DE60113095D1 - Oberflächen entmineralisiertes osteoimplantat und verfahren zu seiner herstellung - Google Patents
Oberflächen entmineralisiertes osteoimplantat und verfahren zu seiner herstellungInfo
- Publication number
- DE60113095D1 DE60113095D1 DE60113095T DE60113095T DE60113095D1 DE 60113095 D1 DE60113095 D1 DE 60113095D1 DE 60113095 T DE60113095 T DE 60113095T DE 60113095 T DE60113095 T DE 60113095T DE 60113095 D1 DE60113095 D1 DE 60113095D1
- Authority
- DE
- Germany
- Prior art keywords
- entmineralized
- plantate
- production
- eastern oil
- eastern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20406900P | 2000-05-12 | 2000-05-12 | |
| US204069P | 2000-05-12 | ||
| US22105600P | 2000-07-27 | 2000-07-27 | |
| US221056P | 2000-07-27 | ||
| PCT/US2001/015599 WO2001087369A2 (en) | 2000-05-12 | 2001-05-14 | Osteoimplant and method for making same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60113095D1 true DE60113095D1 (de) | 2005-10-06 |
| DE60113095T2 DE60113095T2 (de) | 2006-05-18 |
Family
ID=26899150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60113095T Expired - Lifetime DE60113095T2 (de) | 2000-05-12 | 2001-05-14 | Oberflächen entmineralisiertes osteoimplantat und verfahren zu seiner herstellung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7179299B2 (de) |
| EP (1) | EP1280564B1 (de) |
| AU (1) | AU6158901A (de) |
| CA (1) | CA2409479A1 (de) |
| DE (1) | DE60113095T2 (de) |
| ES (1) | ES2247113T3 (de) |
| WO (1) | WO2001087369A2 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1383549A1 (de) * | 2001-02-14 | 2004-01-28 | Osteotech, Inc. | Implantat auf knochen-basis |
| AU2002366381A1 (en) * | 2001-12-18 | 2003-06-30 | Ebi, L.P. | Spinal implants |
| JP2005516972A (ja) * | 2002-01-22 | 2005-06-09 | ファイザー・インク | 血栓疾患の治療のためのtafi−a阻害剤として使用される3−(イミダゾリル)−2−アミノプロピオン酸 |
| US7744597B2 (en) | 2002-06-26 | 2010-06-29 | Lifenet Health | Device and process for producing fiber products and fiber products produced thereby |
| US8771719B2 (en) * | 2002-08-12 | 2014-07-08 | Warsaw Orthopedic, Inc. | Synthesis of a bone-polymer composite material |
| US9107751B2 (en) * | 2002-12-12 | 2015-08-18 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
| US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
| US7985414B2 (en) * | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
| NZ541535A (en) | 2003-02-04 | 2009-02-28 | Osteotech Inc | Biodegradable polyurethane composite for osteoimplants |
| WO2004084742A1 (en) * | 2003-03-24 | 2004-10-07 | Theken Surgical Llc | Spinal implant adjustment device |
| US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
| US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
| US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7494811B2 (en) * | 2003-05-01 | 2009-02-24 | Lifenet Health | In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
| WO2005062868A2 (en) * | 2003-12-19 | 2005-07-14 | Osteotech, Inc. | Tissue-derived mesh for orthopedic regeneration |
| CA2535169A1 (en) * | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
| US20070231788A1 (en) * | 2003-12-31 | 2007-10-04 | Keyvan Behnam | Method for In Vitro Assay of Demineralized Bone Matrix |
| US8012210B2 (en) * | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
| KR20070004656A (ko) * | 2004-01-30 | 2007-01-09 | 오스테오테크, 인코포레이티드 | 척추 융합을 위한 임플란트 적층 |
| WO2005097004A2 (en) * | 2004-03-26 | 2005-10-20 | Synthes (U.S.A.) | Allograft implant |
| US7544208B1 (en) | 2004-05-03 | 2009-06-09 | Theken Spine, Llc | Adjustable corpectomy apparatus |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
| US7879109B2 (en) * | 2004-12-08 | 2011-02-01 | Biomet Manufacturing Corp. | Continuous phase composite for musculoskeletal repair |
| US20070038303A1 (en) * | 2006-08-15 | 2007-02-15 | Ebi, L.P. | Foot/ankle implant and associated method |
| US8535357B2 (en) | 2004-12-09 | 2013-09-17 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
| AU2006236548A1 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| EP1926459B1 (de) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon |
| CN101365499A (zh) | 2005-11-01 | 2009-02-11 | 骨骼技术股份有限公司 | 骨基质组合物和方法 |
| US20070162132A1 (en) | 2005-12-23 | 2007-07-12 | Dominique Messerli | Flexible elongated chain implant and method of supporting body tissue with same |
| US9034356B2 (en) | 2006-01-19 | 2015-05-19 | Warsaw Orthopedic, Inc. | Porous osteoimplant |
| CA2658934A1 (en) | 2006-07-25 | 2008-01-31 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| USD580551S1 (en) | 2007-02-01 | 2008-11-11 | Zimmer Spine, Inc. | Spinal implant |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20080294270A1 (en) * | 2007-05-24 | 2008-11-27 | Zimmer Orthobiologics, Inc. | Differentially processed tissue and processing methods thereof |
| US8642061B2 (en) | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
| CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| US9554920B2 (en) * | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
| WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
| US20110054408A1 (en) * | 2007-07-10 | 2011-03-03 | Guobao Wei | Delivery systems, devices, tools, and methods of use |
| US9358113B2 (en) * | 2007-07-10 | 2016-06-07 | Warsaw Orthopedic, Inc. | Delivery system |
| US9138509B2 (en) * | 2007-09-14 | 2015-09-22 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
| EP2211921B1 (de) | 2007-10-19 | 2013-12-25 | Warsaw Orthopedic, Inc. | Demineralisierte knochenmatrix-zusammensetzungen und verfahren |
| CA2708147A1 (en) * | 2007-12-05 | 2009-06-18 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
| US8313528B1 (en) | 2008-03-27 | 2012-11-20 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
| US8333804B1 (en) | 2008-03-27 | 2012-12-18 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
| EP2306913A4 (de) * | 2008-03-28 | 2014-06-04 | Warsaw Orthopedic Inc | Knochenanker für orthopädische anwendungen |
| WO2012134540A2 (en) | 2010-10-22 | 2012-10-04 | Vanderbilt University | Injectable synthetic pur composite |
| US9333276B2 (en) * | 2008-10-30 | 2016-05-10 | Vanderbilt University | Bone/polyurethane composites and methods thereof |
| US20100274355A1 (en) * | 2009-01-21 | 2010-10-28 | Mcguire David A | Bone-tendon-bone assembly with cancellous allograft bone block having cortical end portion |
| WO2010093959A2 (en) * | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery systems, tools, and methods of use |
| US9427324B1 (en) * | 2010-02-22 | 2016-08-30 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
| USD623298S1 (en) | 2010-03-12 | 2010-09-07 | Omni Surgical | Bone fusion device |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8343229B2 (en) | 2010-07-16 | 2013-01-01 | Ebi, Llc | Textured bone block implants |
| US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
| US9358122B2 (en) | 2011-01-07 | 2016-06-07 | K2M, Inc. | Interbody spacer |
| US9539109B2 (en) | 2011-09-16 | 2017-01-10 | Globus Medical, Inc. | Low profile plate |
| US10881526B2 (en) | 2011-09-16 | 2021-01-05 | Globus Medical, Inc. | Low profile plate |
| US9398960B2 (en) | 2011-09-16 | 2016-07-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9149365B2 (en) | 2013-03-05 | 2015-10-06 | Globus Medical, Inc. | Low profile plate |
| US9681959B2 (en) | 2011-09-16 | 2017-06-20 | Globus Medical, Inc. | Low profile plate |
| US9770340B2 (en) | 2011-09-16 | 2017-09-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9204975B2 (en) | 2011-09-16 | 2015-12-08 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US9848994B2 (en) | 2011-09-16 | 2017-12-26 | Globus Medical, Inc. | Low profile plate |
| US8961606B2 (en) | 2011-09-16 | 2015-02-24 | Globus Medical, Inc. | Multi-piece intervertebral implants |
| US10245155B2 (en) | 2011-09-16 | 2019-04-02 | Globus Medical, Inc. | Low profile plate |
| US9237957B2 (en) | 2011-09-16 | 2016-01-19 | Globus Medical, Inc. | Low profile plate |
| US9554914B2 (en) | 2011-12-12 | 2017-01-31 | Wright Medical Technology, Inc. | Fusion implant |
| US9968455B2 (en) | 2012-04-27 | 2018-05-15 | Howmedica Osteonics Corp. | Multiple component bone void filling implant |
| US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
| US9345589B2 (en) * | 2013-12-19 | 2016-05-24 | Ilion Medical, Inc. | Bone implants for orthopedic procedures and corresponding methods |
| US20150366668A1 (en) * | 2014-06-23 | 2015-12-24 | Community Blood Center | Cellular-scale surface modification for increased osteogenic protein expression |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3297694A1 (de) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modifizierte demineralisierte kortikale knochenfasern |
| US20170312079A1 (en) * | 2016-04-28 | 2017-11-02 | Warsaw Orthopedic, Inc. | Mechanically entangled demineralized bone fibers |
| JP6988818B2 (ja) * | 2016-11-09 | 2022-01-05 | 昭和電工マテリアルズ株式会社 | プリント配線板及び半導体パッケージ |
| US10376385B2 (en) | 2017-04-05 | 2019-08-13 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
| US11452608B2 (en) | 2017-04-05 | 2022-09-27 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
| WO2021076245A1 (en) | 2019-10-18 | 2021-04-22 | Sparta Biopharma LLC | Connective tissue to bone interface scaffolds |
| WO2022046701A1 (en) | 2020-08-24 | 2022-03-03 | Sparta Biopharma LLC | Methods of forming bone interface scaffolds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061286A (en) * | 1989-08-18 | 1991-10-29 | Osteotech, Inc. | Osteoprosthetic implant |
| US5290558A (en) * | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| US6652592B1 (en) * | 1997-10-27 | 2003-11-25 | Regeneration Technologies, Inc. | Segmentally demineralized bone implant |
| US6090998A (en) * | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
| US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
| US6123731A (en) * | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
| US6458375B1 (en) * | 1998-02-27 | 2002-10-01 | Musculoskeletal Transplant Foundation | Malleable paste with allograft bone reinforcement for filling bone defects |
| US6200347B1 (en) * | 1999-01-05 | 2001-03-13 | Lifenet | Composite bone graft, method of making and using same |
| US6206923B1 (en) * | 1999-01-08 | 2001-03-27 | Sdgi Holdings, Inc. | Flexible implant using partially demineralized bone |
| US6277149B1 (en) * | 1999-06-08 | 2001-08-21 | Osteotech, Inc. | Ramp-shaped intervertebral implant |
| US6436101B1 (en) * | 1999-10-13 | 2002-08-20 | James S. Hamada | Rasp for use in spine surgery |
| US6340477B1 (en) * | 2000-04-27 | 2002-01-22 | Lifenet | Bone matrix composition and methods for making and using same |
| US6638310B2 (en) * | 2000-07-26 | 2003-10-28 | Osteotech, Inc. | Intervertebral spacer and implant insertion instrumentation |
| US6855169B2 (en) * | 2001-02-28 | 2005-02-15 | Synthes (Usa) | Demineralized bone-derived implants |
| WO2003037228A2 (en) * | 2001-10-30 | 2003-05-08 | Osteotech, Inc. | Bone implant and insertion tools |
-
2001
- 2001-05-14 AU AU6158901A patent/AU6158901A/xx active Pending
- 2001-05-14 WO PCT/US2001/015599 patent/WO2001087369A2/en not_active Ceased
- 2001-05-14 CA CA002409479A patent/CA2409479A1/en not_active Abandoned
- 2001-05-14 ES ES01935499T patent/ES2247113T3/es not_active Expired - Lifetime
- 2001-05-14 EP EP01935499A patent/EP1280564B1/de not_active Expired - Lifetime
- 2001-05-14 DE DE60113095T patent/DE60113095T2/de not_active Expired - Lifetime
-
2002
- 2002-11-01 US US10/285,715 patent/US7179299B2/en not_active Expired - Lifetime
-
2007
- 2007-02-19 US US11/676,429 patent/US7662184B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070168030A1 (en) | 2007-07-19 |
| ES2247113T3 (es) | 2006-03-01 |
| CA2409479A1 (en) | 2001-11-22 |
| AU6158901A (en) | 2001-11-26 |
| WO2001087369A2 (en) | 2001-11-22 |
| US20030144743A1 (en) | 2003-07-31 |
| EP1280564A2 (de) | 2003-02-05 |
| DE60113095T2 (de) | 2006-05-18 |
| US7662184B2 (en) | 2010-02-16 |
| WO2001087369A3 (en) | 2002-07-04 |
| US7179299B2 (en) | 2007-02-20 |
| EP1280564B1 (de) | 2005-08-31 |
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