DE60223274D1 - Verfahren zur herstellung von 17beta-(substituierten)-3-oxo-delta 1,2-4-azasteroiden - Google Patents
Verfahren zur herstellung von 17beta-(substituierten)-3-oxo-delta 1,2-4-azasteroidenInfo
- Publication number
- DE60223274D1 DE60223274D1 DE60223274T DE60223274T DE60223274D1 DE 60223274 D1 DE60223274 D1 DE 60223274D1 DE 60223274 T DE60223274 T DE 60223274T DE 60223274 T DE60223274 T DE 60223274T DE 60223274 D1 DE60223274 D1 DE 60223274D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- formula
- aza
- preparation
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- 150000001534 azasteroids Chemical class 0.000 abstract 2
- -1 hydroxy-oxazolidinedione aza-steroid Chemical class 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- VEQRKWQRKUHFAI-UHFFFAOYSA-N 3-hydroxy-1,3-oxazolidine-2,4-dione Chemical class ON1C(=O)COC1=O VEQRKWQRKUHFAI-UHFFFAOYSA-N 0.000 abstract 1
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 abstract 1
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 abstract 1
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 abstract 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 abstract 1
- FUEGTWPJYMDZSE-UHFFFAOYSA-N 5-ethenylidene-1,3-oxazolidine-2,4-dione Chemical class C=C=C1OC(=O)NC1=O FUEGTWPJYMDZSE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CUILPNURFADTPE-UHFFFAOYSA-N hypobromous acid Chemical compound BrO CUILPNURFADTPE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200102190A ES2185503B1 (es) | 2001-09-29 | 2001-09-29 | Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios. |
| PCT/ES2002/000453 WO2003029267A2 (es) | 2001-09-29 | 2002-09-26 | PROCEDIMIENTO PARA LA OBTENCION DE 17β-(SUSTITUIDO)-3-OXO-Δ1,2-4-AZAESTEROIDES E INTERMEDIOS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60223274D1 true DE60223274D1 (de) | 2007-12-13 |
Family
ID=8499062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60223274T Expired - Lifetime DE60223274D1 (de) | 2001-09-29 | 2002-09-26 | Verfahren zur herstellung von 17beta-(substituierten)-3-oxo-delta 1,2-4-azasteroiden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7057045B2 (de) |
| EP (1) | EP1437361B1 (de) |
| JP (1) | JP2005504130A (de) |
| AT (1) | ATE377021T1 (de) |
| AU (1) | AU2002342928A1 (de) |
| CA (1) | CA2461221A1 (de) |
| DE (1) | DE60223274D1 (de) |
| ES (2) | ES2185503B1 (de) |
| WO (1) | WO2003029267A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066196A1 (en) * | 2003-12-30 | 2005-07-21 | Ranbaxy Laboratories Limited | Amorphous form of finasteride and processes for its preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ225100A (en) * | 1987-06-29 | 1991-09-25 | Merck & Co Inc | Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates |
| US5084574A (en) * | 1988-04-18 | 1992-01-28 | Merck & Co., Inc. | Dehydrogenation process |
| US5021575A (en) * | 1989-11-13 | 1991-06-04 | Merck & Co., Inc. | Method for introducing a 1,2 double bond into azasteroids |
| US5091534A (en) * | 1990-08-27 | 1992-02-25 | Merck & Co., Inc. | Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids |
| US5120847A (en) * | 1990-08-27 | 1992-06-09 | Merck & Co., Inc. | Process for iodinating or brominating the α-methylenic carbon of a secondary amide |
-
2001
- 2001-09-29 ES ES200102190A patent/ES2185503B1/es not_active Expired - Fee Related
-
2002
- 2002-09-26 DE DE60223274T patent/DE60223274D1/de not_active Expired - Lifetime
- 2002-09-26 JP JP2003532513A patent/JP2005504130A/ja active Pending
- 2002-09-26 CA CA002461221A patent/CA2461221A1/en not_active Abandoned
- 2002-09-26 WO PCT/ES2002/000453 patent/WO2003029267A2/es not_active Ceased
- 2002-09-26 AT AT02779579T patent/ATE377021T1/de not_active IP Right Cessation
- 2002-09-26 EP EP02779579A patent/EP1437361B1/de not_active Expired - Lifetime
- 2002-09-26 ES ES02779579T patent/ES2295419T3/es not_active Expired - Lifetime
- 2002-09-26 AU AU2002342928A patent/AU2002342928A1/en not_active Abandoned
-
2004
- 2004-03-26 US US10/810,128 patent/US7057045B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2185503B1 (es) | 2004-08-01 |
| US20040254209A1 (en) | 2004-12-16 |
| US7057045B2 (en) | 2006-06-06 |
| AU2002342928A1 (en) | 2003-04-14 |
| EP1437361A2 (de) | 2004-07-14 |
| WO2003029267A3 (es) | 2003-06-19 |
| ES2295419T3 (es) | 2008-04-16 |
| ATE377021T1 (de) | 2007-11-15 |
| JP2005504130A (ja) | 2005-02-10 |
| CA2461221A1 (en) | 2003-04-10 |
| ES2185503A1 (es) | 2003-04-16 |
| EP1437361B1 (de) | 2007-10-31 |
| WO2003029267A2 (es) | 2003-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |