv) | 2000-06-29 | 2000-06-29 | Siemens Elema Ab | Method and arrangement for evaluating effective flow resistance of a patient breathing circuit |
| FR2812203B1 (fr) * | 2000-07-31 | 2003-01-03 | Saime Sarl | Appareil d'aide a la ventilation d'un patient |
| US6644310B1 (en) | 2000-09-29 | 2003-11-11 | Mallinckrodt Inc. | Apparatus and method for providing a breathing gas employing a bi-level flow generator with an AC synchronous motor |
| US7987847B2 (en) | 2000-12-29 | 2011-08-02 | Resmed Limited | Characterisation of mask systems |
| US7168429B2 (en) * | 2001-10-12 | 2007-01-30 | Ric Investments, Llc | Auto-titration pressure support system and method of using same |
-
2003
- 2003-03-10 EP EP03710150A patent/EP1483007B1/de not_active Expired - Lifetime
- 2003-03-10 AU AU2003214570A patent/AU2003214570A1/en not_active Abandoned
- 2003-03-10 AT AT03712532T patent/ATE366127T1/de not_active IP Right Cessation
- 2003-03-10 EP EP03712519A patent/EP1485155B1/de not_active Revoked
- 2003-03-10 AT AT03712519T patent/ATE354394T1/de not_active IP Right Cessation
- 2003-03-10 AU AU2003220760A patent/AU2003220760A1/en not_active Abandoned
- 2003-03-10 WO PCT/IB2003/001403 patent/WO2003075990A2/en not_active Ceased
- 2003-03-10 US US10/506,979 patent/US7500481B2/en not_active Expired - Lifetime
- 2003-03-10 DE DE60311969T patent/DE60311969T2/de not_active Revoked
- 2003-03-10 DE DE60314731T patent/DE60314731T2/de not_active Expired - Lifetime
- 2003-03-10 AU AU2003216622A patent/AU2003216622A1/en not_active Abandoned
- 2003-03-10 EP EP03712532A patent/EP1485156B1/de not_active Expired - Lifetime
- 2003-03-10 WO PCT/IB2003/001392 patent/WO2003075989A2/en not_active Ceased
- 2003-03-10 WO PCT/IB2003/001422 patent/WO2003075991A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003075989A2 (en) | 2003-09-18 |
| EP1485155B1 (de) | 2007-02-21 |
| ATE366127T1 (de) | 2007-07-15 |
| WO2003075989A3 (en) | 2003-11-13 |
| US7500481B2 (en) | 2009-03-10 |
| EP1485155A2 (de) | 2004-12-15 |
| US20050166920A1 (en) | 2005-08-04 |
| EP1483007A2 (de) | 2004-12-08 |
| EP1485156A1 (de) | 2004-12-15 |
| DE60311969T2 (de) | 2007-10-31 |
| WO2003075990A3 (en) | 2003-11-27 |
| AU2003214570A1 (en) | 2003-09-22 |
| WO2003075990A2 (en) | 2003-09-18 |
| WO2003075991A1 (en) | 2003-09-18 |
| AU2003214570A8 (en) | 2003-09-22 |
| AU2003216622A1 (en) | 2003-09-22 |
| EP1483007B1 (de) | 2012-06-13 |
| DE60314731T2 (de) | 2008-04-10 |
| ATE354394T1 (de) | 2007-03-15 |
| AU2003220760A1 (en) | 2003-09-22 |
| DE60311969D1 (de) | 2007-04-05 |
| EP1485156B1 (de) | 2007-07-04 |
| AU2003220760A8 (en) | 2003-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |