DE60133581D1 - Von lactobacillus casei ke01 stamm abgeleitete probiotische verbindungen - Google Patents
Von lactobacillus casei ke01 stamm abgeleitete probiotische verbindungenInfo
- Publication number
- DE60133581D1 DE60133581D1 DE60133581T DE60133581T DE60133581D1 DE 60133581 D1 DE60133581 D1 DE 60133581D1 DE 60133581 T DE60133581 T DE 60133581T DE 60133581 T DE60133581 T DE 60133581T DE 60133581 D1 DE60133581 D1 DE 60133581D1
- Authority
- DE
- Germany
- Prior art keywords
- lactobacillus casei
- stem
- compounds derived
- probiotic compositions
- probiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006041 probiotic Substances 0.000 title abstract 5
- 230000000529 probiotic effect Effects 0.000 title abstract 5
- 235000018291 probiotics Nutrition 0.000 title abstract 5
- 244000199866 Lactobacillus casei Species 0.000 title abstract 3
- 235000013958 Lactobacillus casei Nutrition 0.000 title abstract 3
- 229940017800 lactobacillus casei Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 244000000021 enteric pathogen Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/856—Lactobacillus casei
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25652800P | 2000-12-18 | 2000-12-18 | |
| US256528P | 2000-12-18 | ||
| PCT/US2001/048707 WO2002058712A2 (en) | 2000-12-18 | 2001-12-17 | Probiotic compounds derived from lactobacillus casei strain ke01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60133581D1 true DE60133581D1 (de) | 2008-05-21 |
| DE60133581T2 DE60133581T2 (de) | 2009-06-04 |
Family
ID=22972567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60133581T Expired - Lifetime DE60133581T2 (de) | 2000-12-18 | 2001-12-17 | Von lactobacillus casei ke01 stamm abgeleitete probiotische verbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6797266B2 (de) |
| EP (1) | EP1345613B1 (de) |
| JP (2) | JP5186077B2 (de) |
| KR (1) | KR20040018319A (de) |
| AT (1) | ATE391509T1 (de) |
| AU (1) | AU2002246679B2 (de) |
| BR (1) | BR0116349A (de) |
| CA (1) | CA2442602A1 (de) |
| DE (1) | DE60133581T2 (de) |
| IL (1) | IL156490A0 (de) |
| MX (1) | MXPA03005465A (de) |
| NZ (1) | NZ526443A (de) |
| WO (1) | WO2002058712A2 (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7029702B2 (en) * | 1998-07-07 | 2006-04-18 | Ritter Natural Sciences Llc | Method for increasing lactose tolerance in mammals exhibiting lactose intolerance |
| US20040197352A1 (en) * | 1999-04-30 | 2004-10-07 | Natarajan Ranganathan | Methods of improving or augmenting kidney function |
| US7998470B2 (en) | 1999-04-30 | 2011-08-16 | Kibow Biotech, Inc. | Compositions and methods improving renal function |
| US20040161422A1 (en) * | 1999-04-30 | 2004-08-19 | Natarajan Ranganathan | Nutritional compositions comprising probiotics |
| US7026160B2 (en) * | 1999-04-30 | 2006-04-11 | Kibow Biotech, Inc. | Oral bacteriotherapy compositions and methods |
| SE0003100D0 (sv) * | 2000-09-01 | 2000-09-01 | Probi Ab | New strains |
| US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| JP5186077B2 (ja) * | 2000-12-18 | 2013-04-17 | プロバイオヘルス・エルエルシー | ラクトバシラス−カゼイke01株から得られたプロバイオティック化合物 |
| PE20030283A1 (es) * | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de lactobacillus casei |
| US20040028665A1 (en) | 2002-01-08 | 2004-02-12 | Garner Bryan E. | Compositions and methods for inhibiting pathogenic growth |
| US20030175305A1 (en) * | 2002-01-08 | 2003-09-18 | Garner Bryan E. | Compositions and methods for inhibiting pathogenic growth |
| US7182943B2 (en) * | 2002-05-15 | 2007-02-27 | UNIVERSITé LAVAL | Method and system for modulation of microbial cell characteristics |
| GB0212975D0 (en) * | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
| AU2003238263A1 (en) * | 2002-06-19 | 2004-01-06 | The Board Of Regents Of The University Of Nebraska | Lactic acid bacteria cultures that inhibit food-borne pathogens |
| CA2820023A1 (en) * | 2002-09-26 | 2007-12-19 | Vita-Herb Nutriceuticals, Inc. | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| US20040241150A1 (en) * | 2002-12-19 | 2004-12-02 | Hargis Billy M. | Defined competitive exclusion cultures for food borne pathogens |
| AU2003300208A1 (en) | 2003-01-06 | 2004-08-10 | Nutrition Physiology Corporation | Compositions and methods for reducing the pathogen content of meat and meat products |
| WO2004104175A2 (en) * | 2003-05-14 | 2004-12-02 | University Of Georgia Research Foundation, Inc. | Probiotic bacteria and methods |
| ATE504645T1 (de) * | 2003-06-23 | 2011-04-15 | Univ North Carolina State | Für fructooligosaccharid-nutzende verbindungen codierende nukleinsäuren aus lactobacillus acidophilus und verwendungen davon |
| WO2005000034A2 (en) * | 2003-06-23 | 2005-01-06 | Agtech Products, Inc. | Lactic bacteria and its use in direct-fed microbials |
| WO2005032591A1 (en) * | 2003-09-30 | 2005-04-14 | Kibow Biotech, Inc. | Compositions and methods for augmenting kidney function |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| MY143693A (en) | 2004-03-24 | 2011-06-30 | Nestec Sa | Shelf stable product wih living micro-organisms |
| US20080126195A1 (en) * | 2004-07-22 | 2008-05-29 | Ritter Andrew J | Methods and Compositions for Treating Lactose Intolerance |
| CA2609617C (en) | 2005-05-31 | 2014-07-08 | The Iams Company | Feline probiotic lactobacilli |
| AU2006253007B2 (en) | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
| PT1962873E (pt) * | 2005-12-14 | 2013-08-29 | Oxthera Inc | Composições farmacêuticas compreendendo bactérias redutoras de oxalato |
| CN101405022A (zh) | 2005-12-16 | 2009-04-08 | 奥克斯赛拉公司 | 用于减少草酸盐的组合物和方法 |
| US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| JP5214464B2 (ja) | 2005-12-28 | 2013-06-19 | アドバンスド バイオニュートリション コーポレーション | 多糖類、糖類およびポリオール類の乾燥マトリックスを含む、ガラス形態の、プロバイオティクス細菌用送達媒体およびその製造方法 |
| WO2008076975A1 (en) | 2006-12-18 | 2008-06-26 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
| RU2436581C2 (ru) | 2007-02-01 | 2011-12-20 | Дзе Иамс Компани | Способ уменьшения воспаления и снижения стресса у млекопитающего |
| ES2381232T3 (es) * | 2007-02-28 | 2012-05-24 | Mead Johnson Nutrition Company | Procedimiento para el tratamiento o la prevención de la inflamación sistémica |
| TW200904340A (en) | 2007-05-11 | 2009-02-01 | Mannatech Inc | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same |
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| BR112012018839B1 (pt) | 2010-01-28 | 2020-04-14 | Advanced Bionutrition Corp | composição vítrea seca compreendendo um material bioativo |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| US7888062B1 (en) | 2010-02-01 | 2011-02-15 | Microbios, Inc. | Process and composition for the manufacture of a microbial-based product |
| US8445226B2 (en) | 2010-02-01 | 2013-05-21 | Microbios, Inc. | Process and composition for the manufacture of a microbial-based product |
| EP3202406A1 (de) | 2010-04-28 | 2017-08-09 | Ritter Pharmaceuticals, Inc. | Präbiotische formulierungen und deren verwendungen |
| IT1405395B1 (it) * | 2010-08-05 | 2014-01-10 | Proge Farm Srl | Composizioni di probiotici e oli e loro uso. |
| PL2603100T3 (pl) | 2010-08-13 | 2019-06-28 | Advanced Bionutrition Corp. | Kompozycja stabilizująca przechowywanie na sucho materiałów biologicznych |
| WO2012044984A1 (en) | 2010-09-30 | 2012-04-05 | The Board Of Trustees Of The University Of Arkansas | Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads |
| CL2010001628A1 (es) | 2010-12-30 | 2011-04-25 | Univerisidad De Concepcion | Alimento probiotico para peces que comprende lactobacillus plantarum, lactococcus lactis lactis, pediococcus acidilactic, pediococcus damnosus y/o plantarum, harina y descartes de pescado, poroto de soya, harina de trigo, aceite de pescado y almidon de maiz; y proceso de elaboracion de dicho alimento. |
| KR101166798B1 (ko) | 2011-12-19 | 2012-07-26 | 김대현 | 락토바실러스 애시도필러스 엘비의 사균을 포함하는 알레르기 질환의 치료 또는 예방용 의약 조성물 |
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| EP3217992A4 (de) * | 2014-11-10 | 2018-07-18 | National Institutes Of Health | Probiotische therapeutische anwendungen |
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| CN111560330B (zh) * | 2020-05-12 | 2022-04-26 | 天津科技大学 | 一种具有免疫调节、抗炎和抗宫颈癌作用的干酪乳杆菌及应用 |
| WO2022082027A1 (en) * | 2020-10-15 | 2022-04-21 | University Of Louisville Research Foundation, Inc. | Probiotic delivery systems and methods of making and using |
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| CN112625979B (zh) * | 2021-01-14 | 2023-01-06 | 四川大学华西医院 | 一种对抗幽门螺杆菌的干酪乳杆菌及其应用 |
| WO2025043142A1 (en) * | 2023-08-23 | 2025-02-27 | The United States Government As Represented By The Department Of Veterans Affairs | Compositions comprising lactobacillus strains, and methods of treating osteoarthritis and osteoarthritis co-morbidities |
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|---|---|---|---|---|
| DE2421066A1 (de) | 1974-05-02 | 1976-03-25 | Solco Basel Ag | Bifidobakterien enthaltendes praeparat |
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| US6274564B1 (en) | 1996-09-18 | 2001-08-14 | William J. Sarill | Compositions of cobalamin and related corrinoids, and uses thereof |
| SE511524C2 (sv) * | 1997-06-02 | 1999-10-11 | Essum Ab | Lactobacillus casei rhamnosus-stam samt farmaceutisk beredning för bekämpning av patogena tarmbakterier |
| US5965128A (en) | 1997-08-13 | 1999-10-12 | University Of Georgia Research Foundation Inc. | Control of enterohemorrhagic E. coli 0157:H7 in cattle by probiotic bacteria and specific strains of E. coli |
| ES2258841T3 (es) * | 1998-04-01 | 2006-09-01 | Ganeden Biotech, Inc. | Procedimientos para reducir el colesterol con esporas de bacillus coagulans, sistemas y composiciones asociados. |
| DE69924141D1 (de) * | 1998-12-11 | 2005-04-14 | Urex Biotech Inc | Orale verabreichung von laktobacillus zur behandlung und prävention von urogenitalen infektionen |
| JP2000197469A (ja) * | 1999-01-08 | 2000-07-18 | New Food Creation Gijutsu Kenkyu Kumiai | 血清脂質改善効果を有する機能性飲食品 |
| SE523771C2 (sv) * | 1999-05-21 | 2004-05-18 | Probi Ab | Sportdryck innehållande mikronäringsämnen i kombination med levande laktobaciller |
| JP5186077B2 (ja) * | 2000-12-18 | 2013-04-17 | プロバイオヘルス・エルエルシー | ラクトバシラス−カゼイke01株から得られたプロバイオティック化合物 |
-
2001
- 2001-12-17 JP JP2002559046A patent/JP5186077B2/ja not_active Expired - Fee Related
- 2001-12-17 CA CA002442602A patent/CA2442602A1/en not_active Abandoned
- 2001-12-17 MX MXPA03005465A patent/MXPA03005465A/es unknown
- 2001-12-17 DE DE60133581T patent/DE60133581T2/de not_active Expired - Lifetime
- 2001-12-17 KR KR10-2003-7008139A patent/KR20040018319A/ko not_active Withdrawn
- 2001-12-17 EP EP01994262A patent/EP1345613B1/de not_active Expired - Lifetime
- 2001-12-17 NZ NZ526443A patent/NZ526443A/en not_active IP Right Cessation
- 2001-12-17 AT AT01994262T patent/ATE391509T1/de not_active IP Right Cessation
- 2001-12-17 AU AU2002246679A patent/AU2002246679B2/en not_active Ceased
- 2001-12-17 US US10/021,871 patent/US6797266B2/en not_active Expired - Lifetime
- 2001-12-17 IL IL15649001A patent/IL156490A0/xx unknown
- 2001-12-17 WO PCT/US2001/048707 patent/WO2002058712A2/en not_active Ceased
- 2001-12-17 BR BR0116349-3A patent/BR0116349A/pt not_active IP Right Cessation
-
2010
- 2010-02-15 JP JP2010029974A patent/JP2010195778A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002246679B2 (en) | 2006-11-16 |
| EP1345613A2 (de) | 2003-09-24 |
| JP2004525106A (ja) | 2004-08-19 |
| DE60133581T2 (de) | 2009-06-04 |
| CA2442602A1 (en) | 2002-08-01 |
| KR20040018319A (ko) | 2004-03-03 |
| US6797266B2 (en) | 2004-09-28 |
| ATE391509T1 (de) | 2008-04-15 |
| NZ526443A (en) | 2005-03-24 |
| MXPA03005465A (es) | 2004-10-14 |
| WO2002058712A3 (en) | 2003-06-05 |
| EP1345613B1 (de) | 2008-04-09 |
| WO2002058712A2 (en) | 2002-08-01 |
| JP2010195778A (ja) | 2010-09-09 |
| JP5186077B2 (ja) | 2013-04-17 |
| BR0116349A (pt) | 2003-12-23 |
| US20020192202A1 (en) | 2002-12-19 |
| IL156490A0 (en) | 2004-01-04 |
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