DE60140700D1 - Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons - Google Patents

Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons

Info

Publication number: DE60140700D1
Authority: DE; Germany
Prior art keywords: antagonists; releasing hormone; gonadotropin releasing; thienoi2; pyridine derivatives
Prior art date: 2000-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60140700T

Other languages

English (en)

Inventor

Zhihua Sui

Mark Macielag

James C Lanter

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Ortho McNeil Janssen Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-12

Filing date

2001-12-11

Publication date

2010-01-14

2001-12-11 Application filed by Ortho McNeil Janssen Pharmaceuticals Inc filed Critical Ortho McNeil Janssen Pharmaceuticals Inc

2010-01-14 Application granted granted Critical

2010-01-14 Publication of DE60140700D1 publication Critical patent/DE60140700D1/de

2021-12-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 4
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 4
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 4
229940035638 gonadotropin-releasing hormone Drugs 0.000 title abstract 4
239000005557 antagonist Substances 0.000 title abstract 2
150000003222 pyridines Chemical class 0.000 title 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940124558 contraceptive agent Drugs 0.000 abstract 1
239000003433 contraceptive agent Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000000509 infertility Diseases 0.000 abstract 1
230000036512 infertility Effects 0.000 abstract 1
231100000535 infertility Toxicity 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE60140700T 2000-12-12 2001-12-11 Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons Expired - Lifetime DE60140700D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25482700P	2000-12-12	2000-12-12
US09/992,785 US6583153B2 (en)	2000-12-12	2001-11-14	7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone

Publications (1)

Publication Number	Publication Date
DE60140700D1 true DE60140700D1 (de)	2010-01-14

Family

ID=26944257

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60140700T Expired - Lifetime DE60140700D1 (de)	2000-12-12	2001-12-11	Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons
DE60122575T Expired - Lifetime DE60122575T2 (de)	2000-12-12	2001-12-11	7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60122575T Expired - Lifetime DE60122575T2 (de)	2000-12-12	2001-12-11	7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS

Country Status (13)

Country	Link
US (2)	US6583153B2 (de)
EP (2)	EP1345907B1 (de)
JP (1)	JP4427251B2 (de)
CN (1)	CN1288137C (de)
AT (2)	ATE337303T1 (de)
AU (2)	AU2002229033B2 (de)
CA (1)	CA2431617C (de)
CY (2)	CY1105712T1 (de)
DE (2)	DE60140700D1 (de)
DK (2)	DK1520855T3 (de)
ES (2)	ES2269499T3 (de)
PT (2)	PT1345907E (de)
WO (1)	WO2002048112A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
TW200413351A (en) *	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
AU2003301299A1 (en)	2002-10-15	2004-05-04	Janssen Pharmaceutica, N.V.	Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
DE602006015851D1 (de) *	2005-12-05	2010-09-09	Merck Sharp & Dohme	Positive allosterische chinolon-m1-rezeptormodulatoren
US8895580B2 (en)	2009-10-21	2014-11-25	Merck Sharp & Dohme Corp.	Quinolinone-pyrazolone M1 receptor positive allosteric modulators
CN116239498B (zh) *	2023-05-11	2023-07-21	北京元延医药科技股份有限公司	制备克立硼罗中间体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4659691A (en)	1985-02-08	1987-04-21	Merck & Co., Inc.	Novel cyclic Hexapeptide LHRH antagonists
US5140009A (en)	1988-02-10	1992-08-18	Tap Pharmaceuticals, Inc.	Octapeptide LHRH antagonists
US5171835A (en)	1988-10-21	1992-12-15	The Administrators Of The Tulane Educational Fund	LHRH antagonists
TW449600B (en) *	1994-04-19	2001-08-11	Takeda Chemical Industries Ltd	Condensed-ring thiophene derivatives, their production and use
US5607939A (en)	1994-04-28	1997-03-04	Takeda Chemical Industries, Ltd.	Condensed heterocyclic compounds, their production and use
US5834463A (en)	1994-04-29	1998-11-10	Takeda Chemical Industries, Ltd.	Condensed heterocyclic compounds, their production and use
WO1996038438A1 (en)	1995-06-01	1996-12-05	Takeda Chemical Industries, Ltd.	TRICYCLIC DIAZEPINES USEFUL AS GnRH RECEPTOR ANTAGONISTS
AU7333396A (en)	1995-10-19	1997-05-07	Takeda Chemical Industries Ltd.	Thienopyridine derivatives as gonadotropin releasing hormone antagonists
CA2229201A1 (en) *	1995-10-19	1997-04-24	Satoshi Sasaki	Quinoline derivatives, their production and use
SK77498A3 (en)	1995-12-14	1999-01-11	Merck & Co Inc	Nonpeptide derivatives, pharmaceutical composition containing them and their use
HUP9902121A3 (en)	1995-12-14	2001-05-28	Merck & Co Inc	Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
EP0900222A1 (de)	1996-04-26	1999-03-10	Takeda Chemical Industries, Ltd.	Thienopyridinderivate, ihre herstellung und verwendung
EP0906115A1 (de)	1996-04-30	1999-04-07	Takeda Chemical Industries, Ltd.	Kombinierte anwendung von gnrh agonist und antagonist
US6162813A (en)	1996-05-20	2000-12-19	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU706818B2 (en)	1996-05-20	1999-06-24	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
EP0920319A4 (de)	1996-05-20	2002-05-02	Merck & Co Inc	Antagonisten des gonadotropin freisetzenden hormins
US6150352A (en)	1996-05-20	2000-11-21	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
GB9610813D0 (en)	1996-05-23	1996-07-31	Pharmacia Spa	Combinatorial solid phase synthesis of a library of benzufuran derivatives

2001
- 2001-11-14 US US09/992,785 patent/US6583153B2/en not_active Expired - Lifetime
- 2001-12-11 PT PT01990166T patent/PT1345907E/pt unknown
- 2001-12-11 AT AT01990166T patent/ATE337303T1/de active
- 2001-12-11 CN CNB018225985A patent/CN1288137C/zh not_active Expired - Lifetime
- 2001-12-11 PT PT04078019T patent/PT1520855E/pt unknown
- 2001-12-11 JP JP2002549643A patent/JP4427251B2/ja not_active Expired - Lifetime
- 2001-12-11 DK DK04078019.9T patent/DK1520855T3/da active
- 2001-12-11 AT AT04078019T patent/ATE450510T1/de active
- 2001-12-11 AU AU2002229033A patent/AU2002229033B2/en not_active Expired
- 2001-12-11 DE DE60140700T patent/DE60140700D1/de not_active Expired - Lifetime
- 2001-12-11 EP EP01990166A patent/EP1345907B1/de not_active Expired - Lifetime
- 2001-12-11 CA CA2431617A patent/CA2431617C/en not_active Expired - Lifetime
- 2001-12-11 WO PCT/US2001/048119 patent/WO2002048112A2/en not_active Ceased
- 2001-12-11 DK DK01990166T patent/DK1345907T3/da active
- 2001-12-11 AU AU2903302A patent/AU2903302A/xx active Pending
- 2001-12-11 ES ES01990166T patent/ES2269499T3/es not_active Expired - Lifetime
- 2001-12-11 DE DE60122575T patent/DE60122575T2/de not_active Expired - Lifetime
- 2001-12-11 EP EP04078019A patent/EP1520855B1/de not_active Expired - Lifetime
- 2001-12-11 ES ES04078019T patent/ES2337898T3/es not_active Expired - Lifetime
2003
- 2003-04-03 US US10/406,393 patent/US6765011B2/en not_active Expired - Lifetime
2006
- 2006-10-18 CY CY20061101492T patent/CY1105712T1/el unknown
2010
- 2010-02-09 CY CY20101100121T patent/CY1110589T1/el unknown

