DE60313292D1 - Oxa- und thiadiazole und ihre verwendung als metalloproteinase-inhibitoren - Google Patents

Oxa- und thiadiazole und ihre verwendung als metalloproteinase-inhibitoren

Info

Publication number: DE60313292D1
Authority: DE; Germany
Prior art keywords: thiadiazole; oxa; inhibitors; metaloproteinase inhibitors; metaloproteinase
Prior art date: 2002-02-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60313292T

Other languages

English (en)

Other versions

DE60313292T2 (de

Inventor

A P Ayscough

S J Davies

Gilles Pain

Jean-Yves Gillon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Serono SA

Vernalis R&D Ltd

Original Assignee

Laboratoires Serono SA

Vernalis R&D Ltd

Serono Laboratories UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-22

Filing date

2003-02-20

Publication date

2007-05-31

2003-02-20 Application filed by Laboratoires Serono SA, Vernalis R&D Ltd, Serono Laboratories UK Ltd filed Critical Laboratoires Serono SA

2007-05-31 Application granted granted Critical

2007-05-31 Publication of DE60313292D1 publication Critical patent/DE60313292D1/de

2007-12-27 Publication of DE60313292T2 publication Critical patent/DE60313292T2/de

2023-02-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE60313292T 2002-02-22 2003-02-20 Oxa- und thiadiazole und ihre verwendung als metalloproteinase-inhibitoren Expired - Lifetime DE60313292T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0204159		2002-02-22
GBGB0204159.8A GB0204159D0 (en)	2002-02-22	2002-02-22	Metalloproteinase inhibitors
PCT/GB2003/000741 WO2003070711A1 (en)	2002-02-22	2003-02-20	Oxa- and thiadiazoles and their use as metalloproteinase inhibitors

Publications (2)

Publication Number	Publication Date
DE60313292D1 true DE60313292D1 (de)	2007-05-31
DE60313292T2 DE60313292T2 (de)	2007-12-27

Family

ID=9931543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60313292T Expired - Lifetime DE60313292T2 (de)	2002-02-22	2003-02-20	Oxa- und thiadiazole und ihre verwendung als metalloproteinase-inhibitoren

Country Status (26)

Country	Link
US (4)	US7358265B2 (de)
EP (1)	EP1476438B1 (de)
JP (1)	JP4615864B2 (de)
KR (1)	KR101098614B1 (de)
CN (1)	CN100351245C (de)
AT (1)	ATE360007T1 (de)
AU (1)	AU2003205910B2 (de)
BR (1)	BR0307899A (de)
CA (1)	CA2475867C (de)
CY (1)	CY1106730T1 (de)
DE (1)	DE60313292T2 (de)
DK (1)	DK1476438T3 (de)
EA (1)	EA007609B1 (de)
ES (1)	ES2286404T3 (de)
GB (1)	GB0204159D0 (de)
HR (1)	HRP20040725A2 (de)
IL (1)	IL163413A (de)
MX (1)	MXPA04008132A (de)
NO (1)	NO330772B1 (de)
PL (1)	PL210773B1 (de)
PT (1)	PT1476438E (de)
RS (1)	RS51354B (de)
SI (1)	SI1476438T1 (de)
UA (1)	UA78275C2 (de)
WO (1)	WO2003070711A1 (de)
ZA (1)	ZA200406755B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004101537A1 (en) *	2003-05-17	2004-11-25	British Biotech Pharmaceuticals Ltd	Metalloproteinase inhibitors
PL1660471T3 (pl) *	2003-08-23	2011-10-31	Vernalis R&D Ltd	Pochodne kwasu hydroksamowego jako inhibitory metaloproteinaz
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
RS52193B (sr)	2004-12-21	2012-10-31	Merck Serono Sa.	Ciklični derivati sulfonil amina i njihova upotreba
DK1844032T3 (da)	2005-01-31	2011-10-24	Merck Serono Sa	N-hydroxyamid-derivater og deres anvendelse
BRPI0613042A2 (pt)	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
AU2006286489B2 (en)	2005-09-01	2012-08-09	Ares Trading S.A.	Treatment of optic neuritis
US8153166B2 (en) *	2006-06-08	2012-04-10	Chih-Hsiung Lin	Composition for prophylaxis or treatment of urinary system infection and method thereof
PL3363790T3 (pl)	2013-09-06	2020-07-27	Aurigene Discovery Technologies Limited	Pochodne 1,2,4-oksadiazolu jako immunomodulatory
MX2017011612A (es) *	2015-03-10	2018-03-23	Aurigene Discovery Tech Ltd	Compuestos de tiadiazol y 1,2,4-oxadiazol 3-sustituidos como inmunomoduladores.
EP4023645A1 (de)	2015-03-10	2022-07-06	Aurigene Discovery Technologies Limited	1,2,4-oxadiazol- und thiadiazol-verbindungen als immunmodulatoren
CN105384736B (zh) *	2015-10-28	2018-11-02	南昌大学	一种ⅳ型胶原酶抑制剂及合成方法
WO2019061324A1 (en)	2017-09-29	2019-04-04	Curis Inc.	CRYSTALLINE FORMS OF IMMUNOMODULATORS
JP7618445B2 (ja)	2017-10-11	2025-01-21	オーリジーンオンコロジーリミテッド	３－置換１，２，４－オキサジアゾールの結晶形態
KR20200083503A (ko)	2017-11-03	2020-07-08	오리진 디스커버리 테크놀로지스 리미티드	Tim-3 경로와 pd-1 경로의 이중 저해제
WO2019087092A1 (en)	2017-11-06	2019-05-09	Aurigene Discovery Technologies Limited	Conjoint therapies for immunomodulation
CN108530378B (zh) *	2018-05-29	2021-09-14	济南大学	一类含有噁二唑结构的氮原子双取代异羟肟酸类化合物、用途及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5665753A (en) *	1994-03-03	1997-09-09	Smithkline Beecham Corporation	Cytokine inhibiting imidazole substituted hydroxamic acid derivatives
GB9404046D0 (en) *	1994-03-03	1994-04-20	Smithkline Beecham Corp	Novel compounds
US5703092A (en) *	1995-04-18	1997-12-30	The Dupont Merck Pharmaceutical Company	Hydroxamic acid compounds as metalloprotease and TNF inhibitors
PT946166E (pt) *	1996-12-17	2004-06-30	Warner Lambert Co	Utilizacao de inibidores das metaloproteinases da matriz para tratar disturbios neurologicos e promover a cicatrizacao de feridas
JP2002506873A (ja) *	1998-03-18	2002-03-05	アリアド・ファーマシューティカルズ・インコーポレイテッド	複素環式シグナル伝達阻害剤、それを含む組成物
JP2001031637A (ja) *	1999-05-17	2001-02-06	Fuji Chemical Industries Ltd	新規なヒドロキサム酸誘導体
GB9930570D0 (en) *	1999-12-23	2000-02-16	Pfizer Ltd	Therapy
US6448278B2 (en)	1999-12-23	2002-09-10	Pfizer Inc.	Procollagen C-proteinase inhibitors

2002
- 2002-02-22 GB GBGB0204159.8A patent/GB0204159D0/en not_active Ceased
2003
- 2003-02-20 MX MXPA04008132A patent/MXPA04008132A/es active IP Right Grant
- 2003-02-20 CA CA2475867A patent/CA2475867C/en not_active Expired - Fee Related
- 2003-02-20 KR KR1020047012821A patent/KR101098614B1/ko not_active Expired - Fee Related
- 2003-02-20 AU AU2003205910A patent/AU2003205910B2/en not_active Ceased
- 2003-02-20 DE DE60313292T patent/DE60313292T2/de not_active Expired - Lifetime
- 2003-02-20 UA UA20040806941A patent/UA78275C2/uk unknown
- 2003-02-20 EA EA200401095A patent/EA007609B1/ru not_active IP Right Cessation
- 2003-02-20 ES ES03702791T patent/ES2286404T3/es not_active Expired - Lifetime
- 2003-02-20 PL PL372268A patent/PL210773B1/pl unknown
- 2003-02-20 AT AT03702791T patent/ATE360007T1/de active
- 2003-02-20 DK DK03702791T patent/DK1476438T3/da active
- 2003-02-20 RS YUP-716/04A patent/RS51354B/sr unknown
- 2003-02-20 JP JP2003569618A patent/JP4615864B2/ja not_active Expired - Fee Related
- 2003-02-20 EP EP03702791A patent/EP1476438B1/de not_active Expired - Lifetime
- 2003-02-20 HR HR20040725A patent/HRP20040725A2/hr not_active Application Discontinuation
- 2003-02-20 BR BR0307899-0A patent/BR0307899A/pt not_active IP Right Cessation
- 2003-02-20 WO PCT/GB2003/000741 patent/WO2003070711A1/en not_active Ceased
- 2003-02-20 SI SI200330870T patent/SI1476438T1/sl unknown
- 2003-02-20 US US10/504,317 patent/US7358265B2/en not_active Expired - Fee Related
- 2003-02-20 CN CNB038089122A patent/CN100351245C/zh not_active Expired - Fee Related
- 2003-02-20 PT PT03702791T patent/PT1476438E/pt unknown
2004
- 2004-08-09 IL IL163413A patent/IL163413A/en not_active IP Right Cessation
- 2004-08-25 ZA ZA200406755A patent/ZA200406755B/en unknown
- 2004-09-14 NO NO20043846A patent/NO330772B1/no not_active IP Right Cessation
2007
- 2007-07-13 CY CY20071100937T patent/CY1106730T1/el unknown
2008
- 2008-02-08 US US12/028,275 patent/US20080227833A1/en not_active Abandoned
2009
- 2009-10-14 US US12/588,372 patent/US20100035943A1/en not_active Abandoned
2010
- 2010-10-07 US US12/900,262 patent/US20110086893A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA007609B1 (ru)	2006-12-29
CN1646505A (zh)	2005-07-27
UA78275C2 (en)	2007-03-15
JP2005522455A (ja)	2005-07-28
YU71604A (sh)	2006-08-17
AU2003205910A1 (en)	2003-09-09
EP1476438B1 (de)	2007-04-18
AU2003205910B2 (en)	2008-12-04
HRP20040725A2 (en)	2005-04-30
US7358265B2 (en)	2008-04-15
GB0204159D0 (en)	2002-04-10
IL163413A (en)	2010-11-30
RS51354B (sr)	2011-02-28
EA200401095A1 (ru)	2005-02-24
PL372268A1 (en)	2005-07-11
KR101098614B1 (ko)	2011-12-23
SI1476438T1 (sl)	2007-10-31
CY1106730T1 (el)	2012-10-24
US20100035943A1 (en)	2010-02-11
DE60313292T2 (de)	2007-12-27
ZA200406755B (en)	2006-07-26
CA2475867C (en)	2011-07-05
CA2475867A1 (en)	2003-08-28
NO330772B1 (no)	2011-07-11
PT1476438E (pt)	2007-07-25
KR20040101232A (ko)	2004-12-02
US20050222189A1 (en)	2005-10-06
EP1476438A1 (de)	2004-11-17
CN100351245C (zh)	2007-11-28
HK1078583A1 (zh)	2006-03-17
DK1476438T3 (da)	2007-08-20
ES2286404T3 (es)	2007-12-01
WO2003070711A1 (en)	2003-08-28
BR0307899A (pt)	2004-12-07
MXPA04008132A (es)	2005-06-17
JP4615864B2 (ja)	2011-01-19
US20080227833A1 (en)	2008-09-18
ATE360007T1 (de)	2007-05-15
PL210773B1 (pl)	2012-02-29
US20110086893A1 (en)	2011-04-14
NO20043846L (no)	2004-09-14

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DE60313292D1 (de)	2007-05-31	Oxa- und thiadiazole und ihre verwendung als metalloproteinase-inhibitoren
DE60310576D1 (en)	2007-02-01	2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
DE60311662D1 (en)	2007-03-22	3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
DE60315516D1 (de)	2007-09-20	Pyridazinon-derivate als cdk2-hemmer
ATE355265T1 (de)	2006-03-15	Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren
BR0313385A (pt)	2005-06-14	Derivados de pirimidina-2,4-diona como inibidores de metaloproteinase da matriz
ATE399168T1 (de)	2008-07-15	Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
TW200600499A (en)	2006-01-01	Novel amido-substituted hydroxy-6-phenylphenanthridines
NO20062629L (no)	2006-09-06	Oksazolderivater av tetrackliner
UA98608C2 (en)	2012-06-11	Benzofused five-membered heterocycles and use thereof
MXPA06003345A (es)	2006-06-08	Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
SG151306A1 (en)	2009-04-30	Novel benzothiazoles and the use thereof as medicaments
ATE368654T1 (de)	2007-08-15	Benzothiazol- und benzoxazol-4,7-dionderivate und ihre verwendung als cdc25-phosphatasen- inhibitoren
ATE403655T1 (de)	2008-08-15	Imidazopyridinderivate als induzierbare no- synthaseinhibitoren
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DK1648906T3 (da)	2008-02-04	Organo-silicium-forbindelser og deres anvendelse
DE60311000D1 (de)	2007-02-15	Indolderivate und deren verwendung als 5-ht liganden
ATE433975T1 (de)	2009-07-15	Als inos-inhibitoren geeignete imidazopyridinderivate
WO2004050608A3 (de)	2004-10-07	2-oxyamino-1-cyclopenten-1-nitrile als materialschutzmittel
GB0322750D0 (en)	2003-10-29	Organic compounds
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Date	Code	Title	Description
2008-05-08	8364	No opposition during term of opposition
2011-06-09	8327	Change in the person/name/address of the patent owner	Owner name: MERCK SERONO SA, COINSINS, VAUD, CH Owner name: VERNALIS (R&D) LTD., ABINGTON, CAMBRIDGE, GB

Date

Code

Title

Description

2008-05-08

8364

No opposition during term of opposition

2011-06-09

8327

Change in the person/name/address of the patent owner

Owner name: MERCK SERONO SA, COINSINS, VAUD, CH

Owner name: VERNALIS (R&D) LTD., ABINGTON, CAMBRIDGE, GB