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DE602007009379D1 - Neue, von podophyllotoxin abgeleitete gem-difluorid-c-glycosidverbindungen, ihre herstellung und anwendungen - Google Patents

Neue, von podophyllotoxin abgeleitete gem-difluorid-c-glycosidverbindungen, ihre herstellung und anwendungen

Info

Publication number
DE602007009379D1
DE602007009379D1 DE602007009379T DE602007009379T DE602007009379D1 DE 602007009379 D1 DE602007009379 D1 DE 602007009379D1 DE 602007009379 T DE602007009379 T DE 602007009379T DE 602007009379 T DE602007009379 T DE 602007009379T DE 602007009379 D1 DE602007009379 D1 DE 602007009379D1
Authority
DE
Germany
Prior art keywords
difluoride
gra
benzyl
alkyl
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007009379T
Other languages
English (en)
Inventor
Jean-Charles Quirion
Deliencourt-Godefroy Geraldine Castelot
Christophe Audouard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST NAT SCIENCES APPLIQ
Institut National des Sciences Appliquees de Rouen
Original Assignee
INST NAT SCIENCES APPLIQ
Institut National des Sciences Appliquees de Rouen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST NAT SCIENCES APPLIQ, Institut National des Sciences Appliquees de Rouen filed Critical INST NAT SCIENCES APPLIQ
Publication of DE602007009379D1 publication Critical patent/DE602007009379D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE602007009379T 2006-04-25 2007-04-24 Neue, von podophyllotoxin abgeleitete gem-difluorid-c-glycosidverbindungen, ihre herstellung und anwendungen Active DE602007009379D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0603766A FR2900154B1 (fr) 2006-04-25 2006-04-25 Nouveaux composes c-glycosides gem-difluores derives de la podophyllotoxine, leur preparation et leurs applications.
PCT/FR2007/000697 WO2007125194A1 (fr) 2006-04-25 2007-04-24 Nouveaux composes c-glycosides gem-difluores derives de la podophyllotoxine, leur preparation et leurs applications

Publications (1)

Publication Number Publication Date
DE602007009379D1 true DE602007009379D1 (de) 2010-11-04

Family

ID=37198762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007009379T Active DE602007009379D1 (de) 2006-04-25 2007-04-24 Neue, von podophyllotoxin abgeleitete gem-difluorid-c-glycosidverbindungen, ihre herstellung und anwendungen

Country Status (8)

Country Link
US (1) US8236935B2 (de)
EP (1) EP2024379B1 (de)
AT (1) ATE482225T1 (de)
CA (1) CA2650384C (de)
DE (1) DE602007009379D1 (de)
ES (1) ES2353436T3 (de)
FR (1) FR2900154B1 (de)
WO (1) WO2007125194A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102234283B (zh) 2010-04-23 2013-06-12 湖北工业大学 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用
MX2013007292A (es) 2010-12-22 2014-01-31 Tfchem Derivados de glico-cf2-serina y glico-cf2-treonina.
US9062313B2 (en) 2011-08-08 2015-06-23 Tfchem Gem-difluorinated C-isopropylgalactoside derivates
JP2016504394A (ja) * 2013-01-14 2016-02-12 アドバンノミクス コーポレーションＡｄｖａｎｏｍｉｃｓ Ｃｏｒｐｏｒａｔｉｏｎ 抗がん剤としてのゲム−ジふっ化ｃ−グリコシド化合物
EP3119800B9 (de) 2014-03-17 2021-06-09 Tfchem Glycopeptidderivate zur konservierung und zum schutz von biologischen materialien und mikroorganismen
CN112961135B (zh) * 2021-02-05 2021-11-26 安庆奇创药业有限公司 一种采用微通道反应装置连续合成苄基取代葡萄糖酸内酯的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197486A (ja) * 1988-02-03 1989-08-09 Nippon Kayaku Co Ltd 新規ポドフィロトキシン誘導体、抗腫瘍剤及び中間体
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
WO2001049693A1 (en) * 2000-01-03 2001-07-12 Korea Research Institute Of Chemical Technology 4-O-[2-(N,N-DIALKYLAMINO)-2-DEOXY-4,6-O,O-beta-D-GLUCOSYL]-4'-O-DEMETHYL-EPI-PODOPHYLLOTOXIN, DERIVATIVES, AND AN ANTICANCER COMPOSITION CONTAINING SAME

Also Published As

Publication number Publication date
CA2650384C (en) 2014-08-05
US8236935B2 (en) 2012-08-07
US20090318675A1 (en) 2009-12-24
ES2353436T3 (es) 2011-03-02
CA2650384A1 (en) 2007-11-08
WO2007125194A1 (fr) 2007-11-08
FR2900154B1 (fr) 2008-07-04
EP2024379A1 (de) 2009-02-18
FR2900154A1 (fr) 2007-10-26
ATE482225T1 (de) 2010-10-15
EP2024379B1 (de) 2010-09-22

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