DE60224524D1 - Verfahren zur Sequenzierung von Polynukleotiden - Google Patents
Verfahren zur Sequenzierung von PolynukleotidenInfo
- Publication number
- DE60224524D1 DE60224524D1 DE60224524T DE60224524T DE60224524D1 DE 60224524 D1 DE60224524 D1 DE 60224524D1 DE 60224524 T DE60224524 T DE 60224524T DE 60224524 T DE60224524 T DE 60224524T DE 60224524 D1 DE60224524 D1 DE 60224524D1
- Authority
- DE
- Germany
- Prior art keywords
- polynucleotide
- enzyme
- effect
- linear
- sequencing polynucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000012163 sequencing technique Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 230000003993 interaction Effects 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0112238 | 2001-05-18 | ||
| GBGB0112238.1A GB0112238D0 (en) | 2001-05-18 | 2001-05-18 | Sequencing method |
| PCT/GB2002/002345 WO2002095070A2 (en) | 2001-05-18 | 2002-05-20 | Polynucleotide sequencing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60224524D1 true DE60224524D1 (de) | 2008-02-21 |
| DE60224524T2 DE60224524T2 (de) | 2009-01-08 |
Family
ID=9914926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60224524T Expired - Fee Related DE60224524T2 (de) | 2001-05-18 | 2002-05-20 | Verfahren zur Sequenzierung von Polynukleotiden |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9476094B2 (de) |
| EP (1) | EP1389241B1 (de) |
| JP (2) | JP4094961B2 (de) |
| KR (1) | KR20030094412A (de) |
| CN (1) | CN1537172B (de) |
| AT (1) | ATE383442T1 (de) |
| AU (1) | AU2002257933B2 (de) |
| BR (1) | BR0209841A (de) |
| CA (1) | CA2447222C (de) |
| DE (1) | DE60224524T2 (de) |
| DK (1) | DK1389241T3 (de) |
| ES (1) | ES2299569T3 (de) |
| GB (1) | GB0112238D0 (de) |
| IL (1) | IL158743A0 (de) |
| IS (1) | IS7039A (de) |
| MX (1) | MXPA03010411A (de) |
| NZ (1) | NZ529349A (de) |
| PT (1) | PT1389241E (de) |
| RU (1) | RU2291197C2 (de) |
| WO (1) | WO2002095070A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152140C (zh) * | 1997-07-28 | 2004-06-02 | 医疗生物系统有限公司 | 核酸序列分析 |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| GB9923644D0 (en) * | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
| WO2002044425A2 (en) | 2000-12-01 | 2002-06-06 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| GB0112238D0 (en) * | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
| US6852492B2 (en) * | 2001-09-24 | 2005-02-08 | Intel Corporation | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication |
| US7361313B2 (en) * | 2003-02-18 | 2008-04-22 | Intel Corporation | Methods for uniform metal impregnation into a nanoporous material |
| GB0317343D0 (en) | 2003-07-24 | 2003-08-27 | Medical Biosystems Ltd | Polynucleotide sequencing |
| US7054528B2 (en) | 2004-04-14 | 2006-05-30 | Lucent Technologies Inc. | Plasmon-enhanced tapered optical fibers |
| US7012687B2 (en) | 2004-05-04 | 2006-03-14 | Lucent Technologies Inc. | Spectral analysis with evanescent field excitation |
| GB0413082D0 (en) * | 2004-06-11 | 2004-07-14 | Medical Biosystems Ltd | Method |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| JP2008513782A (ja) | 2004-09-17 | 2008-05-01 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | 分子解析のための装置及び方法 |
| DK1987159T4 (da) * | 2006-02-08 | 2020-11-16 | Illumina Cambridge Ltd | Fremgangsmåde til sekventering af en polynukleotidtemplate |
| JP4890926B2 (ja) * | 2006-04-28 | 2012-03-07 | キヤノン株式会社 | 検出方法、およびキット |
| WO2007143034A1 (en) | 2006-05-30 | 2007-12-13 | University Of Utah Research Foundation | Simultaneous amplification and detection if ribonucleic acid by an optical method using surface plasmon resonance |
| US8697138B2 (en) | 2007-03-28 | 2014-04-15 | Aker Biomarine As | Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders |
| EP2134871B1 (de) * | 2007-03-30 | 2012-03-07 | Pacific Biosciences of California, Inc. | System und verfahren zur verstärkung von fluoreszenzsignalen |
| JP5222599B2 (ja) * | 2007-07-20 | 2013-06-26 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス及びそれを用いた核酸分析装置 |
| US20100331195A1 (en) * | 2007-10-04 | 2010-12-30 | William Andregg | Sequencing Nucleic Acid Polymers with Electron Microscopy |
| JP5175584B2 (ja) * | 2008-03-13 | 2013-04-03 | 地方独立行政法人 東京都立産業技術研究センター | 局所表面プラズモン共鳴イメージング装置 |
| WO2009120372A2 (en) | 2008-03-28 | 2009-10-01 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
| JP5854350B2 (ja) * | 2010-12-08 | 2016-02-09 | 公立大学法人大阪府立大学 | 金属ナノ粒子集積構造体を利用した圧力検出装置、温度検出装置、圧力検出方法、および温度検出方法 |
| US9428789B2 (en) | 2011-03-21 | 2016-08-30 | Biodesy, Inc. | Classification of kinase inhibitors using nonlinear optical techniques |
| US9279154B2 (en) | 2011-12-21 | 2016-03-08 | Illumina, Inc. | Apparatus and methods for kinetic analysis and determination of nucleic acid sequences |
| US20130288271A1 (en) | 2012-04-25 | 2013-10-31 | Biodesy, Llc | Methods for detecting allosteric modulators of protein |
| GB2520111A (en) | 2012-02-05 | 2015-05-13 | Biodesy Inc | Methods for identifying modulators of Ras using nonlinear techniques |
| US9395358B2 (en) | 2012-02-05 | 2016-07-19 | Biodesy, Inc. | Methods for detecting allosteric modulators of protein |
| US9708656B2 (en) | 2013-05-06 | 2017-07-18 | Pacific Biosciences Of California, Inc. | Real-time electronic sequencing |
| EP3161168B1 (de) | 2014-06-30 | 2021-08-04 | Bluelight Therapeutics, Inc. | Systeme und verfahren zur analyse mit hohem durchsatz von konformation in biologischen entitäten |
| WO2016106286A1 (en) | 2014-12-23 | 2016-06-30 | Biodesy, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
| JP2018516358A (ja) | 2015-04-02 | 2018-06-21 | バイオデシー, インコーポレイテッド | 表面選択的非線形光学技法を使用してタンパク質構造を決定するための方法 |
| WO2017014762A1 (en) * | 2015-07-21 | 2017-01-26 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| EP3455628A4 (de) | 2016-05-09 | 2019-12-04 | Biodesy, Inc. | Verfahren und vorrichtungen zur detektion von interaktionen peripherer membranproteine unter verwendung nichtlinearer optischer techniken |
| ES2917403T3 (es) | 2017-01-06 | 2022-07-08 | Illumina Inc | Corrección de ajuste de fase |
| AU2018231017B2 (en) * | 2017-03-07 | 2021-09-09 | Illumina Cambridge Limited | Single light source, two-optical channel sequencing |
| CN107064106B (zh) * | 2017-04-11 | 2019-07-05 | 北京航空航天大学 | 一种二维表面等离子体最佳激发角位置的高精度识别方法 |
| CN110511991A (zh) * | 2019-09-11 | 2019-11-29 | 胡志刚 | 大规模dna芯片技术 |
| GB2593729B (en) | 2020-03-31 | 2022-05-11 | Perkins Engines Co Ltd | Spacer for use in an air intake system of an internal combustion chamber |
| US11188778B1 (en) | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
| KR20240031968A (ko) | 2021-07-19 | 2024-03-08 | 일루미나, 인코포레이티드 | 염기 호출에 대한 보간 및 적응을 갖는 강도 추출 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048982A (en) * | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| WO1995006138A1 (en) | 1993-08-25 | 1995-03-02 | The Regents Of The University Of California | Microscopic method for detecting micromotions |
| GB9508559D0 (en) * | 1995-04-27 | 1995-06-14 | Polytech Transfer Ltd | Surface second harmonic and sum-frequency generation immuno and enzyme assays |
| US5814516A (en) * | 1995-10-13 | 1998-09-29 | Lockheed Martin Energy Systems, Inc. | Surface enhanced Raman gene probe and methods thereof |
| US6072043A (en) * | 1996-06-04 | 2000-06-06 | Polyprobe, Inc. | Optimally fluorescent oligonucleotides |
| US5866430A (en) * | 1996-06-13 | 1999-02-02 | Grow; Ann E. | Raman optrode processes and devices for detection of chemicals and microorganisms |
| US6331392B1 (en) * | 1997-03-05 | 2001-12-18 | Anadys Pharmaceutical, Inc. | Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids |
| US5958696A (en) * | 1997-07-17 | 1999-09-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Quantitative solid phase helicase assay |
| CN1152140C (zh) * | 1997-07-28 | 2004-06-02 | 医疗生物系统有限公司 | 核酸序列分析 |
| FR2771028A1 (fr) * | 1997-11-18 | 1999-05-21 | Total Sa | Dispositif pour la separation des constituants d'un melange heterogene |
| US5786389A (en) * | 1997-12-28 | 1998-07-28 | Lambert Technologies Inc. | Guerbet castor esters |
| WO1999044045A1 (en) * | 1998-02-27 | 1999-09-02 | Massachusetts Institute Of Technology | Single molecule detection with surface-enhanced raman scattering and applications in dna or rna sequencing |
| DE19816202A1 (de) * | 1998-04-09 | 1999-10-14 | Karl Seitz | Raumkörper zur Errichtung von Bauwerken |
| AU772281B2 (en) | 1998-12-14 | 2004-04-22 | Li-Cor Inc. | A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis |
| US7270951B1 (en) * | 1999-03-10 | 2007-09-18 | Asm Scientific, Inc. | Method for direct nucleic acid sequencing |
| GB9907812D0 (en) * | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Sequencing |
| US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| WO2001006257A1 (en) * | 1999-07-16 | 2001-01-25 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
| AU7086800A (en) | 1999-08-30 | 2001-03-26 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | High speed parallel molecular nucleic acid sequencing |
| AU7616100A (en) * | 1999-09-27 | 2001-04-30 | Array Bioscience Corporation | Addressable arrays using morphology dependent resonance for analyte detection |
| US6908736B1 (en) * | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
| GB9923644D0 (en) * | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
| JP2004530105A (ja) * | 2001-01-08 | 2004-09-30 | サラフスカイ,ジョシュア,エス. | 表面選択性の非線形光学技法を使用する方法および装置 |
| JP2004521323A (ja) * | 2001-03-27 | 2004-07-15 | サラフスカイ,ジョシュア,エス. | 表面選択的非線形光学技法を使用してプローブ−ターゲット相互作用を検出する方法および装置 |
| GB0112238D0 (en) * | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
| GB0317343D0 (en) * | 2003-07-24 | 2003-08-27 | Medical Biosystems Ltd | Polynucleotide sequencing |
| GB0413082D0 (en) * | 2004-06-11 | 2004-07-14 | Medical Biosystems Ltd | Method |
-
2001
- 2001-05-18 GB GBGB0112238.1A patent/GB0112238D0/en not_active Ceased
-
2002
- 2002-05-20 ES ES02727736T patent/ES2299569T3/es not_active Expired - Lifetime
- 2002-05-20 CN CN028101456A patent/CN1537172B/zh not_active Expired - Lifetime
- 2002-05-20 BR BR0209841-5A patent/BR0209841A/pt not_active IP Right Cessation
- 2002-05-20 WO PCT/GB2002/002345 patent/WO2002095070A2/en not_active Ceased
- 2002-05-20 AT AT02727736T patent/ATE383442T1/de not_active IP Right Cessation
- 2002-05-20 RU RU2003136429/13A patent/RU2291197C2/ru not_active IP Right Cessation
- 2002-05-20 AU AU2002257933A patent/AU2002257933B2/en not_active Ceased
- 2002-05-20 JP JP2002591533A patent/JP4094961B2/ja not_active Expired - Fee Related
- 2002-05-20 KR KR10-2003-7014760A patent/KR20030094412A/ko not_active Withdrawn
- 2002-05-20 IL IL15874302A patent/IL158743A0/xx unknown
- 2002-05-20 MX MXPA03010411A patent/MXPA03010411A/es unknown
- 2002-05-20 DE DE60224524T patent/DE60224524T2/de not_active Expired - Fee Related
- 2002-05-20 EP EP02727736A patent/EP1389241B1/de not_active Expired - Lifetime
- 2002-05-20 US US10/478,036 patent/US9476094B2/en active Active
- 2002-05-20 PT PT02727736T patent/PT1389241E/pt unknown
- 2002-05-20 NZ NZ529349A patent/NZ529349A/en unknown
- 2002-05-20 CA CA2447222A patent/CA2447222C/en not_active Expired - Lifetime
- 2002-05-20 DK DK02727736T patent/DK1389241T3/da active
-
2003
- 2003-11-17 IS IS7039A patent/IS7039A/is unknown
-
2007
- 2007-11-14 JP JP2007295468A patent/JP4907498B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-08 US US12/206,536 patent/US20090029383A1/en not_active Abandoned
-
2016
- 2016-09-29 US US15/280,636 patent/US20170022556A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE383442T1 (de) | 2008-01-15 |
| NZ529349A (en) | 2006-10-27 |
| CA2447222C (en) | 2012-09-18 |
| IS7039A (is) | 2003-11-17 |
| JP2004535800A (ja) | 2004-12-02 |
| KR20030094412A (ko) | 2003-12-11 |
| CN1537172A (zh) | 2004-10-13 |
| US9476094B2 (en) | 2016-10-25 |
| US20170022556A1 (en) | 2017-01-26 |
| US20040241678A1 (en) | 2004-12-02 |
| US20090029383A1 (en) | 2009-01-29 |
| WO2002095070A3 (en) | 2003-09-18 |
| GB0112238D0 (en) | 2001-07-11 |
| EP1389241A2 (de) | 2004-02-18 |
| MXPA03010411A (es) | 2004-06-25 |
| BR0209841A (pt) | 2006-02-07 |
| RU2291197C2 (ru) | 2007-01-10 |
| HK1061047A1 (en) | 2004-09-03 |
| JP2008104463A (ja) | 2008-05-08 |
| JP4094961B2 (ja) | 2008-06-04 |
| PT1389241E (pt) | 2008-04-17 |
| DE60224524T2 (de) | 2009-01-08 |
| CA2447222A1 (en) | 2002-11-28 |
| JP4907498B2 (ja) | 2012-03-28 |
| EP1389241B1 (de) | 2008-01-09 |
| IL158743A0 (en) | 2004-05-12 |
| RU2003136429A (ru) | 2005-05-27 |
| CN1537172B (zh) | 2013-02-20 |
| DK1389241T3 (da) | 2008-05-26 |
| WO2002095070A2 (en) | 2002-11-28 |
| ES2299569T3 (es) | 2008-06-01 |
| AU2002257933B2 (en) | 2006-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |