DE602005005456D1 - Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number: DE602005005456D1
Authority: DE; Germany
Prior art keywords: azabic; derivatives; manufacturing; new; same
Prior art date: 2004-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602005005456T

Other languages

English (en)

Other versions

DE602005005456T2 (de

Inventor

Patrick Casara

Anne-Marie Chollet

Alain Dhainaut

Lionel Bert

Pierre Lestage

Brian Lockhart

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Les Laboratoires Servier SAS

Original Assignee

Les Laboratoires Servier SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-20

Filing date

2005-02-18

Publication date

2008-04-30

2005-02-18 Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS

2008-04-30 Publication of DE602005005456D1 publication Critical patent/DE602005005456D1/de

2009-04-09 Application granted granted Critical

2009-04-09 Publication of DE602005005456T2 publication Critical patent/DE602005005456T2/de

2025-02-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DE602005005456T 2004-02-20 2005-02-18 Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen Expired - Lifetime DE602005005456T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0401690		2004-02-20
FR0401690A FR2866647B1 (fr)	2004-02-20	2004-02-20	Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2005/000382 WO2005089747A1 (fr)	2004-02-20	2005-02-18	Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
DE602005005456D1 true DE602005005456D1 (de)	2008-04-30
DE602005005456T2 DE602005005456T2 (de)	2009-04-09

Family

ID=34833930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005005456T Expired - Lifetime DE602005005456T2 (de)	2004-02-20	2005-02-18	Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen

Country Status (29)

Country	Link
US (1)	US7576120B2 (de)
EP (1)	EP1720544B1 (de)
JP (1)	JP4519861B2 (de)
KR (1)	KR100885104B1 (de)
CN (2)	CN101230033B (de)
AR (3)	AR047685A1 (de)
AT (1)	ATE389398T1 (de)
AU (1)	AU2005224129B2 (de)
BR (1)	BRPI0507830A (de)
CA (1)	CA2555216C (de)
CY (1)	CY1108529T1 (de)
DE (1)	DE602005005456T2 (de)
DK (1)	DK1720544T3 (de)
EA (1)	EA010300B1 (de)
ES (1)	ES2303233T3 (de)
FR (1)	FR2866647B1 (de)
GE (1)	GEP20094578B (de)
HR (1)	HRP20080184T5 (de)
MA (1)	MA28342A1 (de)
ME (1)	ME01400B (de)
MY (1)	MY137282A (de)
NO (1)	NO337013B1 (de)
NZ (1)	NZ548898A (de)
PL (1)	PL1720544T3 (de)
PT (1)	PT1720544E (de)
RS (1)	RS50577B (de)
SI (1)	SI1720544T1 (de)
WO (1)	WO2005089747A1 (de)
ZA (1)	ZA200606558B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1717235A3 (de) *	2005-04-29	2007-02-28	Bioprojet	Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
EP1717234A1 (de) *	2005-04-29	2006-11-02	Bioprojet	Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
TW200900072A (en) *	2007-03-22	2009-01-01	Arete Therapeutics Inc	Soluble epoxide hydrolase inhibitors
FR2932479A1 (fr) *	2008-06-13	2009-12-18	Servier Lab	Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2937251B1 (fr) *	2008-10-16	2011-03-18	Servier Lab	Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil
FR2953521B1 (fr) *	2009-12-09	2011-11-18	Servier Lab	Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953515B1 (fr) *	2009-12-09	2011-12-23	Servier Lab	Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953513B1 (fr)	2009-12-09	2011-12-23	Servier Lab	Nouveaux derives azabicyclo[3.2.0]hept-6-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953514B1 (fr) *	2009-12-09	2011-12-23	Servier Lab	Nouveaux derives azabicyclo[3.2.0]hept-3-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2974729B1 (fr) *	2011-05-02	2013-04-19	Servier Lab	Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR2976286B1 (fr) *	2011-06-08	2013-05-24	Servier Lab	4-{3-[trans-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, son procede de preparation et les compositions pharmaceutiques qui le contiennent
FR2976285B1 (fr) *	2011-06-08	2013-05-24	Servier Lab	Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
CN103958499A (zh)	2011-12-08	2014-07-30	大正制药株式会社	苯基吡咯衍生物
FR2983732B1 (fr) *	2011-12-09	2013-11-22	Servier Lab	Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent
US20150045553A1 (en) *	2011-12-27	2015-02-12	Taisho Pharmaceutical Co., Ltd	Phenyltriazole derivative
CN103183632A (zh) *	2011-12-29	2013-07-03	山东方明药业集团股份有限公司	一种3-氮杂双环辛烷盐酸盐的提纯方法
FR2999179A1 (fr) *	2012-12-07	2014-06-13	Servier Lab	Procede de synthese d'un sel d'addition a un acide pharmaceutiquement acceptable du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, ainsi que les formes cristallines associees
FR3003466B1 (fr)	2013-03-22	2015-08-07	Servier Lab	Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques
EP3594205A1 (de)	2018-07-09	2020-01-15	Abivax	Phenyl-n-aryl-derivate zur behandlung einer rna-virusinfektion
EP3594206A1 (de)	2018-07-09	2020-01-15	Abivax	Phenyl-n-chinolin-derivate zur behandlung einer rna-virusinfektion
CN111377911B (zh) *	2018-12-27	2022-05-24	江苏恩华药业股份有限公司	一种吗啉苯甲酰胺类化合物及其应用
CN111377846B (zh) *	2018-12-27	2022-05-24	江苏恩华药业股份有限公司	一种哌嗪苯甲酰胺类衍生物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2962496A (en) *	1957-01-28	1960-11-29	Geschickter Fund Med Res	Nu-substituted-3-azabicyclooctanes [3: 3: 0] and salts thereof
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
MXPA02012560A (es) *	2000-06-30	2003-05-14	Elan Pharm Inc	Compuestos para tratar la enfermedad de alzheimer.
CA2415396C (en) *	2000-07-13	2011-03-08	Abbott Laboratories	1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
FR2827288B1 (fr) *	2001-07-12	2003-10-31	Servier Lab	Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2004
- 2004-02-20 FR FR0401690A patent/FR2866647B1/fr not_active Expired - Fee Related
2005
- 2005-02-18 HR HR20080184T patent/HRP20080184T5/xx unknown
- 2005-02-18 PT PT05717646T patent/PT1720544E/pt unknown
- 2005-02-18 RS RSP-2008/0226A patent/RS50577B/sr unknown
- 2005-02-18 EA EA200601512A patent/EA010300B1/ru not_active IP Right Cessation
- 2005-02-18 CN CN2008100828098A patent/CN101230033B/zh not_active Expired - Fee Related
- 2005-02-18 ES ES05717646T patent/ES2303233T3/es not_active Expired - Lifetime
- 2005-02-18 SI SI200530217T patent/SI1720544T1/sl unknown
- 2005-02-18 GE GEAP20059627A patent/GEP20094578B/en unknown
- 2005-02-18 MY MYPI20050619A patent/MY137282A/en unknown
- 2005-02-18 JP JP2006553623A patent/JP4519861B2/ja not_active Expired - Fee Related
- 2005-02-18 AU AU2005224129A patent/AU2005224129B2/en not_active Ceased
- 2005-02-18 NZ NZ548898A patent/NZ548898A/en not_active IP Right Cessation
- 2005-02-18 KR KR1020067019301A patent/KR100885104B1/ko not_active Expired - Fee Related
- 2005-02-18 EP EP05717646A patent/EP1720544B1/de not_active Expired - Lifetime
- 2005-02-18 AR ARP050100585A patent/AR047685A1/es active IP Right Grant
- 2005-02-18 ME MEP-2008-947A patent/ME01400B/me unknown
- 2005-02-18 CA CA2555216A patent/CA2555216C/fr not_active Expired - Fee Related
- 2005-02-18 DK DK05717646T patent/DK1720544T3/da active
- 2005-02-18 PL PL05717646T patent/PL1720544T3/pl unknown
- 2005-02-18 WO PCT/FR2005/000382 patent/WO2005089747A1/fr not_active Ceased
- 2005-02-18 BR BRPI0507830-0A patent/BRPI0507830A/pt not_active IP Right Cessation
- 2005-02-18 CN CN200580005456A patent/CN100577160C/zh not_active Expired - Fee Related
- 2005-02-18 AT AT05717646T patent/ATE389398T1/de active
- 2005-02-18 DE DE602005005456T patent/DE602005005456T2/de not_active Expired - Lifetime
- 2005-02-20 US US10/589,831 patent/US7576120B2/en not_active Expired - Fee Related
2006
- 2006-08-03 MA MA29229A patent/MA28342A1/fr unknown
- 2006-08-07 ZA ZA2006/06558A patent/ZA200606558B/en unknown
- 2006-09-14 NO NO20064160A patent/NO337013B1/no not_active IP Right Cessation
2008
- 2008-05-20 CY CY20081100520T patent/CY1108529T1/el unknown
2012
- 2012-12-26 AR ARP120104964A patent/AR089451A2/es unknown
2014
- 2014-01-28 AR ARP140100250A patent/AR094601A2/es unknown

Also Published As

Publication number	Publication date
KR100885104B1 (ko)	2009-02-20
CA2555216C (fr)	2011-10-11
FR2866647A1 (fr)	2005-08-26
HRP20080184T3 (hr)	2008-05-31
US20070197625A1 (en)	2007-08-23
HK1123789A1 (en)	2009-06-26
MA28342A1 (fr)	2006-12-01
CN101230033B (zh)	2011-03-09
AU2005224129A1 (en)	2005-09-29
HRP20080184T5 (en)	2008-10-31
BRPI0507830A (pt)	2007-07-10
FR2866647B1 (fr)	2006-10-27
CN100577160C (zh)	2010-01-06
CY1108529T1 (el)	2014-04-09
NZ548898A (en)	2010-06-25
DK1720544T3 (da)	2008-07-21
JP4519861B2 (ja)	2010-08-04
PT1720544E (pt)	2008-05-08
EA200601512A1 (ru)	2007-02-27
EA010300B1 (ru)	2008-08-29
RS50577B (sr)	2010-05-07
CN1921848A (zh)	2007-02-28
EP1720544B1 (de)	2008-03-19
GEP20094578B (en)	2009-01-12
NO337013B1 (no)	2015-12-21
US7576120B2 (en)	2009-08-18
AU2005224129B2 (en)	2010-08-12
CN101230033A (zh)	2008-07-30
MY137282A (en)	2009-01-30
ATE389398T1 (de)	2008-04-15
CA2555216A1 (fr)	2005-09-29
ME01400B (en)	2013-12-20
ES2303233T3 (es)	2008-08-01
SI1720544T1 (sl)	2008-06-30
AR047685A1 (es)	2006-02-01
ZA200606558B (en)	2008-01-08
JP2007523135A (ja)	2007-08-16
AR094601A2 (es)	2015-08-12
KR20060114382A (ko)	2006-11-06
AR089451A2 (es)	2014-08-27
NO20064160L (no)	2006-09-14
DE602005005456T2 (de)	2009-04-09
PL1720544T3 (pl)	2008-05-30
WO2005089747A1 (fr)	2005-09-29
EP1720544A1 (de)	2006-11-15

Publication	Publication Date	Title
DE602005005456D1 (de)	2008-04-30	Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen
BRPI0508263B8 (pt)	2021-05-25	derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina
IL187224A0 (en)	2008-02-09	Bicyclic derivatives and pharmaceutical compositions containing the same
IL183583A0 (en)	2007-09-20	Quinazoline derivatives and pharmaceutical compositions containing the same
IL181524A (en)	2013-04-30	Heterocyclic compounds, pharmaceuticals containing them and their use in the preparation of drugs
IL216734A0 (en)	2012-01-31	Azaindole derivatives and pharmaceutical compositions containing the same
IL178414A0 (en)	2007-02-11	Azaindole derivatives and pharmaceutical compositions containing the same
IL192184A0 (en)	2009-02-11	Heterocyclic derivatives and pharmaceutical compositions containing the same
IL186738A0 (en)	2008-02-09	Pyrizole derivatives and pharmaceutical compositions containing the same
IL185353A0 (en)	2008-02-09	Azabicycloalkane derivatives , pharmaceutical compositions containing the same and methods for the preparation thereof
IL221323A0 (en)	2012-09-24	1-methyl-1h- pyridin-2-one- phenanthridine derivatives and pharmaceutical compositions containing the same
IL183919A0 (en)	2007-10-31	Triazolophthalazine derivatives and pharmaceutical compositions containing the same
IL189782A0 (en)	2008-08-07	Sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
IL177168A0 (en)	2006-12-10	N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
ITMI20031570A1 (it)	2005-02-01	Composizione per uso dietetico, farmaceutico o cosmetico
DK1587478T3 (da)	2013-10-21	Farmaceutisk sammensætning
EP1919288A4 (de)	2009-12-16	Famotidin- und ibuprofenhaltige arzneimittel und ihre verabreichung
BRPI0607198A2 (pt)	2016-11-01	composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica
IL181730A0 (en)	2007-07-04	Benzodiazinone derivatives and pharmaceutical compositions containing the same
IL184996A0 (en)	2007-12-03	Dihydroimidazothiazole derivatives and pharmaceutical compositions containing the same
IL189172A0 (en)	2008-06-05	Cercosporamide derivatives and pharmaceutical compositions containing the same
ATE538125T1 (de)	2012-01-15	Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren
IL188011A0 (en)	2008-03-20	Spiro-benzimidazole derivatives and pharmaceutical compositions containing the same
IL180303A0 (en)	2007-06-03	Azaindole derivatives and pharmaceutical compositions containing the same
IL177498A0 (en)	2006-12-10	Difluoroethoxy -substituted hydroxy-6-phenylphenanthridine derivatives and pharmaceutical compositions containing the same

Legal Events

Date	Code	Title	Description
2009-05-14	8364	No opposition during term of opposition