[go: up one dir, main page]

DE60142228D1 - Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal - Google Patents

Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal

Info

Publication number
DE60142228D1
DE60142228D1 DE60142228T DE60142228T DE60142228D1 DE 60142228 D1 DE60142228 D1 DE 60142228D1 DE 60142228 T DE60142228 T DE 60142228T DE 60142228 T DE60142228 T DE 60142228T DE 60142228 D1 DE60142228 D1 DE 60142228D1
Authority
DE
Germany
Prior art keywords
methods
compositions
identifying
cancer cells
targeting cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142228T
Other languages
English (en)
Inventor
Scott A Waldman
Jason Park
Stephanie Schulz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Application granted granted Critical
Publication of DE60142228D1 publication Critical patent/DE60142228D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G01N33/5753—
    • G01N33/57535—
    • G01N33/57557—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60142228T 2000-03-27 2001-03-27 Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal Expired - Lifetime DE60142228D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19222900P 2000-03-27 2000-03-27
PCT/US2001/009790 WO2001073132A1 (en) 2000-03-27 2001-03-27 Compositions and methods for identifying and targeting cancer cells of alimentary canal origin

Publications (1)

Publication Number Publication Date
DE60142228D1 true DE60142228D1 (de) 2010-07-08

Family

ID=22708782

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60140865T Expired - Lifetime DE60140865D1 (de) 2000-03-27 2001-03-27 Zusammensetzungen und methoden zur identifizierung von krebszellen
DE60142228T Expired - Lifetime DE60142228D1 (de) 2000-03-27 2001-03-27 Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60140865T Expired - Lifetime DE60140865D1 (de) 2000-03-27 2001-03-27 Zusammensetzungen und methoden zur identifizierung von krebszellen

Country Status (10)

Country Link
US (20) US20020012931A1 (de)
EP (6) EP1268854A4 (de)
JP (3) JP2003535580A (de)
AT (2) ATE469242T1 (de)
AU (3) AU2001249504A1 (de)
CA (3) CA2404431C (de)
DE (2) DE60140865D1 (de)
ES (2) ES2548381T3 (de)
PT (1) PT1272665E (de)
WO (3) WO2001073131A1 (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
ATE469242T1 (de) 2000-03-27 2010-06-15 Univ Jefferson Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal
JP2004526411A (ja) * 2000-09-18 2004-09-02 トマス・ジエフアーソン・ユニバーシテイ 胃および食道癌細胞を同定および標的とするための組成物および方法
AU2002306768A1 (en) * 2001-03-20 2002-10-03 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
WO2004044178A2 (en) * 2002-11-13 2004-05-27 Genentech, Inc. Methods and compositions for diagnosing dysplasia
DE10259703A1 (de) * 2002-12-19 2004-07-08 Ivonex Gmbh Trennungsverfahren
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
WO2004071436A2 (en) * 2003-02-10 2004-08-26 Thomas Jefferson University The use of gcc ligands
EP1604184A4 (de) * 2003-02-27 2010-10-27 Stephen A Lesko Standardisierte bewertung von therapeutischer wirksamkeit auf basis zellulärer biomarker
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20070160503A1 (en) * 2003-06-13 2007-07-12 Palaniappan Sethu Microfluidic systems for size based removal of red blood cells and platelets from blood
AU2004251890B2 (en) 2003-06-25 2010-09-23 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
JP2007531494A (ja) * 2003-07-03 2007-11-08 ジェントロン リミテッド ライアビリティー カンパニー Ｃｎｓ試料において非中枢神経系（ｃｎｓ）疾病を診断するための方法およびシステム
WO2005028433A2 (en) * 2003-09-15 2005-03-31 Research Development Foundation CRIPTO ANTAGONISM OF ACTIVIN AND TGF-β SIGNALING
WO2005040163A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
DK1692113T3 (en) 2003-11-14 2018-01-08 Lorus Therapeutics Inc ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES
WO2005084374A2 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
EP2722060A3 (de) 2004-06-25 2015-01-07 Thomas Jefferson University Guanylylcyclase-C-Liganden
AU2005271961B8 (en) * 2004-07-09 2011-11-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Identification of markers in esophageal cancer, colon cancer, head and neck cancer and melanoma
RU2269341C1 (ru) * 2004-07-16 2006-02-10 ГОУ ВПО "Красноярская государственная медицинская академия Министерства здравоохранения РФ" Способ комбинированного лечения рака прямой кишки
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US8535914B2 (en) * 2005-01-21 2013-09-17 Canon Kabushiki Kaisha Probe, probe set and information acquisition method using the same
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
WO2007030473A2 (en) * 2005-09-06 2007-03-15 Stanford University Luciferases and methods for making and using the same
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
EP1963536B1 (de) 2005-12-22 2016-05-04 Pacific Biosciences of California, Inc. Polymerasen zur nukleotid-analog-einfügung
WO2007075873A2 (en) * 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Protein engineering strategies to optimize activity of surface attached proteins
WO2007075987A2 (en) * 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
JP2007215412A (ja) * 2006-02-14 2007-08-30 Shizuoka Prefecture 悪性転移性胃癌の判定方法
US20070207467A1 (en) * 2006-03-01 2007-09-06 Ming Xu Detection of lymph node metastasis from gastric carcinoma
EP2021113A2 (de) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Mikrofluidische vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
JP2010527577A (ja) * 2006-05-22 2010-08-19 クリニカル ジェノミクス ピーティーワイ リミテッド 検出方法
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2007147074A2 (en) * 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP3536396B1 (de) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
ES2375453T3 (es) * 2006-09-07 2012-03-01 Universitätsklinikum Hamburg-Eppendorf Método para la detección de células epiteliales cancerosas utilizando citoqueratinas liberadas como marcadores para dichas células.
US8343746B2 (en) * 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009018446A1 (en) * 2007-08-01 2009-02-05 The Johns Hopkins University Esophageal cancer markers
DK2225563T3 (en) * 2007-11-27 2015-02-09 Janssen Diagnostics Llc AUTOMATIC DETERMINATION AND CHARACTERIZATION OF FAN melanoma BLOOD
CA2760050A1 (en) * 2008-05-13 2009-11-19 Thomas Jefferson University Guanylyl cyclase c qrt-pcr
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
SI2562268T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
RU2392983C1 (ru) * 2008-11-13 2010-06-27 Андрей Иванович Кожушков Способ лечения и профилактики рецидивирования и метастазирования рака
EP2401394B1 (de) 2009-02-25 2013-11-27 Diagnocure Inc. Verfahren für den nachweis von metastasen eines magendarmtumors
EP3415235B1 (de) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation von mikrofluidiktröpfchen
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2491116A4 (de) 2009-10-22 2013-12-11 Univ Jefferson Zellbasierte antikrebszusammensetzungen sowie verfahren zu ihrer herstellung und verwendung
CA3031851C (en) 2009-10-23 2020-07-07 Amgen British Columbia Anti-gcc antibody molecules and related compositions and methods
CA2778639A1 (en) * 2009-11-05 2011-05-12 Sequent Medical Inc. Multiple layer filamentary devices or treatment of vascular defects
GB0920014D0 (en) * 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9217032B2 (en) * 2010-01-08 2015-12-22 Les Laboratoires Servier Methods for treating colorectal cancer
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2550294B1 (de) 2010-03-24 2019-08-21 Progastrine et Cancers S.à r.l. Prophylaxe von kolorektalem und gastrointestinalem karzinom
US8932866B2 (en) 2010-04-06 2015-01-13 Kagoshima University Method for inspecting gastroenterological cancer by utilizing N-linked sugar chain
EP2622103B2 (de) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwichassays in tröpfchen
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
EP3736281A1 (de) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
AU2012229102B2 (en) 2011-03-17 2016-02-04 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
CN102311458A (zh) * 2011-05-31 2012-01-11 江苏省原子医学研究所 一种99mTcO核标记的苯丁酸氮芥类配合物、其制备分离纯化方法及其用途
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR20140067047A (ko) * 2011-08-29 2014-06-03 도레이 카부시키가이샤 대장암 또는 식도암의 검출용 마커 및 검사 방법
JP2013083490A (ja) 2011-10-06 2013-05-09 Kagoshima Univ 消化器癌診断用マーカー、および消化器癌の検査方法
WO2013120089A1 (en) 2012-02-10 2013-08-15 Raindance Technologies, Inc. Molecular diagnostic screening assay
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
CA2871614C (en) 2012-04-27 2021-08-31 Millennium Pharmaceuticals, Inc. Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy
EP3524693A1 (de) 2012-04-30 2019-08-14 Raindance Technologies, Inc. Digitale analytanalyse
AU2013284448B2 (en) 2012-06-27 2019-04-18 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
US9396532B2 (en) * 2012-11-15 2016-07-19 Siemens Healthcare Diagnostics, Inc. Cell feature-based automatic circulating tumor cell detection
US20140356383A1 (en) * 2013-02-28 2014-12-04 Ole Petter Veiby Administration of an anti-gcc antibody-drug conjugate and a dna damaging agent in the treatment of cancer
WO2014172288A2 (en) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Digital analyte analysis
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015051304A1 (en) 2013-10-04 2015-04-09 Aptose Biosciences Inc. Compositions, biomarkers and their use in treatment of cancer
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
US20170067912A1 (en) * 2014-03-13 2017-03-09 The Penn State Research Foundation Compositions and methods for diagnosing barrett's esophagus stages
WO2016094425A1 (en) 2014-12-08 2016-06-16 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
CN108368169A (zh) 2015-03-18 2018-08-03 约翰霍普金斯大学 靶向钾通道kcnk9的新的单克隆抗体抑制剂
CN108348492B (zh) 2015-07-31 2021-09-28 约翰霍普金斯大学 使用谷氨酰胺类似物的用于癌症和免疫疗法的方法
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
EP3380840B1 (de) 2015-11-25 2020-08-19 Cernostics, Inc. Verfahren zur vorhersage der progression von barrett-ösophagus
GB201604806D0 (en) * 2016-03-22 2016-05-04 Singapore Volition Pte Ltd Method of identifying a cancer of unknown origin
CN106124764B (zh) * 2016-08-12 2018-03-09 上海市嘉定区中心医院 以hoxb9和pbx1作为生物标志物的胃癌检测试剂盒及应用
JP6864089B2 (ja) * 2017-03-14 2021-04-21 ノヴォミクス・カンパニー・リミテッド 進行性胃癌患者の手術後の予後または抗癌剤適合性予測システム
KR20200108409A (ko) * 2017-08-18 2020-09-18 토마스 제퍼슨 유니버시티 암 치료에서의 정상 조직의 보호
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
WO2019041045A1 (en) 2017-09-01 2019-03-07 The Hospital For Sick Children PROFILING AND TREATMENT OF HYPERMUTANT CANCER
US11149047B2 (en) 2017-10-30 2021-10-19 Aptose Biosciences, Inc. Aryl imidazoles for treatment of cancer
FI128634B (en) * 2019-06-07 2020-09-15 Nokia Solutions & Networks Oy Obtaining information
US20230269606A1 (en) * 2020-05-05 2023-08-24 Nokia Technologies Oy Measurement configuration for local area machine learning radio resource management
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3130883A (en) * 1962-03-01 1964-04-28 Lewis J Mackool Hatchet scabbard
US4375414A (en) 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
US4022878A (en) 1972-05-15 1977-05-10 Biological Developments, Inc. Methods and compounds for producing specific antibodies
US4526716A (en) 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US4329281A (en) 1978-06-05 1982-05-11 Hoffmann-La Roche Inc. Hapten compositions
US4264024A (en) * 1978-12-21 1981-04-28 Harris Jr Ellsworth L Smoking pipe sling
US4341763A (en) 1981-03-10 1982-07-27 Smithkline-Rit Methods of vaccinating humans against rotavirus infection
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4584268A (en) 1981-10-13 1986-04-22 Ceriani Roberto Luis Method and compositions for carcinoma diagnosis
US4867973A (en) 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
GB8328918D0 (en) 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
ZA839512B (en) 1983-12-12 1984-08-29 Scripps Clinic Res Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof
US4601896A (en) 1984-03-21 1986-07-22 Mark Nugent Pharmaceutical capsule compositions and structures for gastric sensitive materials
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4729893A (en) 1984-12-26 1988-03-08 Robert L. Letcher Enteric encapsulation of ancrod for oral administration
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US5160723A (en) 1985-04-19 1992-11-03 Sloan-Kettering Institute For Cancer Research Method of imaging colorectal carcinoma lesion and composition for use therein
GB8519457D0 (en) 1985-08-02 1985-09-11 Faulk Ward Page Tumour imaging agents
JPS62162963A (ja) 1986-01-10 1987-07-18 Sadao Shiosaka 金属コロイド粒子を担体とする低分子物質に対する特異抗体の作成法
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
IN165717B (de) 1986-08-07 1989-12-23 Battelle Memorial Institute
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US4963263A (en) 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5217869A (en) 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5340474A (en) 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5350741A (en) 1988-07-30 1994-09-27 Kanji Takada Enteric formulations of physiologically active peptides and proteins
US4923949A (en) 1988-08-03 1990-05-08 Kanegafuchi Chemical Industry Co., Ltd. Ethynylene-disilanylene copolymers and method of preparing same
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5049656A (en) 1988-12-21 1991-09-17 Board Of Regents Of The University Of Nebraska Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
EP1026253B2 (de) 1989-03-21 2012-12-19 Vical Incorporated Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5366862A (en) 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5430138A (en) 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
US5237051A (en) 1990-12-06 1993-08-17 Vanderbilt University Purified enterotoxin receptor protein
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
KR930702985A (ko) 1991-02-21 1993-11-29 스튜어트 알.슈터 식도암의 치료
US5330892A (en) 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
AU662906B2 (en) 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
US5140102A (en) * 1991-09-23 1992-08-18 Monsanto Company Pentadecapeptide, guanylin, which stimulates intestinal guanylate cyclase
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5395750A (en) 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
US5969097A (en) * 1992-06-23 1999-10-19 G. D. Searle & Co. Human guanylin
US5585479A (en) 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5324483B1 (en) 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5397639A (en) 1992-11-25 1995-03-14 Tollini; Dennis R. Securing tape
US5595739A (en) 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
US5879656A (en) 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US5601990A (en) * 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
WO1995011694A1 (en) 1993-10-26 1995-05-04 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US7097839B1 (en) * 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5962220A (en) 1993-10-26 1999-10-05 Thomas Jefferson University Compositions that specifically bind to colorectal cells and methods of using the same
US5518888A (en) * 1993-10-26 1996-05-21 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5489670A (en) * 1993-10-29 1996-02-06 G. D. Searle & Co. Human uroguanylin
US5885574A (en) * 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5858011A (en) 1995-08-02 1999-01-12 The Procter & Gamble Company Disposable absorbent article having a resilient member
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
US6225051B1 (en) * 1996-04-16 2001-05-01 Haruo Sugiyama Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation
WO1997042506A1 (en) 1996-05-03 1997-11-13 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
CA2254082C (en) 1996-05-03 2012-09-11 Thomas Jefferson University Metastatic colorectal cancer vaccine
US5914238A (en) * 1996-06-05 1999-06-22 Matritech, Inc. Materials and methods for detection of breast cancer
AU4003597A (en) * 1996-09-04 1998-03-26 Howard Florey Institute Of Experimental Physiology And Medicine Methods of diagnosing and treating cancer
FI971124A0 (fi) * 1997-03-18 1997-03-18 Locus Genex Oy Metod foer diagnostisering av magcancer
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
WO1998050567A1 (en) * 1997-05-02 1998-11-12 Abbott Laboratories Reagents and methods useful for detecting diseases of the prostate
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
CA2345000A1 (en) 1998-10-02 2000-04-13 Diadexus, Inc. A novel method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancers
WO2000047998A1 (en) * 1999-02-10 2000-08-17 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids and methods of use
WO2000073479A1 (en) * 1999-05-28 2000-12-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
ATE469242T1 (de) 2000-03-27 2010-06-15 Univ Jefferson Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal
JP2004526411A (ja) * 2000-09-18 2004-09-02 トマス・ジエフアーソン・ユニバーシテイ 胃および食道癌細胞を同定および標的とするための組成物および方法
US6652378B2 (en) 2001-06-01 2003-11-25 Igt Gaming machines and systems offering simultaneous play of multiple games and methods of gaming
EP1532581A2 (de) * 2002-08-30 2005-05-25 Koninklijke Philips Electronics N.V. Fingerabdruckeinbettung
WO2004071436A2 (en) * 2003-02-10 2004-08-26 Thomas Jefferson University The use of gcc ligands
EP2722060A3 (de) * 2004-06-25 2015-01-07 Thomas Jefferson University Guanylylcyclase-C-Liganden
DE102005041131B4 (de) 2005-08-30 2008-01-31 Phoenix Contact Gmbh & Co. Kg Übertrager
US9001515B2 (en) 2012-04-20 2015-04-07 Cisco Technology, Inc. Universal pull tab release for modules including fiber optic and cable accessibilities
US9707467B2 (en) 2013-10-18 2017-07-18 Under Armour, Inc. Athletic glove
US9707565B2 (en) 2014-04-09 2017-07-18 II Lyman Burdette Lyne Screen assembly for shredding machine

Also Published As

Publication number Publication date
CA2404432A1 (en) 2001-10-04
WO2001073133A9 (en) 2003-06-12
US20100015167A1 (en) 2010-01-21
ES2346637T3 (es) 2010-10-19
DE60140865D1 (de) 2010-02-04
US20050059008A1 (en) 2005-03-17
US20010029019A1 (en) 2001-10-11
EP1272665B1 (de) 2010-05-26
US20040033520A1 (en) 2004-02-19
US7745114B2 (en) 2010-06-29
AU2001249548A1 (en) 2001-10-08
EP1268854A4 (de) 2003-05-02
EP2949762B1 (de) 2018-05-09
US7479376B2 (en) 2009-01-20
EP1274861A4 (de) 2005-09-28
WO2001073133A1 (en) 2001-10-04
EP1272665A4 (de) 2005-01-12
US20050164267A1 (en) 2005-07-28
CA2404431A1 (en) 2001-10-04
EP3388534A1 (de) 2018-10-17
US7485422B2 (en) 2009-02-03
ATE469242T1 (de) 2010-06-15
US20010039016A1 (en) 2001-11-08
AU2001249503A1 (en) 2001-10-08
WO2001073131A1 (en) 2001-10-04
US20020012931A1 (en) 2002-01-31
US7854933B2 (en) 2010-12-21
WO2001073132A1 (en) 2001-10-04
EP1274861A1 (de) 2003-01-15
EP1268854A1 (de) 2003-01-02
US8067007B2 (en) 2011-11-29
AU2001249504A1 (en) 2001-10-08
US20150104382A1 (en) 2015-04-16
EP2230320B1 (de) 2015-07-01
US20050196793A1 (en) 2005-09-08
ES2548381T3 (es) 2015-10-16
JP2003535580A (ja) 2003-12-02
US20120321552A1 (en) 2012-12-20
US20010029020A1 (en) 2001-10-11
US20090215089A1 (en) 2009-08-27
US6767704B2 (en) 2004-07-27
US8946168B2 (en) 2015-02-03
EP1272665A1 (de) 2003-01-08
JP2003532389A (ja) 2003-11-05
US6844153B2 (en) 2005-01-18
US20010036635A1 (en) 2001-11-01
US20170049869A1 (en) 2017-02-23
US20040224355A1 (en) 2004-11-11
US20080241064A1 (en) 2008-10-02
US9429576B2 (en) 2016-08-30
JP5122713B2 (ja) 2013-01-16
EP2949762A1 (de) 2015-12-02
US7785817B2 (en) 2010-08-31
US20110250228A1 (en) 2011-10-13
US20010039017A1 (en) 2001-11-08
PT1272665E (pt) 2010-08-31
JP2003528628A (ja) 2003-09-30
US20110104050A1 (en) 2011-05-05
US20110086064A1 (en) 2011-04-14
EP1274861B1 (de) 2009-12-23
EP2230320A1 (de) 2010-09-22
ATE452989T1 (de) 2010-01-15
CA2404428A1 (en) 2001-10-04
CA2404431C (en) 2011-06-07

Similar Documents

Publication Publication Date Title
DE60142228D1 (de) Zusammensetzungen und methoden zur identifizierung und zum targeting von krebszellen aus dem verdauungskanal
WO2003004989A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
WO2003021227A3 (en) Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors
EP1254267A4 (de) Zusammensetzungen und methoden zur früherkennung von eierstockkrebs
AU2003265556A1 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
DE69807878D1 (de) Erkennung und Modulierung von IAPS und NAIP zur Diagnose und Behandlung von proliferativen Erkrankungen
EP1257287A4 (de) Verbindungen und methoden zur frühdiagnose von eierstockkrebs
DE69918089D1 (de) Btk inhibitoren und verfahren zur identifizierung und verwendung
WO2003009814A3 (en) Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer
DE60136099D1 (de) Zusammensetzungen zur behandlung und diagnose von eierstockkrebs
ATE419516T1 (de) Monoklonale antikörper und zelloberflächenantigene zum nachweis und zur behandlung von kleinzelligem lungenkrebs (sclc)
BR0315689A (pt) Alvo para terapia de dano cognitivo
WO2003000012A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer
WO2004106495A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
ATE386742T1 (de) Imidazonaphthyridine
AU3392901A (en) Proteins
WO2001042792A3 (en) Diagnosis of cervical cancer using marker proteins
WO2004047757A3 (en) Diagnosing and treating hematopoietic cancers
MXPA05001690A (es) Estrategia de deteccion para farmacos anticancer.
DE69938729D1 (de) Verfahren zur diagnose von knochenmetastasen aus malignen tumoren
WO2004031775A3 (en) Method for treating or preventing metastasis of colorectal cancers
EP1322339A4 (de) METHODE ZUR FRüHEN VORHERSAGE DES AUFTRETENS VON INVASIVEM KREBS.
ATE332970T1 (de) Verfahren und zusammensetzungen zur hemmung von neoplastischem zellwachstums
ATE447622T1 (de) Methoden und zusammensetzungen zur diagnose und behandlung von pseudoxanthoma elasticum und ähnlichen zuständen
DE602007013234D1 (de) Verfahren und zusammensetzungen zur diagnose und behandlung von krebs

Legal Events

Date Code Title Description
8364 No opposition during term of opposition