DE60141844D1 - Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegen - Google Patents
Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegenInfo
- Publication number
- DE60141844D1 DE60141844D1 DE60141844T DE60141844T DE60141844D1 DE 60141844 D1 DE60141844 D1 DE 60141844D1 DE 60141844 T DE60141844 T DE 60141844T DE 60141844 T DE60141844 T DE 60141844T DE 60141844 D1 DE60141844 D1 DE 60141844D1
- Authority
- DE
- Germany
- Prior art keywords
- highly specific
- activated protein
- assay
- specific monoclonal
- monoclonal antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003556 assay Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23748100P | 2000-10-02 | 2000-10-02 | |
| PCT/US2001/030802 WO2002029015A1 (en) | 2000-10-02 | 2001-10-02 | Assay for rapid detection of human activated protein c and highly specific monoclonal antibody therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60141844D1 true DE60141844D1 (de) | 2010-05-27 |
Family
ID=22893898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60141844T Expired - Lifetime DE60141844D1 (de) | 2000-10-02 | 2001-10-02 | Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6989241B2 (de) |
| EP (1) | EP1322749B1 (de) |
| AT (1) | ATE464374T1 (de) |
| AU (2) | AU2001296483B2 (de) |
| DE (1) | DE60141844D1 (de) |
| WO (1) | WO2002029015A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003056312A1 (en) * | 2001-12-27 | 2003-07-10 | Arkray, Inc. | Concentration measuring method |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| ES2268961B1 (es) * | 2005-03-17 | 2008-03-16 | Proyecto De Biomedicina Cima, S.L. | Nueva proteina epcr soluble de origen no proteolitico y su uso. |
| DE102007041476B4 (de) | 2007-08-31 | 2017-03-30 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamere, die an ein an der Hämostase beteiligtes Zielmolekül binden |
| AU2015200348B2 (en) * | 2007-10-26 | 2016-04-14 | Oklahoma Medical Research Foundation | Monoclonal antibodies against activated and unactivated protein c |
| AU2016203760B2 (en) * | 2007-10-26 | 2017-12-21 | Oklahoma Medical Research Foundation | Monoclonal antibodies against activated and unactivated protein c |
| CN101918453A (zh) * | 2007-10-26 | 2010-12-15 | 俄克拉荷马医学研究基金会 | 针对活化蛋白c的单克隆抗体 |
| US20100081915A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, Alimited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
| US20100081927A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
| US20100081926A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
| US20100081916A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware. | Histological facilitation systems and methods |
| US20100081924A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
| LT3903829T (lt) | 2009-02-13 | 2023-06-12 | Immunomedics, Inc. | Imunokonjugatai su viduląsteliniu būdu skaldoma jungtimi |
| IN2012DN01663A (de) | 2009-09-16 | 2015-06-05 | Immunomedics Inc | |
| WO2011068845A1 (en) | 2009-12-02 | 2011-06-09 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| AU2012250924B2 (en) | 2011-05-02 | 2017-05-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| EP3586874A1 (de) | 2012-08-14 | 2020-01-01 | IBC Pharmaceuticals, Inc. | Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten |
| JP2016501875A (ja) | 2012-11-29 | 2016-01-21 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ | 活性化プロテインｃに対するヒト化モノクローナル抗体およびその使用 |
| HK1212896A1 (zh) * | 2012-11-29 | 2016-06-24 | Bayer Healthcare Llc | 針對活化蛋白c(apc)的單克隆抗體 |
| MX379460B (es) | 2012-12-13 | 2025-03-11 | Immunomedics Inc | Dosis de inmunoconjugados de anticuerpos y sn-38 para eficacia mejorada y toxicidad reducida. |
| WO2017004144A1 (en) | 2015-07-01 | 2017-01-05 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| MX384646B (es) | 2014-02-21 | 2025-03-14 | Ibc Pharmaceuticals Inc | Anticuerpo biespecífico que comprende al menos un sitio de unión para trop-2 y al menos sitio de unión para cd3 y su uso para inducir una respuesta inmune |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| EP3160504B1 (de) | 2014-06-24 | 2020-09-16 | Immunomedics, Inc. | Antihistontherapie für vaskuläre nekrose bei schwerer glomerulonephritis |
| PT3204018T (pt) | 2014-10-07 | 2021-11-12 | Immunomedics Inc | Uso neoadjuvante de conjugados anticorpo-fármaco |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| EP3313443B9 (de) | 2015-06-25 | 2023-10-04 | Immunomedics, Inc. | Kombination von anti-hla-dr- oder anti-trop-2-antikörpern mit mikrotubuli-inhibitoren, parp-inhibitoren, bruton-kinase-inhibitoren oder phosphoinositol-3-kinase-inhibitoren zur signifikanten verbesserung des therapeutischen ergebnisses bei krebs |
| US11077187B2 (en) | 2015-11-17 | 2021-08-03 | Oklahoma Medical Research Foundation | Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof |
| WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0287028B1 (de) | 1987-04-17 | 1993-07-21 | Teijin Limited | Verfahren zur Trennung von aktiviertem menschlichem Protein C |
| JPH03200066A (ja) | 1989-12-28 | 1991-09-02 | Tosoh Corp | 活性化ヒトプロテインｃの測定方法 |
-
2001
- 2001-10-02 DE DE60141844T patent/DE60141844D1/de not_active Expired - Lifetime
- 2001-10-02 AU AU2001296483A patent/AU2001296483B2/en not_active Ceased
- 2001-10-02 US US10/398,063 patent/US6989241B2/en not_active Expired - Fee Related
- 2001-10-02 EP EP01977357A patent/EP1322749B1/de not_active Expired - Lifetime
- 2001-10-02 WO PCT/US2001/030802 patent/WO2002029015A1/en not_active Ceased
- 2001-10-02 AU AU9648301A patent/AU9648301A/xx active Pending
- 2001-10-02 AT AT01977357T patent/ATE464374T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9648301A (en) | 2002-04-15 |
| WO2002029015A9 (en) | 2003-09-12 |
| US6989241B2 (en) | 2006-01-24 |
| EP1322749B1 (de) | 2010-04-14 |
| AU2001296483B2 (en) | 2006-02-16 |
| WO2002029015A1 (en) | 2002-04-11 |
| ATE464374T1 (de) | 2010-04-15 |
| US20040014138A1 (en) | 2004-01-22 |
| EP1322749A1 (de) | 2003-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |