DE60209014D1 - Tricylische CRF Rezeptorantagonisten - Google Patents

Tricylische CRF Rezeptorantagonisten

Info

Publication number: DE60209014D1
Authority: DE; Germany
Prior art keywords: tricylic; receptor antagonists; crf receptor; formula; crf
Prior art date: 2001-07-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60209014T

Other languages

English (en)

Other versions

DE60209014T2 (de

Inventor

Fabio Romanoiglaxosmithklin Di

Fabrizioiglaxosmithkli Micheli

F Ineurocrine Bioscience Regan

K Ineurocrine Bioscie Schwaebe

Yvesiglaxosmithkline St-Denis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Neurocrine Biosciences Inc

SB Pharmco Puerto Rico Inc

Original Assignee

Neurocrine Biosciences Inc

SB Pharmco Puerto Rico Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-15

Publication date

2006-04-13

2002-07-15 Application filed by Neurocrine Biosciences Inc, SB Pharmco Puerto Rico Inc filed Critical Neurocrine Biosciences Inc

2006-04-13 Publication of DE60209014D1 publication Critical patent/DE60209014D1/de

2006-07-13 Application granted granted Critical

2006-07-13 Publication of DE60209014T2 publication Critical patent/DE60209014T2/de

2022-07-16 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
External Artificial Organs (AREA)

DE60209014T 2001-07-17 2002-07-15 Tricylische CRF Rezeptorantagonisten Expired - Fee Related DE60209014T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0117395		2001-07-17
GBGB0117395.4A GB0117395D0 (en)	2001-07-17	2001-07-17	Chemical compounds
PCT/US2002/022394 WO2003008414A1 (en)	2001-07-17	2002-07-15	Chemical compounds

Publications (2)

Publication Number	Publication Date
DE60209014D1 true DE60209014D1 (de)	2006-04-13
DE60209014T2 DE60209014T2 (de)	2006-07-13

Family

ID=9918654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60209014T Expired - Fee Related DE60209014T2 (de)	2001-07-17	2002-07-15	Tricylische CRF Rezeptorantagonisten

Country Status (20)

Country	Link
EP (1)	EP1425281B1 (de)
JP (1)	JP2004537555A (de)
KR (1)	KR20040027880A (de)
CN (1)	CN1541217A (de)
AT (1)	ATE316972T1 (de)
AU (1)	AU2002354916B2 (de)
BR (1)	BR0211220A (de)
CA (1)	CA2452009A1 (de)
DE (1)	DE60209014T2 (de)
ES (1)	ES2256506T3 (de)
GB (1)	GB0117395D0 (de)
HU (1)	HUP0400460A2 (de)
IL (1)	IL159521A0 (de)
MX (1)	MXPA04000492A (de)
NO (1)	NO20040203L (de)
NZ (1)	NZ530508A (de)
PL (1)	PL367965A1 (de)
RU (1)	RU2004104464A (de)
WO (1)	WO2003008414A1 (de)
ZA (1)	ZA200309942B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ528364A (en)	2001-04-30	2005-12-23	Glaxo Group Ltd	CRF receptor antagonists
CN1529705A (zh)	2001-05-21	2004-09-15	Ŧ�޿��ѧ��˾	作为crf受体拮抗剂的三-与四-氮杂苊衍生物
DE602008003055D1 (de) *	2007-05-31	2010-12-02	Nerviano Medical Sciences Srl	Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken
CN102459267B (zh)	2009-06-08	2014-11-26	武田药品工业株式会社	用作jak抑制剂的二氢吡咯并萘啶酮化合物
RU2498986C2 (ru) *	2011-07-20	2013-11-20	Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран)	ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
CN106279011A (zh) *	2016-08-16	2017-01-04	成都百事兴科技实业有限公司	一种2,4‑二羟基‑6‑甲基烟酸乙酯的制备方法
KR102462991B1 (ko) *	2020-11-02	2022-11-04	한국해양과학기술원	남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
BR9915129A (pt) *	1998-11-12	2001-08-07	Neurocrine Biosciences Inc	Antagonistas do receptor de crf e processos relacionados aos mesmos
US6514982B1 (en) *	1998-11-12	2003-02-04	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto

2001
- 2001-07-17 GB GBGB0117395.4A patent/GB0117395D0/en not_active Ceased
2002
- 2002-07-15 IL IL15952102A patent/IL159521A0/xx unknown
- 2002-07-15 WO PCT/US2002/022394 patent/WO2003008414A1/en not_active Ceased
- 2002-07-15 RU RU2004104464/04A patent/RU2004104464A/ru not_active Application Discontinuation
- 2002-07-15 PL PL02367965A patent/PL367965A1/xx not_active Application Discontinuation
- 2002-07-15 KR KR10-2004-7000714A patent/KR20040027880A/ko not_active Withdrawn
- 2002-07-15 MX MXPA04000492A patent/MXPA04000492A/es active IP Right Grant
- 2002-07-15 NZ NZ530508A patent/NZ530508A/en unknown
- 2002-07-15 DE DE60209014T patent/DE60209014T2/de not_active Expired - Fee Related
- 2002-07-15 JP JP2003513973A patent/JP2004537555A/ja active Pending
- 2002-07-15 CN CNA02815746XA patent/CN1541217A/zh active Pending
- 2002-07-15 CA CA002452009A patent/CA2452009A1/en not_active Abandoned
- 2002-07-15 ES ES02752340T patent/ES2256506T3/es not_active Expired - Lifetime
- 2002-07-15 HU HU0400460A patent/HUP0400460A2/hu unknown
- 2002-07-15 BR BR0211220-5A patent/BR0211220A/pt not_active IP Right Cessation
- 2002-07-15 EP EP02752340A patent/EP1425281B1/de not_active Expired - Lifetime
- 2002-07-15 AT AT02752340T patent/ATE316972T1/de not_active IP Right Cessation
- 2002-07-15 AU AU2002354916A patent/AU2002354916B2/en not_active Ceased
2003
- 2003-12-23 ZA ZA200309942A patent/ZA200309942B/xx unknown
2004
- 2004-01-16 NO NO20040203A patent/NO20040203L/no unknown

Also Published As

Publication number	Publication date
NO20040203L (no)	2004-03-16
KR20040027880A (ko)	2004-04-01
WO2003008414A1 (en)	2003-01-30
AU2002354916B2 (en)	2006-10-19
IL159521A0 (en)	2004-06-01
NZ530508A (en)	2005-11-25
CN1541217A (zh)	2004-10-27
JP2004537555A (ja)	2004-12-16
RU2004104464A (ru)	2005-08-10
MXPA04000492A (es)	2005-03-07
ATE316972T1 (de)	2006-02-15
EP1425281A1 (de)	2004-06-09
HUP0400460A2 (hu)	2005-01-28
ZA200309942B (en)	2004-05-25
PL367965A1 (en)	2005-03-07
EP1425281B1 (de)	2006-02-01
ES2256506T3 (es)	2006-07-16
GB0117395D0 (en)	2001-09-05
DE60209014T2 (de)	2006-07-13
CA2452009A1 (en)	2003-01-30
BR0211220A (pt)	2004-07-13

Publication	Publication Date	Title
DE602004005960D1 (de)	2007-05-31	Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
MXPA03005464A (es)	2004-04-20	Agentes antivirales.
TW200508212A (en)	2005-03-01	Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
MY139446A (en)	2009-10-30	Novel quinoline derivatives
EA200700099A1 (ru)	2007-08-31	Производные пиридина
PL1716152T3 (pl)	2009-01-30	Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
EA200801909A1 (ru)	2009-06-30	Соединения пиридина для лечения заболеваний, опосредованных действием простагландина
ATE338042T1 (de)	2006-09-15	Hetero-bicyclische crf antagonisten
IS8377A (is)	2006-03-27	Arýlindenópyridín og arýlindenópyrimidín og notkun þeirra sem mótlyf A2A viðtaka adenósíns
DE60209014D1 (de)	2006-04-13	Tricylische CRF Rezeptorantagonisten
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
DE60226971D1 (de)	2008-07-17	Corticotropinfreisetzungsfaktor antagonisten
BR0209035A (pt)	2004-08-10	Antagonistas de receptor crf
YU82302A (sh)	2005-11-28	Derivati 2-aminokarbonil-9h-purina
BG105427A (en)	2001-12-29	Esters of (+)-alpha-(2,3-dimethyloxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pi peridinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 100,907

Legal Events

Date	Code	Title	Description
2007-02-22	8364	No opposition during term of opposition
2010-05-20	8339	Ceased/non-payment of the annual fee