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DE602005016836D1 - Chotischer und anxiolytischer aktivität - Google Patents

Chotischer und anxiolytischer aktivität

Info

Publication number
DE602005016836D1
DE602005016836D1 DE602005016836T DE602005016836T DE602005016836D1 DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1 DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1
Authority
DE
Germany
Prior art keywords
receptors
chotic
towards dopamine
affinity
anxiolytic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005016836T
Other languages
English (en)
Inventor
Jose I Andres-Gil
Jose M Bartolome-Nebreda
Manuel J Alcazar-Vaca
M Garcia-Martin
Antonius A H P Megens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005016836D1 publication Critical patent/DE602005016836D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602005016836T 2004-11-26 2005-11-25 Chotischer und anxiolytischer aktivität Expired - Lifetime DE602005016836D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106123 2004-11-26
PCT/EP2005/056229 WO2006056600A1 (en) 2004-11-26 2005-11-25 Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity

Publications (1)

Publication Number Publication Date
DE602005016836D1 true DE602005016836D1 (de) 2009-11-05

Family

ID=34929957

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016836T Expired - Lifetime DE602005016836D1 (de) 2004-11-26 2005-11-25 Chotischer und anxiolytischer aktivität

Country Status (10)

Country Link
US (1) US7635696B2 (de)
EP (1) EP1819713B1 (de)
JP (1) JP2008521771A (de)
CN (1) CN101084225B (de)
AT (1) ATE443707T1 (de)
AU (1) AU2005308778B2 (de)
CA (1) CA2585857A1 (de)
DE (1) DE602005016836D1 (de)
ES (1) ES2331144T3 (de)
WO (1) WO2006056600A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322520A4 (de) * 2008-07-28 2012-04-25 Jiangsu Guohua Invest Co Ltd Aralkylsubstituierte piperidin- oder piperazinderivate und deren verwendung zur behandlung von schizophrenie
US8829001B2 (en) 2008-10-10 2014-09-09 The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
EP2263672A1 (de) * 2009-05-19 2010-12-22 Bioprojet Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen
EP2796456A1 (de) * 2010-12-09 2014-10-29 Amgen Inc. Bicyclische Verbindungen als PIM-Hemmer
AU2012230890A1 (en) 2011-03-22 2013-09-26 Amgen Inc. Azole compounds as Pim inhibitors
WO2023114325A1 (en) * 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Constrained amine psychoplastogens and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965595A (en) 1993-07-01 1999-10-12 The Procter & Gamble Company 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5698571A (en) 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
WO1998022455A1 (en) 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Oxygenic heterocyclic compounds
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
CA2330452A1 (en) 1998-04-29 1999-11-04 American Home Products Corporation Antipsychotic indolyl derivatives
US6313126B1 (en) 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
WO2000040581A1 (en) 1999-01-07 2000-07-13 American Home Products Corporation 3,4-dihydro-2h-benzo[1,4]oxazine derivatives
TW546299B (en) 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
AR028475A1 (es) 1999-04-22 2003-05-14 Wyeth Corp Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
AU4552200A (en) * 1999-05-12 2000-12-05 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
FR2797874B1 (fr) 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002048105A2 (en) 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
AU2002235250A1 (en) 2000-11-17 2002-05-27 Wyeth Aryloxy piperidinyl indoles for treating depression
WO2002066484A1 (en) * 2001-02-21 2002-08-29 Janssen Pharmaceutica N.V. Isoxazoline derivatives as anti-depressants
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6800641B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
CZ2004155A3 (cs) 2001-06-29 2004-07-14 H. Lundbeck A/S Název neuveden
ATE312094T1 (de) 2001-06-29 2005-12-15 Lundbeck & Co As H Neue heteroarylderivate, deren herstellung und verwendung
US6903110B2 (en) 2001-07-25 2005-06-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
DK1492796T3 (da) 2002-04-02 2007-12-03 Janssen Pharmaceutica Nv Substituerede aminoisoxazolinderivater og deres anvendelse som antidepressive midler
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CA2494557C (en) * 2002-08-15 2011-10-18 Janssen Pharmaceutica N.V. Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
JP4478570B2 (ja) * 2002-08-21 2010-06-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ６−およびｃ９−置換’４，３−ｃ！イソキサゾリン誘導体およびそれらの抗鬱薬としての使用
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives

Also Published As

Publication number Publication date
EP1819713B1 (de) 2009-09-23
EP1819713A1 (de) 2007-08-22
JP2008521771A (ja) 2008-06-26
CN101084225B (zh) 2011-03-02
ATE443707T1 (de) 2009-10-15
US20080113988A1 (en) 2008-05-15
WO2006056600A1 (en) 2006-06-01
US7635696B2 (en) 2009-12-22
AU2005308778B2 (en) 2011-03-24
ES2331144T3 (es) 2009-12-22
AU2005308778A1 (en) 2006-06-01
CA2585857A1 (en) 2006-06-01
CN101084225A (zh) 2007-12-05

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