DE60312474D1 - 5-ht3-rezeptorantagonisten und verwendungsverfahren - Google Patents
5-ht3-rezeptorantagonisten und verwendungsverfahrenInfo
- Publication number
- DE60312474D1 DE60312474D1 DE60312474T DE60312474T DE60312474D1 DE 60312474 D1 DE60312474 D1 DE 60312474D1 DE 60312474 T DE60312474 T DE 60312474T DE 60312474 T DE60312474 T DE 60312474T DE 60312474 D1 DE60312474 D1 DE 60312474D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor antagonists
- use method
- provides methods
- subject invention
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000035037 5-HT3 receptors Human genes 0.000 title 1
- 108091005477 5-HT3 receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35050402P | 2002-01-18 | 2002-01-18 | |
| US350504P | 2002-01-18 | ||
| PCT/US2003/001876 WO2003061657A1 (en) | 2002-01-18 | 2003-01-21 | 5-ht3 receptor antagonists and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60312474D1 true DE60312474D1 (de) | 2007-04-26 |
| DE60312474T2 DE60312474T2 (de) | 2007-12-06 |
Family
ID=27613396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60312474T Expired - Lifetime DE60312474T2 (de) | 2002-01-18 | 2003-01-21 | 5-ht3-rezeptorantagonisten und verwendungsverfahren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6770655B2 (de) |
| EP (1) | EP1465629B1 (de) |
| JP (1) | JP2005523892A (de) |
| AT (1) | ATE356623T1 (de) |
| AU (1) | AU2003210610B2 (de) |
| CA (1) | CA2473392A1 (de) |
| DE (1) | DE60312474T2 (de) |
| ES (1) | ES2281646T3 (de) |
| WO (1) | WO2003061657A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| GB0216027D0 (en) | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| AU2003210610B2 (en) * | 2002-01-18 | 2007-11-29 | Aryx Therapeutics | 5-HT3 receptor antagonists and methods of use |
| KR20050094843A (ko) | 2003-01-13 | 2005-09-28 | 다이노젠 파마세우티컬스, 인코포레이티드 | 욕지기, 구토, 구역질 또는 이들의 조합을 치료하는 방법 |
| WO2004062623A2 (en) * | 2003-01-13 | 2004-07-29 | Dynogen Pharmaceuticals, Inc. | Method of treating functional bowel disorders |
| US6846823B2 (en) * | 2003-04-04 | 2005-01-25 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| JP2008506651A (ja) * | 2004-07-14 | 2008-03-06 | ノバルティス アクチエンゲゼルシャフト | Ｄｐｐ−ｉｖ阻害剤と５−ｈｔ３および／または５−ｈｔ４受容体を調節する化合物の組合せ剤 |
| US20060293309A1 (en) * | 2005-03-28 | 2006-12-28 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| RU2544856C2 (ru) * | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| JP5666036B2 (ja) * | 2008-01-25 | 2015-02-04 | メディベイション テクノロジーズ， インコーポレイテッド | 新規２，３，４，５−テトラヒドロ−１Ｈ−ピリド［４，３−ｂ］インドール化合物およびその使用方法 |
| CA2724449C (en) * | 2008-05-29 | 2017-05-30 | Albany Molecular Research, Inc. | 5-ht3 receptor modulators, methods of making, and use thereof |
| KR101779991B1 (ko) | 2009-05-20 | 2017-09-19 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 병소성 전정 질환을 치료하기 위한 세로토닌 5-ｈｔ3 수용체 길항제의 용도 |
| ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| WO2012154261A1 (en) | 2011-02-18 | 2012-11-15 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| US9907786B2 (en) | 2014-10-21 | 2018-03-06 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof |
| US10092550B2 (en) | 2014-10-21 | 2018-10-09 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof |
| US10659046B2 (en) * | 2015-09-25 | 2020-05-19 | Intel Corporation | Local cell-level power gating switch |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202343A (en) * | 1986-11-28 | 1993-04-13 | Glaxo Group Limited | Tricyclic ketones useful as HT3 -receptor antagonists |
| GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
| PH25493A (en) | 1987-09-03 | 1991-07-24 | Glaxo Group Ltd | 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3 |
| HU207078B (en) * | 1988-08-02 | 1993-03-01 | Glaxo Group Ltd | Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds |
| DK169922B1 (da) | 1988-08-02 | 1995-04-03 | Glaxo Group Ltd | Substituerede (imidazol-4-yl)methylpyrido-, og -azepino-, indolonderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne |
| GB9106571D0 (en) * | 1991-03-27 | 1991-05-15 | Erba Carlo Spa | Derivatives of substituted imidazol-2-one and process for their preparation |
| GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| KR100584650B1 (ko) | 1998-03-31 | 2006-05-30 | 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 | 치환된 인돌알칸산 |
| AU2003210610B2 (en) * | 2002-01-18 | 2007-11-29 | Aryx Therapeutics | 5-HT3 receptor antagonists and methods of use |
-
2003
- 2003-01-21 AU AU2003210610A patent/AU2003210610B2/en not_active Ceased
- 2003-01-21 JP JP2003561601A patent/JP2005523892A/ja active Pending
- 2003-01-21 AT AT03732034T patent/ATE356623T1/de not_active IP Right Cessation
- 2003-01-21 CA CA002473392A patent/CA2473392A1/en not_active Abandoned
- 2003-01-21 US US10/348,669 patent/US6770655B2/en not_active Expired - Fee Related
- 2003-01-21 DE DE60312474T patent/DE60312474T2/de not_active Expired - Lifetime
- 2003-01-21 WO PCT/US2003/001876 patent/WO2003061657A1/en not_active Ceased
- 2003-01-21 EP EP03732034A patent/EP1465629B1/de not_active Expired - Lifetime
- 2003-01-21 ES ES03732034T patent/ES2281646T3/es not_active Expired - Lifetime
-
2004
- 2004-05-28 US US10/857,108 patent/US7125886B2/en not_active Expired - Fee Related
-
2006
- 2006-10-20 US US11/551,562 patent/US7501436B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE356623T1 (de) | 2007-04-15 |
| US6770655B2 (en) | 2004-08-03 |
| JP2005523892A (ja) | 2005-08-11 |
| US7501436B2 (en) | 2009-03-10 |
| US20040220246A1 (en) | 2004-11-04 |
| CA2473392A1 (en) | 2003-07-31 |
| US7125886B2 (en) | 2006-10-24 |
| EP1465629A1 (de) | 2004-10-13 |
| DE60312474T2 (de) | 2007-12-06 |
| EP1465629B1 (de) | 2007-03-14 |
| US20070197580A1 (en) | 2007-08-23 |
| WO2003061657A1 (en) | 2003-07-31 |
| AU2003210610B2 (en) | 2007-11-29 |
| ES2281646T3 (es) | 2007-10-01 |
| US20030158221A1 (en) | 2003-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60312474D1 (de) | 5-ht3-rezeptorantagonisten und verwendungsverfahren | |
| EA200301073A1 (ru) | N-(2-арилэтил)бензиламины в качестве антагонистов 5-ht-рецептора | |
| NO983431D0 (no) | Anti-kl°emidler | |
| EA200601555A1 (ru) | Замещенные индазол-о-глюкозиды | |
| DE60212801D1 (de) | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie | |
| NO20050429L (no) | Substituert kinolin-CCR5-reseptorantagonister | |
| EA200601552A1 (ru) | Замещенные конденсированные гетероциклические с-гликозиды | |
| EA200601553A1 (ru) | Замещенные бензимидазол-, бензтриазол- и бензимидазолон-о-глюкозиды | |
| NO20071740L (no) | Humaniserte anti-beta7-antagonister og anvendelser derav | |
| DE602004016499D1 (de) | Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung | |
| GEP20074192B (en) | Agonism of the 5ht2a receptor for treatment of thermoregulatory dysfunction | |
| CY1105980T1 (el) | Βελτιωμενη διαδικασια παρασκευης υδροβρωμικου αλατος του αλφα-πολυμορφικου ελετριπτανιου | |
| DE502004011551D1 (de) | 1,3,4-substituierte pyrazole als 5-ht rezeptor-antagonisten zur behandlung von psychosen und neurologischen störungen | |
| ATE421501T1 (de) | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck | |
| NO20055741D0 (no) | Nye kjemiske forbindelser | |
| HRP20041014B1 (hr) | Novi spojevi kao modulatori opioidnog receptora | |
| MXPA03007413A (es) | Composicion y metodo para tratar enfermedades inflamatorias. | |
| IS8377A (is) | Arýlindenópyridín og arýlindenópyrimidín og notkun þeirra sem mótlyf A2A viðtaka adenósíns | |
| GB0103045D0 (en) | Organic Compounds | |
| DE60319989D1 (de) | Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande | |
| SE0303418D0 (sv) | New use 1 | |
| SE0303489D0 (sv) | New use VII | |
| SE0301794D0 (sv) | New use III | |
| TW200509904A (en) | Use of substituted chromans or thiocromans for the treatment of IBS | |
| ATE335500T1 (de) | Die verwendung von antagonisten des bradykinin-b2 rezeptors zur behandlung von osteoarthrose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ARYX THERAPEUTICS, FREMONT, CALIF., US |
|
| 8364 | No opposition during term of opposition |