DE60115274D1 - Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen - Google Patents

Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen

Info

Publication number: DE60115274D1
Authority: DE; Germany
Prior art keywords: hormone; antiprogestines; prophylaxis; treatment; related diseases
Prior art date: 2000-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60115274T

Other languages

English (en)

Other versions

DE60115274T2 (de

Inventor

Jens Hoffmann

Rosemarie Lichtner

Gerhard Siemeister

Martin Schneider

Ulrike Fuhrmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-18

Filing date

2001-10-17

Publication date

2005-12-29

2001-10-17 Application filed by Schering AG filed Critical Schering AG

2005-12-29 Publication of DE60115274D1 publication Critical patent/DE60115274D1/de

2006-07-27 Application granted granted Critical

2006-07-27 Publication of DE60115274T2 publication Critical patent/DE60115274T2/de

2021-10-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE60115274T 2000-10-18 2001-10-17 Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen Expired - Lifetime DE60115274T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US24099800P	2000-10-18	2000-10-18
US240998P		2000-10-18
EP00250341		2000-10-18
EP00250341		2000-10-18
PCT/EP2001/012005 WO2002032430A1 (en)	2000-10-18	2001-10-17	Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases

Publications (2)

Publication Number	Publication Date
DE60115274D1 true DE60115274D1 (de)	2005-12-29
DE60115274T2 DE60115274T2 (de)	2006-07-27

Family

ID=26072951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60115274T Expired - Lifetime DE60115274T2 (de)	2000-10-18	2001-10-17	Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen

Country Status (26)

Country	Link
US (1)	US7378406B2 (de)
EP (1)	EP1328276B1 (de)
JP (2)	JP2004511522A (de)
KR (1)	KR100632908B1 (de)
CN (1)	CN1512886A (de)
AT (1)	ATE310522T1 (de)
AU (2)	AU1824302A (de)
BG (1)	BG107743A (de)
BR (1)	BR0114665A (de)
CA (1)	CA2423017C (de)
CY (1)	CY1104981T1 (de)
CZ (1)	CZ299942B6 (de)
DE (1)	DE60115274T2 (de)
DK (1)	DK1328276T3 (de)
EE (1)	EE05259B1 (de)
ES (1)	ES2253443T3 (de)
HR (1)	HRP20030387A2 (de)
HU (1)	HUP0301460A3 (de)
IL (2)	IL154975A0 (de)
MX (1)	MXPA03002954A (de)
NO (1)	NO20031740L (de)
NZ (1)	NZ538346A (de)
PL (1)	PL360151A1 (de)
SI (1)	SI1328276T1 (de)
SK (1)	SK287124B6 (de)
WO (1)	WO2002032430A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY27301A1 (es) *	2001-05-25	2003-02-28	Schering Ag	Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
DE10159217A1 (de)	2001-11-27	2003-06-05	Schering Ag	17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
US20040242551A1 (en) *	2003-05-28	2004-12-02	Schering Ag	Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
US9517240B2 (en) *	2006-09-26	2016-12-13	The Regents Of The University Of California	Methods and compositions for cancer prevention and treatment
EP2136796A2 (de) *	2007-04-23	2009-12-30	Bayer Schering Pharma Aktiengesellschaft	Progesteronrezeptorantagonist zur alleinigen oder in kombination mit einem antiöstrogen erfolgenden verwendung gegen brca-vermittelten krebs
US20080261929A1 (en) *	2007-04-23	2008-10-23	Jens Hoffmann	Combination of progesterone-receptor antagonist together with an aromatase inhibitor for use in brca mediated diseases
US20080268041A1 (en) *	2007-04-23	2008-10-30	Jens Hoffmann	Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
TWI477276B (zh) *	2008-04-28	2015-03-21	Repros Therapeutics Inc	抗黃體素給藥方案
TWI539953B (zh) *	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
DE102009034366A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de)	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de)	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten
DE102010007719A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten
US20130018027A1 (en) *	2010-03-22	2013-01-17	Repros Therapeutics Inc.	Compositions and methods for non-toxic delivery of antiprogestins
SG11201407397WA (en)	2012-05-31	2014-12-30	Repros Therapeutics Inc	Formulations and methods for vaginal delivery of antiprogestins
JP6343619B2 (ja)	2012-11-02	2018-06-13	レプロスセラピューティクスインコーポレイティド	プロゲステロン依存性病態を処置する方法およびその組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3733478A1 (de) *	1987-10-01	1989-04-13	Schering Ag	Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
DE19706061A1 (de)	1997-02-07	1998-08-13	Schering Ag	Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette

2001
- 2001-10-17 IL IL15497501A patent/IL154975A0/xx active IP Right Grant
- 2001-10-17 MX MXPA03002954A patent/MXPA03002954A/es active IP Right Grant
- 2001-10-17 JP JP2002535668A patent/JP2004511522A/ja not_active Ceased
- 2001-10-17 NZ NZ538346A patent/NZ538346A/en unknown
- 2001-10-17 AU AU1824302A patent/AU1824302A/xx active Pending
- 2001-10-17 WO PCT/EP2001/012005 patent/WO2002032430A1/en not_active Ceased
- 2001-10-17 CZ CZ20031072A patent/CZ299942B6/cs not_active IP Right Cessation
- 2001-10-17 DK DK01987668T patent/DK1328276T3/da active
- 2001-10-17 PL PL36015101A patent/PL360151A1/xx not_active Application Discontinuation
- 2001-10-17 AU AU2002218243A patent/AU2002218243B2/en not_active Ceased
- 2001-10-17 DE DE60115274T patent/DE60115274T2/de not_active Expired - Lifetime
- 2001-10-17 CN CNA018175686A patent/CN1512886A/zh active Pending
- 2001-10-17 BR BR0114665-3A patent/BR0114665A/pt not_active Application Discontinuation
- 2001-10-17 ES ES01987668T patent/ES2253443T3/es not_active Expired - Lifetime
- 2001-10-17 HR HR20030387A patent/HRP20030387A2/xx not_active Application Discontinuation
- 2001-10-17 EP EP01987668A patent/EP1328276B1/de not_active Expired - Lifetime
- 2001-10-17 SI SI200130486T patent/SI1328276T1/sl unknown
- 2001-10-17 US US10/399,320 patent/US7378406B2/en not_active Expired - Fee Related
- 2001-10-17 CA CA002423017A patent/CA2423017C/en not_active Expired - Fee Related
- 2001-10-17 SK SK474-2003A patent/SK287124B6/sk not_active IP Right Cessation
- 2001-10-17 AT AT01987668T patent/ATE310522T1/de not_active IP Right Cessation
- 2001-10-17 HU HU0301460A patent/HUP0301460A3/hu unknown
- 2001-10-17 KR KR1020037005359A patent/KR100632908B1/ko not_active Expired - Fee Related
- 2001-10-17 EE EEP200300155A patent/EE05259B1/xx not_active IP Right Cessation
2003
- 2003-03-18 IL IL154975A patent/IL154975A/en not_active IP Right Cessation
- 2003-04-15 NO NO20031740A patent/NO20031740L/no not_active Application Discontinuation
- 2003-04-18 BG BG107743A patent/BG107743A/bg unknown
2006
- 2006-02-22 CY CY20061100251T patent/CY1104981T1/el unknown
2009
- 2009-12-16 JP JP2009284779A patent/JP2010077158A/ja not_active Ceased

Also Published As

Publication number	Publication date
CY1104981T1 (el)	2010-03-03
SI1328276T1 (sl)	2006-04-30
CN1512886A (zh)	2004-07-14
ATE310522T1 (de)	2005-12-15
IL154975A0 (en)	2003-10-31
SK4742003A3 (en)	2004-09-08
IL154975A (en)	2007-05-15
CA2423017C (en)	2009-01-06
EE200300155A (et)	2003-08-15
SK287124B6 (sk)	2009-12-07
NO20031740D0 (no)	2003-04-15
KR20030044007A (ko)	2003-06-02
EP1328276A1 (de)	2003-07-23
HRP20030387A2 (en)	2005-04-30
CZ299942B6 (cs)	2008-12-29
AU2002218243B2 (en)	2006-07-13
US20040048841A1 (en)	2004-03-11
MXPA03002954A (es)	2003-08-07
HUP0301460A3 (en)	2010-01-28
NZ538346A (en)	2007-03-30
EP1328276B1 (de)	2005-11-23
NO20031740L (no)	2003-06-17
CA2423017A1 (en)	2002-04-25
WO2002032430A1 (en)	2002-04-25
KR100632908B1 (ko)	2006-10-13
US7378406B2 (en)	2008-05-27
BG107743A (bg)	2004-01-30
BR0114665A (pt)	2004-01-13
DE60115274T2 (de)	2006-07-27
JP2004511522A (ja)	2004-04-15
JP2010077158A (ja)	2010-04-08
DK1328276T3 (da)	2006-04-03
HUP0301460A2 (hu)	2003-10-28
PL360151A1 (en)	2004-09-06
EE05259B1 (et)	2010-02-15
ES2253443T3 (es)	2006-06-01
AU1824302A (en)	2002-04-29

Publication	Publication Date	Title
DE60115274D1 (de)	2005-12-29	Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen
EA200201000A1 (ru)	2003-02-27	Гормон-заместительная терапия
EA200301022A1 (ru)	2004-02-26	Гормональная заместительная терапия
DE69413829D1 (de)	1998-11-12	Antiglucocorticoidsteroide zur behandlung von angststörungen
NO20025157D0 (no)	2002-10-25	Kreftterapi
BR0008437A (pt)	2001-10-30	Inibidores esteróides de sulfatase e métodos parafabricação e uso dos mesmos
EA200100674A1 (ru)	2001-12-24	Клатраты дегидроэпиандростерона и соответствующие фармацевтические композиции
MXPA05012841A (es)	2006-02-13	Composicion que comprende antagonistas de receptores de progesterona y antiestrogenos puros para la profilaxis y el tratamiento de enfermedades dependientes de hormonas.
DE60121980D1 (de)	2006-09-14	Verwendung von 11beta-(4-acetylphenyl)-17beta-hydroxy-17alpha-(1,1,2,2-pentafluoroethyl)estra-4,9-dien-3-on zur herstellung eines medikaments zur behandlung von brust-, eierstock-, endometrium-krebs, myelom und meningiom
YU30103A (sh)	2006-08-17	Upotreba antiprogestina za profilaksu i lečenje hormonski zavisnih bolesti
TW200733955A (en)	2007-09-16	Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases
EA200700979A1 (ru)	2007-10-26	Пероральные твердые лекарственные формы, содержащие низкую дозу эстрадиола
YU29903A (sh)	2006-08-17	Upotreba antiprogestina za indukciju apoptoze u ćeliji
ATE337790T1 (de)	2006-09-15	Verwendung von cortisol-sequestriermitteln zur behandlung von hypercortisolaemie-verwandten erkrankungen
UY27301A1 (es)	2003-02-28	Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata

Legal Events

Date	Code	Title	Description
2006-12-14	8364	No opposition during term of opposition
2007-05-31	8327	Change in the person/name/address of the patent owner	Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE
2008-03-27	8327	Change in the person/name/address of the patent owner	Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE