DE60118527D1 - Sensible und multiplexe diagnostische tests zur proteinanalyse - Google Patents
Sensible und multiplexe diagnostische tests zur proteinanalyseInfo
- Publication number
- DE60118527D1 DE60118527D1 DE60118527T DE60118527T DE60118527D1 DE 60118527 D1 DE60118527 D1 DE 60118527D1 DE 60118527 T DE60118527 T DE 60118527T DE 60118527 T DE60118527 T DE 60118527T DE 60118527 D1 DE60118527 D1 DE 60118527D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- protein
- binding reagents
- sample
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17787300P | 2000-01-24 | 2000-01-24 | |
| PCT/US2001/000291 WO2001053539A1 (en) | 2000-01-24 | 2001-01-04 | Sensitive, multiplexed diagnostic assays for protein analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60118527D1 true DE60118527D1 (de) | 2006-05-18 |
Family
ID=22650272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60118527T Expired - Lifetime DE60118527D1 (de) | 2000-01-24 | 2001-01-04 | Sensible und multiplexe diagnostische tests zur proteinanalyse |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6489116B2 (de) |
| EP (1) | EP1250463B1 (de) |
| JP (1) | JP2003520050A (de) |
| AT (1) | ATE322558T1 (de) |
| AU (1) | AU783689B2 (de) |
| CA (1) | CA2396810A1 (de) |
| DE (1) | DE60118527D1 (de) |
| WO (1) | WO2001053539A1 (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004532981A (ja) * | 2001-04-10 | 2004-10-28 | チルドレンズ メディカル センター コーポレーション | タンパク質−タンパク質相互作用の解析および標識の方法 |
| EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| JP2004537312A (ja) * | 2001-07-31 | 2004-12-16 | フィロス インク． | 核酸−蛋白質融合多量体のモジュラーアッセンブリ |
| DE10145226A1 (de) * | 2001-09-13 | 2003-04-10 | Lifebits Ag | Herstellung von trägergebundenen Molekülen |
| US7045311B2 (en) * | 2001-10-25 | 2006-05-16 | Monogram Biosciences, Inc. | Whole cell assay systems for cell surface proteases |
| US7125669B2 (en) * | 2001-11-27 | 2006-10-24 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| AU2003209272A1 (en) * | 2002-01-16 | 2003-09-02 | Zyomyx, Inc. | Engineered binding proteins |
| WO2003072054A2 (en) * | 2002-02-25 | 2003-09-04 | Cabot Corporation | Custom ligand design for biomolecular filtration and purification for bioseperation |
| DE60324778D1 (de) | 2002-03-15 | 2009-01-02 | Nuevolution As | Eine verbesserte methode zur synthese von matritzenabhängigen molekülen |
| US20030198973A1 (en) * | 2002-04-23 | 2003-10-23 | The Molecular Sciences Institute, Inc. | Chimeric fusion molecule for analyte detection and quantitation |
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| EP1539980B1 (de) | 2002-08-01 | 2016-02-17 | Nuevolution A/S | MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN |
| EP1558744B1 (de) | 2002-10-30 | 2011-06-15 | Nuevolution A/S | Enzymatisches codieren |
| DE60330406D1 (de) | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
| WO2004094456A2 (en) | 2003-04-18 | 2004-11-04 | Becton, Dickinson And Company | Immuno-amplification |
| JP4805158B2 (ja) * | 2003-05-16 | 2011-11-02 | アメリカ合衆国 | 核酸増幅系に用いる内部コントロール核酸分子 |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| EP1636250B1 (de) * | 2003-06-25 | 2016-01-06 | Massachusetts Institute Of Technology | Selbstorganisierendes, modifikationen enthaltende peptide und deren anwendung |
| DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
| US7402399B2 (en) * | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
| US7785843B2 (en) * | 2004-06-23 | 2010-08-31 | Sequenom, Inc. | Target-specific compomers and methods of use |
| US20060110724A1 (en) | 2004-11-19 | 2006-05-25 | Burkhardt William Iii | Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard |
| US20060204999A1 (en) * | 2005-03-14 | 2006-09-14 | Stephen Macevicz | Detecting molecular complexes |
| JP5204646B2 (ja) * | 2005-04-25 | 2013-06-05 | マサチューセッツ インスティテュート オブ テクノロジー | 止血および他の生理学的活性を促進するための組成物および方法 |
| KR20080079643A (ko) | 2005-11-16 | 2008-09-01 | 암브룩스, 인코포레이티드 | 비-천연 아미노산을 포함하는 방법 및 조성물 |
| EP3305900B1 (de) | 2005-12-01 | 2021-07-21 | Nuevolution A/S | Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken |
| US9084837B2 (en) | 2006-04-25 | 2015-07-21 | Massachusetts Institute Of Technology | Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or affecting other physiological conditions |
| US8022178B2 (en) * | 2006-09-26 | 2011-09-20 | Massachusetts Institute Of Technology | Modified self-assembling peptides |
| KR20210049186A (ko) | 2007-11-30 | 2021-05-04 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| CN102177438A (zh) | 2008-07-25 | 2011-09-07 | 理查德·W·瓦格纳 | 蛋白筛选方法 |
| US9439941B2 (en) | 2009-12-14 | 2016-09-13 | The University Of Hong Kong | Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| EP3540059A1 (de) | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe |
| US9880160B2 (en) | 2011-03-15 | 2018-01-30 | X-Body, Inc. | Antibody screening methods |
| DK3415619T3 (da) | 2011-04-28 | 2021-03-08 | Univ Leland Stanford Junior | Identifikation af polynukleotider forbundet med en prøve |
| AU2012347972B2 (en) | 2011-12-05 | 2018-05-10 | X-Body, Inc. | PDGF receptor beta binding polypeptides |
| JP6375230B2 (ja) | 2012-02-27 | 2018-08-15 | セルラー リサーチ， インコーポレイテッド | 分子計数のための組成物およびキット |
| MY191368A (en) | 2013-06-28 | 2022-06-20 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| EP3039158B1 (de) | 2013-08-28 | 2018-11-14 | Cellular Research, Inc. | Massiv parallele einzelzellanalyse |
| EP3049811B1 (de) | 2013-09-23 | 2020-09-09 | X-Body, Inc. | Verfahren und zusammensetzungen zur erzeugung von bindemitteln gegen zelloberflächenantigene |
| US20170343545A1 (en) * | 2014-06-06 | 2017-11-30 | Herlev Hospital | Determining Antigen Recognition through Barcoding of MHC Multimers |
| EP4270006A3 (de) | 2014-06-13 | 2024-01-10 | Immudex ApS | Allgemeiner nachweis und isolierung spezifischer zellen durch binden markierter moleküle |
| ES2836802T3 (es) | 2015-02-27 | 2021-06-28 | Becton Dickinson Co | Códigos de barras moleculares espacialmente direccionables |
| CN107406888A (zh) | 2015-03-30 | 2017-11-28 | 赛卢拉研究公司 | 用于组合条形编码的方法和组合物 |
| EP4582556A3 (de) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Verfahren und zusammensetzungen zur gesamttranskriptomamplifikation |
| WO2017044574A1 (en) | 2015-09-11 | 2017-03-16 | Cellular Research, Inc. | Methods and compositions for nucleic acid library normalization |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| EP4300099A3 (de) | 2016-09-26 | 2024-03-27 | Becton, Dickinson and Company | Messung der proteinexpression mit reagenzien mit strichcodierten oligonukleotidsequenzen |
| EP3577232A1 (de) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selektive amplifikation unter verwendung von blockierenden oligonukleotiden |
| EP4345172A3 (de) | 2017-06-05 | 2024-07-03 | Becton, Dickinson and Company | Probenindizierung für einzelzellen |
| US11773441B2 (en) | 2018-05-03 | 2023-10-03 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
| JP7670607B2 (ja) | 2018-10-01 | 2025-04-30 | ベクトン・ディキンソン・アンド・カンパニー | ５’転写物配列の決定 |
| EP3877520B1 (de) | 2018-11-08 | 2025-03-19 | Becton, Dickson And Company | Ganze transkriptomanalyse von einzelzellen mittels random-priming |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| WO2020154247A1 (en) | 2019-01-23 | 2020-07-30 | Cellular Research, Inc. | Oligonucleotides associated with antibodies |
| EP3924506A1 (de) | 2019-02-14 | 2021-12-22 | Becton Dickinson and Company | Hybride gezielte und gesamttranskriptomamplifikation |
| CN114051534B (zh) | 2019-07-22 | 2025-02-21 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| US11773436B2 (en) | 2019-11-08 | 2023-10-03 | Becton, Dickinson And Company | Using random priming to obtain full-length V(D)J information for immune repertoire sequencing |
| WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| WO2021173719A1 (en) | 2020-02-25 | 2021-09-02 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| WO2021247593A1 (en) | 2020-06-02 | 2021-12-09 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| US12391940B2 (en) | 2020-07-31 | 2025-08-19 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| EP4247967A1 (de) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profilierung von stark exprimierten und schwach exprimierten proteinen |
| WO2022132206A1 (en) | 2020-12-15 | 2022-06-23 | Becton, Dickinson And Company | Single cell secretome analysis |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587044A (en) | 1983-09-01 | 1986-05-06 | The Johns Hopkins University | Linkage of proteins to nucleic acids |
| WO1986005803A1 (fr) | 1985-03-30 | 1986-10-09 | Marc Ballivet | Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| ATE168416T1 (de) | 1989-10-05 | 1998-08-15 | Optein Inc | Zellfreie synthese und isolierung von genen und polypeptiden |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| WO1992002536A1 (en) | 1990-08-02 | 1992-02-20 | The Regents Of The University Of Colorado | Systematic polypeptide evolution by reverse translation |
| US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| DE4112440C1 (de) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
| US5795747A (en) | 1991-04-16 | 1998-08-18 | Evotec Biosystems Gmbh | Process for manufacturing new biopolymers |
| AU2313392A (en) | 1991-08-01 | 1993-03-02 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
| US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
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| US5559000A (en) | 1995-01-18 | 1996-09-24 | The Scripps Research Institute | Encoded reaction cassette |
| US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| DE19646372C1 (de) | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
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| US6261804B1 (en) * | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| RU2233878C2 (ru) * | 1997-01-21 | 2004-08-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления |
| GB9703369D0 (en) * | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
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| JP2002510505A (ja) * | 1998-04-03 | 2002-04-09 | フィロス インク． | 位置特定可能な蛋白質アレイ |
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| PT1105360E (pt) | 1998-08-17 | 2009-09-30 | Bristol Myers Squibb Co | Identificação de interacções entre compostos-proteínas, utilizando bibliotecas de moléculas de fusão entre proteínas-ácidos nucleicos |
| WO2000032823A1 (en) * | 1998-12-02 | 2000-06-08 | Phylos, Inc. | Dna-protein fusions and uses thereof |
| AU775076B2 (en) | 1998-12-10 | 2004-07-15 | Bristol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
-
2001
- 2001-01-04 WO PCT/US2001/000291 patent/WO2001053539A1/en not_active Ceased
- 2001-01-04 AU AU29279/01A patent/AU783689B2/en not_active Ceased
- 2001-01-04 CA CA002396810A patent/CA2396810A1/en not_active Abandoned
- 2001-01-04 DE DE60118527T patent/DE60118527D1/de not_active Expired - Lifetime
- 2001-01-04 US US09/755,663 patent/US6489116B2/en not_active Expired - Lifetime
- 2001-01-04 AT AT01942678T patent/ATE322558T1/de not_active IP Right Cessation
- 2001-01-04 JP JP2001553398A patent/JP2003520050A/ja active Pending
- 2001-01-04 EP EP01942678A patent/EP1250463B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6489116B2 (en) | 2002-12-03 |
| EP1250463B1 (de) | 2006-04-05 |
| AU2927901A (en) | 2001-07-31 |
| EP1250463A1 (de) | 2002-10-23 |
| EP1250463A4 (de) | 2004-03-24 |
| WO2001053539A1 (en) | 2001-07-26 |
| JP2003520050A (ja) | 2003-07-02 |
| US20010024784A1 (en) | 2001-09-27 |
| ATE322558T1 (de) | 2006-04-15 |
| AU783689B2 (en) | 2005-11-24 |
| CA2396810A1 (en) | 2001-07-26 |
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