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DE60217114D1 - BROKEN BICYCLIC SERINE PROTEASE INHIBITORS - Google Patents

BROKEN BICYCLIC SERINE PROTEASE INHIBITORS

Info

Publication number
DE60217114D1
DE60217114D1 DE60217114T DE60217114T DE60217114D1 DE 60217114 D1 DE60217114 D1 DE 60217114D1 DE 60217114 T DE60217114 T DE 60217114T DE 60217114 T DE60217114 T DE 60217114T DE 60217114 D1 DE60217114 D1 DE 60217114D1
Authority
DE
Germany
Prior art keywords
serine protease
bicyclic
broken
compounds
protease inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60217114T
Other languages
German (de)
Other versions
DE60217114T2 (en
Inventor
Luc Farmer
Janos Pitlik
Robert Perni
Lawrence Courtney
Drie John Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE60217114D1 publication Critical patent/DE60217114D1/en
Application granted granted Critical
Publication of DE60217114T2 publication Critical patent/DE60217114T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to peptidomimetic compounds which inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The compounds of this invention have a bridged bicyclic moiety at the P2 position. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
DE60217114T 2001-07-11 2002-07-11 BROKEN BICYCLIC SERINE PROTEASE INHIBITORS Expired - Lifetime DE60217114T2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30461501P 2001-07-11 2001-07-11
US304615P 2001-07-11
US32271401P 2001-09-17 2001-09-17
US322714P 2001-09-17
PCT/US2002/022027 WO2003006490A1 (en) 2001-07-11 2002-07-11 Bridged bicyclic serine protease inhibitors

Publications (2)

Publication Number Publication Date
DE60217114D1 true DE60217114D1 (en) 2007-02-08
DE60217114T2 DE60217114T2 (en) 2007-10-25

Family

ID=26974129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217114T Expired - Lifetime DE60217114T2 (en) 2001-07-11 2002-07-11 BROKEN BICYCLIC SERINE PROTEASE INHIBITORS

Country Status (14)

Country Link
US (1) US6909000B2 (en)
EP (1) EP1404704B9 (en)
JP (1) JP4455056B2 (en)
KR (1) KR100926244B1 (en)
CN (1) CN100402549C (en)
AT (1) ATE349463T1 (en)
CA (1) CA2449504A1 (en)
DE (1) DE60217114T2 (en)
ES (1) ES2279879T3 (en)
IL (2) IL159087A0 (en)
MX (1) MXPA04000293A (en)
NO (1) NO20040127L (en)
NZ (1) NZ530000A (en)
WO (1) WO2003006490A1 (en)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA66767C2 (en) 1996-10-18 2004-06-15 Вертекс Фармасьютикалс Інкорпорейтед Serine proteases inhibitors, pharmaceutical composition, a method for inhibitining activity and a method for treatment or prevention of viral infection of hepatitis c
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
ES2240446T3 (en) * 2000-04-03 2005-10-16 Vertex Pharma SERINE PROTEASE INHIBITORS, PARTICULARLY THE NS3 PROTEASE OF HEPATITIS VIRUS C.
PE20011350A1 (en) 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
SV2003000617A (en) * 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
JP4460294B2 (en) * 2001-10-24 2010-05-12 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease, incorporating a condensed ring system
MXPA04009938A (en) 2002-04-11 2004-12-13 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 - ns4 protease.
EP1613620A1 (en) * 2003-04-11 2006-01-11 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
NZ544789A (en) 2003-07-18 2010-01-29 Vertex Pharma Dithia-azaspiro-nonane and decane derivatives as inhibitors of serine proteases
US7449447B2 (en) * 2003-08-26 2008-11-11 Schering Corporation Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus
AR045596A1 (en) 2003-09-05 2005-11-02 Vertex Pharma INHIBITORS OF SERINE PROTEASES IN PARTICULAR HCV PROTEASA NS3-NS4A
AU2004274468B2 (en) 2003-09-18 2009-07-23 Vertex Pharmaceuticals, Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
MXPA06004006A (en) * 2003-10-10 2006-06-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease.
US7491794B2 (en) * 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
EP1944042A1 (en) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Combinations for HCV treatment
WO2005043118A2 (en) 2003-10-27 2005-05-12 Vertex Pharmaceuticals Incorporated Drug discovery method
CA2552319C (en) * 2004-01-30 2012-08-21 Medivir Ab Hcv ns-3 serine protease inhibitors
EP1711515A2 (en) * 2004-02-04 2006-10-18 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
JP4898658B2 (en) * 2004-03-12 2012-03-21 バーテックス ファーマシューティカルズ インコーポレイテッド Methods and intermediates for the preparation of aspartate acetal caspase inhibitors
GEP20105124B (en) 2005-07-25 2010-11-25 Array Biopharma Inc Novel macrocyclic inhibitors of hepatitis c virus replication
DK1913015T3 (en) 2005-07-29 2014-03-10 Janssen R & D Ireland Macrocyclic inhibitors of hepatitis C virus
ME01318B (en) 2005-07-29 2013-12-20 Tibotec Pharm Ltd Macrocylic inhibitors of hepatitis c virus
EP2256113A1 (en) * 2005-08-02 2010-12-01 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CN102382170A (en) 2005-08-19 2012-03-21 弗特克斯药品有限公司 Method for preparation of protease inhibitors and intermediates
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (en) * 2005-08-26 2007-08-22 Vertex Pharma INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CN101415705B (en) 2005-10-11 2011-10-26 因特蒙公司 Compounds and methods for inhibiting hepatitis c viral replication
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
KR20080072906A (en) 2005-11-11 2008-08-07 버텍스 파마슈티칼스 인코포레이티드 Hepatitis C Virus Variants
CN101489557B (en) 2006-02-27 2013-12-18 弗特克斯药品有限公司 Co-crystals comprising vx-950 and pharmaceutical compositions comprising the same
KR20080112303A (en) 2006-03-16 2008-12-24 버텍스 파마슈티칼스 인코포레이티드 Deuterated Hepatitis C Protease Inhibitor
EP2027143A2 (en) 2006-05-23 2009-02-25 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR20090024834A (en) * 2006-07-05 2009-03-09 인터뮨, 인크. New Inhibitors of Hepatitis C Virus Replication
TW200827364A (en) * 2006-11-02 2008-07-01 Taigen Biotechnology Co Ltd HCV protease inhibitors
WO2008074035A1 (en) * 2006-12-27 2008-06-19 Abbott Laboratories Hcv protease inhibitors and uses thereof
WO2008097676A1 (en) 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2008106151A2 (en) * 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US8575208B2 (en) * 2007-02-27 2013-11-05 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
HRP20110713T1 (en) * 2007-02-28 2011-11-30 Conatus Pharmaceuticals CHRONIC Viral HEPATITIS C TREATMENT PROCEDURES USING RO 113-0830
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AP2009005053A0 (en) * 2007-05-03 2009-12-31 Intermune Inc Novel macrocyclic inhibitors of hepatitis c virus replication
NZ580917A (en) 2007-05-04 2012-06-29 Vertex Pharma Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection
KR20100027134A (en) * 2007-05-10 2010-03-10 인터뮨, 인크. Novel peptide inhibitors of hepatitis c virus replication
CA2704284A1 (en) * 2007-08-30 2009-03-12 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US8419332B2 (en) * 2007-10-19 2013-04-16 Atlas Bolt & Screw Company Llc Non-dimpling fastener
WO2009055335A2 (en) * 2007-10-25 2009-04-30 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
WO2009142842A2 (en) * 2008-04-15 2009-11-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
CN101580535B (en) * 2008-05-16 2012-10-03 太景生物科技股份有限公司 Hepatitis C virus protease inhibitors
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA201100851A1 (en) 2008-12-23 2012-04-30 Фармассет, Инк. NUCLEOSIDE ANALOGUES
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EA019341B1 (en) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Nucleoside phosphoramidates
AR075584A1 (en) * 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS THAT INCLUDE beta-D-2'-DESOXI-2'-FLUORO-2'-C-METHYLYCTIDINE AND A CARDIEX ISOINDOL ACID DERIVATIVE AND ITS USES. COMPOUND.
TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8980920B2 (en) 2009-05-29 2015-03-17 Merck Sharp & Dohme Corp. Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C
JP5702388B2 (en) * 2009-09-15 2015-04-15 タイゲン バイオテクノロジー カンパニー，リミテッド HCV protease inhibitor
US20120276047A1 (en) 2009-11-25 2012-11-01 Rosenblum Stuart B Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
AU2010332010A1 (en) * 2009-12-14 2012-08-02 Inspire Pharmaceuticals, Inc. Bridged bicyclic Rho kinase inhibitor compounds, composition and use
WO2011087740A1 (en) 2009-12-22 2011-07-21 Schering Corporation Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
US20110178107A1 (en) * 2010-01-20 2011-07-21 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
EP2545060B1 (en) 2010-03-09 2015-11-25 Merck Sharp & Dohme Corp. Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases
UY33312A (en) 2010-03-31 2011-10-31 Pharmasset Inc PURINE NUCLEOSIDE PHOSPHORAMIDATE
MX2012011171A (en) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Nucleoside phosphoramidates.
EP2598149A4 (en) 2010-07-26 2014-09-10 Merck Sharp & Dohme SUBSTITUTED BIPHENYLENE COMPOUNDS AND METHODS OF USING SAID COMPOUNDS FOR TREATING VIRAL DISEASES
JP2013540122A (en) 2010-09-29 2013-10-31 メルク・シャープ・エンド・ドーム・コーポレイション Fused tetracyclic compound derivatives and methods of use thereof for the treatment of viral diseases
JP6069215B2 (en) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー Compound
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013039876A1 (en) 2011-09-14 2013-03-21 Merck Sharp & Dohme Corp. Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
SG11201400664WA (en) 2011-09-16 2014-04-28 Gilead Pharmassett Llc Methods for treating hcv
US20130123276A1 (en) 2011-11-14 2013-05-16 Sven Ruf Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2014053533A1 (en) 2012-10-05 2014-04-10 Sanofi Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation
US20140212491A1 (en) 2013-01-31 2014-07-31 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
EP3038601B1 (en) 2013-08-27 2020-04-08 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
WO2015065817A1 (en) 2013-10-30 2015-05-07 Merck Sharp & Dohme Corp. Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof
EP2899207A1 (en) 2014-01-28 2015-07-29 Amikana.Biologics New method for testing HCV protease inhibition

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2575753B1 (en) * 1985-01-07 1987-02-20 Adir NOVEL PEPTIDE DERIVATIVES WITH NITROGEN POLYCYCLIC STRUCTURE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
CA2254122A1 (en) 1996-05-10 1997-11-20 Schering Corporation Synthetic inhibitors of hepatitis c virus ns3 protease
UA66767C2 (en) * 1996-10-18 2004-06-15 Вертекс Фармасьютикалс Інкорпорейтед Serine proteases inhibitors, pharmaceutical composition, a method for inhibitining activity and a method for treatment or prevention of viral infection of hepatitis c
HUP0100669A3 (en) * 1996-12-06 2001-12-28 Cortech Inc Denver Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
AU757072B2 (en) 1997-08-11 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptide analogues
IL134232A0 (en) 1997-08-11 2001-04-30 Boehringer Ingelheim Ca Ltd Hepatitis c inhibitor peptides
ATE346035T1 (en) 1998-03-31 2006-12-15 Vertex Pharma INHIBITORS OF SERINE PROTEASES, IN PARTICULAR HEPATITIS C VIRUS NS3 PROTEASE
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
AR022061A1 (en) * 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd INHIBITING PEPTIDES OF HEPATITIS C, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, THE USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION, THE USE OF AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF THESE PEPTIDES AND A PROCEDURE FOR THE PREPARATION OF ANOGRAPH .
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
ES2240446T3 (en) 2000-04-03 2005-10-16 Vertex Pharma SERINE PROTEASE INHIBITORS, PARTICULARLY THE NS3 PROTEASE OF HEPATITIS VIRUS C.
CN102206247B (en) 2000-07-21 2013-03-27 默沙东公司 Novel peptides as NS3/NS4a serine protease inhibitors of hepatitis C virus

Also Published As

Publication number Publication date
CN1525979A (en) 2004-09-01
ES2279879T3 (en) 2007-09-01
NZ530000A (en) 2007-03-30
JP2005522409A (en) 2005-07-28
EP1404704B1 (en) 2006-12-27
JP4455056B2 (en) 2010-04-21
NO20040127L (en) 2004-03-11
HK1065322A1 (en) 2005-02-18
EP1404704A1 (en) 2004-04-07
WO2003006490A1 (en) 2003-01-23
EP1404704B9 (en) 2008-02-20
KR20040018445A (en) 2004-03-03
DE60217114T2 (en) 2007-10-25
KR100926244B1 (en) 2009-11-12
MXPA04000293A (en) 2004-05-04
CN100402549C (en) 2008-07-16
IL159087A0 (en) 2004-05-12
US20030119752A1 (en) 2003-06-26
US6909000B2 (en) 2005-06-21
CA2449504A1 (en) 2003-01-23
IL159087A (en) 2009-08-03
ATE349463T1 (en) 2007-01-15

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