DE60309251D1 - Verfahren zur Herstellung von Donepezil - Google Patents
Verfahren zur Herstellung von DonepezilInfo
- Publication number
- DE60309251D1 DE60309251D1 DE60309251T DE60309251T DE60309251D1 DE 60309251 D1 DE60309251 D1 DE 60309251D1 DE 60309251 T DE60309251 T DE 60309251T DE 60309251 T DE60309251 T DE 60309251T DE 60309251 D1 DE60309251 D1 DE 60309251D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- donepezil
- compound
- formula
- decarboxylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 title 2
- 229960003530 donepezil Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15098202 | 2002-07-30 | ||
| IL150982A IL150982A (en) | 2002-07-30 | 2002-07-30 | Process for making Donafzil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60309251D1 true DE60309251D1 (de) | 2006-12-07 |
| DE60309251T2 DE60309251T2 (de) | 2007-05-31 |
Family
ID=29596379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60309251T Expired - Lifetime DE60309251T2 (de) | 2002-07-30 | 2003-05-28 | Verfahren zur Herstellung von Donepezil |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6844440B2 (de) |
| EP (1) | EP1386607B1 (de) |
| JP (1) | JP4662695B2 (de) |
| AT (1) | ATE343385T1 (de) |
| AU (1) | AU2003204939B2 (de) |
| CA (1) | CA2429563C (de) |
| DE (1) | DE60309251T2 (de) |
| ES (1) | ES2275066T3 (de) |
| HR (1) | HRP20030435B1 (de) |
| IL (1) | IL150982A (de) |
| PL (1) | PL360499A1 (de) |
| SI (1) | SI1386607T1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1209151B1 (de) * | 1999-09-01 | 2007-04-25 | Eisai R&D Management Co., Ltd. | In 4-stellung substituierte piperidinderivate |
| EP1300395B1 (de) * | 2000-06-21 | 2009-09-02 | Eisai R&D Management Co., Ltd. | 4-substituierte piperidinverbindung |
| AU2005288521A1 (en) | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| US20060122226A1 (en) * | 2004-12-08 | 2006-06-08 | Itai Adin | Crystalline forms of Donepezil base |
| EP1858848A1 (de) * | 2005-03-17 | 2007-11-28 | Synthon B.V. | Verfahren zur herstellung von kristallinem donepezilhydrochlorid-monohydrat |
| GB0515803D0 (en) | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
| US20100113793A1 (en) * | 2006-03-20 | 2010-05-06 | Ind-Swift Laboratories Limited | Process for the Preparation of Highly Pure Donepezil |
| KR100914691B1 (ko) | 2007-08-10 | 2009-08-28 | 주식회사유한양행 | 도네페질 또는 그의 제조용 중간체의 제조방법 |
| KR100953038B1 (ko) * | 2007-12-12 | 2010-04-14 | 일동제약주식회사 | 염산 도네페질의 개량된 제조방법 |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| WO2011154953A1 (en) | 2010-06-10 | 2011-12-15 | Technion R&D Foundation Ltd. | Process for the preparation of iodides |
| WO2014196557A1 (ja) * | 2013-06-04 | 2014-12-11 | 国立大学法人名古屋工業大学 | 光学活性２－［（１，２，３，６－テトラヒドロピリジン－４－イル）メチル］－２－フルオロ－２，３－ジヒドロインデン－１－オンの製造方法 |
| FR3006686A1 (fr) | 2013-06-05 | 2014-12-12 | Univ Caen | Composes inhibiteurs de l'acetylcholinesterase et agonistes des recepteurs serotoninergiques 5ht4, a effet promnesiant, leurs procedes de preparation et compositions pharmaceutiques les contenant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| DE4439822A1 (de) | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
| EP0883607A1 (de) | 1995-12-15 | 1998-12-16 | Pfizer Inc. | VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON 1-BENZYL-4-((5-DIMETHOXY-1-Indanon)-2-YL)METHYLPIPERIDIN |
| JP4022332B2 (ja) * | 1998-01-16 | 2007-12-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ドネペジル誘導体の製造法およびその中間体 |
| ATE292116T1 (de) | 1998-01-16 | 2005-04-15 | Eisai Co Ltd | Verfahren zur herstellung von donepezilderivaten |
| IL125809A (en) * | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
-
2002
- 2002-07-30 IL IL150982A patent/IL150982A/en not_active IP Right Cessation
-
2003
- 2003-05-23 CA CA2429563A patent/CA2429563C/en not_active Expired - Fee Related
- 2003-05-28 EP EP03253336A patent/EP1386607B1/de not_active Expired - Lifetime
- 2003-05-28 SI SI200330606T patent/SI1386607T1/sl unknown
- 2003-05-28 DE DE60309251T patent/DE60309251T2/de not_active Expired - Lifetime
- 2003-05-28 AT AT03253336T patent/ATE343385T1/de not_active IP Right Cessation
- 2003-05-28 HR HR20030435A patent/HRP20030435B1/xx not_active IP Right Cessation
- 2003-05-28 ES ES03253336T patent/ES2275066T3/es not_active Expired - Lifetime
- 2003-05-30 JP JP2003154618A patent/JP4662695B2/ja not_active Expired - Fee Related
- 2003-06-04 PL PL03360499A patent/PL360499A1/xx unknown
- 2003-06-11 US US10/459,662 patent/US6844440B2/en not_active Expired - Fee Related
- 2003-06-25 AU AU2003204939A patent/AU2003204939B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2429563A1 (en) | 2004-01-30 |
| HRP20030435B1 (en) | 2011-10-31 |
| DE60309251T2 (de) | 2007-05-31 |
| EP1386607A1 (de) | 2004-02-04 |
| JP2004131465A (ja) | 2004-04-30 |
| IL150982A0 (en) | 2003-02-12 |
| SI1386607T1 (sl) | 2007-04-30 |
| PL360499A1 (en) | 2004-02-09 |
| CA2429563C (en) | 2012-02-07 |
| EP1386607B1 (de) | 2006-10-25 |
| ATE343385T1 (de) | 2006-11-15 |
| JP4662695B2 (ja) | 2011-03-30 |
| ES2275066T3 (es) | 2007-06-01 |
| AU2003204939A1 (en) | 2004-02-19 |
| IL150982A (en) | 2007-02-11 |
| US20040048893A1 (en) | 2004-03-11 |
| HRP20030435A2 (en) | 2004-06-30 |
| US6844440B2 (en) | 2005-01-18 |
| AU2003204939B2 (en) | 2009-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |