[go: up one dir, main page]

DE60100786D1 - Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon - Google Patents

Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon

Info

Publication number
DE60100786D1
DE60100786D1 DE60100786T DE60100786T DE60100786D1 DE 60100786 D1 DE60100786 D1 DE 60100786D1 DE 60100786 T DE60100786 T DE 60100786T DE 60100786 T DE60100786 T DE 60100786T DE 60100786 D1 DE60100786 D1 DE 60100786D1
Authority
DE
Germany
Prior art keywords
citalopram
hydrochloride
hydrobromide salt
crystalline base
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE60100786T
Other languages
English (en)
Other versions
DE60100786T2 (de
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60100786(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE60100786D1 publication Critical patent/DE60100786D1/de
Application granted granted Critical
Publication of DE60100786T2 publication Critical patent/DE60100786T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
DE60100786T 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon Revoked DE60100786T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK200000402 2000-03-13
DKPA200000402 2000-03-13
DKPCT/DK00/00183 2000-04-13
WOPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
DE60100786D1 true DE60100786D1 (de) 2003-10-23
DE60100786T2 DE60100786T2 (de) 2004-07-15

Family

ID=8159320

Family Applications (7)

Application Number Title Priority Date Filing Date
DE20007303U Ceased DE20007303U1 (de) 2000-03-13 2000-04-20 Kristalline Base von Citalopram
DE10164687A Revoked DE10164687B4 (de) 2000-03-13 2001-02-20 Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram
DE10108042A Withdrawn DE10108042A1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE20121240U Ceased DE20121240U1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE60100022T Expired - Fee Related DE60100022T3 (de) 2000-03-13 2001-02-28 Verfahren zur herstellung von citalopram-salzen
DE60100786T Revoked DE60100786T2 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon
DE1227088T Pending DE1227088T1 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon

Family Applications Before (5)

Application Number Title Priority Date Filing Date
DE20007303U Ceased DE20007303U1 (de) 2000-03-13 2000-04-20 Kristalline Base von Citalopram
DE10164687A Revoked DE10164687B4 (de) 2000-03-13 2001-02-20 Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram
DE10108042A Withdrawn DE10108042A1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE20121240U Ceased DE20121240U1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE60100022T Expired - Fee Related DE60100022T3 (de) 2000-03-13 2001-02-28 Verfahren zur herstellung von citalopram-salzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1227088T Pending DE1227088T1 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon

Country Status (41)

Country Link
US (7) US20010031784A1 (de)
EP (2) EP1227088B1 (de)
JP (1) JP2003527383A (de)
KR (1) KR20020080486A (de)
CN (2) CN1258530C (de)
AR (1) AR029811A1 (de)
AT (3) ATE250050T1 (de)
AU (2) AU746664B2 (de)
BE (1) BE1013210A3 (de)
BG (1) BG107065A (de)
BR (1) BR0109373A (de)
CA (2) CA2411732A1 (de)
CH (2) CH691537A5 (de)
CZ (1) CZ292077B6 (de)
DE (7) DE20007303U1 (de)
DK (3) DK173903B1 (de)
EA (1) EA200200972A1 (de)
ES (3) ES2180471T3 (de)
FI (2) FI20010156A0 (de)
FR (1) FR2806086B1 (de)
GB (2) GB2357762B (de)
GR (1) GR1003796B (de)
HR (1) HRP20020756A2 (de)
HU (3) HU0001581D0 (de)
IE (1) IES20010109A2 (de)
IL (2) IL147339A (de)
IS (1) IS5841A (de)
IT (2) IT1319645B1 (de)
MX (1) MXPA02008793A (de)
NL (2) NL1016435C1 (de)
NO (2) NO312031B1 (de)
PL (1) PL360158A1 (de)
PT (2) PT1169314E (de)
SE (2) SE517136C2 (de)
SI (2) SI1169314T2 (de)
SK (1) SK285528B6 (de)
TR (1) TR200202185T2 (de)
UA (1) UA74360C2 (de)
WO (1) WO2001068627A1 (de)
YU (1) YU68802A (de)
ZA (1) ZA200207148B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227473B1 (en) 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
CA2353693C (en) * 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
EP1345542B1 (de) 2000-12-20 2011-02-23 Fox Hollow Technologies, Inc. Verkleinerungskatheter
ES2228824T3 (es) * 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
MXPA03008777A (es) * 2001-05-01 2004-02-12 Lundbeck & Co As H El uso de escitalopram enantiomericamente puro.
DK1522539T3 (da) 2001-07-31 2007-05-07 Lundbeck & Co As H Krystallinsk komposition indeholdende excitalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB2387596B (en) * 2002-02-27 2004-02-11 Matrix Lab Ltd Process
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
EP1346989A1 (de) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
EP1486492A3 (de) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. Ein Verfahren zur Hydrogenolyse von [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran
GB0317475D0 (en) 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
WO2006123243A2 (en) * 2005-05-20 2006-11-23 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
AU2006261788B2 (en) 2005-06-27 2012-05-31 Valeant International Bermuda Modified-release formulations of a bupropion salt
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
US8414604B2 (en) 2008-10-13 2013-04-09 Covidien Lp Devices and methods for manipulating a catheter shaft
CA2760449A1 (en) 2009-04-29 2010-11-04 Tyco Healthcare Group Lp Methods and devices for cutting and abrading tissue
WO2010132748A1 (en) 2009-05-14 2010-11-18 Fox Hollow Technologies, Inc. Easily cleaned atherectomy catheters and methods of use
RU2526915C2 (ru) 2009-12-02 2014-08-27 ТАЙКО ХЕЛСКЕА ГРУП эЛПи Способы и устройства для срезания ткани
KR20140006106A (ko) 2009-12-11 2014-01-15 코비디엔 엘피 물질 포획 효율이 향상된 물질 제거 장치 및 사용 방법
CA2800920C (en) 2010-06-14 2015-04-14 Covidien Lp Material removal device
CN103200886B (zh) 2010-10-28 2015-07-29 科维蒂恩有限合伙公司 物质移除装置和使用方法
EP2659840B1 (de) 2010-11-11 2017-02-01 Covidien LP Flexibler Debulking-Katheter mit Bildgebung
US8992717B2 (en) 2011-09-01 2015-03-31 Covidien Lp Catheter with helical drive shaft and methods of manufacture
US9532844B2 (en) 2012-09-13 2017-01-03 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2233970A (en) * 1941-03-04 Quinoline compound and process of
US2584429A (en) * 1950-12-29 1952-02-05 Rohm & Haas 1,1-diphenyl-4-tert.-amino-2-butyne-1-ols
GB1143703A (de) * 1965-03-18
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
CN1206207C (zh) * 1997-07-08 2005-06-15 H.隆德贝克有限公司 氰酞氟苯胺的制备方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) * 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
HU227473B1 (en) 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof

Also Published As

Publication number Publication date
ZA200207148B (en) 2003-04-23
SK285528B6 (sk) 2007-03-01
DE60100786T2 (de) 2004-07-15
PL360158A1 (en) 2004-09-06
ITMI20002425A1 (it) 2002-05-09
YU68802A (sh) 2005-11-28
GR1003796B (el) 2002-02-08
SE517136C2 (sv) 2002-04-16
HUP0100531A2 (hu) 2002-01-28
ES2159491B1 (es) 2002-05-01
MXPA02008793A (es) 2003-02-12
DE60100022T2 (de) 2003-03-06
CH691477A5 (de) 2001-07-31
CA2360287A1 (en) 2001-09-20
CN1429220A (zh) 2003-07-09
US20040132808A1 (en) 2004-07-08
IT1319645B1 (it) 2003-10-23
US20040167210A1 (en) 2004-08-26
WO2001068627A1 (en) 2001-09-20
FR2806086B1 (fr) 2003-05-09
HU0100450D0 (en) 2001-04-28
BG107065A (bg) 2003-05-30
DK173903B1 (da) 2002-02-11
FI20010225A0 (fi) 2001-02-07
DE1227088T1 (de) 2003-02-06
FI20010225L (fi) 2001-09-14
GB0102797D0 (en) 2001-03-21
FR2806086A1 (fr) 2001-09-14
ES2180471T3 (es) 2004-05-01
NO315851B1 (no) 2003-11-03
ITMI20010406A1 (it) 2002-08-28
IL147339A0 (en) 2002-08-14
NO20020356L (no) 2001-09-14
CH691537A5 (de) 2001-08-15
SE0200730L (sv) 2002-08-29
EP1169314A1 (de) 2002-01-09
GB2357762B (en) 2002-01-30
ES2173054T3 (es) 2002-12-16
SE0103046D0 (sv) 2001-09-14
SI1227088T1 (en) 2003-12-31
NO20010619L (no) 2001-09-14
HRP20020756A2 (en) 2004-12-31
NO20010619D0 (no) 2001-02-06
CN1258530C (zh) 2006-06-07
CZ292077B6 (cs) 2003-07-16
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
AU3725201A (en) 2001-09-13
ATE250050T1 (de) 2003-10-15
SE526022C2 (sv) 2005-06-14
DK1169314T3 (da) 2002-10-14
SI1169314T2 (sl) 2011-08-31
EP1169314B2 (de) 2011-06-01
DE10164687B4 (de) 2006-04-27
HU0100531D0 (en) 2001-03-28
EA200200972A1 (ru) 2003-02-27
EP1169314B1 (de) 2002-09-04
IES20010109A2 (en) 2002-02-20
DE20121240U1 (de) 2002-07-04
US20060247451A1 (en) 2006-11-02
CN1680350A (zh) 2005-10-12
IL158072A0 (en) 2004-03-28
NO20020356D0 (no) 2002-01-23
BR0109373A (pt) 2002-12-24
US20010031784A1 (en) 2001-10-18
GB2357762A (en) 2001-07-04
FI20010156A0 (fi) 2001-01-25
NO312031B1 (no) 2002-03-04
DE60100022T3 (de) 2011-11-17
SI1169314T1 (en) 2002-12-31
KR20020080486A (ko) 2002-10-23
AU2001100197A4 (en) 2001-09-20
ES2180471T1 (es) 2003-02-16
EP1227088A1 (de) 2002-07-31
HK1054750A1 (en) 2003-12-12
ES2173054T1 (es) 2002-10-16
SK13132002A3 (sk) 2003-01-09
AU746664B2 (en) 2002-05-02
TR200202185T2 (tr) 2002-12-23
US20030078442A1 (en) 2003-04-24
DE10108042A1 (de) 2001-10-18
CA2411732A1 (en) 2001-09-20
ES2159491A1 (es) 2001-10-01
JP2003527383A (ja) 2003-09-16
AU2001100197B4 (en) 2001-12-06
HUP0100531A3 (en) 2004-04-28
PT1169314E (pt) 2002-11-29
DE60100022D1 (de) 2002-10-10
IL147339A (en) 2004-09-27
SE0200730D0 (sv) 2002-03-12
AT4364U1 (de) 2001-06-25
ATE223396T1 (de) 2002-09-15
NL1016435C1 (nl) 2000-11-06
US20050165244A1 (en) 2005-07-28
GB0105982D0 (en) 2001-05-02
AR029811A1 (es) 2003-07-16
DK1227088T3 (da) 2003-12-22
SE0103046L (sv) 2001-11-14
FI109022B (fi) 2002-05-15
HU0001581D0 (en) 2000-06-28
PT1227088E (pt) 2003-12-31
CA2360287C (en) 2003-09-09
DE20007303U1 (de) 2000-07-27
BE1013210A3 (fr) 2001-10-02
CZ2001808A3 (cs) 2002-01-16
EP1227088B1 (de) 2003-09-17
NL1017413C1 (nl) 2001-09-13
IS5841A (is) 2001-09-14

Similar Documents

Publication Publication Date Title
DE60100786D1 (de) Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon
NO20024742D0 (no) Heterocykliske forbindelser, deres fremstilling og anvendelse
NO20014135L (no) Nye sulfonamidforbindelser og deres anvendelse
DE60136303D1 (de) Kombination von Handfräsmaschine, Grundplatte und Koffer
DE60122196D1 (de) Synergistische antioxidans-kombination von delta tocols und polyphenolen
NO20005266D0 (no) Nye substituerte amider, deres fremstilling og anvendelse
NO20020307D0 (no) N-(indolkarbonyl)piperazinderivater
NO20023532D0 (no) Dihydro-1,3,5-triazinaminderivater og deres terapeutiske anvendelser
DE60035581D1 (de) Salz von amlodipin und atorvastatin
DE50103764D1 (de) Salze von bicyclischen, n-acylierten imidazo-3-aminen und imidazo-5-aminen
EE200200316A (et) N-asendatud tsükliliste või atsükliliste amiinidekvaternaarsed soolad kui ravimid
PT1446399E (pt) Derivados de piperazina tendo actividade antagonista de sst1
DE60107074D1 (de) Kristallin form ii von cabergolin
NO20030868D0 (no) N-(3,5-diklor-2-metoksyfenyl)-4-metoksy-3-piperazin-1-yl- benzensulfonamid
DE60031450D1 (de) Polymorph v von torasemid
DE60020583D1 (de) Synchronisierung von pcm und pseudozufallstaktgebern
DE60007360T2 (de) Amorphe modifikation von torasemid
MA25653A1 (fr) Derives d'amides heterocycliques.
DE60203919D1 (de) Solvate von lercanidipin-hydrochlorid und kristalline formen von lercanidipin-hydrochlorid
HUP0400868A3 (en) Crystalline base of citalopram and it's hydrochloride or hydrobromide salt
DK1492781T3 (da) N,N'-disubstituerede piperazinforbindelser og deres anvendelse som smertestillende midler
NO20022844D0 (no) N-(1-fenyletyl)-5-fenyl-imidazol-2-aminforbindelser, deres sammensetninger og anvendelser
NO20015564D0 (no) Imidazo-inneholdende heterocykliske forbindelser, deres sammensetninger og anvendelser
DK1246828T3 (da) Benzosulfoner med calciummantagonist-aktivitet
DK0880352T3 (da) Stabilisering af naloxon-hydrochlorid

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation