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DE602007005779D1 - Tricyclische n-heteroaryl-carboxamid-derivate mit einer benzimidazol-einheit, verfahren zu ihrer herstellung und ihre therapeutische verwendung - Google Patents

Tricyclische n-heteroaryl-carboxamid-derivate mit einer benzimidazol-einheit, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Info

Publication number
DE602007005779D1
DE602007005779D1 DE602007005779T DE602007005779T DE602007005779D1 DE 602007005779 D1 DE602007005779 D1 DE 602007005779D1 DE 602007005779 T DE602007005779 T DE 602007005779T DE 602007005779 T DE602007005779 T DE 602007005779T DE 602007005779 D1 DE602007005779 D1 DE 602007005779D1
Authority
DE
Germany
Prior art keywords
tricyclic
production
therapeutic use
carboxamide derivatives
benzimidazole unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007005779T
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Luc Even
Catherine Gille
Andre Malanda
David Machnik
Nathalie Rakotoarisoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE602007005779D1 publication Critical patent/DE602007005779D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Pregnancy & Childbirth (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602007005779T 2006-02-03 2007-02-01 Tricyclische n-heteroaryl-carboxamid-derivate mit einer benzimidazol-einheit, verfahren zu ihrer herstellung und ihre therapeutische verwendung Active DE602007005779D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0601007A FR2897061B1 (fr) 2006-02-03 2006-02-03 Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.
PCT/FR2007/000183 WO2007088277A1 (fr) 2006-02-03 2007-02-01 Dérivés de ν-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
DE602007005779D1 true DE602007005779D1 (de) 2010-05-20

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DE602007005779T Active DE602007005779D1 (de) 2006-02-03 2007-02-01 Tricyclische n-heteroaryl-carboxamid-derivate mit einer benzimidazol-einheit, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Country Status (32)

Country Link
US (2) US8143248B2 (de)
EP (1) EP1987010B1 (de)
JP (1) JP5136938B2 (de)
KR (1) KR20080090495A (de)
CN (1) CN101379041B (de)
AR (1) AR059279A1 (de)
AT (1) ATE463484T1 (de)
AU (1) AU2007211399B2 (de)
BR (1) BRPI0710480A2 (de)
CA (1) CA2637333C (de)
CY (1) CY1110168T1 (de)
DE (1) DE602007005779D1 (de)
DK (1) DK1987010T3 (de)
DO (1) DOP2007000022A (de)
EA (1) EA014450B1 (de)
ES (1) ES2344087T3 (de)
FR (1) FR2897061B1 (de)
HR (1) HRP20100327T1 (de)
IL (1) IL192648A (de)
JO (1) JO2602B1 (de)
MA (1) MA30229B1 (de)
NO (1) NO20083520L (de)
NZ (1) NZ569669A (de)
PE (1) PE20071325A1 (de)
PL (1) PL1987010T3 (de)
PT (1) PT1987010E (de)
RS (1) RS51366B (de)
SI (1) SI1987010T1 (de)
TW (1) TWI401256B (de)
UY (1) UY30130A1 (de)
WO (1) WO2007088277A1 (de)
ZA (1) ZA200806139B (de)

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FR2911604B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
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FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
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RS63190B1 (sr) 2014-08-04 2022-06-30 Nuevolution As Opciono fuzionisani derivati pirimidina zamenjeni heterociklilom korisni za lečenje zapaljenskih, metaboličkih, onkoloških i autoimunskih bolesti
ES2809208T3 (es) * 2015-06-25 2021-03-03 Promega Corp Compuestos de tienopirrol y usos de los mismos como inhibidores de luciferasas procedentes de Oplophorus
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JP2020517618A (ja) 2017-04-21 2020-06-18 エピザイム，インコーポレイティド Ｅｈｍｔ２阻害剤との併用療法
CN109761974B (zh) * 2019-01-21 2021-05-14 河南大学 1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚类TRPV1拮抗剂及其应用
US11685727B2 (en) 2019-12-20 2023-06-27 Nuevolution A/S Compounds active towards nuclear receptors
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
EP4126875A1 (de) 2020-03-31 2023-02-08 Nuevolution A/S Gegen nukleare rezeptoren aktive verbindungen
MX2022012260A (es) 2020-03-31 2022-11-30 Nuevolution As Compuestos activos frente a receptores nucleares.
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FR2897061B1 (fr) 2010-09-03
IL192648A (en) 2012-06-28
US8288376B2 (en) 2012-10-16
BRPI0710480A2 (pt) 2012-08-14
TW200738726A (en) 2007-10-16
CN101379041B (zh) 2012-08-29
US8143248B2 (en) 2012-03-27
NO20083520L (no) 2008-09-11
HK1129670A1 (en) 2009-12-04
NZ569669A (en) 2011-05-27
US20120122852A1 (en) 2012-05-17
TWI401256B (zh) 2013-07-11
KR20080090495A (ko) 2008-10-08
US20090042873A1 (en) 2009-02-12
EA200870226A1 (ru) 2009-02-27
HRP20100327T1 (hr) 2010-08-31
WO2007088277A1 (fr) 2007-08-09
AU2007211399B2 (en) 2012-09-20
JP2009525313A (ja) 2009-07-09
PE20071325A1 (es) 2008-02-21
AR059279A1 (es) 2008-03-19
DOP2007000022A (es) 2007-09-15
CY1110168T1 (el) 2015-01-14
CA2637333A1 (fr) 2007-08-09
ZA200806139B (en) 2010-05-26
EP1987010A1 (de) 2008-11-05
JP5136938B2 (ja) 2013-02-06
EA014450B1 (ru) 2010-12-30
DK1987010T3 (da) 2010-08-02
PL1987010T3 (pl) 2010-09-30
UY30130A1 (es) 2007-09-28
AU2007211399A1 (en) 2007-08-09
SI1987010T1 (sl) 2010-07-30
PT1987010E (pt) 2010-06-25
ATE463484T1 (de) 2010-04-15
CN101379041A (zh) 2009-03-04
EP1987010B1 (de) 2010-04-07
CA2637333C (fr) 2015-12-29
JO2602B1 (en) 2011-11-01
IL192648A0 (en) 2009-02-11
FR2897061A1 (fr) 2007-08-10
MA30229B1 (fr) 2009-02-02
ES2344087T3 (es) 2010-08-17
RS51366B (sr) 2011-02-28

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