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DE602007006950D1 - Benzimidazol-substituierte thiophenderivate mit wirkung auf plk - Google Patents

Benzimidazol-substituierte thiophenderivate mit wirkung auf plk

Info

Publication number
DE602007006950D1
DE602007006950D1 DE602007006950T DE602007006950T DE602007006950D1 DE 602007006950 D1 DE602007006950 D1 DE 602007006950D1 DE 602007006950 T DE602007006950 T DE 602007006950T DE 602007006950 T DE602007006950 T DE 602007006950T DE 602007006950 D1 DE602007006950 D1 DE 602007006950D1
Authority
DE
Germany
Prior art keywords
plk
benzimidazol
effect
substituted thiophene
thiophene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007006950T
Other languages
English (en)
Inventor
Kevin Kuntz
Kyle Allen Emmitte
Tara Renae Rheault
Stephon Smith
Keith Hornberger
Hamilton Dickson
Mui Cheung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of DE602007006950D1 publication Critical patent/DE602007006950D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE602007006950T 2006-06-02 2007-05-29 Benzimidazol-substituierte thiophenderivate mit wirkung auf plk Active DE602007006950D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81052606P 2006-06-02 2006-06-02
PCT/US2007/069879 WO2007143456A2 (en) 2006-06-02 2007-05-29 Benzimidazol substituted thiophene derivatives with activity on plk

Publications (1)

Publication Number Publication Date
DE602007006950D1 true DE602007006950D1 (de) 2010-07-15

Family

ID=38657232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007006950T Active DE602007006950D1 (de) 2006-06-02 2007-05-29 Benzimidazol-substituierte thiophenderivate mit wirkung auf plk

Country Status (9)

Country Link
US (1) US20100075960A1 (de)
EP (1) EP2032563B1 (de)
JP (1) JP2009539770A (de)
AR (1) AR060979A1 (de)
AT (1) ATE469894T1 (de)
DE (1) DE602007006950D1 (de)
PE (1) PE20080710A1 (de)
TW (1) TW200808756A (de)
WO (1) WO2007143456A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2621879A1 (en) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Benzimidazole thiophene compounds as plk inhibitors
PE20110837A1 (es) * 2009-01-09 2011-11-27 Panacea Biotec Ltd Suspension farmaceutica de liberacion doble
JP7569688B2 (ja) 2017-12-22 2024-10-18 ハイバーセル，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
AU2020311297A1 (en) * 2019-07-10 2022-02-03 Aucentra Therapeutics Pty Ltd DERIVATIVES OF 4-(IMIDAZO[l,2-a]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313160A (pt) * 2002-08-08 2005-07-12 Smithkline Beecham Corp Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto
US7465807B2 (en) * 2003-10-16 2008-12-16 Smithkline Beecham Corporation Process for preparing benzimidazole thiophenes
GB0402809D0 (en) * 2004-02-09 2004-03-10 Glaxo Group Ltd Chemical compounds
CA2621879A1 (en) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Benzimidazole thiophene compounds as plk inhibitors
WO2007030359A1 (en) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Benzimidazole thiophene compounds as plk modulators
EP2474546A1 (de) * 2006-01-23 2012-07-11 Vertex Pharmaceuticals Inc. Thiophencarboxamide als Proteinkinaseinhibitoren
US7615643B2 (en) * 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds

Also Published As

Publication number Publication date
JP2009539770A (ja) 2009-11-19
US20100075960A1 (en) 2010-03-25
ATE469894T1 (de) 2010-06-15
WO2007143456A2 (en) 2007-12-13
EP2032563A2 (de) 2009-03-11
AR060979A1 (es) 2008-07-23
PE20080710A1 (es) 2008-08-07
WO2007143456A3 (en) 2008-02-14
EP2032563B1 (de) 2010-06-02
TW200808756A (en) 2008-02-16

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