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DE60223681D1 - Verwendung von natriumkanalblockern und aspirin zur herstellung von medikamenten zum erzeugen eines synergistischen analgetischen effekts in säugetieren - Google Patents

Verwendung von natriumkanalblockern und aspirin zur herstellung von medikamenten zum erzeugen eines synergistischen analgetischen effekts in säugetieren

Info

Publication number
DE60223681D1
DE60223681D1 DE60223681T DE60223681T DE60223681D1 DE 60223681 D1 DE60223681 D1 DE 60223681D1 DE 60223681 T DE60223681 T DE 60223681T DE 60223681 T DE60223681 T DE 60223681T DE 60223681 D1 DE60223681 D1 DE 60223681D1
Authority
DE
Germany
Prior art keywords
aspirin
medicaments
mammals
manufacture
sodium channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223681T
Other languages
English (en)
Other versions
DE60223681T2 (de
Inventor
Baoshan Ku
Hay Kong Shum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wex Medical Ltd
Original Assignee
Wex Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wex Medical Ltd filed Critical Wex Medical Ltd
Application granted granted Critical
Publication of DE60223681D1 publication Critical patent/DE60223681D1/de
Publication of DE60223681T2 publication Critical patent/DE60223681T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60223681T 2001-06-22 2002-06-18 Verwendung von natriumkanalblockern und aspirin zur herstellung von medikamenten zum erzeugen eines synergistischen analgetischen effekts in säugetieren Expired - Lifetime DE60223681T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN01115990 2001-06-22
CNB011159901A CN1203860C (zh) 2001-06-22 2001-06-22 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
PCT/CN2002/000428 WO2003000268A1 (en) 2001-06-22 2002-06-18 Use of na+ channel blockers and aspirin in manufacturing drugs for producing analgesia synergistically in mammals

Publications (2)

Publication Number Publication Date
DE60223681D1 true DE60223681D1 (de) 2008-01-03
DE60223681T2 DE60223681T2 (de) 2008-10-30

Family

ID=4662323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223681T Expired - Lifetime DE60223681T2 (de) 2001-06-22 2002-06-18 Verwendung von natriumkanalblockern und aspirin zur herstellung von medikamenten zum erzeugen eines synergistischen analgetischen effekts in säugetieren

Country Status (8)

Country Link
US (2) US20040192659A1 (de)
EP (1) EP1405639B1 (de)
JP (1) JP2004534821A (de)
CN (1) CN1203860C (de)
CA (1) CA2493885C (de)
DE (1) DE60223681T2 (de)
ES (1) ES2296975T3 (de)
WO (1) WO2003000268A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1568999A (zh) * 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
WO2006032459A1 (en) * 2004-09-22 2006-03-30 Laboratorios Del Dr. Esteve S.A. Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain
US20100144767A1 (en) * 2005-08-25 2010-06-10 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
CA2619668A1 (en) * 2005-08-25 2007-03-01 Edge Renfeng Wang Use of sodium channel blockers for the management of musculoskeletal pain
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
CN101563079B (zh) * 2006-03-27 2012-12-05 威克斯药业有限公司 钠通道阻滞剂在制备治疗由于化疗而产生的神经病理性疼痛的药物中的用途
CN100438873C (zh) * 2006-06-26 2008-12-03 黄致强 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
CN104118237A (zh) * 2013-04-27 2014-10-29 王静娴 编号文件夹

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966934A (en) * 1971-12-08 1976-06-29 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US4022899A (en) * 1973-06-12 1977-05-10 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US3892847A (en) * 1973-08-14 1975-07-01 Astra Pharma Prod Spinal anesthesia using small amount of saxitoxin
JPS5594319A (en) * 1979-01-09 1980-07-17 Yoshio Otaka Drug for external use consisting of liver oil of swellfish
US6759057B1 (en) * 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5814655A (en) * 1996-11-14 1998-09-29 Insite Vision Incorporated Non-steroidal ophthalmic mixtures
WO1998043619A2 (en) * 1997-04-02 1998-10-08 The Regents Of The University Of California Method of local anesthesia
GB2339534A (en) * 1998-07-16 2000-02-02 Edko Trading Representation Epidural or intrathecal administration of NSAID's
CN1284536C (zh) * 2000-09-18 2006-11-15 威克斯医药有限公司 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用

Also Published As

Publication number Publication date
DE60223681T2 (de) 2008-10-30
WO2003000268A8 (en) 2004-03-04
WO2003000268A1 (en) 2003-01-03
CN1393223A (zh) 2003-01-29
CA2493885A1 (en) 2003-01-03
US20090105197A1 (en) 2009-04-23
EP1405639A1 (de) 2004-04-07
CN1203860C (zh) 2005-06-01
EP1405639B1 (de) 2007-11-21
EP1405639A4 (de) 2004-08-04
JP2004534821A (ja) 2004-11-18
CA2493885C (en) 2007-08-21
ES2296975T3 (es) 2008-05-01
US20040192659A1 (en) 2004-09-30

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Legal Events

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