DE60216321D1 - 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazinoä4,5-büindol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung - Google Patents

3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazinoä4,5-büindol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung

Info

Publication number: DE60216321D1
Authority: DE; Germany
Prior art keywords: büindol; dihydro; heteroaryl; oxo; preparation
Prior art date: 2001-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60216321T

Other languages

English (en)

Other versions

DE60216321T2 (de

Inventor

Philippe Burnier

Jacques Froissant

Benoit Marabout

Frank Marguet

Frederic Puech

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-21

Filing date

2002-11-20

Publication date

2007-01-04

2002-11-20 Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France

2007-01-04 Publication of DE60216321D1 publication Critical patent/DE60216321D1/de

2007-06-21 Application granted granted Critical

2007-06-21 Publication of DE60216321T2 publication Critical patent/DE60216321T2/de

2022-11-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Dermatology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DE60216321T 2001-12-21 2002-11-20 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazinoä4,5-büindol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung Expired - Lifetime DE60216321T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0116701A FR2833953B1 (fr)	2001-12-21	2001-12-21	DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR0116701		2001-12-21
PCT/FR2002/003979 WO2003055884A1 (fr)	2001-12-21	2002-11-20	Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number	Publication Date
DE60216321D1 true DE60216321D1 (de)	2007-01-04
DE60216321T2 DE60216321T2 (de)	2007-06-21

Family

ID=8870861

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60216321T Expired - Lifetime DE60216321T2 (de)	2001-12-21	2002-11-20	3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazinoä4,5-büindol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung

Country Status (32)

Country	Link
US (4)	US7109194B2 (de)
EP (1)	EP1458721B1 (de)
JP (1)	JP5087204B2 (de)
KR (1)	KR100936565B1 (de)
CN (1)	CN100376579C (de)
AR (1)	AR038024A1 (de)
AT (1)	ATE346069T1 (de)
AU (1)	AU2002361325B2 (de)
BR (1)	BR0215174A (de)
CA (1)	CA2465750C (de)
CY (1)	CY1106029T1 (de)
DE (1)	DE60216321T2 (de)
DK (1)	DK1458721T3 (de)
EA (1)	EA006251B1 (de)
ES (1)	ES2276978T3 (de)
FR (1)	FR2833953B1 (de)
HR (1)	HRP20040549B1 (de)
HU (1)	HU229419B1 (de)
IL (2)	IL161859A0 (de)
IS (1)	IS2380B (de)
ME (2)	ME00117B (de)
MX (1)	MXPA04006144A (de)
NO (1)	NO328587B1 (de)
NZ (1)	NZ532996A (de)
PL (1)	PL371201A1 (de)
PT (1)	PT1458721E (de)
RS (1)	RS51103B (de)
SI (1)	SI1458721T1 (de)
TW (1)	TWI275391B (de)
UA (1)	UA77984C2 (de)
WO (1)	WO2003055884A1 (de)
ZA (1)	ZA200404245B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6278893B1 (en)	1998-01-05	2001-08-21	Nycomed Imaging As	Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
FR2838124B1 (fr) *	2002-04-03	2004-05-28	Sanofi Synthelabo	Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
US7732447B2 (en) *	2006-06-22	2010-06-08	Cephalon, Inc.	Fused [d]pyridazin-7-ones
CN1995041B (zh) *	2006-12-18	2012-06-27	沈阳药科大学	哒嗪并吲哚类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2754262B1 (fr) *	1996-10-08	1998-10-30	Synthelabo	Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) *	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) *	1999-01-26	2001-02-23	Synthelabo	Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811990A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

2001
- 2001-12-21 FR FR0116701A patent/FR2833953B1/fr not_active Expired - Fee Related
2002
- 2002-11-20 CN CNB028253353A patent/CN100376579C/zh not_active Expired - Fee Related
- 2002-11-20 DK DK02796852T patent/DK1458721T3/da active
- 2002-11-20 CA CA2465750A patent/CA2465750C/en not_active Expired - Fee Related
- 2002-11-20 EA EA200400560A patent/EA006251B1/ru not_active IP Right Cessation
- 2002-11-20 EP EP02796852A patent/EP1458721B1/de not_active Expired - Lifetime
- 2002-11-20 MX MXPA04006144A patent/MXPA04006144A/es active IP Right Grant
- 2002-11-20 HU HU0402578A patent/HU229419B1/hu not_active IP Right Cessation
- 2002-11-20 IL IL16185902A patent/IL161859A0/xx unknown
- 2002-11-20 ME MEP-2008-224A patent/ME00117B/me unknown
- 2002-11-20 ES ES02796852T patent/ES2276978T3/es not_active Expired - Lifetime
- 2002-11-20 AT AT02796852T patent/ATE346069T1/de active
- 2002-11-20 NZ NZ532996A patent/NZ532996A/en not_active IP Right Cessation
- 2002-11-20 SI SI200230482T patent/SI1458721T1/sl unknown
- 2002-11-20 KR KR1020047009601A patent/KR100936565B1/ko not_active Expired - Fee Related
- 2002-11-20 ME MEP-224/08A patent/MEP22408A/xx unknown
- 2002-11-20 PT PT02796852T patent/PT1458721E/pt unknown
- 2002-11-20 UA UA20040503612A patent/UA77984C2/uk unknown
- 2002-11-20 RS YUP-503/04A patent/RS51103B/sr unknown
- 2002-11-20 US US10/499,725 patent/US7109194B2/en not_active Expired - Lifetime
- 2002-11-20 WO PCT/FR2002/003979 patent/WO2003055884A1/fr not_active Ceased
- 2002-11-20 JP JP2003556414A patent/JP5087204B2/ja not_active Expired - Fee Related
- 2002-11-20 AU AU2002361325A patent/AU2002361325B2/en not_active Ceased
- 2002-11-20 HR HRP20040549AA patent/HRP20040549B1/hr not_active IP Right Cessation
- 2002-11-20 DE DE60216321T patent/DE60216321T2/de not_active Expired - Lifetime
- 2002-11-20 PL PL02371201A patent/PL371201A1/xx unknown
- 2002-11-20 BR BR0215174-0A patent/BR0215174A/pt not_active IP Right Cessation
- 2002-12-18 AR ARP020104928A patent/AR038024A1/es active IP Right Grant
- 2002-12-18 TW TW091136504A patent/TWI275391B/zh not_active IP Right Cessation
2004
- 2004-05-06 IL IL161859A patent/IL161859A/en not_active IP Right Cessation
- 2004-05-10 IS IS7259A patent/IS2380B/is unknown
- 2004-05-31 ZA ZA2004/04245A patent/ZA200404245B/en unknown
- 2004-06-17 NO NO20042536A patent/NO328587B1/no not_active IP Right Cessation
2006
- 2006-06-29 US US11/427,508 patent/US7402682B2/en not_active Expired - Fee Related
2007
- 2007-02-20 CY CY20071100220T patent/CY1106029T1/el unknown
2008
- 2008-06-17 US US12/140,608 patent/US7569567B2/en not_active Expired - Fee Related
2009
- 2009-06-19 US US12/487,902 patent/US20090275576A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7109194B2 (en)	2006-09-19
FR2833953B1 (fr)	2004-12-03
PT1458721E (pt)	2007-02-28
IL161859A0 (en)	2005-11-20
KR20040068958A (ko)	2004-08-02
ES2276978T3 (es)	2007-07-01
BR0215174A (pt)	2004-11-30
CY1106029T1 (el)	2011-04-06
RS50304A (sr)	2006-12-15
NO20042536L (no)	2004-09-21
FR2833953A1 (fr)	2003-06-27
TW200301120A (en)	2003-07-01
HUP0402578A2 (hu)	2005-03-29
NZ532996A (en)	2006-11-30
AR038024A1 (es)	2004-12-22
PL371201A1 (en)	2005-06-13
CN1604898A (zh)	2005-04-06
HRP20040549B1 (hr)	2012-10-31
CN100376579C (zh)	2008-03-26
EA006251B1 (ru)	2005-10-27
IL161859A (en)	2009-11-18
US20050096321A1 (en)	2005-05-05
TWI275391B (en)	2007-03-11
JP2005513158A (ja)	2005-05-12
CA2465750C (en)	2011-05-31
ZA200404245B (en)	2005-08-31
KR100936565B1 (ko)	2010-01-13
CA2465750A1 (en)	2003-07-10
EP1458721B1 (de)	2006-11-22
IS7259A (is)	2004-05-10
RS51103B (sr)	2010-10-31
MXPA04006144A (es)	2004-11-01
US7569567B2 (en)	2009-08-04
HK1065792A1 (en)	2005-03-04
EP1458721A1 (de)	2004-09-22
SI1458721T1 (sl)	2007-04-30
EA200400560A1 (ru)	2004-12-30
WO2003055884A1 (fr)	2003-07-10
DK1458721T3 (da)	2007-03-26
DE60216321T2 (de)	2007-06-21
US20060241116A1 (en)	2006-10-26
AU2002361325A1 (en)	2003-07-15
HUP0402578A3 (en)	2009-01-28
US20090275576A1 (en)	2009-11-05
NO328587B1 (no)	2010-03-22
MEP22408A (en)	2010-06-10
UA77984C2 (en)	2007-02-15
HU229419B1 (en)	2013-12-30
ME00117B (me)	2010-06-10
US20080249098A1 (en)	2008-10-09
ATE346069T1 (de)	2006-12-15
HRP20040549A2 (en)	2004-10-31
US7402682B2 (en)	2008-07-22
AU2002361325B2 (en)	2008-10-02
JP5087204B2 (ja)	2012-12-05
IS2380B (is)	2008-07-15

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