DE60119696D1 - Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch - Google Patents
Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauchInfo
- Publication number
- DE60119696D1 DE60119696D1 DE60119696T DE60119696T DE60119696D1 DE 60119696 D1 DE60119696 D1 DE 60119696D1 DE 60119696 T DE60119696 T DE 60119696T DE 60119696 T DE60119696 T DE 60119696T DE 60119696 D1 DE60119696 D1 DE 60119696D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- naltrexone
- naloxone
- analogs
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18937200P | 2000-03-15 | 2000-03-15 | |
| US189372P | 2000-03-15 | ||
| PCT/US2001/008225 WO2001068080A2 (en) | 2000-03-15 | 2001-03-15 | Neutral antagonists and use thereof in treating drug abuse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60119696D1 true DE60119696D1 (de) | 2006-06-22 |
| DE60119696T2 DE60119696T2 (de) | 2007-01-25 |
Family
ID=22697044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60119696T Expired - Lifetime DE60119696T2 (de) | 2000-03-15 | 2001-03-15 | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20010049375A1 (de) |
| EP (1) | EP1263438B1 (de) |
| AT (1) | ATE326222T1 (de) |
| AU (1) | AU4743601A (de) |
| CA (1) | CA2403252A1 (de) |
| DE (1) | DE60119696T2 (de) |
| WO (1) | WO2001068080A2 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| US20040024006A1 (en) * | 1996-05-06 | 2004-02-05 | Simon David Lew | Opioid pharmaceutical compositions |
| US6277384B1 (en) | 1997-12-22 | 2001-08-21 | Euro-Celtique S.A. | Opioid agonist/antagonist combinations |
| ES2540103T3 (es) | 2000-02-08 | 2015-07-08 | Euro-Celtique S.A. | Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas |
| CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
| DK1416842T3 (da) | 2001-07-18 | 2009-03-16 | Euro Celtique Sa | Farmaceutiske kombinationer af oxycodon og naloxon |
| PL367427A1 (en) | 2001-08-06 | 2005-02-21 | Euro-Celtique S.A. | Opioid agonist formulations with releasable and sequestered antagonist |
| AU2002324624A1 (en) | 2001-08-06 | 2003-02-24 | Euro-Celtique S.A. | Sequestered antagonist formulations |
| EP1436012B1 (de) * | 2001-10-18 | 2017-12-20 | Nektar Therapeutics | Polymerkonjugate von opioid antagonisten |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| KR100784341B1 (ko) | 2002-04-05 | 2007-12-13 | 유로-셀띠끄 소시에떼 아노님 | 활성 화합물의 지속적, 불변적 및 독립적 방출용 매트릭스 |
| US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
| EP2301537A1 (de) * | 2002-05-17 | 2011-03-30 | Duke University | Zonisamid zur Behandlung von Fettleibigkeit |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2422772A3 (de) | 2002-09-20 | 2012-04-18 | Alpharma, Inc. | Sequestriermitteluntereinheit und zugehörige Zusammensetzungen und Verfahren |
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| DK2316456T3 (en) * | 2003-04-29 | 2017-09-11 | Orexigen Therapeutics Inc | Compositions for affecting weight loss comprising an opioid antagonist and bupropion |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| RS53279B (sr) * | 2003-12-16 | 2014-08-29 | Nektar Therapeutics | Monodisperzne smeše pegilisanog naloksola |
| EP1734955A2 (de) * | 2004-01-13 | 2006-12-27 | Duke University | Zusammensetzungen eines antikonvulsiven mittels und eines antipsychotischen mittels zur beeinflussung des gewichtsverlustes |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| BRPI0510593A (pt) * | 2004-05-03 | 2007-11-20 | Univ Duke | composições para afetar a perda de peso |
| AU2005286733B2 (en) * | 2004-09-23 | 2009-11-05 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
| US20070197573A1 (en) * | 2005-10-04 | 2007-08-23 | Wolfgang Sadee | Compositions and methods in the treatment of bone metabolic disorders |
| CN1813740B (zh) * | 2005-11-22 | 2010-05-05 | 岳振江 | 一种含有盐酸纳洛酮的舌下膜剂及其制备方法 |
| JP5180092B2 (ja) | 2005-11-22 | 2013-04-10 | オレキシジェン・セラピューティクス・インコーポレーテッド | インスリン感受性を増すための組成物および方法 |
| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| US8916195B2 (en) * | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| ES2600141T3 (es) | 2006-06-19 | 2017-02-07 | Alpharma Pharmaceuticals Llc | Composiciones farmacéuticas |
| AU2007319472B2 (en) | 2006-11-09 | 2013-01-17 | Nalpropion Pharmaceuticals Llc | Methods Of Administering Weight Loss Medications |
| AU2007319471B9 (en) | 2006-11-09 | 2012-10-04 | Nalpropion Pharmaceuticals Llc | Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| WO2008136989A2 (en) * | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Polymorphisms in genes affecting sod2-related disorders and uses thereof |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| WO2009051824A2 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| US20110195433A1 (en) * | 2007-12-17 | 2011-08-11 | The Ohio State University Research Foundation | Methods for Screening of Opioid Receptor Neutral Antagonists and Inverse Agonists and Uses Thereof |
| CA2725930A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
| SMT201900023T1 (it) | 2009-03-10 | 2019-02-28 | Euro Celtique Sa | Composizioni farmaceutiche a rilascio immediato comprendenti ossicodone e naloxone |
| ES2762113T3 (es) * | 2010-01-11 | 2020-05-22 | Nalpropion Pharmaceuticals Inc | Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor |
| WO2011139525A1 (en) * | 2010-05-05 | 2011-11-10 | Philadelphia Health & Education Corporation | Stereoisomer of naloxone and potential therapeutic action of opioid drugs to reverse clinical tolerance to these agents |
| WO2012054566A2 (en) | 2010-10-19 | 2012-04-26 | Memorial Sloan-Kettering Cancer Center | 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| KR20210012056A (ko) | 2012-06-06 | 2021-02-02 | 오렉시젠 세러퓨틱스 인크. | 과체중 및 비만의 치료 방법 |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
| WO2015011189A1 (en) | 2013-07-23 | 2015-01-29 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| ES2881626T3 (es) | 2014-05-30 | 2021-11-30 | Univ New York State Res Found | Composiciones y procedimientos para favorecer la formación ósea |
| EP3291676B1 (de) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Mitragynin-analoga und verwendungen davon |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| CN108778423A (zh) * | 2016-01-08 | 2018-11-09 | 俄亥俄州国家创新基金会 | 阿片类新生儿脱瘾综合征的治疗和预防 |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| EP3600433B1 (de) | 2017-03-28 | 2021-05-05 | LDN Pharma Limited | Mittel zur erhöhung der expression des bcl2-assoziierten agonisten des zelltods zur behandlung von krebs |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| WO2020142644A1 (en) | 2019-01-04 | 2020-07-09 | Aether Therapeutics Inc. | Method for treating drug or alcohol dependency |
| WO2020178447A1 (en) * | 2019-03-06 | 2020-09-10 | LDN Pharma Limited | Method for determining efficacy |
| WO2021011529A1 (en) | 2019-07-15 | 2021-01-21 | Rovaxa | Opioid growth factor receptor (ogfr) antagonists, in particular naloxone and/or naltrexone for treating cancer |
| EP4181981A4 (de) | 2020-07-17 | 2024-08-21 | Zetagen Therapeutics, Inc. | Verfahren und zusammensetzungen zur knochentransplantation mit eisenträgern |
| US20240325379A1 (en) * | 2021-07-06 | 2024-10-03 | Aether Therapeutics Inc. | Low-dose naltrexol and uses thereof |
| US11957676B1 (en) * | 2023-08-07 | 2024-04-16 | Zetagen Therapeutics, Inc. | Controlled release formulation and minimally invasive method of administration to locally treat cancer |
| US12403118B1 (en) | 2025-03-05 | 2025-09-02 | Zetagen Therapeutics, Inc. | Cancer treatments using modified fatty acids and the carriers to administer them |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
| NL280825A (de) | 1962-07-11 | |||
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| JPS523342B2 (de) | 1972-01-26 | 1977-01-27 | ||
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US5266574A (en) | 1984-04-09 | 1993-11-30 | Ian S. Zagon | Growth regulation and related applications of opioid antagonists |
| US4689332A (en) | 1984-04-09 | 1987-08-25 | Research Corporation | Growth regulation and related applications of opioid antagonists |
| US4760069A (en) * | 1985-09-23 | 1988-07-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4889860A (en) * | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
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| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| US5256669A (en) | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
| USRE36547E (en) | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
| US5882944A (en) | 1993-06-23 | 1999-03-16 | The Regents Of The University Of California | Methods for G protein coupled receptor activity screening |
| US6007986A (en) | 1993-06-23 | 1999-12-28 | The Regents Of The University Of California | Methods for anti-addictive narcotic analgesic activity screening |
| US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| WO1996014071A1 (es) * | 1994-11-04 | 1996-05-17 | Legarda Ibanez Juan Jose | Combinacion de farmacos como medicamento destinado a supresion de dependencia de individuos a opiaceos |
| DE69637089T2 (de) | 1995-03-31 | 2008-01-17 | Xenova Research Ltd., Slough | Hapten-Träger-Konjugate zur Anwendung in der Drogen-Missbrauchs-Therapie |
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| WO1997018781A1 (en) * | 1995-11-20 | 1997-05-29 | University Of Miami | Method of treating nicotine dependence |
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| US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| US5760044A (en) * | 1996-05-16 | 1998-06-02 | Archer; Sydney | Method for treating cocaine and amphetamine dependency |
| US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
| EP1011671A1 (de) * | 1997-05-20 | 2000-06-28 | Yale University | Entwöhnungstherapie mit opiat- und serotoninantagonisten |
| US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US6109269A (en) | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
-
2001
- 2001-03-15 AU AU4743601A patent/AU4743601A/xx active Pending
- 2001-03-15 CA CA002403252A patent/CA2403252A1/en not_active Abandoned
- 2001-03-15 WO PCT/US2001/008225 patent/WO2001068080A2/en not_active Ceased
- 2001-03-15 EP EP01920377A patent/EP1263438B1/de not_active Expired - Lifetime
- 2001-03-15 DE DE60119696T patent/DE60119696T2/de not_active Expired - Lifetime
- 2001-03-15 US US09/809,637 patent/US20010049375A1/en not_active Abandoned
- 2001-03-15 AT AT01920377T patent/ATE326222T1/de not_active IP Right Cessation
-
2002
- 2002-06-14 US US10/173,337 patent/US6713488B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6713488B2 (en) | 2004-03-30 |
| EP1263438B1 (de) | 2006-05-17 |
| AU4743601A (en) | 2001-09-24 |
| US20030069262A1 (en) | 2003-04-10 |
| WO2001068080A3 (en) | 2002-07-04 |
| CA2403252A1 (en) | 2001-09-20 |
| DE60119696T2 (de) | 2007-01-25 |
| US20010049375A1 (en) | 2001-12-06 |
| EP1263438A2 (de) | 2002-12-11 |
| WO2001068080A2 (en) | 2001-09-20 |
| ATE326222T1 (de) | 2006-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |