DE60140936D1 - Glycosylierte hybrid-verbindungen, deren herstellung und verwendung - Google Patents
Glycosylierte hybrid-verbindungen, deren herstellung und verwendungInfo
- Publication number
- DE60140936D1 DE60140936D1 DE60140936T DE60140936T DE60140936D1 DE 60140936 D1 DE60140936 D1 DE 60140936D1 DE 60140936 T DE60140936 T DE 60140936T DE 60140936 T DE60140936 T DE 60140936T DE 60140936 D1 DE60140936 D1 DE 60140936D1
- Authority
- DE
- Germany
- Prior art keywords
- polyketides
- polyketide
- glycosylated
- ability
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229930001119 polyketide Natural products 0.000 abstract 5
- 125000000830 polyketide group Chemical group 0.000 abstract 4
- 235000000346 sugar Nutrition 0.000 abstract 4
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 2
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 2
- 108700023372 Glycosyltransferases Proteins 0.000 abstract 2
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003881 polyketide derivatives Chemical class 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 150000008163 sugars Chemical class 0.000 abstract 2
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 102000051366 Glycosyltransferases Human genes 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 102000045442 glycosyltransferase activity proteins Human genes 0.000 abstract 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0009207.2A GB0009207D0 (en) | 2000-04-13 | 2000-04-13 | Hybrid glycosylated products and their production and use |
| US69421800A | 2000-10-23 | 2000-10-23 | |
| PCT/GB2001/001743 WO2001079520A1 (en) | 2000-04-13 | 2001-04-17 | Hybrid glycosylated products and their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60140936D1 true DE60140936D1 (de) | 2010-02-11 |
Family
ID=26244108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60140936T Expired - Lifetime DE60140936D1 (de) | 2000-04-13 | 2001-04-17 | Glycosylierte hybrid-verbindungen, deren herstellung und verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7482137B2 (de) |
| EP (1) | EP1278881B1 (de) |
| JP (1) | JP5037771B2 (de) |
| AT (1) | ATE453719T1 (de) |
| AU (2) | AU2001248588B2 (de) |
| CA (1) | CA2405958C (de) |
| DE (1) | DE60140936D1 (de) |
| DK (1) | DK1278881T3 (de) |
| ES (1) | ES2338212T3 (de) |
| WO (1) | WO2001079520A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128680D0 (en) * | 2001-11-29 | 2002-01-23 | Biotica Tech Ltd | Hybrid glycosylated products and their production and use |
| WO2004007709A2 (en) | 2002-07-16 | 2004-01-22 | Biotica Technology Limited | Production of polyketides |
| EP2388333A3 (de) | 2003-06-19 | 2012-04-04 | Evolva SA | Verfahren zur Herstellung einer organischen Verbindung mit geringem Molekulargewicht in einer Zelle |
| GB0327720D0 (en) | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| GB0327721D0 (en) * | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Polyketides and their synthesis |
| WO2006003456A2 (en) * | 2004-07-07 | 2006-01-12 | Isis Innovation Limited | Glycosylation of antibiotics |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| JP5196856B2 (ja) * | 2007-05-14 | 2013-05-15 | キヤノン株式会社 | プローブセット、プローブ担体及び検査方法 |
| WO2010034243A1 (en) | 2008-09-24 | 2010-04-01 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
| CN103849591B (zh) * | 2012-12-05 | 2017-07-07 | 中国科学院上海有机化学研究所 | 一种泰乐菌素产生菌、遗传改造方法及其应用 |
| CN103215282B (zh) * | 2013-04-09 | 2016-08-03 | 中国科学院上海有机化学研究所 | 越野他汀的生物合成基因簇及其应用 |
| CN107075461B (zh) | 2014-11-14 | 2020-10-23 | 浙江海正药业股份有限公司 | 多杀菌素异源表达菌株及其构建方法和应用 |
| WO2018153954A1 (en) | 2017-02-22 | 2018-08-30 | Immune System Regulation Holding Ab | Novel immune stimulating macrolide |
| EP3585796B1 (de) | 2017-02-22 | 2021-06-16 | ISR Immune System Regulation Holding AB (publ) | Neuartige immun-stimulierende macrolide |
| CN110678476A (zh) | 2017-02-22 | 2020-01-10 | 免疫系统调节控股有限公司 | 新型免疫刺激大环内酯 |
| US11059846B2 (en) | 2017-02-22 | 2021-07-13 | ISR Immune System Regulation Holding AB (publ) | Immune stimulating compound |
