[go: up one dir, main page]

DE60224524D1 - Verfahren zur Sequenzierung von Polynukleotiden - Google Patents

Verfahren zur Sequenzierung von Polynukleotiden

Info

Publication number
DE60224524D1
DE60224524D1 DE60224524T DE60224524T DE60224524D1 DE 60224524 D1 DE60224524 D1 DE 60224524D1 DE 60224524 T DE60224524 T DE 60224524T DE 60224524 T DE60224524 T DE 60224524T DE 60224524 D1 DE60224524 D1 DE 60224524D1
Authority
DE
Germany
Prior art keywords
polynucleotide
enzyme
effect
linear
sequencing polynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60224524T
Other languages
English (en)
Other versions
DE60224524T2 (de
Inventor
Daniel Henry Densham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Biosystems Ltd
Original Assignee
Medical Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Biosystems Ltd filed Critical Medical Biosystems Ltd
Publication of DE60224524D1 publication Critical patent/DE60224524D1/de
Application granted granted Critical
Publication of DE60224524T2 publication Critical patent/DE60224524T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE60224524T 2001-05-18 2002-05-20 Verfahren zur Sequenzierung von Polynukleotiden Expired - Fee Related DE60224524T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0112238 2001-05-18
GBGB0112238.1A GB0112238D0 (en) 2001-05-18 2001-05-18 Sequencing method
PCT/GB2002/002345 WO2002095070A2 (en) 2001-05-18 2002-05-20 Polynucleotide sequencing method

Publications (2)

Publication Number Publication Date
DE60224524D1 true DE60224524D1 (de) 2008-02-21
DE60224524T2 DE60224524T2 (de) 2009-01-08

Family

ID=9914926

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60224524T Expired - Fee Related DE60224524T2 (de) 2001-05-18 2002-05-20 Verfahren zur Sequenzierung von Polynukleotiden

Country Status (20)

Country Link
US (3) US9476094B2 (de)
EP (1) EP1389241B1 (de)
JP (2) JP4094961B2 (de)
KR (1) KR20030094412A (de)
CN (1) CN1537172B (de)
AT (1) ATE383442T1 (de)
AU (1) AU2002257933B2 (de)
BR (1) BR0209841A (de)
CA (1) CA2447222C (de)
DE (1) DE60224524T2 (de)
DK (1) DK1389241T3 (de)
ES (1) ES2299569T3 (de)
GB (1) GB0112238D0 (de)
IL (1) IL158743A0 (de)
IS (1) IS7039A (de)
MX (1) MXPA03010411A (de)
NZ (1) NZ529349A (de)
PT (1) PT1389241E (de)
RU (1) RU2291197C2 (de)
WO (1) WO2002095070A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1152140C (zh) * 1997-07-28 2004-06-02 医疗生物系统有限公司 核酸序列分析
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
GB9923644D0 (en) * 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
US6852492B2 (en) * 2001-09-24 2005-02-08 Intel Corporation Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication
US7361313B2 (en) * 2003-02-18 2008-04-22 Intel Corporation Methods for uniform metal impregnation into a nanoporous material
GB0317343D0 (en) 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
US7054528B2 (en) 2004-04-14 2006-05-30 Lucent Technologies Inc. Plasmon-enhanced tapered optical fibers
US7012687B2 (en) 2004-05-04 2006-03-14 Lucent Technologies Inc. Spectral analysis with evanescent field excitation
GB0413082D0 (en) * 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
JP2008513782A (ja) 2004-09-17 2008-05-01 パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド 分子解析のための装置及び方法
DK1987159T4 (da) * 2006-02-08 2020-11-16 Illumina Cambridge Ltd Fremgangsmåde til sekventering af en polynukleotidtemplate
JP4890926B2 (ja) * 2006-04-28 2012-03-07 キヤノン株式会社 検出方法、およびキット
WO2007143034A1 (en) 2006-05-30 2007-12-13 University Of Utah Research Foundation Simultaneous amplification and detection if ribonucleic acid by an optical method using surface plasmon resonance
US8697138B2 (en) 2007-03-28 2014-04-15 Aker Biomarine As Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders
EP2134871B1 (de) * 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. System und verfahren zur verstärkung von fluoreszenzsignalen
JP5222599B2 (ja) * 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
US20100331195A1 (en) * 2007-10-04 2010-12-30 William Andregg Sequencing Nucleic Acid Polymers with Electron Microscopy
JP5175584B2 (ja) * 2008-03-13 2013-04-03 地方独立行政法人 東京都立産業技術研究センター 局所表面プラズモン共鳴イメージング装置
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
JP5854350B2 (ja) * 2010-12-08 2016-02-09 公立大学法人大阪府立大学 金属ナノ粒子集積構造体を利用した圧力検出装置、温度検出装置、圧力検出方法、および温度検出方法
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
US9279154B2 (en) 2011-12-21 2016-03-08 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
US20130288271A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of protein
GB2520111A (en) 2012-02-05 2015-05-13 Biodesy Inc Methods for identifying modulators of Ras using nonlinear techniques
US9395358B2 (en) 2012-02-05 2016-07-19 Biodesy, Inc. Methods for detecting allosteric modulators of protein
US9708656B2 (en) 2013-05-06 2017-07-18 Pacific Biosciences Of California, Inc. Real-time electronic sequencing
EP3161168B1 (de) 2014-06-30 2021-08-04 Bluelight Therapeutics, Inc. Systeme und verfahren zur analyse mit hohem durchsatz von konformation in biologischen entitäten
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
JP2018516358A (ja) 2015-04-02 2018-06-21 バイオデシー, インコーポレイテッド 表面選択的非線形光学技法を使用してタンパク質構造を決定するための方法
WO2017014762A1 (en) * 2015-07-21 2017-01-26 Omniome, Inc. Nucleic acid sequencing methods and systems
US10077470B2 (en) 2015-07-21 2018-09-18 Omniome, Inc. Nucleic acid sequencing methods and systems
EP3455628A4 (de) 2016-05-09 2019-12-04 Biodesy, Inc. Verfahren und vorrichtungen zur detektion von interaktionen peripherer membranproteine unter verwendung nichtlinearer optischer techniken
ES2917403T3 (es) 2017-01-06 2022-07-08 Illumina Inc Corrección de ajuste de fase
AU2018231017B2 (en) * 2017-03-07 2021-09-09 Illumina Cambridge Limited Single light source, two-optical channel sequencing
CN107064106B (zh) * 2017-04-11 2019-07-05 北京航空航天大学 一种二维表面等离子体最佳激发角位置的高精度识别方法
CN110511991A (zh) * 2019-09-11 2019-11-29 胡志刚 大规模dna芯片技术
GB2593729B (en) 2020-03-31 2022-05-11 Perkins Engines Co Ltd Spacer for use in an air intake system of an internal combustion chamber
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
KR20240031968A (ko) 2021-07-19 2024-03-08 일루미나, 인코포레이티드 염기 호출에 대한 보간 및 적응을 갖는 강도 추출

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048982A (en) * 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
WO1995006138A1 (en) 1993-08-25 1995-03-02 The Regents Of The University Of California Microscopic method for detecting micromotions
GB9508559D0 (en) * 1995-04-27 1995-06-14 Polytech Transfer Ltd Surface second harmonic and sum-frequency generation immuno and enzyme assays
US5814516A (en) * 1995-10-13 1998-09-29 Lockheed Martin Energy Systems, Inc. Surface enhanced Raman gene probe and methods thereof
US6072043A (en) * 1996-06-04 2000-06-06 Polyprobe, Inc. Optimally fluorescent oligonucleotides
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US6331392B1 (en) * 1997-03-05 2001-12-18 Anadys Pharmaceutical, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
US5958696A (en) * 1997-07-17 1999-09-28 Boehringer Ingelheim Pharmaceuticals, Inc. Quantitative solid phase helicase assay
CN1152140C (zh) * 1997-07-28 2004-06-02 医疗生物系统有限公司 核酸序列分析
FR2771028A1 (fr) * 1997-11-18 1999-05-21 Total Sa Dispositif pour la separation des constituants d'un melange heterogene
US5786389A (en) * 1997-12-28 1998-07-28 Lambert Technologies Inc. Guerbet castor esters
WO1999044045A1 (en) * 1998-02-27 1999-09-02 Massachusetts Institute Of Technology Single molecule detection with surface-enhanced raman scattering and applications in dna or rna sequencing
DE19816202A1 (de) * 1998-04-09 1999-10-14 Karl Seitz Raumkörper zur Errichtung von Bauwerken
AU772281B2 (en) 1998-12-14 2004-04-22 Li-Cor Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
US7270951B1 (en) * 1999-03-10 2007-09-18 Asm Scientific, Inc. Method for direct nucleic acid sequencing
GB9907812D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Sequencing
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
WO2001006257A1 (en) * 1999-07-16 2001-01-25 Wm. Marsh Rice University Metal nanoshells for biosensing applications
AU7086800A (en) 1999-08-30 2001-03-26 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The High speed parallel molecular nucleic acid sequencing
AU7616100A (en) * 1999-09-27 2001-04-30 Array Bioscience Corporation Addressable arrays using morphology dependent resonance for analyte detection
US6908736B1 (en) * 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
GB9923644D0 (en) * 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
JP2004530105A (ja) * 2001-01-08 2004-09-30 サラフスカイ,ジョシュア,エス. 表面選択性の非線形光学技法を使用する方法および装置
JP2004521323A (ja) * 2001-03-27 2004-07-15 サラフスカイ,ジョシュア,エス. 表面選択的非線形光学技法を使用してプローブ−ターゲット相互作用を検出する方法および装置
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB0317343D0 (en) * 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
GB0413082D0 (en) * 2004-06-11 2004-07-14 Medical Biosystems Ltd Method

Also Published As

Publication number Publication date
ATE383442T1 (de) 2008-01-15
NZ529349A (en) 2006-10-27
CA2447222C (en) 2012-09-18
IS7039A (is) 2003-11-17
JP2004535800A (ja) 2004-12-02
KR20030094412A (ko) 2003-12-11
CN1537172A (zh) 2004-10-13
US9476094B2 (en) 2016-10-25
US20170022556A1 (en) 2017-01-26
US20040241678A1 (en) 2004-12-02
US20090029383A1 (en) 2009-01-29
WO2002095070A3 (en) 2003-09-18
GB0112238D0 (en) 2001-07-11
EP1389241A2 (de) 2004-02-18
MXPA03010411A (es) 2004-06-25
BR0209841A (pt) 2006-02-07
RU2291197C2 (ru) 2007-01-10
HK1061047A1 (en) 2004-09-03
JP2008104463A (ja) 2008-05-08
JP4094961B2 (ja) 2008-06-04
PT1389241E (pt) 2008-04-17
DE60224524T2 (de) 2009-01-08
CA2447222A1 (en) 2002-11-28
JP4907498B2 (ja) 2012-03-28
EP1389241B1 (de) 2008-01-09
IL158743A0 (en) 2004-05-12
RU2003136429A (ru) 2005-05-27
CN1537172B (zh) 2013-02-20
DK1389241T3 (da) 2008-05-26
WO2002095070A2 (en) 2002-11-28
ES2299569T3 (es) 2008-06-01
AU2002257933B2 (en) 2006-08-10

Similar Documents

Publication Publication Date Title
ATE383442T1 (de) Verfahren zur sequenzierung von polynukleotiden
ATE388242T1 (de) Methode zur dns sequenzierung
DE69836012D1 (de) Zwei-schritt hybridisierung und einfang von einem polynukleotid
DK244889D0 (da) Fremgangsmaade til bestemmelse af en analyt
DE3486400D1 (de) Bestimmungsmethode unter Verwendung von Polynucleotidsequenzen.
ATE416376T1 (de) Analysegeräte, biosensoren und verfahren
DK0925373T3 (da) Fremgangsmåde til påvisning af nukleinsyrer ved fastlæggelse af massen
ATE414169T1 (de) Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
ATE419392T1 (de) Verfahren zum nachweis von alkyliertem cytosin in dna
DK0407789T3 (da) Fremgangsmåde til detektering af nukleinsyrer
EP1243659A4 (de) Verfahren zur erkennung von zielnukleinsauren
DE69833660D1 (de) Nukleinsäuresonden zur detektion von candida-spezies
DE69919503D1 (de) Verfahren zur bestimmung eines analyten und kit dafür
ATE384139T1 (de) Multi-test-analyse von echzeit- nukleinsäureamplifikationen
ATE168781T1 (de) Neue antikoagulant-cofaktor aktivität
DK1360329T3 (da) Biokemisk fremgangsmåde og apparat til detektion af genetiske egenskaber
ATE440964T1 (de) Verfahren zur detektion von polynukleotidkinase und deren verwendung als markierung
DK1360491T3 (da) Biokemisk fremgangsmåde og apparat til detektion af proteinegenskaber
ATE280836T1 (de) Test zur gleichzeitigen messung von verschiedenen enzymatischen aktivitäten
ATE107704T1 (de) Verfahren zur selbstdurchführung von enzymkinetik.
ATE359513T1 (de) Hochdurchsatzscreening von verbindungen für biologische wirksamkeit
ATE269417T1 (de) Verfahren zur erkennung und messung von gespleisten nukleinsäuren
ATE446377T1 (de) Diagnostisches verfahren zur erkennung von trägern der marburg l-variante der faktor vii- aktivierenden protease (fsap) anhand differenzieller modulation der fsap-aktivität
ATE213274T1 (de) Verfahren zur beurteilung der aktivität von arzneistoffen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee