DE60213407D1 - Zusammensetzungen zur hemmung der angiogenese - Google Patents
Zusammensetzungen zur hemmung der angiogeneseInfo
- Publication number
- DE60213407D1 DE60213407D1 DE60213407T DE60213407T DE60213407D1 DE 60213407 D1 DE60213407 D1 DE 60213407D1 DE 60213407 T DE60213407 T DE 60213407T DE 60213407 T DE60213407 T DE 60213407T DE 60213407 D1 DE60213407 D1 DE 60213407D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- inhibiting
- inhibiting angiogenesis
- methods
- oleouropein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000033115 angiogenesis Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000022873 Ocular disease Diseases 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29294701P | 2001-05-23 | 2001-05-23 | |
| US292947P | 2001-05-23 | ||
| PCT/US2002/016191 WO2002094193A1 (en) | 2001-05-23 | 2002-05-22 | Methods for inhibiting angiogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60213407D1 true DE60213407D1 (de) | 2006-09-07 |
| DE60213407T2 DE60213407T2 (de) | 2007-08-23 |
Family
ID=23126933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60213407T Expired - Fee Related DE60213407T2 (de) | 2001-05-23 | 2002-05-22 | Zusammensetzungen zur hemmung der angiogenese |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6632798B2 (de) |
| EP (1) | EP1397105B1 (de) |
| JP (1) | JP2005508856A (de) |
| CN (1) | CN1315479C (de) |
| AT (1) | ATE333882T1 (de) |
| AU (1) | AU2002311985B9 (de) |
| BR (1) | BR0209922A (de) |
| CA (1) | CA2447231A1 (de) |
| DE (1) | DE60213407T2 (de) |
| DK (1) | DK1397105T3 (de) |
| ES (1) | ES2266512T3 (de) |
| IL (1) | IL158899A0 (de) |
| MX (1) | MXPA03010528A (de) |
| PT (1) | PT1397105E (de) |
| WO (1) | WO2002094193A1 (de) |
| ZA (1) | ZA200308763B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3629939B2 (ja) * | 1998-03-18 | 2005-03-16 | セイコーエプソン株式会社 | トランジスタ回路、表示パネル及び電子機器 |
| US20030086986A1 (en) * | 1998-08-06 | 2003-05-08 | Bruijn Chris De | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives |
| US7468355B2 (en) * | 2002-05-22 | 2008-12-23 | H2Rc Corporation | Methods for inhibiting cancer and scar formation |
| FR2853549B1 (fr) * | 2003-04-11 | 2007-11-09 | Agronomique Inst Nat Rech | Composition nutritionnelle ou therapeutique contenant le compose oleuropeine ou l'un de ses derives |
| US20060100368A1 (en) * | 2004-11-08 | 2006-05-11 | Park Edward H | Elastomer gum polymer systems |
| EP1819356A4 (de) * | 2004-11-18 | 2010-07-07 | Biopharmacopae Design Internat | Pflanzenextrakt mit matrixmetalloproteasehemmender wirksamkeit und seine verwendungen in der dermatologie |
| KR101351674B1 (ko) * | 2005-09-30 | 2014-01-14 | 디에스엠 아이피 어셋츠 비.브이. | 폴리페놀을 함유하는 신규 조성물 |
| ES2274721B1 (es) * | 2005-11-03 | 2008-06-01 | Laboratorios Belmac, S.A. | Nuevo agente terapeutico para el tratamiento de una condicion asociada a la enfermedad vascular periferica. |
| ES2289897B1 (es) * | 2005-11-08 | 2008-12-16 | Laboratorios Belmac, S.A. | Composicion para administracion transdermica de agentes fisiologicamente activos. |
| WO2007088492A2 (en) * | 2006-02-01 | 2007-08-09 | Philips Intellectual Property & Standards Gmbh | Improved radiation therapy planning procedure |
| CN101516364B (zh) * | 2006-07-14 | 2011-12-28 | 帝斯曼知识产权资产管理有限公司 | 组合物及其用于治疗、共治疗或预防炎性病症的用途 |
| JP5175481B2 (ja) * | 2006-10-23 | 2013-04-03 | エーザイフード・ケミカル株式会社 | 軟骨再生促進剤 |
| KR100834444B1 (ko) * | 2007-01-15 | 2008-06-09 | 원광대학교산학협력단 | 물푸레나무로부터 분리된 올레우로페인 화합물을 포함하는톡소플라즈마증 예방 및 치료용 약학조성물 |
| EP2134333A1 (de) * | 2007-04-18 | 2009-12-23 | DSM IP Assets B.V. | Neuartige verwendung von hydroxytyrosol und dieses enthaltenden olivenextrakten-konzentraten |
| ES2343880B8 (es) * | 2007-05-10 | 2011-12-01 | Universidad De Malaga | Piridotienotriazinas como compuestos antiangiogenicos. |
| JP5138341B2 (ja) * | 2007-11-07 | 2013-02-06 | 日本メナード化粧品株式会社 | 抗アレルギー剤 |
| KR101098952B1 (ko) * | 2009-05-08 | 2011-12-28 | 한국생명공학연구원 | 갈잎떨기나무 추출물을 포함하는 염증성 질환 또는 감염성 질환의 예방 또는 치료용 조성물 |
| WO2011141611A1 (es) | 2010-05-14 | 2011-11-17 | Sanidad Y Residencias 21, S.A., | Composiciones de oleuropeína para cicatrización de heridas y úlceras en ancianos y/o diabéticos |
| ES2349976B1 (es) * | 2009-05-14 | 2011-11-10 | Sanidad Y Residencias 21 Sa | Utilizacion de extractos de hojas de olivo en una composicion farmaceutica para inducir angiogenesis y vasculogenesis. |
| US8092843B2 (en) * | 2009-09-23 | 2012-01-10 | East Park Research, Inc. | Method and composition for cutaneous treatment of herpes simplex infections |
| ITMI20111042A1 (it) * | 2011-06-09 | 2012-12-10 | Flavia Franconi | Frazioni standardizzate da olea europaea l. e loro uso genere specifico per la prevenzione delle patologie invecchiamento-correlate |
| US9073824B2 (en) | 2012-01-26 | 2015-07-07 | Prairie Pharms, Llc | Method for cultivation of Monarda fistulosa for production of thymoquinone |
| KR101269490B1 (ko) * | 2012-07-09 | 2013-05-30 | 연세대학교 산학협력단 | 세코이리도이드 글루코사이드 유도체를 유효성분으로 포함하는 탈모의 예방 또는 치료용 조성물 |
| CN102942605B (zh) * | 2012-11-30 | 2016-06-15 | 沈阳药科大学 | 清香藤中环烯醚萜类化合物的制备方法及其应用 |
| CN104784241A (zh) * | 2014-01-22 | 2015-07-22 | 上海御先医药科技有限公司 | 一种橄榄树叶粗提物的新用途 |
| CN104473949A (zh) * | 2014-11-11 | 2015-04-01 | 济南星懿医药技术有限公司 | 一种治疗肝癌的药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014064A1 (en) * | 1994-11-07 | 1996-05-17 | Strecker, Robert, B. | Method and composition for antiviral therapy |
| MXPA01000776A (es) * | 1998-07-23 | 2002-04-08 | Creagri Inc | Extracto de oliva soluble en agua. |
| US6358542B2 (en) * | 1999-12-20 | 2002-03-19 | Usana, Inc. | Antioxidant compositions extracted from olives and olive by-products |
| AU2000258901A1 (en) * | 2000-04-06 | 2001-10-23 | Nicholas V. Perricone | Treatment of skin damage using olive oil polyphenols |
| US6440465B1 (en) * | 2000-05-01 | 2002-08-27 | Bioderm, Inc. | Topical composition for the treatment of psoriasis and related skin disorders |
-
2002
- 2002-05-22 US US10/153,003 patent/US6632798B2/en not_active Expired - Fee Related
- 2002-05-22 MX MXPA03010528A patent/MXPA03010528A/es active IP Right Grant
- 2002-05-22 IL IL15889902A patent/IL158899A0/xx unknown
- 2002-05-22 AT AT02739332T patent/ATE333882T1/de not_active IP Right Cessation
- 2002-05-22 WO PCT/US2002/016191 patent/WO2002094193A1/en not_active Ceased
- 2002-05-22 DE DE60213407T patent/DE60213407T2/de not_active Expired - Fee Related
- 2002-05-22 AU AU2002311985A patent/AU2002311985B9/en not_active Ceased
- 2002-05-22 CN CNB028121252A patent/CN1315479C/zh not_active Expired - Fee Related
- 2002-05-22 EP EP02739332A patent/EP1397105B1/de not_active Expired - Lifetime
- 2002-05-22 DK DK02739332T patent/DK1397105T3/da active
- 2002-05-22 PT PT02739332T patent/PT1397105E/pt unknown
- 2002-05-22 BR BR0209922-5A patent/BR0209922A/pt not_active IP Right Cessation
- 2002-05-22 CA CA002447231A patent/CA2447231A1/en not_active Abandoned
- 2002-05-22 ES ES02739332T patent/ES2266512T3/es not_active Expired - Lifetime
- 2002-05-22 JP JP2002590914A patent/JP2005508856A/ja active Pending
-
2003
- 2003-11-11 ZA ZA200308763A patent/ZA200308763B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1397105B1 (de) | 2006-07-26 |
| BR0209922A (pt) | 2004-07-27 |
| AU2002311985B2 (en) | 2008-04-10 |
| DK1397105T3 (da) | 2006-11-27 |
| CN1531435A (zh) | 2004-09-22 |
| DE60213407T2 (de) | 2007-08-23 |
| AU2002311985B9 (en) | 2008-07-10 |
| CA2447231A1 (en) | 2002-11-28 |
| PT1397105E (pt) | 2006-12-29 |
| US6632798B2 (en) | 2003-10-14 |
| US20030004117A1 (en) | 2003-01-02 |
| ATE333882T1 (de) | 2006-08-15 |
| ZA200308763B (en) | 2004-05-26 |
| MXPA03010528A (es) | 2005-04-19 |
| JP2005508856A (ja) | 2005-04-07 |
| EP1397105A1 (de) | 2004-03-17 |
| IL158899A0 (en) | 2004-05-12 |
| CN1315479C (zh) | 2007-05-16 |
| ES2266512T3 (es) | 2007-03-01 |
| WO2002094193A1 (en) | 2002-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE333882T1 (de) | Zusammensetzungen zur hemmung der angiogenese | |
| DK1187918T4 (da) | TEK-antagonister | |
| ATE320426T1 (de) | Harnstoffderivate und ihre verwendung | |
| MA25809A1 (fr) | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase | |
| DZ3402A1 (fr) | Cyclopentanoindoles, compositions contenant ces composes et methodes de traitement | |
| BG105880A (en) | Compounds useful as anti-inflammatory agents | |
| BR0011130A (pt) | Inibidores de metaloproteases | |
| WO2004098589A8 (en) | 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | |
| IL157652A (en) | Metalloproteinase inhibitors, compositions comprising them and uses thereof for the preparation of medicaments for treating diseases or conditions mediated by metalloproteinase enzymes | |
| ATE404552T1 (de) | Substituierte isochinolinderivate und anwendungsverfahren | |
| WO2004078712A3 (en) | Isoquinoline derivatives and methods of use thereof | |
| BG106406A (en) | Pyrimidine-2,4,6-trione metalloproteinase inhibitors | |
| EA200900663A1 (ru) | Лечение синдрома "сухого глаза" | |
| DE60323133D1 (de) | Cyclohexylverbindungen als ccr5-antagonisten | |
| ATE452884T1 (de) | Arylmethylamin-derivate zur verwendung als inhibitoren von tryptase | |
| NO20060278L (no) | Piperazinderivater og fremgangsmater for anvendelse | |
| MXPA02011858A (es) | Inhibidores de adhesion de celula mediada por alfabeta2. | |
| ATE365735T1 (de) | Cycloalkylsulfanyl-substituierte benzo böthiophene als therapeutische mittel | |
| MXPA05012953A (es) | Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos. | |
| ATE319473T1 (de) | Melagatran zur behandlung von entzündungen | |
| IS6130A (is) | Bólgueyðandi meðhöndlun fyrir bólgu tengt smit | |
| DE60226313D1 (de) | Verwendung von sesquiterpene enthaltenden zusammenstellungen zur behandlung von krebs | |
| BR0208655A (pt) | Composição farmacêuticas | |
| WO2006041888A3 (en) | Substituted aryl or heteroarylsulfonylbutanamides for use as anti-inflammatory agents | |
| WO2002076397A3 (en) | Telomerase inhibitors and methods of their use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |