DE602005001576D1 - Pyrrolidin- und thiazolidin-Derivate, deren Darstellung und Anwendung zur Behandlung von Hyperglykämie und Typ II Diabetes - Google Patents

Pyrrolidin- und thiazolidin-Derivate, deren Darstellung und Anwendung zur Behandlung von Hyperglykämie und Typ II Diabetes

Info

Publication number: DE602005001576D1
Authority: DE; Germany
Prior art keywords: hyperglycemia; pyrrolidine; diabetes; presentation; treatment
Prior art date: 2004-05-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602005001576T

Other languages

English (en)

Other versions

DE602005001576T2 (de

Inventor

Nanteuil Guillaume De

Alain Benoist

Murielle Combettes

Elizabeth Harley

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Les Laboratoires Servier SAS

Original Assignee

Les Laboratoires Servier SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-19

Filing date

2005-05-18

Publication date

2007-08-23

2005-05-18 Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS

2007-08-23 Publication of DE602005001576D1 publication Critical patent/DE602005001576D1/de

2008-04-17 Application granted granted Critical

2008-04-17 Publication of DE602005001576T2 publication Critical patent/DE602005001576T2/de

2025-05-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyrrole Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DE602005001576T 2004-05-19 2005-05-18 Pyrrolidin- und Thiazolidin-Derivate, deren Darstellung und Anwendung zur Behandlung von Hyperglykämie und Typ II Diabetes Expired - Lifetime DE602005001576T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0405454A FR2870538B1 (fr)	2004-05-19	2004-05-19	Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0405454		2004-05-19

Publications (2)

Publication Number	Publication Date
DE602005001576D1 true DE602005001576D1 (de)	2007-08-23
DE602005001576T2 DE602005001576T2 (de)	2008-04-17

Family

ID=34942306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005001576T Expired - Lifetime DE602005001576T2 (de)	2004-05-19	2005-05-18	Pyrrolidin- und Thiazolidin-Derivate, deren Darstellung und Anwendung zur Behandlung von Hyperglykämie und Typ II Diabetes

Country Status (28)

