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DE60111769D1 - Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit - Google Patents

Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit

Info

Publication number
DE60111769D1
DE60111769D1 DE60111769T DE60111769T DE60111769D1 DE 60111769 D1 DE60111769 D1 DE 60111769D1 DE 60111769 T DE60111769 T DE 60111769T DE 60111769 T DE60111769 T DE 60111769T DE 60111769 D1 DE60111769 D1 DE 60111769D1
Authority
DE
Germany
Prior art keywords
competitiveness
pharmaceutical formulations
liquid pharmaceutical
improved oral
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60111769T
Other languages
English (en)
Other versions
DE60111769T2 (de
Inventor
Mark Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE60111769D1 publication Critical patent/DE60111769D1/de
Application granted granted Critical
Publication of DE60111769T2 publication Critical patent/DE60111769T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60111769T 2000-12-04 2001-11-30 Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit Expired - Lifetime DE60111769T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US729406 2000-12-04
US09/729,406 US6391886B1 (en) 2000-12-04 2000-12-04 Oral compositions having improved consumer aesthetics
PCT/US2001/045035 WO2002045714A1 (en) 2000-12-04 2001-11-30 Drug formulation having improved oral tolerability

Publications (2)

Publication Number Publication Date
DE60111769D1 true DE60111769D1 (de) 2005-08-04
DE60111769T2 DE60111769T2 (de) 2006-04-20

Family

ID=24930887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60111769T Expired - Lifetime DE60111769T2 (de) 2000-12-04 2001-11-30 Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit

Country Status (11)

Country Link
US (1) US6391886B1 (de)
EP (1) EP1339408B1 (de)
JP (1) JP2004515478A (de)
CN (1) CN100577166C (de)
AR (1) AR031450A1 (de)
AT (1) ATE298571T1 (de)
AU (1) AU2002239397A1 (de)
DE (1) DE60111769T2 (de)
MX (1) MXPA03004941A (de)
PE (1) PE20020694A1 (de)
WO (1) WO2002045714A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US20030211136A1 (en) * 1998-09-25 2003-11-13 Neema Kulkarni Fast dissolving orally consumable films containing a sweetener
CA2440412A1 (en) * 2001-03-05 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Taste masked liquid pharmaceutical compositions
US20030060422A1 (en) 2001-08-31 2003-03-27 Balaji Venkataraman Tannate compositions and methods of treatment
DE10208313A1 (de) * 2002-02-27 2003-09-11 Boehringer Ingelheim Pharma Ambroxol für die Behandlung von schmerzhaften Zuständen im Mund und Rachenraum
US20040028622A1 (en) * 2002-08-12 2004-02-12 Michael Gurin Multifunctional flavor systems and method of use
EP1565153A4 (de) * 2002-11-22 2008-10-01 Noville Inc Orale zusammensetzungen, die den salzigengeschmack von salzen maskieren
US20040142084A1 (en) * 2003-01-21 2004-07-22 Knueven Carl J. Alkali metal bisulfates to mask aftertaste of artificial sweeteners
US20040185093A1 (en) * 2003-03-18 2004-09-23 Szymczak Christopher E. Compositions containing sucralose
EP1466949A1 (de) * 2003-04-10 2004-10-13 Symrise GmbH & Co. KG Nichttoxische Beschichtungszusammensetzung, Verwendungsverfahren und gegen die Anlagerung von Biofouling-Organismen behandelte Gegenstände
US7361376B2 (en) * 2003-04-11 2008-04-22 International Flavors & Fragrances Inc. Alkyldienamides exhibiting taste and sensory effect in flavor compositions
US7632531B2 (en) * 2003-04-11 2009-12-15 International Flavors & Fragnances Inc. Alkyldienamides exhibiting taste and sensory effect in flavor compositions
US6884906B2 (en) * 2003-07-01 2005-04-26 International Flavors & Fragrances Inc. Menthyl half acid ester derivatives, processes for preparing same, and uses thereof for their cooling/refreshing effect in consumable materials
US7141686B2 (en) * 2003-07-10 2006-11-28 International Flavors & Fragrances Inc. E2, E4, Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same
US7329767B2 (en) * 2003-10-03 2008-02-12 International Flavors & Fragrances Inc. Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
US8007839B2 (en) * 2003-10-03 2011-08-30 International Flavors & Fragrances Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
US7482378B2 (en) * 2004-05-28 2009-01-27 Millenium Specialty Chemicals, Inc. Physiological cooling compositions
EP1669056A3 (de) * 2004-08-12 2007-05-30 The Procter and Gamble Company Mundpflegemittel und System
US20060034784A1 (en) * 2004-08-12 2006-02-16 The Procter & Gamble Company Oral compositions and systems
US7427421B2 (en) * 2004-09-10 2008-09-23 International Flavors & Fragrances Inc. Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions
US7541055B2 (en) * 2004-09-10 2009-06-02 International Flavors & Fragrances Inc. Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions
US20060062811A1 (en) 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
EP1940377A4 (de) * 2005-10-24 2010-12-08 Teikoku Pharma Usa Inc Topische schmerzlindernde zusammensetzungen von n,2,3-trimethyl-2-isopropylbutamid und anwendungsverfahren dafür
CA2636061C (en) * 2006-01-27 2015-06-02 Cadbury Adams Usa Llc Flavor-enhancing compositions, methods of manufacture, and methods of use
US7803353B2 (en) * 2006-03-29 2010-09-28 The Procter & Gamble Company Oral care compositions having improved consumer aesthetics and taste
EP1958627A3 (de) * 2007-01-04 2010-09-01 Symrise GmbH & Co. KG Verwendung bestimmter Menthyl-3-oxocarbonsäureester als physiologisch wirksame Kühlsubstanzen
JP2009007311A (ja) * 2007-06-29 2009-01-15 Lintec Corp ジフェンヒドラミン−アセスルファム付加物、その製造方法及び該付加物を含有する経口製剤
JP2013532119A (ja) * 2010-04-21 2013-08-15 テイコク ファーマ ユーエスエー インコーポレーテッド 局所麻酔エマルジョン組成物ならびに該組成物の製造および使用方法
KR101297354B1 (ko) * 2011-01-13 2013-08-19 동광제약주식회사 안정하고 불쾌한 맛이 차폐된 덱시부프로펜을 함유한 투명한 시럽 조성물
CA2831566A1 (en) * 2011-03-31 2012-10-04 Jitendra Krishan Somani Menthol liquids composition
AU2014369916A1 (en) 2013-12-24 2016-06-16 Durect Corporation Uses of oxygenated cholesterol sulfates (OCS)
US9867779B2 (en) 2015-03-26 2018-01-16 Patheon Softgels Inc. Liquisoft capsules
JP6794758B2 (ja) * 2015-10-21 2020-12-02 大正製薬株式会社 経口液体医薬組成物
GB2551971B (en) * 2016-06-29 2020-09-16 Syri Ltd Taste masked liquid pharmaceutical composition of mebeverine or pharmaceutically acceptable salts thereof
WO2018045170A1 (en) * 2016-09-01 2018-03-08 The Procter & Gamble Company Medication with improved taste and sensory experience
US12427120B2 (en) * 2018-10-09 2025-09-30 Symrise Ag Compositions comprising guaifenesin and flavour compounds containing an isovanillyl group
US12053447B2 (en) 2019-06-25 2024-08-06 NuBioPharma, LLC Oral solution and powder to liquid compositions of balsalazide
CN112439072A (zh) * 2019-08-29 2021-03-05 鲁南制药集团股份有限公司 一种掩味组合物及其制备方法、用途
CN112439077A (zh) * 2019-08-29 2021-03-05 鲁南制药集团股份有限公司 一种矫味剂组合物、制备方法及其用途
CN115297846A (zh) 2020-04-10 2022-11-04 宝洁公司 流变固体口服组合物
CN111714477B (zh) * 2020-07-23 2021-06-15 山东迅达康兽药有限公司 祛痰组合物及其口服液制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136163A (en) 1971-02-04 1979-01-23 Wilkinson Sword Limited P-menthane carboxamides having a physiological cooling effect
CA1027347A (en) 1972-07-20 1978-03-07 David G. Rowsell Compounds having a physiological cooling effect and compositions containing them
JPS5888334A (ja) 1981-11-20 1983-05-26 Takasago Corp ３−ｌ−メントキシプロパン−１、２−ジオ−ル
US4822597A (en) 1987-07-13 1989-04-18 Warner-Lambert Company Anesthetic-containing chewing gum compositions
US4853212A (en) 1987-07-13 1989-08-01 Warner-Lambert Company Reduced base content chewing gum compositions having anesthetic properties
US5009893A (en) * 1989-07-17 1991-04-23 Warner-Lambert Company Breath-freshening edible compositions of methol and a carboxamide
US5196436A (en) * 1990-10-31 1993-03-23 The Procter & Gamble Company Dextromethorphan antitussive compositions
AU4116993A (en) 1992-05-18 1993-12-13 Procter & Gamble Company, The Coolant compositions
AU8084594A (en) * 1993-10-28 1995-05-22 Procter & Gamble Company, The Fast dissolving dosage forms containing magnesium aluminum silicate and multiple active ingredients
US5616621A (en) 1995-01-30 1997-04-01 American Home Products Corporation Taste masking liquids
US5725865A (en) 1995-08-29 1998-03-10 V. Mane Fils S.A. Coolant compositions
US5843466A (en) 1995-08-29 1998-12-01 V. Mane Fils S.A. Coolant compositions
US5766622A (en) * 1996-08-14 1998-06-16 The Procter & Gamble Company Inhibiting undesirable taste in oral compositions
AU7916798A (en) 1997-05-22 1998-12-11 Boots Company Plc, The Pharmaceutical compositions of flurbiprofen and burn-masking agent for treating sore throat
JP4300652B2 (ja) * 1998-09-21 2009-07-22 大正製薬株式会社 経口用固形製剤
US6596298B2 (en) * 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
JP2000273050A (ja) 1999-03-19 2000-10-03 Kobayashi Pharmaceut Co Ltd 苦みがマスキングされた液状製剤
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1

Also Published As

Publication number Publication date
EP1339408B1 (de) 2005-06-29
EP1339408A1 (de) 2003-09-03
US6391886B1 (en) 2002-05-21
MXPA03004941A (es) 2003-09-10
AU2002239397A1 (en) 2002-06-18
ATE298571T1 (de) 2005-07-15
JP2004515478A (ja) 2004-05-27
CN1575175A (zh) 2005-02-02
CN100577166C (zh) 2010-01-06
WO2002045714A1 (en) 2002-06-13
AR031450A1 (es) 2003-09-24
PE20020694A1 (es) 2002-09-25
DE60111769T2 (de) 2006-04-20

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Legal Events

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8364 No opposition during term of opposition