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DE60038386D1 - Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben - Google Patents

Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben

Info

Publication number
DE60038386D1
DE60038386D1 DE60038386T DE60038386T DE60038386D1 DE 60038386 D1 DE60038386 D1 DE 60038386D1 DE 60038386 T DE60038386 T DE 60038386T DE 60038386 T DE60038386 T DE 60038386T DE 60038386 D1 DE60038386 D1 DE 60038386D1
Authority
DE
Germany
Prior art keywords
protein solution
hydrophobic resin
stabilizing
reservoir
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038386T
Other languages
English (en)
Other versions
DE60038386T2 (de
Inventor
Nobuyuki Suzuki
Naoki Mitsui
Takaya Hiraishi
Yoshirou Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE60038386D1 publication Critical patent/DE60038386D1/de
Application granted granted Critical
Publication of DE60038386T2 publication Critical patent/DE60038386T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DE60038386T 1999-09-08 2000-09-08 Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben Expired - Lifetime DE60038386T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25489699 1999-09-08
JP25489699 1999-09-08
PCT/JP2000/006144 WO2001017542A1 (fr) 1999-09-08 2000-09-08 Preparation de solution de proteines et procede de stabilisation associe

Publications (2)

Publication Number Publication Date
DE60038386D1 true DE60038386D1 (de) 2008-04-30
DE60038386T2 DE60038386T2 (de) 2009-04-23

Family

ID=17271358

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038386T Expired - Lifetime DE60038386T2 (de) 1999-09-08 2000-09-08 Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben

Country Status (8)

Country Link
US (1) US7253142B1 (de)
EP (1) EP1232753B1 (de)
JP (3) JP5450508B2 (de)
AT (1) ATE389414T1 (de)
AU (1) AU6875900A (de)
DE (1) DE60038386T2 (de)
TW (1) TWI245645B (de)
WO (1) WO2001017542A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1232753B1 (de) * 1999-09-08 2008-03-19 Chugai Seiyaku Kabushiki Kaisha Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben
DE60109625T3 (de) † 2000-05-15 2017-08-03 F. Hoffmann-La Roche Ag Flüssige arzneizubereitung enthaltend ein erythropoietin derivat
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
WO2003055512A1 (en) 2001-12-21 2003-07-10 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
PL207018B1 (pl) 2002-06-21 2010-10-29 Novo Nordisk Helth Care Ag Kompozycja farmaceutyczna, sposób przygotowania stabilnego polipeptydu czynnika VII i zastosowanie polipeptydu czynnika VII
EP1541165A4 (de) * 2002-08-27 2009-06-24 Chugai Pharmaceutical Co Ltd Verfahren zur stabilisierung einer proteinl sungszubereitung
AU2004222625A1 (en) * 2003-03-18 2004-09-30 Novo Nordisk Health Care Ag Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
ATE454900T1 (de) * 2003-05-23 2010-01-15 Novo Nordisk Healthcare Ag Stabilisierung von proteinen in lösung
CA2528988C (en) * 2003-06-10 2012-05-01 Lg Life Sciences Ltd. Stable, aqueous solution of human erythropoietin, not containing serum albumin
JP4658041B2 (ja) * 2003-06-25 2011-03-23 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドの液体組成物
KR20120104619A (ko) 2003-08-14 2012-09-21 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인자 ｖｉｉ 폴리펩티드의 액상 수성 약학적 조성물
CN1917861B (zh) 2003-12-19 2012-03-21 诺和诺德医疗保健公司 因子vii多肽的稳定化固体组合物
TWI556829B (zh) * 2004-04-09 2016-11-11 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
JP2006182960A (ja) * 2004-12-28 2006-07-13 Nipro Corp 医療用潤滑剤およびこれを塗布したシリンジ
WO2006125229A2 (en) 2005-05-16 2006-11-23 Abbott Biotechnology Ltd. Use of tnf inhibitor for treatment of erosive polyarthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
MX2010008696A (es) * 2008-02-07 2010-08-30 Amgen Inc Composiciones de proteina estabilizadas.
CA2895198A1 (en) * 2012-12-20 2014-06-26 Medimmune, Llc Liquid antibody formulation with improved aggregation properties
KR20220140025A (ko) 2013-03-12 2022-10-17 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 인간 파밀로마 바이러스용 개선된 백신 및 이것을 사용하는 방법
CN107106409A (zh) * 2014-10-02 2017-08-29 泰尔茂株式会社 用于容纳蛋白质溶液制剂的医疗用容器
CN107109493A (zh) * 2014-12-31 2017-08-29 皇家飞利浦有限公司 经由物理吸附将修饰的寡核苷酸固定至聚合物基体上
RU2732109C2 (ru) 2016-02-10 2020-09-11 Бектон Дикинсон Франс Способ оценки стабильности композиции на основе белка
JP7071914B2 (ja) 2016-03-24 2022-05-19 テルモ株式会社 シリンジ用外筒およびシリンジ
JP7153999B2 (ja) * 2016-04-22 2022-10-17 ロート製薬株式会社 水性組成物
WO2017188267A1 (ja) * 2016-04-25 2017-11-02 テルモ株式会社 プレフィルドシリンジ用のシリンジ本体、シリンジシステム及びプレフィルドシリンジ
WO2018117242A1 (ja) 2016-12-22 2018-06-28 日本ゼオン株式会社 オリゴペプチドの探索方法、オリゴペプチド、修飾ペプチド、及び免疫測定方法
US20190099489A1 (en) * 2017-09-29 2019-04-04 Janssen Biotech, Inc. Novel Formulations Which Stabilize Low Dose Antibody Compositions
PL3797752T3 (pl) * 2018-05-21 2024-10-28 Chugai Seiyaku Kabushiki Kaisha Preparat liofilizowany szczelnie zamknięty w pojemniku szklanym
CN112243423B (zh) 2018-05-28 2022-11-04 中外制药株式会社 填充喷嘴
US12466881B2 (en) * 2018-07-31 2025-11-11 Zeon Corporation Pre-filled syringe and method of producing pre-filled syringe
US20210260297A1 (en) * 2018-07-31 2021-08-26 Zeon Corporation Pre-filled syringe and method of producing pre-filled syringe
JPWO2021006057A1 (de) 2019-07-05 2021-01-14
CN114980851A (zh) * 2020-01-28 2022-08-30 日本瑞翁株式会社 预填充药剂包装和预填充药剂包装的制造方法
IL302317A (en) * 2020-10-28 2023-06-01 Dompe Farm Spa Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788319A (en) * 1971-07-30 1974-01-29 Univ Iowa State Res Found Inc System for exchanging blood ultrafiltrate
JPS54135215A (en) * 1978-04-10 1979-10-20 Ss Pharmaceutical Co Stable aqueous lisozyme solution
US4732889A (en) 1985-02-06 1988-03-22 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis
DE3777845D1 (de) 1986-01-22 1992-05-07 Chugai Pharmaceutical Co Ltd Pharmazeutischer stoff fuer die behandlung von myelogener leukaemie.
US4838861A (en) * 1986-05-02 1989-06-13 Sharp David E Blood preservation by ultrahemodilution
GR871067B (en) 1986-07-18 1987-11-19 Chugai Pharmaceutical Co Ltd Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor
JP2629000B2 (ja) * 1986-07-18 1997-07-09 中外製薬株式会社 安定な顆粒球コロニー刺激因子含有製剤
US4810249A (en) * 1987-03-12 1989-03-07 Habley Medical Technology Corp. Linear and Vernier-type syringe
DE3729863A1 (de) 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
US5728437A (en) 1987-08-26 1998-03-17 Astra Meditec Aktiebolag Articles exhibiting a blood-compatible surface layer and process for providing articles with such a surface layer
SE8703310D0 (sv) 1987-08-26 1987-08-26 Astra Meditec Ab Articles exhibiting a blood-compatible surface layer and process for providing articles with such a surface layer
ES2008948A6 (es) * 1988-01-07 1989-08-16 Martinez Gimeno Carlos Vicente Jeringa de un solo uso auto-inutilizable.
US5213814A (en) * 1989-04-10 1993-05-25 Cryopharm Corporation Lyophilized and reconstituted blood platelet compositions
JPH0669956B2 (ja) * 1988-09-30 1994-09-07 旭化成工業株式会社 ポリペプタイド類の吸着防止剤
JP3179538B2 (ja) * 1990-12-11 2001-06-25 ノバルティス アクチエンゲゼルシャフト 安定なヒトカルシトニンの水性溶液
ATE145661T1 (de) * 1991-07-22 1996-12-15 Daikyo Gomu Seiko Kk Behälter für hygienische artikel
US5571788A (en) 1991-12-09 1996-11-05 Ciba-Geigy Corporation Stable calcitonin pharmaceutical compositions
US6007520A (en) 1992-02-12 1999-12-28 Daikyo Gomu Seiko, Ltd. Medical instrument
ES2159516T5 (es) 1992-02-12 2005-05-01 Daikyo Gomu Seiko Ltd. Un instrumento medico.
JP3666884B2 (ja) * 1992-05-21 2005-06-29 日本ゼオン株式会社 医療用器材
US5468803A (en) * 1992-03-03 1995-11-21 Nippon Zeon Co. Ltd. Medical implement, polymer composition, and optical material
DE69332756T2 (de) * 1992-05-29 2004-02-19 University Of North Carolina At Chapel Hill Im immobilisierten zustand getrocknete pharmazeutische verträgliche menschliche blutplättchen
US5496718A (en) 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
JP3895782B2 (ja) * 1992-10-26 2007-03-22 生化学工業株式会社 コンドロイチナーゼ組成物およびそれを含有する注射用製剤
US5661125A (en) 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
NZ260909A (en) 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
JP2747979B2 (ja) * 1994-08-19 1998-05-06 雪印乳業株式会社 ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬
JPH08155007A (ja) * 1994-12-02 1996-06-18 Mitsui Petrochem Ind Ltd 薬剤充填容器製剤及びこれに用いる容器
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
BE1009403A3 (fr) 1995-06-02 1997-03-04 Solvay Composition souple a base de polymere de chlorure de vinyle, utilisation de cette composition pour la fabrication d'un article et article comprenant cette composition.
TW518219B (en) * 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
IL130433A0 (en) * 1996-12-23 2000-06-01 Novo Nordisk As A medicament container of polymer of linear olefin for storing a liquid medicament
JP3480672B2 (ja) * 1997-04-25 2003-12-22 稔 寺野 生体適合性ポリオレフィン成形品、及び生体適合性高分子材料
JP3387775B2 (ja) * 1997-05-22 2003-03-17 株式会社大協精工 注射器用密封栓及びプレフィルド注射器
JP3568398B2 (ja) * 1997-09-11 2004-09-22 中外製薬株式会社 アポトーシスを誘起するモノクローナル抗体
JP3103535B2 (ja) * 1998-05-29 2000-10-30 大洋薬品工業株式会社 カルシトニン類のプレフィルドシリンジ製剤
WO2000015241A1 (fr) 1998-09-11 2000-03-23 Chugai Seiyaku Kabushiki Kaisha Preparation d'une solution proteinique et son procede de stabilisation
EP1232753B1 (de) * 1999-09-08 2008-03-19 Chugai Seiyaku Kabushiki Kaisha Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben
JP5271481B2 (ja) * 1999-09-08 2013-08-21 中外製薬株式会社 タンパク質溶液製剤およびその安定化方法
JP5765281B2 (ja) * 2012-03-27 2015-08-19 株式会社Ｊｖｃケンウッド 復号装置、復号方法、及び、プログラム

Also Published As

Publication number Publication date
JP2011168610A (ja) 2011-09-01
JP2016056176A (ja) 2016-04-21
JP2014051502A (ja) 2014-03-20
JP6134370B2 (ja) 2017-05-24
AU6875900A (en) 2001-04-10
ATE389414T1 (de) 2008-04-15
JP5450508B2 (ja) 2014-03-26
EP1232753B1 (de) 2008-03-19
EP1232753A4 (de) 2004-08-11
JP6076226B2 (ja) 2017-02-08
DE60038386T2 (de) 2009-04-23
TWI245645B (en) 2005-12-21
EP1232753A1 (de) 2002-08-21
US7253142B1 (en) 2007-08-07
WO2001017542A1 (fr) 2001-03-15

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: WATANABE, YOSHIROU, TOKYO, JP

Inventor name: HIRAISHI, TAKAYA, TOKYO, JP

Inventor name: MITSUI, NAOKI, TOKYO, JP

Inventor name: SUZUKI, NOBUYUKI, TOKYO, JP

8364 No opposition during term of opposition