Country	Link
US (1)	US7439263B2 (de)
EP (1)	EP1598350B1 (de)
JP (1)	JP4335171B2 (de)
KR (1)	KR100747967B1 (de)
CN (1)	CN100381438C (de)
AR (1)	AR049278A1 (de)
AT (1)	ATE366731T1 (de)
AU (1)	AU2005202180B2 (de)
BR (1)	BRPI0501769A (de)
CA (1)	CA2506491C (de)
CY (1)	CY1106878T1 (de)
DE (1)	DE602005001576T2 (de)
DK (1)	DK1598350T3 (de)
EA (1)	EA009292B1 (de)
ES (1)	ES2290864T3 (de)
FR (1)	FR2870538B1 (de)
GE (1)	GEP20074103B (de)
HR (1)	HRP20070376T3 (de)
MX (1)	MXPA05005256A (de)
MY (1)	MY139481A (de)
NO (1)	NO330294B1 (de)
NZ (1)	NZ540108A (de)
PL (1)	PL1598350T3 (de)
PT (1)	PT1598350E (de)
RS (1)	RS50526B (de)
SG (1)	SG117551A1 (de)
SI (1)	SI1598350T1 (de)
ZA (1)	ZA200504050B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2020413A1 (de) *	2007-08-02	2009-02-04	Bayer CropScience AG	Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate
US8338450B2 (en) *	2007-09-21	2012-12-25	Lupin Limited	Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
RU2487866C2 (ru) *	2008-01-23	2013-07-20	Цзянсу Хэнсох Фармасьютикал Ко., Лтд.	Производные дициклоазаалкана, способы их получения и их применение в медицине
GB2483614B (en)	2009-06-18	2014-12-03	Lupin Ltd	2-Amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors
US8440710B2 (en) *	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
EP2865666B1 (de) *	2012-06-25	2017-05-31	Sunshine Lake Pharma Co., Ltd.	Hexahydropentalenoderivate, herstellungsverfahren und verwendung in der medizin
KR102449196B1 (ko)	2016-01-15	2022-09-29	삼성전자주식회사	비휘발성 메모리 장치 및 비휘발성 메모리 장치의 프로그램 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0618957B2 (ja) *	1988-01-26	1994-03-16	日本合成化学工業株式会社	成形物の製造方法
CA2046801C (en) *	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles
DE4222459C2 (de) *	1992-07-08	1995-09-14	Sigma Tau Ind Farmaceuti	3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
BR9407046A (pt) *	1993-07-02	1996-08-13	Bayer Ag	Derivados de 1h-3-aril-pirrolidina-2,4-diona espiroheterociclicos substituidos processos para sua preparaçao e seu uso como pesticidas
TW492957B (en) *	1996-11-07	2002-07-01	Novartis Ag	N-substituted 2-cyanopyrrolidnes
US6110949A (en) *	1999-06-24	2000-08-29	Novartis Ag	N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
TW583185B (en) *	2000-06-13	2004-04-11	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
PT1308439E (pt) *	2000-08-10	2008-12-12	Mitsubishi Tanabe Pharma Corp	Derivados de prolina e sua utilização como fármacos
ATE337318T1 (de) *	2000-09-25	2006-09-15	Toray Industries	Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren
FR2824825B1 (fr) *	2001-05-15	2005-05-06	Servier Lab	Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003057144A2 (en) *	2001-12-26	2003-07-17	Guilford Pharmaceuticals	Change inhibitors of dipeptidyl peptidase iv
HUP0200849A2 (hu) *	2002-03-06	2004-08-30	Sanofi-Synthelabo	N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
CN1633420A (zh) *	2002-04-08	2005-06-29	托伦脱药品有限公司	噻唑烷－4－腈和类似物以及它们作为二肽基－肽酶抑制剂的用途
TW200404796A (en) *	2002-08-19	2004-04-01	Ono Pharmaceutical Co	Nitrogen-containing compound
US7262207B2 (en) *	2002-09-19	2007-08-28	Abbott Laboratories	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
BR0315796A (pt) *	2002-11-07	2005-09-13	Merck & Co Inc	Composto, composição farmacêutica, e, métodos para tratar diabetes, para tratar hiperglicemia, e para tratar obesidade em um mamìfero

2004
- 2004-05-19 FR FR0405454A patent/FR2870538B1/fr not_active Expired - Fee Related
2005
- 2005-05-04 SG SG200502766A patent/SG117551A1/en unknown
- 2005-05-05 CA CA002506491A patent/CA2506491C/fr not_active Expired - Fee Related
- 2005-05-17 MX MXPA05005256A patent/MXPA05005256A/es active IP Right Grant
- 2005-05-18 DK DK05291066T patent/DK1598350T3/da active
- 2005-05-18 PT PT05291066T patent/PT1598350E/pt unknown
- 2005-05-18 GE GEAP20058802A patent/GEP20074103B/en unknown
- 2005-05-18 ES ES05291066T patent/ES2290864T3/es not_active Expired - Lifetime
- 2005-05-18 KR KR1020050041742A patent/KR100747967B1/ko not_active Expired - Fee Related
- 2005-05-18 RS RSP-2007/0392A patent/RS50526B/sr unknown
- 2005-05-18 EP EP05291066A patent/EP1598350B1/de not_active Expired - Lifetime
- 2005-05-18 PL PL05291066T patent/PL1598350T3/pl unknown
- 2005-05-18 EA EA200500683A patent/EA009292B1/ru not_active IP Right Cessation
- 2005-05-18 DE DE602005001576T patent/DE602005001576T2/de not_active Expired - Lifetime
- 2005-05-18 AT AT05291066T patent/ATE366731T1/de active
- 2005-05-18 AR ARP050102045A patent/AR049278A1/es unknown
- 2005-05-18 NZ NZ540108A patent/NZ540108A/en unknown
- 2005-05-18 SI SI200530030T patent/SI1598350T1/sl unknown
- 2005-05-18 US US11/131,510 patent/US7439263B2/en not_active Expired - Fee Related
- 2005-05-18 MY MYPI20052248A patent/MY139481A/en unknown
- 2005-05-19 ZA ZA200504050A patent/ZA200504050B/en unknown
- 2005-05-19 BR BR0501769-6A patent/BRPI0501769A/pt not_active IP Right Cessation
- 2005-05-19 NO NO20052414A patent/NO330294B1/no not_active IP Right Cessation
- 2005-05-19 AU AU2005202180A patent/AU2005202180B2/en not_active Ceased
- 2005-05-19 CN CNB200510087845XA patent/CN100381438C/zh not_active Expired - Fee Related
- 2005-05-19 JP JP2005146186A patent/JP4335171B2/ja not_active Expired - Fee Related
2007
- 2007-09-03 HR HR20070376T patent/HRP20070376T3/xx unknown
- 2007-09-19 CY CY20071101205T patent/CY1106878T1/el unknown

Also Published As

Publication number	Publication date
CY1106878T1 (el)	2012-09-26
US7439263B2 (en)	2008-10-21
DK1598350T3 (da)	2007-11-12
CA2506491C (fr)	2009-09-01
KR20060048007A (ko)	2006-05-18
EA200500683A1 (ru)	2005-12-29
NO20052414L (no)	2005-11-21
FR2870538B1 (fr)	2006-07-14
KR100747967B1 (ko)	2007-08-08
AU2005202180A1 (en)	2005-12-08
ES2290864T3 (es)	2008-02-16
SG117551A1 (en)	2005-12-29
JP2005350456A (ja)	2005-12-22
AR049278A1 (es)	2006-07-12
GEP20074103B (en)	2007-05-10
AU2005202180B2 (en)	2010-10-28
NO20052414D0 (no)	2005-05-19
EP1598350A1 (de)	2005-11-23
CN100381438C (zh)	2008-04-16
BRPI0501769A (pt)	2006-01-10
CA2506491A1 (fr)	2005-11-19
US20050261501A1 (en)	2005-11-24
FR2870538A1 (fr)	2005-11-25
PL1598350T3 (pl)	2007-10-31
HRP20070376T3 (en)	2007-12-31
HK1086259A1 (zh)	2006-09-15
RS50526B (sr)	2010-05-07
DE602005001576T2 (de)	2008-04-17
JP4335171B2 (ja)	2009-09-30
EP1598350B1 (de)	2007-07-11
MXPA05005256A (es)	2005-11-24
MY139481A (en)	2009-10-30
PT1598350E (pt)	2007-10-04
NZ540108A (en)	2006-04-28
ATE366731T1 (de)	2007-08-15
CN1721417A (zh)	2006-01-18
NO330294B1 (no)	2011-03-21
SI1598350T1 (sl)	2007-10-31
ZA200504050B (en)	2006-07-26
EA009292B1 (ru)	2007-12-28

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EP1758597A4 (de)	2008-02-27	Verwendung von arzneimittelkombinationen zur behandlung der insulinresistenz
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ATE447570T1 (de)	2009-11-15	Pyrimidinderivate zur verwendung als vanilloidrezeptorliganden und deren verwendung bei der behandlung von schmerzen
ZA200711105B (en)	2009-08-26	Novel physiological substance nesfatin substance relevant thereto, and use of the substances
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ATE504595T1 (de)	2011-04-15	Il-22 zur behandlung von fettleibigkeit, diabetes,hyperlipidämie, hyperglykämie und insulinresistenz
DE602005001576D1 (de)	2007-08-23	Pyrrolidin- und thiazolidin-Derivate, deren Darstellung und Anwendung zur Behandlung von Hyperglykämie und Typ II Diabetes
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