DE60303314D1 - Verfahren zum carboxygruppenschutz der säuren c-terminalen aminosäuren bei chemischer verknüpfung von oligopeptiden - Google Patents
Verfahren zum carboxygruppenschutz der säuren c-terminalen aminosäuren bei chemischer verknüpfung von oligopeptidenInfo
- Publication number
- DE60303314D1 DE60303314D1 DE60303314T DE60303314T DE60303314D1 DE 60303314 D1 DE60303314 D1 DE 60303314D1 DE 60303314 T DE60303314 T DE 60303314T DE 60303314 T DE60303314 T DE 60303314T DE 60303314 D1 DE60303314 D1 DE 60303314D1
- Authority
- DE
- Germany
- Prior art keywords
- oligopeptides
- acids
- present
- carboxyl group
- chemical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010038807 Oligopeptides Proteins 0.000 title abstract 6
- 102000015636 Oligopeptides Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- -1 CARBOXYL GROUP Chemical group 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000007970 thio esters Chemical class 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38782502P | 2002-06-10 | 2002-06-10 | |
| US387825P | 2002-06-10 | ||
| PCT/IB2003/005473 WO2004007661A2 (en) | 2002-06-10 | 2003-06-09 | Carboxy protection strategies for acidic c-terminal amino acids in chemical ligation of oligopeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60303314D1 true DE60303314D1 (de) | 2006-04-06 |
| DE60303314T2 DE60303314T2 (de) | 2006-08-17 |
Family
ID=30115507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60303314T Expired - Lifetime DE60303314T2 (de) | 2002-06-10 | 2003-06-09 | Verfahren zum carboxygruppenschutz der säuren c-terminalen aminosäuren bei chemischer verknüpfung von oligopeptiden |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7566697B2 (de) |
| EP (1) | EP1511760B1 (de) |
| JP (1) | JP4327718B2 (de) |
| AT (1) | ATE316096T1 (de) |
| AU (1) | AU2003280206A1 (de) |
| CA (1) | CA2487378A1 (de) |
| DE (1) | DE60303314T2 (de) |
| WO (1) | WO2004007661A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ578298A (en) | 2005-03-31 | 2010-07-30 | Amylin Pharmaceuticals Inc | Amylin and amylin agonists for treating psychiatric an anxiety disorder |
| WO2006133962A1 (en) * | 2005-06-16 | 2006-12-21 | Amylin Pharmaceuticals, Inc. | Side-chain extended ligation |
| WO2008097536A2 (en) | 2007-02-05 | 2008-08-14 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating psychiatric diseases and disorders |
| JP2010537984A (ja) * | 2007-08-28 | 2010-12-09 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | ポリペプチドおよび蛋白質の化学合成のための方法および中間体 |
| US20100204449A1 (en) * | 2007-09-04 | 2010-08-12 | Zheng Xin Dong | Methods and intermediates for chemical synthesis of polypeptides and proteins |
| DK2684899T3 (en) * | 2011-03-10 | 2018-07-30 | Glytech Inc | PROCEDURE FOR PREPARING GLYCOPEPTIDE WITH SIALYL SUGAR CHAIN, SIALYL SUGAR CHAIN WITH AMINO ACID DERIVATIVES FOR USE THEREOF AND GLYCOPEPTIDE |
| US9169287B2 (en) * | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184344B1 (en) | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
-
2003
- 2003-06-09 AU AU2003280206A patent/AU2003280206A1/en not_active Abandoned
- 2003-06-09 CA CA002487378A patent/CA2487378A1/en not_active Abandoned
- 2003-06-09 US US10/517,392 patent/US7566697B2/en not_active Expired - Fee Related
- 2003-06-09 JP JP2004521045A patent/JP4327718B2/ja not_active Expired - Fee Related
- 2003-06-09 DE DE60303314T patent/DE60303314T2/de not_active Expired - Lifetime
- 2003-06-09 WO PCT/IB2003/005473 patent/WO2004007661A2/en not_active Ceased
- 2003-06-09 AT AT03764091T patent/ATE316096T1/de active
- 2003-06-09 EP EP03764091A patent/EP1511760B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1511760A2 (de) | 2005-03-09 |
| WO2004007661A2 (en) | 2004-01-22 |
| AU2003280206A1 (en) | 2004-02-02 |
| ATE316096T1 (de) | 2006-02-15 |
| JP2005529188A (ja) | 2005-09-29 |
| CA2487378A1 (en) | 2004-01-22 |
| US7566697B2 (en) | 2009-07-28 |
| WO2004007661A3 (en) | 2004-07-22 |
| JP4327718B2 (ja) | 2009-09-09 |
| US20050261473A1 (en) | 2005-11-24 |
| DE60303314T2 (de) | 2006-08-17 |
| EP1511760B1 (de) | 2006-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: AMYLIN PHARMACEUTICALS, INC., SAN DIEGO, CALIF, US |