DE60120427D1 - Radicicol und monocillin und ihre analogen und ihre anwendungen - Google Patents
Radicicol und monocillin und ihre analogen und ihre anwendungenInfo
- Publication number
- DE60120427D1 DE60120427D1 DE60120427T DE60120427T DE60120427D1 DE 60120427 D1 DE60120427 D1 DE 60120427D1 DE 60120427 T DE60120427 T DE 60120427T DE 60120427 T DE60120427 T DE 60120427T DE 60120427 D1 DE60120427 D1 DE 60120427D1
- Authority
- DE
- Germany
- Prior art keywords
- monocillin
- radicicol
- analogs
- applications
- sub
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229930190086 Monocillin Natural products 0.000 title 1
- XTUZVEOWUSGCSV-HKCOAVLJSA-N Monocillin I Natural products CC1CC2OC2C=C/C=C/C(=O)Cc3cc(O)cc(O)c3C(=O)O1 XTUZVEOWUSGCSV-HKCOAVLJSA-N 0.000 title 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 title 1
- VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 title 1
- WYZWZEOGROVVHK-GTMNPGAYSA-N radicicol Chemical compound C/1=C/C=C/C(=O)CC2=C(Cl)C(O)=CC(O)=C2C(=O)O[C@H](C)C[C@H]2O[C@@H]2\1 WYZWZEOGROVVHK-GTMNPGAYSA-N 0.000 title 1
- 229930192524 radicicol Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Circuits Of Receivers In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22827700P | 2000-08-25 | 2000-08-25 | |
| US30455301P | 2001-07-11 | 2001-07-11 | |
| PCT/US2001/026577 WO2002016369A2 (en) | 2000-08-25 | 2001-08-24 | Novel macrocycles and uses thereof |
| US09/938,754 US7115651B2 (en) | 2000-08-25 | 2001-08-24 | Macrocycles and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60120427D1 true DE60120427D1 (de) | 2006-07-20 |
Family
ID=27397829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60120427T Expired - Lifetime DE60120427D1 (de) | 2000-08-25 | 2001-08-24 | Radicicol und monocillin und ihre analogen und ihre anwendungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7115651B2 (de) |
| EP (1) | EP1315732B1 (de) |
| AT (1) | ATE328888T1 (de) |
| AU (1) | AU2001286768A1 (de) |
| DE (1) | DE60120427D1 (de) |
| WO (1) | WO2002016369A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7705120B2 (en) | 2001-06-21 | 2010-04-27 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20050182129A1 (en) * | 2002-04-17 | 2005-08-18 | Akiko Ikeda | Hair growth tonic |
| ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
| US7538224B2 (en) | 2003-06-27 | 2009-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90 family protein inhibitors |
| US20070004674A1 (en) * | 2003-08-22 | 2007-01-04 | Kyowa Hakko Kogyo Co. Ltd. | Remedy for diseases associated with immunoglobulin gene translocation |
| US8329683B2 (en) | 2006-06-02 | 2012-12-11 | Nexgenix Pharmaceuticals, Llc | Treatment of neurofibromatosis with radicicol and its derivatives |
| WO2008150302A1 (en) * | 2007-06-04 | 2008-12-11 | Nexgenix Pharmaceuticals | Treatment of neurofibromatosis with radicicol and its derivatives |
| WO2008021213A1 (en) | 2006-08-11 | 2008-02-21 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
| CN101820757A (zh) | 2007-06-01 | 2010-09-01 | 普林斯顿大学托管委员会 | 通过调节宿主细胞代谢途径治疗病毒感染 |
| EP2173733A2 (de) | 2007-06-05 | 2010-04-14 | WINSSINGER, Nicolas | Zusammensetzungen und verfahren mit analogen von radicicol a |
| EP2200653A2 (de) | 2007-09-10 | 2010-06-30 | University of Massachusetts | Antitumorale mittel gegen mitochondrien |
| WO2009105755A2 (en) | 2008-02-21 | 2009-08-27 | Nexgenix Pharmaceuticals | Macrocyclic prodrug compounds useful as therapeutics |
| KR101835253B1 (ko) * | 2008-01-15 | 2018-03-06 | 유니베르시떼 드 스트라스부르 | 치료제로서 유용한 레조르실산 락톤의 합성 |
| US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
| US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| WO2016196256A2 (en) | 2015-06-04 | 2016-12-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
| PL3658148T3 (pl) | 2017-07-28 | 2024-10-07 | Turning Point Therapeutics, Inc. | Związki makrocykliczne i ich zastosowania |
| WO2022082108A1 (en) * | 2020-10-16 | 2022-04-21 | The Brigham And Women's Hospital, Inc. | Compositions for inducing tumor immunity and reducing drug tolerance |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR96016E (fr) | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Composé utilisable comme supplément alimentaire pour les animaux. |
| FR96046E (fr) * | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Composé utilisable comme supplément alimentaire pour les animaux. |
| US3621036A (en) * | 1969-02-27 | 1971-11-16 | Merck & Co Inc | Derivatives of zearalane |
| BE757083A (fr) * | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Nouveaux produits a activite antibacterienne |
| BE757082A (fr) * | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Procede de preparation de nouveaux produits a activite antibacterienne |
| US3901921A (en) * | 1972-04-25 | 1975-08-26 | Commercial Solvents Corp | Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof |
| US4035504A (en) * | 1975-05-12 | 1977-07-12 | Imc Chemical Group, Inc. | Method for treating cholesterolemia by administering resorcylic acid lactone derivatives |
| US4088658A (en) * | 1976-11-04 | 1978-05-09 | Imc Chemical Group, Inc. | Synthesis of dideoxyzearalane and related compounds |
| US4228079A (en) | 1978-10-30 | 1980-10-14 | W. R. Grace & Co. | Dialkoxy monorden derivatives |
| US4166764A (en) * | 1978-02-01 | 1979-09-04 | W. R. Grace & Co. | Production of monorden |
| US5650430A (en) * | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
| KR920000763A (ko) | 1990-06-06 | 1992-01-29 | 가와무라 요시부미 | 라디시콜 유도체, 그 제조방법 및 그의 항종양 활성 |
| GB9225396D0 (en) | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5731343A (en) | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
| ATE194610T1 (de) * | 1995-04-26 | 2000-07-15 | Kyowa Hakko Kogyo Kk | Derivate des radicicols |
| JPH09202781A (ja) * | 1996-01-25 | 1997-08-05 | Sankyo Co Ltd | ラディシコール誘導体 |
| KR19990076764A (ko) * | 1996-10-25 | 1999-10-15 | 히라타 다다시 | 래디시콜 유도체 |
| AU3534499A (en) | 1998-04-24 | 1999-11-16 | Kyowa Hakko Kogyo Co. Ltd. | Radicicol derivatives |
| US6635671B1 (en) * | 1998-12-24 | 2003-10-21 | Novation Pharmaceuticals Inc. | Compounds which affect mRNA stability and uses therefor |
| JP2002541255A (ja) | 1999-04-09 | 2002-12-03 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
| ATE392215T1 (de) | 1999-12-22 | 2008-05-15 | Scripps Research Inst | Modulatoren und inhibitoren von angiogenese und vaskulärer durchlässigkeit |
-
2001
- 2001-08-24 DE DE60120427T patent/DE60120427D1/de not_active Expired - Lifetime
- 2001-08-24 AT AT01966236T patent/ATE328888T1/de not_active IP Right Cessation
- 2001-08-24 WO PCT/US2001/026577 patent/WO2002016369A2/en not_active Ceased
- 2001-08-24 US US09/938,754 patent/US7115651B2/en not_active Expired - Fee Related
- 2001-08-24 AU AU2001286768A patent/AU2001286768A1/en not_active Abandoned
- 2001-08-24 EP EP01966236A patent/EP1315732B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE328888T1 (de) | 2006-06-15 |
| WO2002016369A3 (en) | 2002-08-29 |
| EP1315732A2 (de) | 2003-06-04 |
| US20020091151A1 (en) | 2002-07-11 |
| US7115651B2 (en) | 2006-10-03 |
| EP1315732B1 (de) | 2006-06-07 |
| AU2001286768A1 (en) | 2002-03-04 |
| WO2002016369A2 (en) | 2002-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |