DE602004007284D1 - Pyrimidine als inhibitoren von phosphoinositid-3-kinasen (pi3k) - Google Patents
Pyrimidine als inhibitoren von phosphoinositid-3-kinasen (pi3k)Info
- Publication number
- DE602004007284D1 DE602004007284D1 DE602004007284T DE602004007284T DE602004007284D1 DE 602004007284 D1 DE602004007284 D1 DE 602004007284D1 DE 602004007284 T DE602004007284 T DE 602004007284T DE 602004007284 T DE602004007284 T DE 602004007284T DE 602004007284 D1 DE602004007284 D1 DE 602004007284D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidines
- phosphoinositide
- pi3k
- kinases
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 108091007960 PI3Ks Proteins 0.000 title 2
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51659103P | 2003-10-31 | 2003-10-31 | |
| US516591P | 2003-10-31 | ||
| PCT/IB2004/003417 WO2005042519A1 (en) | 2003-10-31 | 2004-10-19 | Pyrimidines as inhibitors of phosphoinositide -3-kinases (pi3k) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004007284D1 true DE602004007284D1 (de) | 2007-08-09 |
| DE602004007284T2 DE602004007284T2 (de) | 2008-02-28 |
Family
ID=34549554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004007284T Expired - Fee Related DE602004007284T2 (de) | 2003-10-31 | 2004-10-19 | PYRIMIDINE ALS INHIBITOREN VON PHOSPHOINOSITID-3-KINASEN (PI3Ks) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090227587A1 (de) |
| EP (1) | EP1682532B1 (de) |
| JP (1) | JP2007509924A (de) |
| AT (1) | ATE365732T1 (de) |
| BR (1) | BRPI0415860A (de) |
| CA (1) | CA2543608A1 (de) |
| DE (1) | DE602004007284T2 (de) |
| ES (1) | ES2285517T3 (de) |
| WO (1) | WO2005042519A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2552664A1 (en) * | 2004-01-08 | 2005-07-28 | Michigan State University | Methods for treating and preventing hypertension and hypertension-related disorders |
| GB0415364D0 (en) | 2004-07-09 | 2004-08-11 | Astrazeneca Ab | Pyrimidine derivatives |
| WO2009117269A1 (en) * | 2008-03-18 | 2009-09-24 | Merck & Co., Inc. | Substituted 4-hydroxypyrimidine-5-carboxamides |
| JP5680638B2 (ja) * | 2009-07-02 | 2015-03-04 | サノフイ | 新規な（６−オキソ−１，６−ジヒドロピリミジン−２−イル）アミド誘導体、この調製およびａｋｔ（ｐｋｂ）リン酸化インヒビターとしてのこの医薬的な使用 |
| WO2011065800A2 (ko) * | 2009-11-30 | 2011-06-03 | 주식회사 오스코텍 | 피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물 |
| KR101301533B1 (ko) | 2010-02-09 | 2013-09-04 | 한미사이언스 주식회사 | 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체 |
| EP2914260A1 (de) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur vorbeugung des antiphospholipid-syndroms (aps) |
| AU2019301628C1 (en) | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3042601A (en) * | 2000-01-24 | 2001-07-31 | Thrombogenix Pty Ltd | Therapeutic morpholino-substituted compounds |
-
2004
- 2004-10-19 WO PCT/IB2004/003417 patent/WO2005042519A1/en not_active Ceased
- 2004-10-19 US US11/664,975 patent/US20090227587A1/en not_active Abandoned
- 2004-10-19 EP EP04769673A patent/EP1682532B1/de not_active Expired - Lifetime
- 2004-10-19 ES ES04769673T patent/ES2285517T3/es not_active Expired - Lifetime
- 2004-10-19 JP JP2006537458A patent/JP2007509924A/ja not_active Withdrawn
- 2004-10-19 BR BRPI0415860-1A patent/BRPI0415860A/pt not_active IP Right Cessation
- 2004-10-19 AT AT04769673T patent/ATE365732T1/de not_active IP Right Cessation
- 2004-10-19 CA CA002543608A patent/CA2543608A1/en not_active Abandoned
- 2004-10-19 DE DE602004007284T patent/DE602004007284T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0415860A (pt) | 2007-01-09 |
| ATE365732T1 (de) | 2007-07-15 |
| DE602004007284T2 (de) | 2008-02-28 |
| ES2285517T3 (es) | 2007-11-16 |
| JP2007509924A (ja) | 2007-04-19 |
| EP1682532B1 (de) | 2007-06-27 |
| US20090227587A1 (en) | 2009-09-10 |
| WO2005042519A1 (en) | 2005-05-12 |
| CA2543608A1 (en) | 2005-05-12 |
| EP1682532A1 (de) | 2006-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: CONNOLLY, MICHAEL KEVIN, ANN ARBOR, MI 48105, US Inventor name: VISNICK, MELEAN, ANN ARBOR, MI 48105, US Inventor name: GOGLIOTTI, ROCCO DEAN, ANN ARBOR, MI 48105, US Inventor name: PLUMMER, MARK STEPHEN, ANN ARBOR, MI 48105, US |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |