DE60109443D1 - Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält - Google Patents
Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthältInfo
- Publication number
- DE60109443D1 DE60109443D1 DE60109443T DE60109443T DE60109443D1 DE 60109443 D1 DE60109443 D1 DE 60109443D1 DE 60109443 T DE60109443 T DE 60109443T DE 60109443 T DE60109443 T DE 60109443T DE 60109443 D1 DE60109443 D1 DE 60109443D1
- Authority
- DE
- Germany
- Prior art keywords
- inosin
- peptide
- polycapic
- cytosine
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000000890 antigenic effect Effects 0.000 title 1
- 229940104302 cytosine Drugs 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT10002000 | 2000-06-08 | ||
| AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
| PCT/EP2001/006437 WO2001093903A1 (en) | 2000-06-08 | 2001-06-07 | Antigenic composition comprising a polycationic peptide and inosine and cytosine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60109443D1 true DE60109443D1 (de) | 2005-04-21 |
| DE60109443T2 DE60109443T2 (de) | 2006-04-13 |
Family
ID=3683921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60109443T Expired - Lifetime DE60109443T2 (de) | 2000-06-08 | 2001-06-07 | Antigene zusammensetzung die ein polykationisches peptid und inosin und cytosin enthält |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7148191B2 (de) |
| EP (1) | EP1286695B1 (de) |
| AT (2) | AT410173B (de) |
| AU (1) | AU2001262345A1 (de) |
| DE (1) | DE60109443T2 (de) |
| WO (1) | WO2001093903A1 (de) |
| ZA (1) | ZA200209479B (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046224A2 (en) * | 1999-12-22 | 2001-06-28 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| HU228264B1 (en) * | 2000-06-08 | 2013-02-28 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| EP1350262B8 (de) * | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung |
| CA2433561C (en) * | 2001-01-03 | 2014-04-01 | Willmar Poultry Company, Inc. | Compositions including gram negative siderophore receptor proteins and methods of use |
| EP1347776A2 (de) * | 2001-01-05 | 2003-10-01 | Intercell Biomedizinische Forschungs- und Entwicklungs AG | Gebrauch von polykationen als entzündungshemmende mittel |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| US20050250716A1 (en) * | 2001-12-07 | 2005-11-10 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| CN1659436A (zh) * | 2002-02-28 | 2005-08-24 | 英特塞尔股份公司 | 分离配体的方法 |
| AU2003243161A1 (en) * | 2002-04-24 | 2003-11-10 | The Regents Of The University Of California | Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses |
| ATE535231T1 (de) * | 2002-07-03 | 2011-12-15 | Oncovir Inc | Verfahren zur herstellung von poly-iclc und seine verwendung |
| CA2484941A1 (en) * | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| CA2484339A1 (en) * | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| EP2314604A3 (de) | 2002-10-15 | 2011-05-25 | Intercell AG | Bindungdsfaktoren von Gruppe B-Streptococcus, dafür kodierende Nukleinsäuren und Verwendungen davon |
| WO2004055041A2 (en) * | 2002-12-13 | 2004-07-01 | Case Western Reserve University | Defensin-inducing peptides from fusobacterium |
| DK1601770T3 (da) | 2003-03-04 | 2009-11-02 | Intercell Ag | Streptococcus pyogenes antigener |
| AU2004224747A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Use of Alum and a th1 immune response inducing adjuvant for enhancing immune responses |
| CA2517673C (en) * | 2003-03-24 | 2013-08-13 | Intercell Ag | Improved vaccines for preventing viral infection |
| ATE449177T1 (de) | 2003-03-31 | 2009-12-15 | Intercell Ag | Staphylococcus epidermidis antigene |
| CN102174534A (zh) | 2003-04-15 | 2011-09-07 | 英特塞尔股份公司 | 肺炎链球菌抗原 |
| EP2287177A3 (de) | 2003-05-07 | 2011-08-31 | Intercell AG | Streptococcus agalactiae-Antigene I + II |
| EP2327720A1 (de) | 2003-05-30 | 2011-06-01 | Intercell AG | Enterokokken-Antigene |
| US8329192B2 (en) | 2003-09-19 | 2012-12-11 | Epitopix Llc | Campylobacter polypeptides and methods of use |
| EP1804822B1 (de) * | 2004-10-29 | 2009-07-22 | Intercell AG | Hcv impfstoff für chronische hcv patienten |
| US8007811B2 (en) | 2005-02-14 | 2011-08-30 | Epitopix, Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
| ES2400531T3 (es) | 2006-06-28 | 2013-04-10 | Statens Serum Institut | Expansión del repertorio de los linfocitos T para incluir epítopos subdominantes mediante vacunación con antígenos administrados en forma de fragmentos proteicos o cócteles peptídicos |
| EP2319862A1 (de) | 2006-07-07 | 2011-05-11 | Intercell AG | Kleine Streptococcus-pyogenes-Antigene und Verwendung dafür |
| WO2008031133A2 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| EP1923069A1 (de) | 2006-11-20 | 2008-05-21 | Intercell AG | Schutzpeptide gegen S. pneumoniae und diesbezügliche Zusammensetzungen, Verfahren und Verwendungen |
| EP2269624A3 (de) | 2007-01-12 | 2012-08-08 | Intercell AG | Schützende Proteine von S. agalactiae, Kombinationen davon und Verwendungsverfahren dafür |
| CA2680060A1 (en) * | 2007-03-07 | 2008-09-12 | Nventa Biopharmaceuticals Corporation | Double-stranded locked nucleic acid compositions |
| CN102015754A (zh) | 2007-05-02 | 2011-04-13 | 英特塞尔股份公司 | 克雷伯菌（Klebsiella）抗原 |
| EP2012122A1 (de) | 2007-07-06 | 2009-01-07 | Medigene AG | Strukturproteine von mutierten Parvoviren als Impfstoffe |
| US20100203083A1 (en) | 2007-05-31 | 2010-08-12 | Medigene Ag | Mutated structural protein of a parvovirus |
| CN101883782A (zh) | 2007-06-18 | 2010-11-10 | 英特塞尔股份公司 | 衣原体抗原 |
| US9498493B2 (en) | 2007-09-27 | 2016-11-22 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| US20110038888A1 (en) * | 2008-01-10 | 2011-02-17 | Peter Emtage | Adjuvant compositions comprising poly-ic and a cationic polymer |
| JP2011514167A (ja) | 2008-03-17 | 2011-05-06 | インターセル アーゲー | 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して保護的なペプチドならびにそれに関連する組成物、方法、および使用 |
| JP5715051B2 (ja) | 2008-06-05 | 2015-05-07 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | リポソーム、抗原、ポリヌクレオチド及び疎水性物質の連続相を含む担体を含む組成物 |
| EP3725328A3 (de) | 2008-06-27 | 2020-12-23 | Zoetis Services LLC | Neue adjuvante zusammensetzungen |
| EP2424882A2 (de) | 2009-02-05 | 2012-03-07 | Intercell AG | Gegen e.-faecalis schützende peptide, verfahren und anwendungen, die damit in zusammenhang stehen |
| EP2405938A2 (de) | 2009-02-13 | 2012-01-18 | Intercell AG | Nicht typisierbare haemophilus influenza-antigene |
| CA2756313A1 (en) | 2009-03-23 | 2010-09-30 | Epitopix, Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
| EP2308896A1 (de) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| RU2558301C2 (ru) | 2009-10-09 | 2015-07-27 | Санофи | Полипептиды для связывания с "рецептором конечных продуктов гликирования", а также их композиции и способы, в которых они принимают участие |
| EP2319871A1 (de) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptide zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| SI2753352T2 (sl) | 2010-09-03 | 2022-10-28 | Valneva Austria Gmbh | Izoliran polipeptid proteinov toksina a in toksina b c. difficile in njegova uporaba |
| WO2012031760A1 (en) | 2010-09-08 | 2012-03-15 | Medigene Ag | Parvovirus mutated structural proteins comprising cross - protective b - cell epitopes of a hpv l2 protein as well as products and methods relating thereto |
| WO2012139094A2 (en) | 2011-04-08 | 2012-10-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of developing a vaccine using peptide-poly ic complexes |
| CN105764525A (zh) | 2013-09-19 | 2016-07-13 | 硕腾服务有限责任公司 | 油基佐剂 |
| PL3244920T3 (pl) | 2015-01-16 | 2023-09-25 | Zoetis Services Llc | Szczepionka przeciw pryszczycy |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| WO2019158636A1 (en) | 2018-02-16 | 2019-08-22 | 2A Pharma Ab | Parvovirus structural protein for the treatment of autoimmune diseases |
| EP3527223A1 (de) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutiertes parvovirus-strukturprotein |
| MY208001A (en) | 2019-05-20 | 2025-04-03 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
| WO2020240268A1 (en) | 2019-05-31 | 2020-12-03 | Universidad De Chile | An immunogenic formulation that induces protection against shiga toxin-producing escherichia coli (stec) |
| WO2022074061A1 (en) | 2020-10-07 | 2022-04-14 | Valneva Sweden Ab | Cholera vaccine formulation |
| AU2022255923A1 (en) | 2021-04-09 | 2023-08-31 | Valneva Se | Human metapneumo virus vaccine |
| WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
| WO2023232901A1 (en) | 2022-06-01 | 2023-12-07 | Valneva Austria Gmbh | Clostridium difficile vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6801650D0 (pt) | 1968-08-20 | 1973-03-07 | R Maes | Processo para preparacao de complexos geradores de interferon |
| US3725545A (en) * | 1971-02-03 | 1973-04-03 | R Maes | Enhancement of antibody production by nucleic acid-polycation complexes |
| RS50101B (sr) | 1996-02-24 | 2009-01-22 | Boehringer Ingelheim International Gmbh., | Farmaceutski preparati za imunomodulaciju |
| CA2261892A1 (en) | 1996-07-24 | 1998-01-29 | Michelle M. Hanna | Base-protected nucleotide analogs with protected thiol groups |
| AU2001267349A1 (en) * | 2000-04-14 | 2001-10-30 | Cistem Biotechnologies Gmbh | Pharmaceutical preparations comprising modified peptides |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
-
2000
- 2000-06-08 AT AT0100000A patent/AT410173B/de not_active IP Right Cessation
-
2001
- 2001-06-07 DE DE60109443T patent/DE60109443T2/de not_active Expired - Lifetime
- 2001-06-07 AT AT01936440T patent/ATE290880T1/de active
- 2001-06-07 AU AU2001262345A patent/AU2001262345A1/en not_active Abandoned
- 2001-06-07 US US10/297,497 patent/US7148191B2/en not_active Expired - Lifetime
- 2001-06-07 WO PCT/EP2001/006437 patent/WO2001093903A1/en not_active Ceased
- 2001-06-07 EP EP01936440A patent/EP1286695B1/de not_active Expired - Lifetime
-
2002
- 2002-11-21 ZA ZA200209479A patent/ZA200209479B/en unknown
-
2006
- 2006-12-12 US US11/609,777 patent/US20070218073A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030162738A1 (en) | 2003-08-28 |
| AT410173B (de) | 2003-02-25 |
| DE60109443T2 (de) | 2006-04-13 |
| US20070218073A1 (en) | 2007-09-20 |
| EP1286695B1 (de) | 2005-03-16 |
| AU2001262345A1 (en) | 2001-12-17 |
| ATE290880T1 (de) | 2005-04-15 |
| EP1286695A1 (de) | 2003-03-05 |
| ATA10002000A (de) | 2002-07-15 |
| ZA200209479B (en) | 2003-11-21 |
| WO2001093903A1 (en) | 2001-12-13 |
| US7148191B2 (en) | 2006-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |