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DE60142226D1 - Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden - Google Patents

Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Info

Publication number
DE60142226D1
DE60142226D1 DE60142226T DE60142226T DE60142226D1 DE 60142226 D1 DE60142226 D1 DE 60142226D1 DE 60142226 T DE60142226 T DE 60142226T DE 60142226 T DE60142226 T DE 60142226T DE 60142226 D1 DE60142226 D1 DE 60142226D1
Authority
DE
Germany
Prior art keywords
polypeptides
mushroom
processes
preparation
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142226T
Other languages
English (en)
Inventor
Carsten M Hjort
Van Den C Mjj Hondel
P J Punt
F H Schuren
Tove Christensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novozymes AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS filed Critical Novozymes AS
Application granted granted Critical
Publication of DE60142226D1 publication Critical patent/DE60142226D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE60142226T 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden Expired - Lifetime DE60142226D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000406 2000-03-14
PCT/DK2001/000169 WO2001068864A1 (en) 2000-03-14 2001-03-14 Fungal transcriptional activator useful in methods for producing polypeptides

Publications (1)

Publication Number Publication Date
DE60142226D1 true DE60142226D1 (de) 2010-07-08

Family

ID=8159325

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142226T Expired - Lifetime DE60142226D1 (de) 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Country Status (8)

Country Link
EP (1) EP1266011B1 (de)
JP (1) JP2003526374A (de)
CN (2) CN1425068B (de)
AT (1) ATE469223T1 (de)
AU (1) AU2001242299A1 (de)
DE (1) DE60142226D1 (de)
DK (1) DK1266011T3 (de)
WO (1) WO2001068864A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101629204A (zh) 2003-03-31 2010-01-20 诺维信股份有限公司 在缺乏酶的黑曲霉突变体中生产生物物质的方法
US7794974B2 (en) 2004-10-12 2010-09-14 Dsm Ip Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
JP2008527985A (ja) 2005-01-24 2008-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 糸状菌細胞において目的の化合物を産生させるための方法
RU2404990C2 (ru) 2005-03-16 2010-11-27 Новозимс Эдениум Байотек А/С Рекомбинантная экспрессия дефенсинов в мицелиальных грибах
ATE514770T1 (de) 2005-10-17 2011-07-15 Novozymes As Verwendung von pilzmutanten zur expression von antikörpern
CA2630455A1 (en) 2005-11-29 2007-06-07 Dsm Ip Assets B.V. Dna binding site of a transcriptional activator useful in gene expression
EA015925B1 (ru) 2006-06-29 2011-12-30 ДСМ АйПи АССЕТС Б.В. Способ получения полипептидов
ATE517188T1 (de) 2007-05-09 2011-08-15 Novozymes As Expressions-cloning-verfahren zur auswahl von bibliotheksklonen zur herstellung eines polypeptids von interesse
CN101182352B (zh) * 2007-11-21 2010-06-09 中国科学院微生物研究所 一种转录激活因子及其编码基因与应用
EP3293264A1 (de) 2009-07-22 2018-03-14 DSM IP Assets B.V. Verbesserte wirtszelle für die herstellung von relevanten produkten
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
WO2012098246A1 (en) 2011-01-20 2012-07-26 Novozymes A/S Expression of plant peroxidases in filamentous fungi
EP2527448A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Gleichzeitige standortspezifische Integrationen von mehreren Genkopien in faserige Pilze
EP2527432A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Bidirektionaler Cytosin-Deaminase-codierender Selektionsmarker
CA2861697C (en) 2012-01-05 2022-03-15 Novartis Ag Protease deficient filamentous fungal cells and methods of use thereof
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
WO2014013074A1 (en) 2012-07-19 2014-01-23 Dsm Ip Assets B.V. Agse-deficient strain
DK3019602T3 (en) 2013-07-10 2018-11-12 Glykos Finland Oy MULTIPLE PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF
US10513724B2 (en) 2014-07-21 2019-12-24 Glykos Finland Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
JP6473339B2 (ja) 2015-02-05 2019-02-20 本田技研工業株式会社 麹菌変異株及び形質転換体
US10883131B2 (en) 2015-02-20 2021-01-05 Roal Oy Methods for controlling protease production
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
WO2018167153A1 (en) 2017-03-17 2018-09-20 Novozymes A/S Improved filamentous fungal host cell
US12195769B2 (en) 2018-06-19 2025-01-14 Dsm Ip Assets B.V. Lipolytic enzyme variants
AU2021207258A1 (en) 2020-01-14 2022-08-04 The Protein Brewery B.V. Expression of ovalbumin and its natural variants
WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2023242273A1 (en) 2022-06-14 2023-12-21 Newmilkbuzz B.V. Expression of milk caseins in filamentous fungi
WO2024110509A1 (en) 2022-11-22 2024-05-30 Newmilkbuzz B.V Improved casein secretion by non-mammalian host cells
WO2024133849A1 (en) 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1333777C (en) 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
DE69333249T2 (de) 1992-04-15 2004-07-29 Novartis Ag Neue Schimmel-Protease
DK52293D0 (de) 1993-05-05 1993-05-05 Novo Nordisk As
DK76893D0 (de) 1993-06-28 1993-06-28 Novo Nordisk As
DK0765394T3 (da) 1994-06-03 2001-12-10 Novozymes As Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse
US6025185A (en) * 1994-06-17 2000-02-15 Novo Nordisk Als Fungus wherein the areA gene has been modified and an areA gene from Aspergillus oryzae
DE69534185T2 (de) 1994-06-30 2006-02-23 Novozymes Biotech, Inc., Davis Nicht-toxisches, nicht-toxigenes, nicht-pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
WO1997012045A1 (en) 1995-09-27 1997-04-03 Chiron Corporation Method of making a protease deficient host
AU2152897A (en) 1996-03-27 1997-10-17 Novo Nordisk A/S Alkaline protease deficient filamentous fungi
EP1616580B1 (de) 1996-07-05 2007-09-19 Novozymes A/S Alpha-Amylase Transkriptionsfaktor
ES2256895T3 (es) 1996-09-19 2006-07-16 Novozymes A/S Celulas huesped y metodos de produccion de proteinas.
EP1783223A1 (de) * 1998-10-05 2007-05-09 Novozymes A/S Transkriptionsaktivator PRTT aus dem Pilz Aspergillus niger, verwendbar in Verfahren zur Herstellung von Polypeptiden

Also Published As

Publication number Publication date
ATE469223T1 (de) 2010-06-15
CN102174535A (zh) 2011-09-07
JP2003526374A (ja) 2003-09-09
EP1266011B1 (de) 2010-05-26
CN1425068B (zh) 2011-05-18
EP1266011A1 (de) 2002-12-18
DK1266011T3 (da) 2010-07-26
WO2001068864A1 (en) 2001-09-20
AU2001242299A1 (en) 2001-09-24
CN102174535B (zh) 2014-04-09
CN1425068A (zh) 2003-06-18

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