DE60228764D1 - R-bambuterol, seine herstellung und therapeutische verwendungen - Google Patents
R-bambuterol, seine herstellung und therapeutische verwendungenInfo
- Publication number
- DE60228764D1 DE60228764D1 DE60228764T DE60228764T DE60228764D1 DE 60228764 D1 DE60228764 D1 DE 60228764D1 DE 60228764 T DE60228764 T DE 60228764T DE 60228764 T DE60228764 T DE 60228764T DE 60228764 D1 DE60228764 D1 DE 60228764D1
- Authority
- DE
- Germany
- Prior art keywords
- bambuterol
- preparation
- therapeutic uses
- enantiomer
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960003060 bambuterol Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- ANZXOIAKUNOVQU-HNNXBMFYSA-N (R)-bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC([C@@H](O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-HNNXBMFYSA-N 0.000 abstract 1
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/025225 WO2004014290A2 (en) | 2002-08-08 | 2002-08-08 | R-bambuterol, its preparation and therapeutic uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60228764D1 true DE60228764D1 (de) | 2008-10-16 |
Family
ID=31713793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60228764T Expired - Lifetime DE60228764D1 (de) | 2002-08-08 | 2002-08-08 | R-bambuterol, seine herstellung und therapeutische verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP2002831A1 (de) |
| JP (1) | JP4979889B2 (de) |
| CN (1) | CN100356913C (de) |
| AT (1) | ATE406887T1 (de) |
| AU (1) | AU2002332488A1 (de) |
| DE (1) | DE60228764D1 (de) |
| ES (1) | ES2312669T3 (de) |
| WO (1) | WO2004014290A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100803291B1 (ko) | 2006-09-08 | 2008-02-13 | (주)팜스웰 | 밤부테롤 염산염의 개선된 제조방법 |
| CN102448309A (zh) * | 2009-06-16 | 2012-05-09 | 谭文 | 左旋(r)班布特罗在制备治疗呼吸性疾病的吸入性药物制剂和药物组合中的应用 |
| CN102617404A (zh) * | 2012-04-06 | 2012-08-01 | 张长利 | 盐酸班布特罗及其中间体的制备工艺 |
| CN103288670B (zh) * | 2013-05-16 | 2014-11-05 | 南京医科大学第一附属医院 | 多羟基二苯甲酮衍生物及其应用 |
| CN104478740B (zh) * | 2014-11-19 | 2017-01-25 | 上海化工研究院 | 一种稳定同位素标记β受体激动剂类化合物的合成方法 |
| CN104557614B (zh) * | 2014-12-15 | 2017-01-04 | 广东东阳光药业有限公司 | 一种胺的还原方法 |
| CN105254512B (zh) * | 2015-11-10 | 2017-03-22 | 山东达因海洋生物制药股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN106831452A (zh) * | 2017-02-15 | 2017-06-13 | 杭州百诚医药科技股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN107445867A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质b的合成方法 |
| CN107445866A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质d的合成方法 |
| CN113271931A (zh) * | 2018-07-31 | 2021-08-17 | 谭文 | 氨基甲酸酯β苯乙醇胺类似物增强胞内LDL胆固醇的清除及与他汀类药物联用的新用途 |
| CN109942462B (zh) * | 2019-03-06 | 2022-01-14 | 宏冠生物药业有限公司 | 一种盐酸班布特罗的合成工艺 |
| JP2022531602A (ja) * | 2019-05-07 | 2022-07-07 | ウェン タン | 肺の炎症および炎症性リモデリングの予防および治療用Ｒ－エナンチオマーβ２アゴニストの、有害作用を軽減するための使用 |
| CN115531368A (zh) * | 2021-06-14 | 2022-12-30 | 谭文 | R-氨基甲酸酯-β-苯乙醇胺类化合物治疗学习和记忆缺陷以及神经退行性疾病的应用 |
| CN117586152A (zh) * | 2023-11-23 | 2024-02-23 | 黑龙江乌苏里江制药有限公司 | 一种盐酸班布特罗的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0043807B1 (de) * | 1980-07-09 | 1984-05-30 | Aktiebolaget Draco | 1-(Dihydroxyphenyl)-2-amino-äthanol-Derivate, Verfahren und Mittel zu ihrer Herstellung sowie diese Derivate enthaltende Mittel |
| SE9000948D0 (sv) * | 1990-03-16 | 1990-03-16 | Draco Ab | New use |
| GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
-
2002
- 2002-08-08 JP JP2004527508A patent/JP4979889B2/ja not_active Expired - Fee Related
- 2002-08-08 AU AU2002332488A patent/AU2002332488A1/en not_active Abandoned
- 2002-08-08 EP EP08015488A patent/EP2002831A1/de not_active Ceased
- 2002-08-08 CN CNB028293975A patent/CN100356913C/zh not_active Expired - Lifetime
- 2002-08-08 AT AT02807678T patent/ATE406887T1/de not_active IP Right Cessation
- 2002-08-08 WO PCT/US2002/025225 patent/WO2004014290A2/en not_active Ceased
- 2002-08-08 DE DE60228764T patent/DE60228764D1/de not_active Expired - Lifetime
- 2002-08-08 ES ES02807678T patent/ES2312669T3/es not_active Expired - Lifetime
- 2002-08-08 EP EP02807678A patent/EP1542672B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1542672A2 (de) | 2005-06-22 |
| AU2002332488A1 (en) | 2004-02-25 |
| CN100356913C (zh) | 2007-12-26 |
| JP2006503816A (ja) | 2006-02-02 |
| EP1542672B1 (de) | 2008-09-03 |
| EP2002831A1 (de) | 2008-12-17 |
| ATE406887T1 (de) | 2008-09-15 |
| EP1542672A4 (de) | 2006-06-07 |
| ES2312669T3 (es) | 2009-03-01 |
| WO2004014290A2 (en) | 2004-02-19 |
| CN1638756A (zh) | 2005-07-13 |
| JP4979889B2 (ja) | 2012-07-18 |
| WO2004014290A3 (en) | 2004-08-05 |
| AU2002332488A8 (en) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |