DE60121150D1 - Verfahren zur herstellung von ansamitocin - Google Patents

Verfahren zur herstellung von ansamitocin

Info

Publication number: DE60121150D1
Authority: DE; Germany
Prior art keywords: ansamitocin; preparation
Prior art date: 2000-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60121150T

Other languages

English (en)

Other versions

DE60121150T2 (de

Inventor

Mark Fulston

Anna Stefanska

Jan Thirkettle

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Ltd

Original Assignee

SmithKline Beecham Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2001-04-11

Publication date

2006-08-10

2001-04-11 Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd

2006-08-10 Publication of DE60121150D1 publication Critical patent/DE60121150D1/de

2007-05-16 Application granted granted Critical

2007-05-16 Publication of DE60121150T2 publication Critical patent/DE60121150T2/de

2021-04-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

PVNFMCBFDPTNQI-UIBOPQHZSA-N [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] acetate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 3-methylbutanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] propanoate Chemical compound CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(C)=O)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CCC(=O)O[C@H]1CC(=O)N(C)c2cc(C\C(C)=C\C=C\[C@@H](OC)[C@@]3(O)C[C@H](OC(=O)N3)[C@@H](C)C3O[C@@]13C)cc(OC)c2Cl.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2.CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)CC(C)C)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2 PVNFMCBFDPTNQI-UIBOPQHZSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

DE60121150T 2000-04-12 2001-04-11 Verfahren zur herstellung von ansamitocin Expired - Lifetime DE60121150T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US19636100P	2000-04-12	2000-04-12
US196361P		2000-04-12
PCT/GB2001/001661 WO2001077360A2 (en)	2000-04-12	2001-04-11	Methods for ansamitocin production

Publications (2)

Publication Number	Publication Date
DE60121150D1 true DE60121150D1 (de)	2006-08-10
DE60121150T2 DE60121150T2 (de)	2007-05-16

Family

ID=22725075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60121150T Expired - Lifetime DE60121150T2 (de)	2000-04-12	2001-04-11	Verfahren zur herstellung von ansamitocin

Country Status (21)

Country	Link
US (2)	US6573074B2 (de)
EP (1)	EP1272653B1 (de)
JP (1)	JP4832697B2 (de)
KR (1)	KR20030036159A (de)
CN (1)	CN1432068A (de)
AR (1)	AR028002A1 (de)
AT (1)	ATE331804T1 (de)
AU (2)	AU2001293335B2 (de)
BR (1)	BR0109975A (de)
CA (1)	CA2406188A1 (de)
CZ (1)	CZ20023356A3 (de)
DE (1)	DE60121150T2 (de)
ES (1)	ES2266243T3 (de)
HU (1)	HUP0300473A3 (de)
IL (1)	IL152241A0 (de)
MX (1)	MXPA02010109A (de)
NO (1)	NO20024893L (de)
NZ (1)	NZ521868A (de)
PL (1)	PL365577A1 (de)
WO (1)	WO2001077360A2 (de)
ZA (1)	ZA200208159B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6333410B1 (en)	2000-08-18	2001-12-25	Immunogen, Inc.	Process for the preparation and purification of thiol-containing maytansinoids
AR030612A1 (es) *	2000-09-12	2003-08-27	Smithkline Beecham Corp	Procedimiento e intermedios
US6790954B2 (en) *	2002-01-29	2004-09-14	Immunogen, Inc.	Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US20050261493A1 (en) *	2002-08-08	2005-11-24	Mark Fulston	Methods for the isolation and purification of ansamitocins
WO2005020883A2 (en) *	2003-05-08	2005-03-10	Immunogen, Inc.	Methods for the production of ansamitocins
US7432088B2 (en) *	2003-05-08	2008-10-07	Immunogen Inc.	Methods for the production of ansamitocins
US7276497B2 (en) *	2003-05-20	2007-10-02	Immunogen Inc.	Cytotoxic agents comprising new maytansinoids
US20070135629A1 (en) *	2005-12-08	2007-06-14	Millennium Pharmaceuticals, Inc.	Isolation of ansamitocins
EP1806365A1 (de)	2006-01-05	2007-07-11	Boehringer Ingelheim International GmbH	Antikörper spezifisch für Fibroblasten-Aktivierungsprotein und Immunokonjugaten, die diese Antikörper enthalten
CN100420754C (zh) *	2006-10-26	2008-09-24	浙江海正药业股份有限公司	一种制备蒽莎姆菌素的方法
HUE063461T2 (hu)	2011-05-27	2024-01-28	Glaxo Group Ltd	BCMA (CD269/TNFRSF17)-kötõ fehérjék
CN102505023A (zh) *	2011-11-18	2012-06-20	华东理工大学	一种dahp合酶的异源可溶性表达方法及其重组载体和基因工程菌
CN108276427A (zh) *	2018-01-14	2018-07-13	常州大学	一种安丝菌素p-3的提取与分离纯化方法
CN110117626A (zh) *	2018-02-06	2019-08-13	上海键合医药科技有限公司	一种制备安丝菌素p3的发酵工艺
FI3956332T3 (fi)	2019-04-18	2023-05-09	Indena Spa	Diastereoselektiivinen menetelmä tiolia tai disulfidia sisältävien maytansinoidiestereiden ja niiden välituotteiden valmistamiseksi
CN113444106A (zh) *	2020-03-25	2021-09-28	重庆乾泰生物医药有限公司	一种高纯度安丝菌素的制备方法
WO2022248870A1 (en)	2021-05-28	2022-12-01	Glaxosmithkline Intellectual Property Development Limited	Combination therapies for treating cancer
WO2022262591A1 (zh) *	2021-06-18	2022-12-22	杭州中美华东制药有限公司	安丝菌素p-3的提纯方法
CA3233953A1 (en)	2021-10-05	2023-04-13	Matthew Bruce	Combination therapies for treating cancer
WO2024218345A1 (en)	2023-04-21	2024-10-24	Glaxosmithkline Intellectual Property Development Limited	Cytotoxicity targeting chimeras for antibody-drug conjugates and bispecific antibodies

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1314019A (en) *	1969-07-19	1973-04-18	Rolland Sa A	Antibiotic substance and process for the extraction of such an antibiotic substance from a strain of pseudomonas
ZA737247B (en)	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
JPS6010718B2 (ja)	1977-03-31	1985-03-19	武田薬品工業株式会社	メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法
US4162940A (en)	1977-03-31	1979-07-31	Takeda Chemical Industries, Ltd.	Method for producing Antibiotic C-15003 by culturing nocardia
JPS6016236B2 (ja) *	1977-11-18	1985-04-24	武田薬品工業株式会社	抗生物質ｃ―１５００３ｐ―３の製造法
JPS55162791A (en)	1979-06-05	1980-12-18	Takeda Chem Ind Ltd	Antibiotic c-15003pnd and its preparation
JPS5645483A (en)	1979-09-19	1981-04-25	Takeda Chem Ind Ltd	C-15003phm and its preparation
JPS56102793A (en)	1979-12-28	1981-08-17	Takeda Chem Ind Ltd	Preparation of antibiotic c-15003 p-3
US4423211A (en) *	1981-12-21	1983-12-27	Merck & Co., Inc.	Process for the whole broth extraction of avermectin
JPH0347090A (ja) *	1988-12-27	1991-02-28	Takeda Chem Ind Ltd	二重特異性を有するハイブリッドモノクローナル抗体
US5208020A (en)	1989-10-25	1993-05-04	Immunogen Inc.	Cytotoxic agents comprising maytansinoids and their therapeutic use
EP0505566A1 (de)	1989-12-15	1992-09-30	Takeda Chemical Industries, Ltd.	Biospezifische antikörper gegen krebszellen und enzyme mit wirkstoffvorläufer-aktivierenden eigenschaften
FR2656874B1 (fr) *	1990-01-11	1992-04-03	Commissariat Energie Atomique	Procede de production et d'extraction d'anti-oxydants a partir d'une culture de micro-organismes et photobioreacteur pour la mise en óoeuvre de ce procede.
DE4037441A1 (de) *	1990-11-24	1992-05-27	Basf Ag	Verfahren zur erhoehung des riboflavin-gahaltes in spruehgetrockneten fermenteraustraegen bei riboflavin-fermentationen
JPH08214870A (ja) *	1995-02-17	1996-08-27	Kanegafuchi Chem Ind Co Ltd	ファフィア・ロドチーマ酵母の細胞壁処理方法
CN1056845C (zh) *	1995-03-03	2000-09-27	弗·哈夫曼-拉罗切有限公司	核黄素的纯化

2001
- 2001-04-09 US US09/828,758 patent/US6573074B2/en not_active Expired - Lifetime
- 2001-04-10 AR ARP010101696A patent/AR028002A1/es unknown
- 2001-04-11 BR BR0109975-2A patent/BR0109975A/pt not_active Application Discontinuation
- 2001-04-11 MX MXPA02010109A patent/MXPA02010109A/es unknown
- 2001-04-11 CN CN01810371A patent/CN1432068A/zh active Pending
- 2001-04-11 ES ES01966770T patent/ES2266243T3/es not_active Expired - Lifetime
- 2001-04-11 WO PCT/GB2001/001661 patent/WO2001077360A2/en not_active Ceased
- 2001-04-11 CZ CZ20023356A patent/CZ20023356A3/cs unknown
- 2001-04-11 PL PL01365577A patent/PL365577A1/xx not_active Application Discontinuation
- 2001-04-11 JP JP2001575214A patent/JP4832697B2/ja not_active Expired - Fee Related
- 2001-04-11 NZ NZ521868A patent/NZ521868A/en not_active IP Right Cessation
- 2001-04-11 AU AU2001293335A patent/AU2001293335B2/en not_active Ceased
- 2001-04-11 CA CA002406188A patent/CA2406188A1/en not_active Abandoned
- 2001-04-11 EP EP01966770A patent/EP1272653B1/de not_active Expired - Lifetime
- 2001-04-11 KR KR1020027013580A patent/KR20030036159A/ko not_active Withdrawn
- 2001-04-11 HU HU0300473A patent/HUP0300473A3/hu unknown
- 2001-04-11 DE DE60121150T patent/DE60121150T2/de not_active Expired - Lifetime
- 2001-04-11 AT AT01966770T patent/ATE331804T1/de not_active IP Right Cessation
- 2001-04-11 IL IL15224101A patent/IL152241A0/xx unknown
- 2001-04-11 AU AU9333501A patent/AU9333501A/xx active Pending
2002
- 2002-10-10 ZA ZA200208159A patent/ZA200208159B/en unknown
- 2002-10-10 NO NO20024893A patent/NO20024893L/no not_active Application Discontinuation
2003
- 2003-03-04 US US10/379,136 patent/US20030157669A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1432068A (zh)	2003-07-23
WO2001077360A2 (en)	2001-10-18
IL152241A0 (en)	2003-05-29
HUP0300473A3 (en)	2004-07-28
US20020015984A1 (en)	2002-02-07
US20030157669A1 (en)	2003-08-21
NO20024893D0 (no)	2002-10-10
EP1272653A2 (de)	2003-01-08
KR20030036159A (ko)	2003-05-09
NO20024893L (no)	2002-10-10
CZ20023356A3 (cs)	2003-04-16
AR028002A1 (es)	2003-04-23
NZ521868A (en)	2004-11-26
ATE331804T1 (de)	2006-07-15
EP1272653B1 (de)	2006-06-28
BR0109975A (pt)	2004-03-23
DE60121150T2 (de)	2007-05-16
HUP0300473A2 (hu)	2003-06-28
CA2406188A1 (en)	2001-10-18
MXPA02010109A (es)	2003-02-12
JP2003530114A (ja)	2003-10-14
ES2266243T3 (es)	2007-03-01
JP4832697B2 (ja)	2011-12-07
PL365577A1 (en)	2005-01-10
US6573074B2 (en)	2003-06-03
ZA200208159B (en)	2003-10-17
AU2001293335B2 (en)	2005-02-24
WO2001077360A3 (en)	2002-09-12
AU9333501A (en)	2001-10-23

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Legal Events

Date	Code	Title	Description
2007-07-19	8364	No opposition during term of opposition