| CN107226830B (zh) * | 2017-05-02 | 2019-12-10 | 北京理工大学 | 一种乙基多杀菌素的化学合成方法 |
| AU2019237257A1 (en) | 2018-03-23 | 2020-10-15 | ISR Immune System Regulation Holding AB (publ) | Combinations of macrolide compounds and immune checkpoint inhibitors |
| KR102705165B1 (ko) | 2019-01-22 | 2024-09-11 | 에오비안 파마슈티컬스, 인크. | Mtorc 조절제 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598805A (en) | 1970-02-26 | 1971-08-10 | Abbott Lab | Erythromycin ester derivatives |
| US3697547A (en) * | 1970-12-18 | 1972-10-10 | Abbott Lab | Erythronolide b derivatives |
| DE3268339D1 (en) * | 1981-01-09 | 1986-02-20 | Pierrel Spa | Novel semisynthetic macrolidic antibiotics, microbiological processes for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them |
| US4423148A (en) * | 1982-07-02 | 1983-12-27 | Eli Lilly And Company | Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin |
| US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| WO1993013663A1 (en) | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| SE9201544L (sv) * | 1991-05-31 | 1992-12-01 | Ciba Geigy Ag | Saett att framstaella glykosyltransferaser |
| GB2256197B (en) * | 1991-05-31 | 1995-11-22 | Ciba Geigy Ag | Yeast as host for expression of heterologous glycosyl transferase enzymes |
| JPH07503363A (ja) * | 1991-11-14 | 1995-04-13 | ノボザイムス アクティーゼルスカブ | バシラス・リヘニフォルミス中で遺伝子を発現させる方法 |
| US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| ES2164713T3 (es) | 1993-09-20 | 2002-03-01 | Univ Leland Stanford Junior | Produccion recombinante de nuevos poliquetidos. |
| US5834251A (en) | 1994-12-30 | 1998-11-10 | Alko Group Ltd. | Methods of modifying carbohydrate moieties |
| US5998194A (en) | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
| WO1998001571A2 (en) | 1996-07-05 | 1998-01-15 | Biotica Technology Limited | Erythromycins and process for their preparation |
| US5871983A (en) | 1996-09-13 | 1999-02-16 | Eli Lilly And Company | Glucosyltransferase gene GTFE from amycolatopsis orientalis |
| AU732909B2 (en) * | 1997-04-30 | 2001-05-03 | Board Of Trustees Of The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
| WO1999005283A2 (fr) | 1997-07-25 | 1999-02-04 | Hoechst Marion Roussel | Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation |
| AR043071A1 (es) | 1997-10-31 | 2005-07-20 | Abbott Lab | Uso de macrolidos para el tratamiento del cancer y degeneracion macular y una composicion farmaceutica |
| GB9814006D0 (en) | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
| EP1095058A4 (de) | 1998-07-14 | 2003-07-16 | Univ Princeton | Glykopeptidantibiotika, kombinatorische bibliotheken von glykopeptidantibiotika und verfahren zu ihrer herstellung |
-
2001
- 2001-04-17 AT AT01921617T patent/ATE453719T1/de active
- 2001-04-17 JP JP2001577503A patent/JP5037771B2/ja not_active Expired - Fee Related
- 2001-04-17 EP EP01921617A patent/EP1278881B1/de not_active Expired - Lifetime
- 2001-04-17 ES ES01921617T patent/ES2338212T3/es not_active Expired - Lifetime
- 2001-04-17 AU AU2001248588A patent/AU2001248588B2/en not_active Ceased
- 2001-04-17 DK DK01921617.5T patent/DK1278881T3/da active
- 2001-04-17 DE DE60140936T patent/DE60140936D1/de not_active Expired - Lifetime
- 2001-04-17 AU AU4858801A patent/AU4858801A/xx active Pending
- 2001-04-17 CA CA2405958A patent/CA2405958C/en not_active Expired - Fee Related
- 2001-04-17 WO PCT/GB2001/001743 patent/WO2001079520A1/en not_active Ceased
-
2006
- 2006-10-12 US US11/580,263 patent/US7482137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001079520A1 (en) | 2001-10-25 |
| ATE453719T1 (de) | 2010-01-15 |
| EP1278881A1 (de) | 2003-01-29 |
| AU4858801A (en) | 2001-10-30 |
| CA2405958A1 (en) | 2001-10-25 |
| US7482137B2 (en) | 2009-01-27 |
| ES2338212T3 (es) | 2010-05-05 |
| EP1278881B1 (de) | 2009-12-30 |
| DK1278881T3 (da) | 2010-05-10 |
| CA2405958C (en) | 2011-08-09 |
| AU2001248588B2 (en) | 2006-02-02 |
| JP5037771B2 (ja) | 2012-10-03 |
| US20070092944A1 (en) | 2007-04-26 |
| JP2003530857A (ja) | 2003-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |