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DE602006007488D1 - Isochinolinderivate - Google Patents

Isochinolinderivate

Info

Publication number
DE602006007488D1
DE602006007488D1 DE602006007488T DE602006007488T DE602006007488D1 DE 602006007488 D1 DE602006007488 D1 DE 602006007488D1 DE 602006007488 T DE602006007488 T DE 602006007488T DE 602006007488 T DE602006007488 T DE 602006007488T DE 602006007488 D1 DE602006007488 D1 DE 602006007488D1
Authority
DE
Germany
Prior art keywords
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006007488T
Other languages
English (en)
Inventor
Peter Christopher Ray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006007488(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon NV filed Critical Organon NV
Publication of DE602006007488D1 publication Critical patent/DE602006007488D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602006007488T 2005-12-08 2006-12-06 Isochinolinderivate Active DE602006007488D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08
PCT/EP2006/069392 WO2007065916A1 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
DE602006007488D1 true DE602006007488D1 (de) 2009-08-06

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006007488T Active DE602006007488D1 (de) 2005-12-08 2006-12-06 Isochinolinderivate

Country Status (17)

Country Link
EP (1) EP1963304B2 (de)
JP (1) JP5313682B2 (de)
CN (1) CN101321748B (de)
AR (1) AR058287A1 (de)
AT (1) ATE434613T1 (de)
CA (1) CA2629915C (de)
CY (1) CY1110489T1 (de)
DE (1) DE602006007488D1 (de)
DK (1) DK1963304T3 (de)
ES (1) ES2327677T3 (de)
HR (1) HRP20090400T1 (de)
PE (1) PE20070808A1 (de)
PL (1) PL1963304T3 (de)
PT (1) PT1963304E (de)
SI (1) SI1963304T1 (de)
TW (1) TW200738682A (de)
WO (1) WO2007065916A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006008945D1 (de) 2005-06-28 2009-10-15 Sanofi Aventis Isochinolinderivate als inhibitoren von rho-kinase
ES2580108T3 (es) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
BRPI0613861B8 (pt) 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase
ES2372067T3 (es) 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
EP2526948A1 (de) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO-Kinase-Hemmer
JP5313919B2 (ja) 2006-12-27 2013-10-09 サノフイ 新規な置換イソキノリン及びイソキノリノン誘導体
CN101573353B (zh) * 2006-12-27 2014-08-06 塞诺菲-安万特股份有限公司 取代的异喹啉和异喹啉酮衍生物
KR101517154B1 (ko) * 2006-12-27 2015-04-30 사노피 Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
RS51655B (sr) 2006-12-27 2011-10-31 Sanofi-Aventis Derivati izohinolina i izohinolinona supstituisani cikloalkilaminom
MY151953A (en) 2006-12-27 2014-07-31 Sanofi Aventis Cycloalkylamine substituted isoquinoline derivatives
JP5405314B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノロン誘導体
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
AU2008340601A1 (en) * 2007-12-26 2009-07-02 Sanofi-Aventis Process for the preparation of 6-substituted-1-(2H)-isoquinolinones
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
KR101638326B1 (ko) 2008-06-24 2016-07-12 사노피 Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논
HRP20131040T1 (hr) 2008-06-24 2013-12-06 Sanofi Bi- i policikliäśki supstituirani izokinolin i derivati izokinolina kao inhibitori rho-kinaze
AU2009262516B8 (en) 2008-06-24 2014-01-30 Sanofi 6-substituted isoquinolines and isoquinolinones
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8394826B2 (en) 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
HUE028550T2 (en) 2011-07-08 2016-12-28 Sanofi Sa Polymorphs of 6- (Piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride
ES2568245T3 (es) 2011-07-08 2016-04-28 Sanofi Solvatos cristalinos de hidrocloruro de 6-(piperidin-4-iloxi)-2H-isoquinolin-1-ona
EP2729463B1 (de) 2011-07-08 2015-07-29 Sanofi Substituierte phenylverbindungen
EP3141235A1 (de) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorbenzylthio)pyrimidin-4-yl)-3-methylazetidin-l-sulfonamid
EP2976080B1 (de) 2013-03-15 2019-12-25 Aerie Pharmaceuticals, Inc. Konjugate von isoquinolinverbindungen und prostaglandinen
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
AU2015414743B2 (en) 2015-11-17 2019-07-18 Alcon Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102568082B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
TWI795381B (zh) * 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
AU2018243687C1 (en) 2017-03-31 2020-12-24 Alcon Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2018228452A1 (zh) * 2017-06-16 2018-12-20 成都先导药物开发有限公司 一种抑制 rock 的化合物及其用途
EP3849555A4 (de) 2018-09-14 2022-05-04 Aerie Pharmaceuticals, Inc. Aryl-cyclopropyl-amino-isochinolinyl-amidverbindungen
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法
EP4402129A1 (de) * 2022-08-01 2024-07-24 Valo Health, Inc. <smallcaps/>?h? ?verfahren zur herstellung von 6-substituierten-1-(2)-isochinolinonen und zwischenprodukte

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
EP1541559A4 (de) * 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-substituiertes isochinolinderivat
US7615564B2 (en) * 2002-09-12 2009-11-10 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
BRPI0613861B8 (pt) * 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase

Also Published As

Publication number Publication date
ES2327677T3 (es) 2009-11-02
ATE434613T1 (de) 2009-07-15
EP1963304B1 (de) 2009-06-24
TW200738682A (en) 2007-10-16
EP1963304B2 (de) 2015-05-13
CA2629915A1 (en) 2007-06-14
JP2009518360A (ja) 2009-05-07
HRP20090400T1 (hr) 2009-08-31
PE20070808A1 (es) 2007-08-27
DK1963304T3 (da) 2009-10-12
AR058287A1 (es) 2008-01-30
PL1963304T3 (pl) 2009-12-31
SI1963304T1 (sl) 2009-12-31
PT1963304E (pt) 2009-09-14
CN101321748A (zh) 2008-12-10
CY1110489T1 (el) 2015-04-29
CN101321748B (zh) 2013-03-27
WO2007065916A1 (en) 2007-06-14
CA2629915C (en) 2014-03-18
EP1963304A1 (de) 2008-09-03
JP5313682B2 (ja) 2013-10-09

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