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DE60116514D1 - Amlodipin-hemimaleat - Google Patents

Amlodipin-hemimaleat

Info

Publication number
DE60116514D1
DE60116514D1 DE60116514T DE60116514T DE60116514D1 DE 60116514 D1 DE60116514 D1 DE 60116514D1 DE 60116514 T DE60116514 T DE 60116514T DE 60116514 T DE60116514 T DE 60116514T DE 60116514 D1 DE60116514 D1 DE 60116514D1
Authority
DE
Germany
Prior art keywords
amlodipine
hemimaleat
new
amlodipine hemimaleate
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60116514T
Other languages
English (en)
Other versions
DE60116514T2 (de
Inventor
Jan Ettema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Publication of DE60116514D1 publication Critical patent/DE60116514D1/de
Application granted granted Critical
Publication of DE60116514T2 publication Critical patent/DE60116514T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60116514T 2000-12-29 2001-08-15 Amlodipinhemimaleat Expired - Fee Related DE60116514T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25860300P 2000-12-29 2000-12-29
US258603P 2000-12-29
US80935601A 2001-03-16 2001-03-16
US809356 2001-03-16
PCT/NL2001/000602 WO2002053539A1 (en) 2000-12-29 2001-08-15 Amlodipine hemimaleate
BE2001/0711A BE1014454A6 (nl) 2000-12-29 2001-11-05 Amlodipinehemimaleaat.

Publications (2)

Publication Number Publication Date
DE60116514D1 true DE60116514D1 (de) 2006-03-30
DE60116514T2 DE60116514T2 (de) 2006-08-17

Family

ID=29740327

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116514T Expired - Fee Related DE60116514T2 (de) 2000-12-29 2001-08-15 Amlodipinhemimaleat

Country Status (10)

Country Link
US (1) US6538012B2 (de)
EP (1) EP1309557B9 (de)
AT (1) ATE315026T1 (de)
BE (1) BE1014454A6 (de)
BR (1) BR0116552A (de)
CA (1) CA2433190C (de)
DE (1) DE60116514T2 (de)
ES (1) ES2254495T4 (de)
MX (1) MXPA03005884A (de)
WO (1) WO2002053539A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
EP1309554A1 (de) * 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Amid-derivat von amlodipin
HRP20030526A2 (en) * 2000-12-29 2005-06-30 Pfizer Limited Process for making amlodipine maleate
MXPA05007876A (es) * 2003-01-27 2005-09-21 Hanmi Pharm Ind Co Ltd Camsilato de amlodipino amorfo, estable, proceso para preparar el mismo y composicion para la administracion oral del mismo.
EP3522872B1 (de) 2016-10-07 2021-08-11 Silvergate Pharmaceuticals, Inc. Amlodipinformulierungen
US10799453B2 (en) 2018-04-11 2020-10-13 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
CN116332832A (zh) * 2023-03-29 2023-06-27 安徽美致诚药业有限公司 一种马来酸左旋氨氯地平无定型晶型及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
ZA9810320B (en) 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
PL189666B1 (pl) 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound

Also Published As

Publication number Publication date
EP1309557B9 (de) 2006-11-15
WO2002053539A1 (en) 2002-07-11
DE60116514T2 (de) 2006-08-17
ES2254495T4 (es) 2007-06-16
US20020128297A1 (en) 2002-09-12
BR0116552A (pt) 2004-02-03
CA2433190A1 (en) 2002-07-11
EP1309557A1 (de) 2003-05-14
ES2254495T3 (es) 2006-06-16
BE1014454A6 (nl) 2003-10-07
ATE315026T1 (de) 2006-02-15
MXPA03005884A (es) 2005-04-08
CA2433190C (en) 2005-11-15
EP1309557B1 (de) 2006-01-04
US6538012B2 (en) 2003-03-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee