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DE60213856D1 - Indolylalkylamin-derivate als 5-hydroxytryptamin-6 liganden - Google Patents

Indolylalkylamin-derivate als 5-hydroxytryptamin-6 liganden

Info

Publication number
DE60213856D1
DE60213856D1 DE60213856T DE60213856T DE60213856D1 DE 60213856 D1 DE60213856 D1 DE 60213856D1 DE 60213856 T DE60213856 T DE 60213856T DE 60213856 T DE60213856 T DE 60213856T DE 60213856 D1 DE60213856 D1 DE 60213856D1
Authority
DE
Germany
Prior art keywords
hydroxytryptamine
indolyl
ligands
alkylamine derivatives
alkylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213856T
Other languages
English (en)
Other versions
DE60213856T2 (de
Inventor
Cecil Cole
Raymond Stock
Joseph Lennox
Ping Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60213856D1 publication Critical patent/DE60213856D1/de
Publication of DE60213856T2 publication Critical patent/DE60213856T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DE60213856T 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin-6 liganden Expired - Lifetime DE60213856T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20
US342907P 2001-12-20
PCT/US2002/040217 WO2003053433A1 (en) 2001-12-20 2002-12-17 Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands

Publications (2)

Publication Number Publication Date
DE60213856D1 true DE60213856D1 (de) 2006-09-21
DE60213856T2 DE60213856T2 (de) 2007-09-13

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60213856T Expired - Lifetime DE60213856T2 (de) 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin-6 liganden

Country Status (29)

Country Link
US (2) US6770642B2 (de)
EP (1) EP1455779B1 (de)
JP (1) JP4335684B2 (de)
KR (1) KR100985140B1 (de)
CN (1) CN1309385C (de)
AR (1) AR037906A1 (de)
AT (1) ATE335477T1 (de)
AU (1) AU2002357270B2 (de)
BR (1) BR0215222A (de)
CA (1) CA2470863C (de)
CO (1) CO5590924A2 (de)
CY (1) CY1105705T1 (de)
DE (1) DE60213856T2 (de)
DK (1) DK1455779T3 (de)
EC (1) ECSP045156A (de)
ES (1) ES2269827T3 (de)
HU (1) HUP0402640A3 (de)
IL (1) IL162243A0 (de)
MX (1) MXPA04005889A (de)
NO (1) NO330338B1 (de)
NZ (1) NZ533666A (de)
PL (1) PL210413B1 (de)
PT (1) PT1455779E (de)
RU (1) RU2309157C2 (de)
SI (1) SI1455779T1 (de)
TW (1) TWI254705B (de)
UA (1) UA78536C2 (de)
WO (1) WO2003053433A1 (de)
ZA (1) ZA200405731B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038532A1 (en) * 2000-11-09 2002-05-16 Mitsui Chemicals, Inc. Optically active amine derivative and method of synthesis
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
EP1654258A1 (de) * 2003-07-23 2006-05-10 Wyeth Sulfonyldihydrobenzimidazolonverbindungen als 5-hydroxytryptamin-6-liganden
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
AU2004261606A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-Hydroxytryptamine-6 ligands
TW200517381A (en) * 2003-08-01 2005-06-01 Genelabs Tech Inc Bicyclic heteroaryl derivatives
KR101049868B1 (ko) 2004-01-02 2011-07-19 수벤 라이프 사이언시스 리미티드 신규한 인데노[2,1ａ]인덴 및 이소인돌[2,1-ａ]인돌
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
BRPI0519036A2 (pt) * 2004-12-14 2008-12-23 Wyeth Corp mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6
RU2007130896A (ru) * 2005-01-14 2009-02-20 Дженелэбс Текнолоджиз, Инк. (Us) Индольные производные для лечения вирусных инфекций
EP1953153A1 (de) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituierte Sulfonamide für die Behandlung von Wahrnehmungsstörungen bzw. Ernährungserkrankungen
BRPI0811225A2 (pt) * 2007-05-24 2014-10-29 Memory Pharm Corp Composto 4'-substituídos tendo afinidade pelo receptor 5-ht6.
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (de) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Verfahren zur Herstellung von 6-substituiertem Imidazo[2,1-b]thiazol-5-sulfonylhalogenid
EP2231160B1 (de) * 2007-12-04 2013-08-14 Merck Sharp & Dohme Corp. Tryptamin-sulfonamide als 5-ht6-antagonisten
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
MX380810B (es) 2014-08-29 2025-03-12 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CA3230779A1 (en) 2021-09-03 2023-03-09 Paul Daley Asymmetric allyl tryptamines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
RU2101283C1 (ru) * 1992-04-07 1998-01-10 Пфайзер Инк. Производные индола или их фармацевтически приемлемые соли
US6194410B1 (en) 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
DE60011269T2 (de) * 1999-08-12 2005-06-23 Nps Allelix Corp., Mississauga Azaidole mit serotonin rezeptor affinität
AU1542201A (en) * 1999-11-05 2001-05-14 Nps Allelix Corp. Compounds having 5-HT6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
KR100985140B1 (ko) 2010-10-05
US7022701B2 (en) 2006-04-04
SI1455779T1 (sl) 2006-12-31
RU2309157C2 (ru) 2007-10-27
HUP0402640A2 (hu) 2005-04-28
TW200301252A (en) 2003-07-01
DE60213856T2 (de) 2007-09-13
JP2005517661A (ja) 2005-06-16
RU2004122129A (ru) 2005-05-10
IL162243A0 (en) 2005-11-20
US20040209867A1 (en) 2004-10-21
US6770642B2 (en) 2004-08-03
CO5590924A2 (es) 2005-12-30
CA2470863C (en) 2012-05-15
TWI254705B (en) 2006-05-11
PL370711A1 (en) 2005-05-30
AU2002357270B2 (en) 2007-06-14
ECSP045156A (es) 2004-07-23
ZA200405731B (en) 2007-02-28
HUP0402640A3 (en) 2012-09-28
BR0215222A (pt) 2005-05-24
US20030171353A1 (en) 2003-09-11
NZ533666A (en) 2006-03-31
PL210413B1 (pl) 2012-01-31
ES2269827T3 (es) 2007-04-01
KR20040075892A (ko) 2004-08-30
UA78536C2 (en) 2007-04-10
NO20043100L (no) 2004-08-26
JP4335684B2 (ja) 2009-09-30
CY1105705T1 (el) 2010-12-22
EP1455779A1 (de) 2004-09-15
MXPA04005889A (es) 2004-11-01
DK1455779T3 (da) 2006-10-30
WO2003053433A1 (en) 2003-07-03
AU2002357270A1 (en) 2003-07-09
AR037906A1 (es) 2004-12-22
CA2470863A1 (en) 2003-07-03
EP1455779B1 (de) 2006-08-09
PT1455779E (pt) 2006-11-30
HK1065949A1 (en) 2005-03-11
ATE335477T1 (de) 2006-09-15
CN1309385C (zh) 2007-04-11
CN1620290A (zh) 2005-05-25
NO330338B1 (no) 2011-03-28

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Legal Events

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