Also Published As

Publication number	Publication date
ATE337303T1 (de)	2006-09-15
PT1345907E (pt)	2006-11-30
ES2269499T3 (es)	2007-04-01
EP1520855B1 (de)	2009-12-02
WO2002048112A3 (en)	2002-08-22
ATE450510T1 (de)	2009-12-15
US20030216429A1 (en)	2003-11-20
US6583153B2 (en)	2003-06-24
JP2004515541A (ja)	2004-05-27
WO2002048112A2 (en)	2002-06-20
US6765011B2 (en)	2004-07-20
EP1345907B1 (de)	2006-08-23
DK1520855T3 (da)	2010-03-15
AU2002229033B2 (en)	2007-09-13
PT1520855E (pt)	2010-01-06
CY1105712T1 (el)	2010-12-22
HK1055957A1 (en)	2004-01-30
AU2903302A (en)	2002-06-24
CA2431617A1 (en)	2002-06-20
EP1345907A2 (de)	2003-09-24
CN1288137C (zh)	2006-12-06
EP1520855A1 (de)	2005-04-06
DE60122575D1 (de)	2006-10-05
JP4427251B2 (ja)	2010-03-03
US20020123506A1 (en)	2002-09-05
ES2337898T3 (es)	2010-04-30
CY1110589T1 (el)	2015-04-29
DK1345907T3 (da)	2006-11-13
CA2431617C (en)	2011-07-12
DE60122575T2 (de)	2007-09-13
CN1489579A (zh)	2004-04-14

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BR9812122A (pt)	2000-07-18	Combinação de inibidor da tirosina quinase e castração quìmica para tratar câncer da próstata
DE69908397D1 (de)	2003-07-03	Betulinsäure derivate zur behandlung von neuroektodermalen tumoren
EP0939627A4 (de)	2000-10-04	Pentafluorobenzensulfonamide und analoge
PT1187918E (pt)	2006-08-31	Antagonistas de tek
HUP9903732A3 (en)	2002-01-28	Use of cgmp elevators for the preparation of pharmaceutical compositions treating benign prostatic hyperplasia
CY1110589T1 (el)	2015-04-29	ΠΑΡΑΓΩΓΑ ΤΗΣ ΘΕΙΕΝΟ(2,3-b)ΠΥΡΙΔΙΝΗΣ ΧΡΗΣΙΜΑ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ ΤΗΣ ΟΡΜΟΝΗΣ ΑΠΕΛΕΥΘΕΡΩΣΕΩΣ ΓΟΝΑΔΟΤΡΟΠΟΥ ΟΡΜΟΝΗΣ
PE20011167A1 (es)	2001-11-13	Composiciones farmaceuticas que comprenden un antagonista del alfa-adrenoreceptor y un antagonista muscarinico para el tratamiento de hiperplasia prostatica benigna
ATE224386T1 (de)	2002-10-15	Neue in 6-position substituierte phenanthridine
TR200003166T2 (tr)	2001-02-21	N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat.
DE60309667D1 (de)	2006-12-28	Biphenylderivate und ihre verwendung als antiandrogene
DE60033649D1 (de)	2007-04-12	Verbindungen und therapeutische methoden
EA200800067A1 (ru)	2008-04-28	Нестероидные антиандрогены, направленные на 12 спираль (рецептора андрогенов)
DE60023025D1 (de)	2006-02-16	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
ATE368040T1 (de)	2007-08-15	Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren
DE60108626D1 (de)	2005-03-03	Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
TR200103457T2 (tr)	2002-04-22	4-Fenil-Pirimidin Türevleri.
BRPI0409958A (pt)	2006-04-25	quinolinas de benzofuranil- e benzotienil-piperazinil quinolinas e métodos para o seu uso
PT916670E (pt)	2003-09-30	Pirrolo-(3,2-b) piridinas e o seu uso como agonistas do 5-ht1f
DE69911017D1 (en)	2003-10-09	Arylsulfonanilid-phosphate
ATE297926T1 (de)	2005-07-15	Hexahydropyrazino(1'2':1,6)-pyrido(3,4-b)indole 1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
EA200401100A1 (ru)	2005-04-28	1α-ФТОР-25-ГИДРОКСИ-16,23E-ДИЕН-26,27-БИСГОМО-20-ЭПИХОЛЕКАЛЬЦИФЕРОЛ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ
TR200100182T2 (tr)	2001-07-23	Antitrombotik etkili ikame edilmiş fenilamidinler
ECSP982362A (es)	1998-12-22	Compuestos de quinolina y quinazolina utiles en terapia

Legal Events

Date	Code	Title	Description
2010-12-23	8364	No opposition during term of opposition