DE60312497D1 - Verwendung von protein maba (fabg1) aus mycobacterium tuberculosis zur herstellung und nachweis von antibiotika - Google Patents
Verwendung von protein maba (fabg1) aus mycobacterium tuberculosis zur herstellung und nachweis von antibiotikaInfo
- Publication number
- DE60312497D1 DE60312497D1 DE60312497T DE60312497T DE60312497D1 DE 60312497 D1 DE60312497 D1 DE 60312497D1 DE 60312497 T DE60312497 T DE 60312497T DE 60312497 T DE60312497 T DE 60312497T DE 60312497 D1 DE60312497 D1 DE 60312497D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- maba
- fabg1
- protein
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 9
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 241000989747 Maba Species 0.000 title abstract 5
- XFDUHJPVQKIXHO-UHFFFAOYSA-N 3-aminobenzoic acid Chemical compound NC1=CC=CC(C(O)=O)=C1 XFDUHJPVQKIXHO-UHFFFAOYSA-N 0.000 title 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0204018A FR2837836B1 (fr) | 2002-03-29 | 2002-03-29 | UTILISATION DE LA PROTEINE Maba (FABG1) DE MYCOBACTERIUM TUBERCULOSIS POUR LA CONCEPTION ET LE CRIBLAGE D'ANTIBIOTIQUES |
| FR0204018 | 2002-03-29 | ||
| PCT/FR2003/000990 WO2003082911A2 (fr) | 2002-03-29 | 2003-03-28 | Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60312497D1 true DE60312497D1 (de) | 2007-04-26 |
| DE60312497T2 DE60312497T2 (de) | 2007-09-20 |
Family
ID=27839347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60312497T Expired - Lifetime DE60312497T2 (de) | 2002-03-29 | 2003-03-28 | Verwendung von protein maba (fabg1) aus mycobacterium tuberculosis zur herstellung und nachweis von antibiotika |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060035294A1 (de) |
| EP (1) | EP1490491B1 (de) |
| AT (1) | ATE356872T1 (de) |
| AU (1) | AU2003258723A1 (de) |
| DE (1) | DE60312497T2 (de) |
| ES (1) | ES2283790T3 (de) |
| FR (1) | FR2837836B1 (de) |
| WO (1) | WO2003082911A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113291A1 (en) * | 2006-03-23 | 2010-05-06 | Centre National De La Recherche Scientifique | Complexes of nadp with the protein maba of mycobacterium tuberculosis or with mutants thereof, and their uses for designing and screening antibiotics |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2162868A1 (en) * | 1993-05-13 | 1994-11-24 | William R. Jacobs, Jr. | Methods and compositions for detecting and treating mycobacterial infections using an inha gene |
| AU6949694A (en) * | 1993-05-13 | 1994-12-12 | Agresearch Limited | Use of genes of m. tuberculosis, m. bovis and m. smegmatis which confer isoniazid resistance |
-
2002
- 2002-03-29 FR FR0204018A patent/FR2837836B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-28 WO PCT/FR2003/000990 patent/WO2003082911A2/fr not_active Ceased
- 2003-03-28 EP EP03740540A patent/EP1490491B1/de not_active Expired - Lifetime
- 2003-03-28 AU AU2003258723A patent/AU2003258723A1/en not_active Abandoned
- 2003-03-28 US US10/503,939 patent/US20060035294A1/en not_active Abandoned
- 2003-03-28 DE DE60312497T patent/DE60312497T2/de not_active Expired - Lifetime
- 2003-03-28 AT AT03740540T patent/ATE356872T1/de not_active IP Right Cessation
- 2003-03-28 ES ES03740540T patent/ES2283790T3/es not_active Expired - Lifetime
-
2009
- 2009-04-14 US US12/423,586 patent/US20100240084A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060035294A1 (en) | 2006-02-16 |
| WO2003082911A2 (fr) | 2003-10-09 |
| WO2003082911A3 (fr) | 2004-04-01 |
| EP1490491A2 (de) | 2004-12-29 |
| EP1490491B1 (de) | 2007-03-14 |
| AU2003258723A8 (en) | 2003-10-13 |
| ATE356872T1 (de) | 2007-04-15 |
| ES2283790T3 (es) | 2007-11-01 |
| US20100240084A1 (en) | 2010-09-23 |
| FR2837836A1 (fr) | 2003-10-03 |
| AU2003258723A1 (en) | 2003-10-13 |
| FR2837836B1 (fr) | 2005-04-22 |
| DE60312497T2 (de) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |