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DE60106641D1 - Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten - Google Patents

Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten

Info

Publication number
DE60106641D1
DE60106641D1 DE60106641T DE60106641T DE60106641D1 DE 60106641 D1 DE60106641 D1 DE 60106641D1 DE 60106641 T DE60106641 T DE 60106641T DE 60106641 T DE60106641 T DE 60106641T DE 60106641 D1 DE60106641 D1 DE 60106641D1
Authority
DE
Germany
Prior art keywords
carbon atoms
alkyl
hydrogen
independently
fluoroalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106641T
Other languages
English (en)
Other versions
DE60106641T2 (de
Inventor
Louise Sabb
Lewis Vogel
Albert Nelson
Joy Rosenzweig-Lipson
Scott Welmaker
Eileen Sabalski
David Smith
Wai-Yin Chan
Miyoko Antane
Panolil Raveendranath
Sreenivasulu Megati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60106641D1 publication Critical patent/DE60106641D1/de
Publication of DE60106641T2 publication Critical patent/DE60106641T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60106641T 2000-11-03 2001-11-01 Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten Expired - Lifetime DE60106641T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US24559300P 2000-11-03 2000-11-03
US24595400P 2000-11-03 2000-11-03
US24584300P 2000-11-03 2000-11-03
US24591500P 2000-11-03 2000-11-03
US24559100P 2000-11-03 2000-11-03
US245954P 2000-11-03
US245843P 2000-11-03
US245593P 2000-11-03
US245915P 2000-11-03
US245591P 2000-11-03
PCT/US2001/045792 WO2002042304A2 (en) 2000-11-03 2001-11-01 Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists

Publications (2)

Publication Number Publication Date
DE60106641D1 true DE60106641D1 (de) 2004-11-25
DE60106641T2 DE60106641T2 (de) 2005-12-01

Family

ID=27540225

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106641T Expired - Lifetime DE60106641T2 (de) 2000-11-03 2001-11-01 Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten

Country Status (6)

Country Link
EP (1) EP1330457B1 (de)
AT (1) ATE280170T1 (de)
AU (1) AU2002239463A1 (de)
DE (1) DE60106641T2 (de)
ES (1) ES2230382T3 (de)
WO (1) WO2002042304A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858604B2 (en) 2000-11-03 2005-02-22 Wyeth Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031200A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
US6777407B2 (en) 2000-11-03 2004-08-17 Wyeth Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
EA008148B1 (ru) 2002-06-19 2007-04-27 Биовитрум Аб Новые соединения, их применение и получение
EP2248524A3 (de) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
RU2008135326A (ru) * 2006-03-24 2010-04-27 Вайет (Us) Терапевтические композиции для лечения депрессии
CN101405005A (zh) * 2006-03-24 2009-04-08 惠氏公司 调节膀胱功能的方法
US8158617B2 (en) 2006-05-16 2012-04-17 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
KR20090047458A (ko) 2006-08-08 2009-05-12 사노피-아벤티스 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도
WO2008144981A1 (en) * 2007-05-25 2008-12-04 Topharman Shanghai Co., Ltd. Methods and intermediates for preparing 4-acetyl-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine
EP2216023A4 (de) 2007-11-15 2013-03-13 Takeda Pharmaceutical Kondensiertes pyridinderivat und seine verwendung
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2011023754A1 (en) 2009-08-26 2011-03-03 Sanofi-Aventis Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2887804B1 (de) * 2012-05-22 2021-01-27 Trustees of Dartmouth College Cycloalkanyl[b]indolen zur verwendung als glp-1 modulatoren
CN103204858A (zh) * 2013-03-20 2013-07-17 广州科瑞生物技术有限公司 基于酒石酸拆分合成工艺制备新型手性抗焦虑症药物
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
MX373319B (es) * 2015-04-27 2020-06-13 Arena Pharm Inc Derivados de hexahidro-[1-4]diazepino[6,7,1-hi]indol-8-carboxamida como agonistas del receptor 5-ht2c y el uso de los mismos en el tratamiento de enfermedades relacionadas con dicho receptor.
WO2019131902A1 (ja) 2017-12-27 2019-07-04 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914250A (en) * 1974-08-01 1975-10-21 American Home Prod 1,4-Diazepino{8 6,5,4-jk{9 carbazoles
SE9500998D0 (sv) * 1995-03-19 1995-03-19 Haakan Wilhelm Wikstroem New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics
AR022687A1 (es) * 1998-12-17 2002-09-04 Wyeth Corp Derivados de 2,3,4,4a-tetrahidro-1h-pirazino[1,2-a] quinoxalin-5(6h)ona, una composicion farmaceutica y el uso de los mismos para la manufactura de losmedicamentos.
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment

Also Published As

Publication number Publication date
WO2002042304A3 (en) 2002-08-29
AU2002239463A1 (en) 2002-06-03
ES2230382T3 (es) 2005-05-01
EP1330457B1 (de) 2004-10-20
EP1330457A2 (de) 2003-07-30
WO2002042304A2 (en) 2002-05-30
DE60106641T2 (de) 2005-12-01
ATE280170T1 (de) 2004-11-15

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