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DE602007005811D1 - 6-substituierte isochinolinderivate als rock-1-inhibitoren - Google Patents

6-substituierte isochinolinderivate als rock-1-inhibitoren

Info

Publication number
DE602007005811D1
DE602007005811D1 DE602007005811T DE602007005811T DE602007005811D1 DE 602007005811 D1 DE602007005811 D1 DE 602007005811D1 DE 602007005811 T DE602007005811 T DE 602007005811T DE 602007005811 T DE602007005811 T DE 602007005811T DE 602007005811 D1 DE602007005811 D1 DE 602007005811D1
Authority
DE
Germany
Prior art keywords
alkyl
halogen
substituted
rock
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007005811T
Other languages
English (en)
Inventor
Peter Christopher Ray
Steven Laats
John Richard Morphy
Brad Sherborne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of DE602007005811D1 publication Critical patent/DE602007005811D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE602007005811T 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1-inhibitoren Active DE602007005811D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119142 2006-08-18
PCT/EP2007/058593 WO2008020081A1 (en) 2006-08-18 2007-08-17 6-substituted isoquinoline derivatives as rock-1 inhibitors

Publications (1)

Publication Number Publication Date
DE602007005811D1 true DE602007005811D1 (de) 2010-05-20

Family

ID=37062542

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007005811T Active DE602007005811D1 (de) 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1-inhibitoren

Country Status (10)

Country Link
US (1) US7893088B2 (de)
EP (1) EP2054389B1 (de)
JP (1) JP5341758B2 (de)
CN (1) CN101522633B (de)
AT (1) ATE463483T1 (de)
CA (1) CA2660489A1 (de)
DE (1) DE602007005811D1 (de)
ES (1) ES2341809T3 (de)
MX (1) MX2009001804A (de)
WO (1) WO2008020081A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006008945D1 (de) * 2005-06-28 2009-10-15 Sanofi Aventis Isochinolinderivate als inhibitoren von rho-kinase
ES2372067T3 (es) 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
BRPI0613861B8 (pt) 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase
MY148514A (en) * 2006-12-27 2013-04-30 Sanofi Aventis Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives
JP5405314B2 (ja) * 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノロン誘導体
KR101517154B1 (ko) * 2006-12-27 2015-04-30 사노피 Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
JP5313919B2 (ja) * 2006-12-27 2013-10-09 サノフイ 新規な置換イソキノリン及びイソキノリノン誘導体
CN101573353B (zh) 2006-12-27 2014-08-06 塞诺菲-安万特股份有限公司 取代的异喹啉和异喹啉酮衍生物
RS51655B (sr) * 2006-12-27 2011-10-31 Sanofi-Aventis Derivati izohinolina i izohinolinona supstituisani cikloalkilaminom
MY151953A (en) * 2006-12-27 2014-07-31 Sanofi Aventis Cycloalkylamine substituted isoquinoline derivatives
KR101638326B1 (ko) * 2008-06-24 2016-07-12 사노피 Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논
AU2009262516B8 (en) * 2008-06-24 2014-01-30 Sanofi 6-substituted isoquinolines and isoquinolinones
HRP20131040T1 (hr) * 2008-06-24 2013-12-06 Sanofi Bi- i policikliäśki supstituirani izokinolin i derivati izokinolina kao inhibitori rho-kinaze
WO2009158587A1 (en) * 2008-06-26 2009-12-30 Inspire Pharmaceuticals, Inc. Method for treating pulmonary diseases using rho kinase inhibitor compounds
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US12398118B2 (en) 2018-11-09 2025-08-26 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and use thereof
EP4096666A4 (de) * 2020-01-29 2024-05-22 Georgetown University Zusammensetzungen und verfahren zur behandlung von neurodegenerativen, neuroentwicklungs-, myodegenerativen und lysosomalen speicherkrankheiten
CN111440150B (zh) * 2020-05-12 2021-04-06 中国药科大学 一种一氧化氮供体型法舒地尔衍生物及其制备方法和用途
EP4504909A1 (de) * 2022-04-05 2025-02-12 University of Washington Verfahren zur verbesserung der lebensfähigkeit von zellen von kardiomyozyten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
EP1541559A4 (de) 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-substituiertes isochinolinderivat
US7615564B2 (en) * 2002-09-12 2009-11-10 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
ES2372067T3 (es) 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives

Also Published As

Publication number Publication date
JP2010501480A (ja) 2010-01-21
CA2660489A1 (en) 2008-02-21
CN101522633A (zh) 2009-09-02
JP5341758B2 (ja) 2013-11-13
EP2054389B1 (de) 2010-04-07
ES2341809T3 (es) 2010-06-28
US7893088B2 (en) 2011-02-22
CN101522633B (zh) 2012-05-09
ATE463483T1 (de) 2010-04-15
US20080045566A1 (en) 2008-02-21
EP2054389A1 (de) 2009-05-06
WO2008020081A1 (en) 2008-02-21
MX2009001804A (es) 2009-02-26

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