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DE60300683D1 - Prucaloprid-n-oxid - Google Patents

Prucaloprid-n-oxid

Info

Publication number
DE60300683D1
DE60300683D1 DE60300683T DE60300683T DE60300683D1 DE 60300683 D1 DE60300683 D1 DE 60300683D1 DE 60300683 T DE60300683 T DE 60300683T DE 60300683 T DE60300683 T DE 60300683T DE 60300683 D1 DE60300683 D1 DE 60300683D1
Authority
DE
Germany
Prior art keywords
noxide
prucalopride
compositions
novel
concerned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60300683T
Other languages
English (en)
Other versions
DE60300683T2 (de
Inventor
Joannes Adrianus Jac Schuurkes
Laerhoven Willy Joannes Ca Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Movetis NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE60300683D1 publication Critical patent/DE60300683D1/de
Application granted granted Critical
Publication of DE60300683T2 publication Critical patent/DE60300683T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE60300683T 2002-01-16 2003-01-13 Prucaloprid-n-oxid Expired - Lifetime DE60300683T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02075157 2002-01-16
EP02075157 2002-01-16
PCT/EP2003/000276 WO2003059906A1 (en) 2002-01-16 2003-01-13 Prucalopride-n-oxide

Publications (2)

Publication Number Publication Date
DE60300683D1 true DE60300683D1 (de) 2005-06-23
DE60300683T2 DE60300683T2 (de) 2006-04-27

Family

ID=8185531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60300683T Expired - Lifetime DE60300683T2 (de) 2002-01-16 2003-01-13 Prucaloprid-n-oxid

Country Status (18)

Country Link
US (2) US20050085510A1 (de)
EP (1) EP1467991B1 (de)
JP (1) JP2005514458A (de)
KR (1) KR101023433B1 (de)
CN (1) CN1330646C (de)
AT (1) ATE295845T1 (de)
AU (1) AU2003206722B2 (de)
CA (1) CA2471729C (de)
DE (1) DE60300683T2 (de)
ES (1) ES2242940T3 (de)
IL (1) IL163025A (de)
MX (1) MXPA04006888A (de)
NO (1) NO326580B1 (de)
NZ (1) NZ533041A (de)
PL (1) PL214274B1 (de)
RU (1) RU2301806C2 (de)
WO (1) WO2003059906A1 (de)
ZA (1) ZA200405654B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2318783T3 (es) * 2005-08-22 2009-05-01 Solvay Pharmaceuticals B.V. N-oxidos como profarmacos de derivados de piperazina y piperadina.
US7750013B2 (en) 2005-08-22 2010-07-06 Solvay Pharmaceuticals, B.V. N-oxides as prodrugs of piperazine and piperidine derivatives
AR058022A1 (es) * 2005-08-22 2008-01-23 Solvay Pharm Bv Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso.
US20070294778A1 (en) * 2006-03-16 2007-12-20 Adam Rich Zebrafish model for assessing gastrointestinal motility
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN112500398A (zh) * 2020-12-24 2021-03-16 艾希尔（深圳）药物研发有限公司 一种普鲁卡必利氧化物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716587D0 (en) * 1987-07-14 1987-08-19 Shell Int Research Preparing thiophene derivatives
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
PL182502B1 (pl) * 1994-09-27 2002-01-31 Janssen Pharmaceutica Nv Nowe związki, pochodne bicyklicznego benzoesanu N-podstawionego piperydynylu, środek farmaceutyczny i sposób wytwarzania pochodnych bicyklicznego benzoesanu N-podstawionego piperydynylu
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
NZ511117A (en) * 1998-11-23 2002-11-26 Janssen Pharmaceutica Nv Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution

Also Published As

Publication number Publication date
KR20040074981A (ko) 2004-08-26
PL214274B1 (pl) 2013-07-31
CN1330646C (zh) 2007-08-08
ES2242940T3 (es) 2005-11-16
CN1615308A (zh) 2005-05-11
KR101023433B1 (ko) 2011-03-25
NO326580B1 (no) 2009-01-12
AU2003206722B2 (en) 2008-01-24
EP1467991B1 (de) 2005-05-18
AU2003206722A1 (en) 2003-07-30
US20050085510A1 (en) 2005-04-21
EP1467991A1 (de) 2004-10-20
US8063069B2 (en) 2011-11-22
WO2003059906A1 (en) 2003-07-24
IL163025A (en) 2010-06-16
US20080125464A1 (en) 2008-05-29
ATE295845T1 (de) 2005-06-15
CA2471729A1 (en) 2003-07-24
RU2004124844A (ru) 2006-01-20
NO20043397L (no) 2004-08-16
MXPA04006888A (es) 2004-12-06
ZA200405654B (en) 2005-09-28
PL370379A1 (pl) 2005-05-16
HK1075894A1 (zh) 2005-12-30
DE60300683T2 (de) 2006-04-27
CA2471729C (en) 2010-03-23
JP2005514458A (ja) 2005-05-19
RU2301806C2 (ru) 2007-06-27
NZ533041A (en) 2006-04-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MOVETIS N.V., TURNHOUT, BE