[go: up one dir, main page]

DE60123277D1 - Makrolidantibiotika - Google Patents

Makrolidantibiotika

Info

Publication number
DE60123277D1
DE60123277D1 DE60123277T DE60123277T DE60123277D1 DE 60123277 D1 DE60123277 D1 DE 60123277D1 DE 60123277 T DE60123277 T DE 60123277T DE 60123277 T DE60123277 T DE 60123277T DE 60123277 D1 DE60123277 D1 DE 60123277D1
Authority
DE
Germany
Prior art keywords
sub
macrolide antibiotics
solvates
prophylaxis
systemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60123277T
Other languages
English (en)
Other versions
DE60123277T2 (de
Inventor
Daniele Andreotti
Stefano Biondi
Sergio Lociuro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE60123277D1 publication Critical patent/DE60123277D1/de
Application granted granted Critical
Publication of DE60123277T2 publication Critical patent/DE60123277T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
DE60123277T 2000-12-21 2001-12-20 Makrolidantibiotika Expired - Fee Related DE60123277T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0031312.2A GB0031312D0 (en) 2000-12-21 2000-12-21 Macrolides
GB0031312 2000-12-21
PCT/GB2001/005669 WO2002050092A1 (en) 2000-12-21 2001-12-20 Macrolide antibiotics

Publications (2)

Publication Number Publication Date
DE60123277D1 true DE60123277D1 (de) 2006-11-02
DE60123277T2 DE60123277T2 (de) 2007-09-13

Family

ID=9905640

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123277T Expired - Fee Related DE60123277T2 (de) 2000-12-21 2001-12-20 Makrolidantibiotika

Country Status (9)

Country Link
US (1) US6900183B2 (de)
EP (1) EP1343797B1 (de)
JP (1) JP2004520314A (de)
AT (1) ATE340184T1 (de)
AU (1) AU2002222296A1 (de)
DE (1) DE60123277T2 (de)
ES (1) ES2272410T3 (de)
GB (1) GB0031312D0 (de)
WO (1) WO2002050092A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2460947A1 (en) * 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
US6720308B1 (en) 2002-11-07 2004-04-13 Enanta Pharmaceuticals, Inc. Anhydrolide derivatives having antibacterial activity
EP3738591A3 (de) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Neuartige antibakterielle wirkstoffe
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
WO2004108745A2 (en) * 2003-06-05 2004-12-16 Enanta Pharmaceuticals, Inc. 11-12 bicyclic erythromycin derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US6716820B1 (en) 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
RU2455308C2 (ru) * 2006-05-01 2012-07-10 Тайсо Фармасьютикал Ко., Лтд. Макролидные производные
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
EP2435460B1 (de) 2009-05-27 2015-01-07 Wockhardt Limited Ketolid-verbindungen mit antimikrobieller wirkung
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
PL2673285T3 (pl) 2010-12-09 2017-12-29 Wockhardt Limited Związki ketolidowe
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
MX2018010652A (es) * 2016-01-12 2021-07-16 Wockhardt Ltd Composiciones farmaceuticas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2739620B1 (fr) 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
DE60010442T2 (de) * 1999-03-15 2005-05-12 Abbott Laboratories, Abbott Park 6-o-substitutierte makrolide mit antibakterieller wirkung
EP1114826A3 (de) * 1999-12-29 2001-10-31 Pfizer Products Inc. Antibakterielle und prokinetische Makroliden

Also Published As

Publication number Publication date
EP1343797A1 (de) 2003-09-17
US6900183B2 (en) 2005-05-31
JP2004520314A (ja) 2004-07-08
WO2002050092A1 (en) 2002-06-27
GB0031312D0 (en) 2001-02-07
US20040082526A1 (en) 2004-04-29
EP1343797B1 (de) 2006-09-20
AU2002222296A1 (en) 2002-07-01
DE60123277T2 (de) 2007-09-13
ES2272410T3 (es) 2007-05-01
ATE340184T1 (de) 2006-10-15

Similar Documents

Publication Publication Date Title
DE60123277D1 (de) Makrolidantibiotika
AP9801253A0 (en) 9-Oxime erythromycin derivatives.
AUPR213700A0 (en) Antiviral agents
BG103969A (en) C-4"-substituted macrolide derivatives
TR199901127T2 (xx) Antibakteriyel etkili 6-O-ikameli ketolitler.
NZ504986A (en) Erythromycin and azalide derivatives and pharmaceutical compositions thereof, useful as antibacterial agents and antoprotozoa agents
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
BG103945A (en) Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
CA2292359A1 (en) Novel azalides and methods of making same
EA200400536A1 (ru) Макролиды
NZ325837A (en) Carbamoyloxy derivatives of mutiline and their use as antibacterials
CA2359708A1 (en) Ketolide antibiotics
CA2351429A1 (en) 13-membered azalides and their use as antibiotic agents
PA8486401A1 (es) Antibioticos cetolidos carbamato y carbazato
DK0623021T3 (da) 4"-deoxyerythromycinderivater
DK0992509T3 (da) Nye makrolid-derivater
CA2280328A1 (en) C11 carbamates of macrolide antibacterials
AP9801377A0 (en) Tricyclic erythromycin derivatives.
WO2004039822A3 (en) 4’’ - modified erythromycin derivatives
MY133397A (en) Novel crystalline forms of a macrolide antibiotic
AP9801235A0 (en) Erythromycin derivatives.
WO2002018353A3 (en) Oxazolidinone chemotherapeutic agents
PT952157E (pt) Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ANDREOTTI, DANIELE, VERONA, IT

Inventor name: BIONDI, STEFANO, VERONA, IT

Inventor name: LOCIURO, SERGIO, VERONA, IT

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee