[go: up one dir, main page]

DE60107872D1 - Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen - Google Patents

Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen

Info

Publication number
DE60107872D1
DE60107872D1 DE60107872T DE60107872T DE60107872D1 DE 60107872 D1 DE60107872 D1 DE 60107872D1 DE 60107872 T DE60107872 T DE 60107872T DE 60107872 T DE60107872 T DE 60107872T DE 60107872 D1 DE60107872 D1 DE 60107872D1
Authority
DE
Germany
Prior art keywords
drug
preparation
aqueous solutions
active substances
evaporation precipitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60107872T
Other languages
English (en)
Other versions
DE60107872T2 (de
Inventor
P Johnston
O Williams
J Young
Xiaoxia Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Application granted granted Critical
Publication of DE60107872D1 publication Critical patent/DE60107872D1/de
Publication of DE60107872T2 publication Critical patent/DE60107872T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE60107872T 2000-11-03 2001-10-22 Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen Expired - Lifetime DE60107872T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US808332 1997-02-28
US24547900P 2000-11-03 2000-11-03
US245479P 2000-11-03
US09/808,332 US6756062B2 (en) 2000-11-03 2001-03-14 Preparation of drug particles using evaporation precipitation into aqueous solutions
PCT/US2001/051337 WO2002047659A2 (en) 2000-11-03 2001-10-22 Preparation of drug particles using evaporation precipitation into aqueous solutions

Publications (2)

Publication Number Publication Date
DE60107872D1 true DE60107872D1 (de) 2005-01-20
DE60107872T2 DE60107872T2 (de) 2005-05-19

Family

ID=26937266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60107872T Expired - Lifetime DE60107872T2 (de) 2000-11-03 2001-10-22 Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen

Country Status (8)

Country Link
US (1) US6756062B2 (de)
EP (1) EP1335705B1 (de)
JP (1) JP2004515525A (de)
AT (1) ATE284676T1 (de)
AU (1) AU2002243441A1 (de)
CA (1) CA2427625A1 (de)
DE (1) DE60107872T2 (de)
WO (1) WO2002047659A2 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425543B2 (en) * 1992-11-16 2008-09-16 The Corporation Of Mercer University Microencapsulated materials and method of making same
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US8551526B2 (en) * 2000-11-03 2013-10-08 Board Of Regents, The University Of Texas System Preparation of drug particles using evaporation precipitation into aqueous solutions
WO2002072636A2 (en) * 2000-12-28 2002-09-19 Altus Biologics Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
WO2003000014A2 (en) * 2001-06-21 2003-01-03 Altus Biologics, Inc. Spherical protein particles and methods of making and using them
EP1401399A2 (de) * 2001-06-22 2004-03-31 Pfizer Products Inc. Pharmzeutische zubereitungen enthaltend anlagerungsprodukte aus polymer und wirkstoff
EP1423096B1 (de) * 2001-08-29 2006-08-16 Dow Global Technologies Inc. Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
CN1826098B (zh) * 2003-05-22 2011-01-12 应用超微系统股份有限公司 小粒子的制造
DE602004022046D1 (de) 2003-05-22 2009-08-27 Applied Nanosystems Bv Herstellung von kleinen teilchen
AU2004283758A1 (en) * 2003-10-24 2005-05-06 Alza Corporation Preparation of lipid particles
US7754243B2 (en) * 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing
AU2005277208B2 (en) 2004-08-20 2011-11-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
WO2006026502A1 (en) * 2004-08-27 2006-03-09 The Dow Chemical Company Enhanced delivery of drug compositions to treat life threatening infections
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
EP2068845A2 (de) * 2006-10-06 2009-06-17 Baxter International Inc. Mikroverkapselungen mit oberflächenmodifizierten mikropartikeln sowie verfahren zu ihrer herstellung und verwendung
WO2008065502A1 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
CN101292958B (zh) * 2007-04-27 2011-04-27 北京化工大学 一种超细达那唑粉体的制备方法
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
US8309129B2 (en) * 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
EP2178518A2 (de) * 2007-07-13 2010-04-28 Bend Research, Inc Nanopartikel mit ionisierbaren und schwach wasserlöslichen zellulose-polymeren
EP2231169B1 (de) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
WO2009073216A1 (en) * 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
US20100151037A1 (en) * 2008-08-07 2010-06-17 Yivan Jiang Method for the preparation of nanoparticles containing a poorly water-soluble pharmaceutically active compound
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (de) 2009-03-11 2013-11-06 MannKind Corporation Gerät, system und verfahren zur messung von widerstand in einem inhaliergerät
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
NZ602057A (en) 2010-03-12 2015-06-26 Berg Pharma Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
US20120141589A1 (en) * 2010-08-23 2012-06-07 Basf Se Particles for drug delivery and other applications
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174559A1 (en) 2011-06-17 2012-12-20 Berg Pharma Llc Inhalable pharmaceutical compositions
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2012178082A1 (en) * 2011-06-24 2012-12-27 The Trustees Of Columbia University In The City Of New York Improved methods, devices and systems to process x-ray diffraction data
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
EP2911690A1 (de) 2012-10-26 2015-09-02 MannKind Corporation Inhalierbare influenza-impfstoffzusammensetzungen und verfahren
ES2754388T3 (es) 2013-03-15 2020-04-17 Mannkind Corp Composiciones y métodos de dicetopiperazina microcristalina
EP3021834A1 (de) 2013-07-18 2016-05-25 MannKind Corporation Hitzestabile pharmazeutische trockenpulverzusammensetzungen und verfahren
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
KR102047025B1 (ko) * 2019-05-07 2019-12-02 엔젯 주식회사 반도체 패키지의 언더필 방법 및 장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5766635A (en) * 1991-06-28 1998-06-16 Rhone-Poulenc Rorer S.A. Process for preparing nanoparticles
GB9313650D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
EP0855906B1 (de) * 1995-10-17 2008-02-20 Jagotec AG Verabreichung unlöslicher arzneistoffe
US5985248A (en) 1996-12-31 1999-11-16 Inhale Therapeutic Systems Processes for spray drying solutions of hydrophobic drugs and compositions thereof

Also Published As

Publication number Publication date
AU2002243441A1 (en) 2002-06-24
US6756062B2 (en) 2004-06-29
DE60107872T2 (de) 2005-05-19
CA2427625A1 (en) 2002-06-20
JP2004515525A (ja) 2004-05-27
EP1335705A2 (de) 2003-08-20
ATE284676T1 (de) 2005-01-15
EP1335705B1 (de) 2004-12-15
WO2002047659A2 (en) 2002-06-20
US20020081334A1 (en) 2002-06-27
WO2002047659A3 (en) 2002-09-06

Similar Documents

Publication Publication Date Title
DE60107872D1 (de) Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen
KR970706799A (ko) 소립자 형성(Small Partical Formation)
EP1127570A3 (de) Verfahren zur Herstellung von wirkstofbeladenen Polymer-Micellen Zusammensetzung
ATE249813T1 (de) Einhüllungssverfahren
CA2099941A1 (en) Method for Producing Sustained Release Microsphere Preparation
DE69906269D1 (de) Wässriges verfahren zur herstellung fester paroxetin-dispersionen
CA2205046A1 (en) Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and speed of dissolution
CY1107059T1 (el) Υδατικη διασπορα που περιεχει σταθερα νανοσωματιδια μιας αδιαλυτης στο νερο δραστικης ουσιας κι ενα εκδοχο οπως τα τριγλυκεριδια μεσης αλυσιδας (mct)
MXPA04002446A (es) Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.
EP1219668A3 (de) Verfahren zur Herstellung feiner Polymerpartikel und diese enthaltende lithogrphische Druckplatte
CA2084452A1 (en) Modified xanthan gum and method for modifying xanthan gum
WO2002038126A3 (en) A process for production of particles for pharmaceutical compositions having increased bioavailability
CN107333759A (zh) 光控缓释农药制剂及其制备方法
CN102352047A (zh) 一种甲壳素球的制备方法
CN1854120A (zh) 无毒离子液体、制备方法及其应用
WO2006091180A2 (en) Fucoidan multiparticulate drug carrier systems
JP2002518348A5 (de)
CN111919842A (zh) 一种尺寸可调控的纳米农药的制备方法
CN1883265A (zh) 一种杀钉螺药物氯硝柳胺乙醇胺盐纳米悬浮剂及其制备方法
EP1240896A3 (de) Einkapseln von wasserlöslischen Peptiden
CN103053601A (zh) 纳米卫生杀虫剂及其制备方法
WO2005094800A3 (en) A co-precipitated cefepime composition and process for preparation thereof
CN107670045A (zh) 一种具有抗光敏作用的药物赋形剂及其制备方法
RU97109813A (ru) Способ получения мелких частиц
KR20030021100A (ko) 벽보, 포스터 제거에 우수한 액상의 합성 polymer 조성물

Legal Events

Date Code Title Description
8364 No opposition during term of opposition